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Electrochemical C–N coupling of 5-hydroxymethylfurfural with methylamine offers a sustainable route to produce value-added amines. Here, the authors present a facet-controlled Ag catalyst that tunes the substrate adsorption geometry and hydrogenation propensity for promoted selectivity.

Van der Waals materials of the MB₂T₄ family (M = transition metal or rare-earth metal, B = Bi or Sb, T = Te, Se, or S) have attracted interest for their magnetic and topological properties, but their direct synthesis into 2D form remains challenging. Here the authors report a flux-assisted, phase-controlled growth strategy to directly grow six magnetic 2D MB₂T₄ crystals.

Molecular bilayer crystals of an organic semiconductor can exhibit metallic charge transport down to 8 K with an electrical conductivity of up to 245 S cm⁻¹, as well as charge carrier mobility values of more than 100 cm² V⁻¹ s⁻¹ at 20 K.

Experiments in mice and pigs revealed that l-theanine produced by Lactobacillus reuteri acts on host cells to increase the catabolism of branched-chain amino acids by stabilizing the expression of branched-chain amino acid transferases.

The bridging hydride species (Zn–H–Zn), commonly formed through H₂ dissociation on ZnO surfaces, are essential for hydrogenating unsaturated hydrocarbons. Here, the authors show that surface hydroxyls on ZnO nanorods can migrate to nearby oxygen vacancies and similarly generate reactive Zn–H–Zn species, which they identify by solid-state NMR spectroscopy as active in CO₂ hydrogenation to methanol.

Sustainable food production under climate change requires farming practices that support plant–soil–microbe interactions. This study suggests that conservation agriculture with warming enhances wheat nitrogen uptake by reducing microbial competition.

Electrocatalysis is a powerful tool in organic synthesis, but asymmetric strategies are still less developed. Now a cobalt/pyridoxal electrocatalytic system facilitates electrochemical single-electron transfer and asymmetric induction for the enantioselective generation of α-quaternary amino esters.

A new architecture based on high-valence sulfur/sulfur tetrachloride cathode chemistry is described for manufacturing high-voltage anode-free sodium–sulfur batteries, demonstrating promise for applications in grid energy storage and wearable electronics.

This study designs covalent organic frameworks with robust dipole moments, enabling efficient hydrogen and hydrogen peroxide production from pure water using mechanical vibration and light.

Endocytosis of TFR1 plays a crucial role in extracelluar iron uptake. Here the authors revealed that PKCβII facilitates the endocytosis of TFR1 and increases cellular iron levels through the phosphorylation of AAK1, thus promoting ferroptosis of tumor cells.

β-thalassemia mutations show striking population differences, but their evolutionary origins are unclear. Here, the authors trace multiple independent origins of common β-thalassemia mutations in southern China, shaped by agricultural expansion, migration, and local selection.

Foamy macrophages are key to atherosclerosis but poorly understood. Here, the authors show that GPNMB regulates lipoprotein processing in macrophages, exacerbating pathological lipid accumulation, and revealing it as a therapeutic target whose inhibition reduces atherosclerosis in mice.

The study provides a comprehensive inventory of global mining footprints, finding that mining causes higher deforestation than previously estimated, with half linked to unrecorded activities, and highlighting the underestimated environmental impacts.

Immunotherapy has improved patient outcomes in those with metastatic or recurrent head and neck squamous cell carcinoma (HNSCC) but less so in the neoadjuvant setting. Here, the authors report the efficacy, safety and exploratory biomarker analysis of a phase II clinical trial investigating neoadjuvant tislelizumab (anti-PD-1) and afatinib (EGFR TKI) in patients with locally advanced HNSCC.

Syntaxin-1A, a SNARE protein mediating membrane fusion for neurotransmission, forms clusters with unclear functions. Using light-controlled clustering, the authors found that phase-separation-driven clusters, regulated by Munc18, suppress fusion, revealing a new phase-separation-based mechanism.

Stem cells are highly resistant to viral infection, irrespective of any interferon response. Here the authors discover that VAMP5 as a potent cell-autonomous defense factor protects ESCs from various viruses’ infection, including SARS-CoV-2 by interacting with RNA replication complexes to defend against viral infection.

Allylic alcohols and ethers are key functional motifs widely found in various bioactive molecules, pharmaceuticals, and natural products. Here, the authors report the synthesis of (E)-allyl ethers from internal alkenes and alcohols or phenols via copper catalyzed selective allylic C–H oxidation.

This work presents a wide-FOV, high-spatiotemporal-resolution LiDAR with astigmatic metalens (AML) coordinated spectral-acousto-optic scanning. A frame-wise point acquisition rate of 36.6 MHz and a FOV of 102° are simultaneously achieved.

Immune checkpoint inhibitors have shown some activity in patients with adrenocortical carcinoma (ACC), a rare aggressive malignancy with limited treatment options. Here the authors report the results of a phase 2 trial of camrelizumab (anti-PD1) plus apatinib (VEGFR inhibitor) for previously treated ACC.

Wu et al. compiled a global database of essential infrastructures and assessed human accessibility to daily necessities and services (living, healthcare, education, entertainment, public transit, and working). Findings reveal uneven access in availability, per capita distribution, and travel time, emphasizing the need for optimized infrastructure planning and management.

Mechanoelectric energy conversion is a potential solution for the power supply of soft devices, but the low current output for low frequency motions limits its applicability. Here, the authors report a hydrogel generator with mechanoionic current generation amplified by orders of magnitudes and its application as controlled drug-releasing system for wound healing.

The combination of plasmon-mediated electron enrichment and a continuous-flow reactor overcomes key challenges in selective methane oxidation, achieving a methanol production rate of over 6.5 mmol·g-1·h-1 with the selectivity of 100% and sustained stability over 100 h under ambient pressure.

The transcription factor ATF6 causes an enrichment in long-chain fatty acids in the colonic epithelium, which leads to changes in the gut microbiota and contributes to the development of colorectal cancer in humans and mice, thereby linking endoplasmic reticulum stress responses to lipid metabolism and tumorigenesis.

This multi-omic longitudinal analysis of the healthy human peripheral immune system constructs the Human Immune Health Atlas and assembles data on immune cell composition and state changes with age, including responses to cytomegalovirus infection and influenza vaccination.

The oxidative intermolecular amination of C-H bonds represents a straightforward method to construct aliphatic allylic amines. However, the utilization of widely available internal alkenes remains a synthetic challenge. Here, the authors present a regioselective Cu-catalyzed oxidative allylic C-H amination of internal olefins with azodiformates.

Developing anti-gout medications that simultaneously reduce uric acid and exert anti-inflammatory effects is of interest for managing gout progression. Here, the authors employ a dual-target pharmacophore model to design derivatives of β-carboline-1-propionic acid and identify a drug candidate demonstrating potent uric acid-lowering activity in male hyperuricemia mouse models and mitigating NLRP3-mediated inflammation.

While the intrinsic strength of graphene has previously been demonstrated to be high, the fracture toughness remains unknown. Here, the authors perform in situtesting of graphene in a scanning electron microscope and report a critical stress intensity factor of ~4.0 MPa√m.

Boron-stereogenic and C–B axially chiral compounds featuring boron-based chirality represent a rarely explored class of chiral scaffolds. Here, the authors report an asymmetric access to boron-stereogenic and C–B axially chiral (hetero)cycles via rhodium-catalyzed C–H activation of (hetero)arenes en route to [4 + 2] or [3 + 2] annulation with two classes of boron-functionalized alkynes.

Osteoporosis was revealed to pyroptosis-related inflammation. Here, the authors show multifunctional microsphere can retard osteoporosis by restoring bone homeostasis thorough pyroptosis blockade and hydrogen-mediated modulation of inflammation.

Here the authors reveal that the prostate cancer risk variant rs4519489 enhances binding of the oncogenic transcription factor USF1, upregulating NOL10. Elevated NOL10 promotes tumor progression, highlighting the rs4519489–USF1–NOL10 axis as a potential biomarker and therapeutic target.

Here the authors analyzed 3.7 petavoxels of 3D imaging data from 204 mouse brains, aiming to comprehensively characterize diverse morphological and modular patterns conserved across six spatial scales of mouse brain anatomy, ranging from the whole-brain scale to synaptic levels.

Single-photon dual-comb ghost imaging spectroscopy was first proposed, achieving high-speed and high-resolution spectral analysis in photon-scarce scenarios and demonstrating applications in fingerprint spectral detection and ultra-long-distance fiber sensing.

The characterization of the surface structure and binding sites of materials is crucial for designing advanced materials for adsorption processes. Here, the authors use ¹⁷O solid-state nuclear magnetic resonance spectroscopy to identify specific CO₂ adsorption sites on MgO nanosheets.

Infection with SARS-CoV-2 causes interstitial pneumonia and viral replication in the lungs of transgenic mice that express a human version of ACE2, confirming the pathogenicity of the virus in this model.

Although ammonia synthesis represents a major chemical industry, developing highly effective non-iron catalysts is a challenging task. Now it has been shown that anchoring fullerene onto non-iron transition metals separates and activates catalytic sites for hydrogen and nitrogen intermediates, boosting ammonia synthesis rates.

A sampling-based manifold learning method is proposed to study the cluster structure of high-dimensional data. Its applicability and scalability have been verified in single-cell data analysis and anomaly detection in electrocardiogram signals.

This Resource provides a multi-omic tissue atlas of aging in nonhuman primates.

A method for acetylome profiling requiring a low quantity of hematopoietic stem cells (HSCs) was developed, revealing a significant reduction in H4K77ac in aged HSCs, associated with decreased lymphocyte differentiation potential.

PLD4 loss-of-function mutations in patients with systemic lupus erythematosus leads to excessive activation of TLR7 and TLR9.