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This study applies generalized linear mixed models (GLMM) and advanced transcriptome wide association study (TWAS) methods to improve the discovery of colorectal cancer risk transcription factors and genes, including potential druggable targets.

The existence of a long-lived, prethermal regime in many-body systems with tunable heating rates, driven by structured random protocols, is observed using a 78-qubit superconducting quantum processor.

A skeletal editing strategy for the direct conversion of oxazoles and isoxazoles into thiazoles and isothiazoles is described. These one-step transformations may be beneficial for drug development programmes by enabling rapid diversification of bioactive compounds and advancing structure–activity relationship studies.

Stone tools illustrate behavioural complexities in Middle Pleistocene hominin populations. Here, the authors present small dimensional flakes and hafted tools from Xigou, central China, dated to ~160–72 thousand years ago that demonstrate early, complex technological advancements.

Understanding the genetic factors that regulate panicle architecture is important for improving rice yields. In this study, Li et al. demonstrate that the gene PTB1is critical for regulating panicle seed setting rate and pollen tube growth.

Urban redevelopment is a key government policy and planning strategy to address various urban challenges. This study investigates where, how and to what extent China’s city hierarchy influences redevelopment activities within China’s rapidly evolving urban landscape.

Monocytes/macrophages exert pro-atherogenic functions depending on their metabolic programming. Here, the authors show the pivotal role of methionine metabolism in the proinflammatory and migratory functions of monocytes/macrophages and identify MAT2A as a potential target for the management of atherosclerosis.

A library preparation method using anchored random reverse primer sequencing for quantitative analysis of novel gene fusions from low-input samples.

The bridging hydride species (Zn–H–Zn), commonly formed through H₂ dissociation on ZnO surfaces, are essential for hydrogenating unsaturated hydrocarbons. Here, the authors show that surface hydroxyls on ZnO nanorods can migrate to nearby oxygen vacancies and similarly generate reactive Zn–H–Zn species, which they identify by solid-state NMR spectroscopy as active in CO₂ hydrogenation to methanol.

The authors conducted a genome-wide association study of bipolar disorder (BD) in Han Chinese and integrated PGC4 East Asian and European datasets, discovering 23 novel loci, prioritizing 39 credible risk genes and implicating BD-related cell types and druggable targets.

Ga₂O₃ devices suffer from poor heat dissipation due to their low thermal conductivity. Here, the authors demonstrate that forming covalent bonds with SiC increases the interfacial thermal conductivity to 162 MW/m²·K, thereby reducing self-heating and enabling reliable high-power operation.

Thorough genetic analyses by four laboratories reinforce the central role of the protein kinase BIK1 in plant immunity. Other unrelated functions proposed for BIK1, however, are associated with genome rearrangement in a single transfer DNA mutant.

Maintaining facial warmth and humidity while ensuring adequate oxygen intake in cold environments is challenging for facial masks. Here, the authors design a MetaMask that recovers heat and moisture from exhaled air to warm inhaled air to 26.2 °C in a − 20 °C environment, while maintaining sufficient oxygen levels.

Regulation of the electronic structure in aromatic systems has a significant influence on their chemical reactivity. Here, the authors employ single-molecule junctions to precisely tune the position of a hydrogen atom through the electric field.

Activation of genes depends on transcription factors and chromatin remodelers. Here, the authors show ARID1A organizes these components through phase separation, co-condensing with specific transcription factors to maintain chromatin accessibility and drive gene expression.

The Taiwan Precision Medicine Initiative (TPMI) has built a cohort of more than half a million individuals with Han Chinese ancestry, providing a rich resource of genetic and medical data for this group.

Wastewater-based surveillance tends to focus on specific pathogens. Here, the authors mapped the wastewater virome from 62 cities worldwide to identify over 2,500 viruses, revealing city-specific virome fingerprints and showing that wastewater metagenomics enables early detection of emerging viruses.

A genome-wide CRISPR knockout screen reveals UHRF1 restricts HCoV-229E by epigenetically silencing its receptor, APN. As UHRF1 declines with age, APN expression rises, enhancing viral susceptibility in macrophages from elderly individuals.

Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

This work introduces a high FA⁺ configurational entropy strategy by adding 2NTD, tuning FA⁺ rotation dynamics and stabilizing photoactive phases to yield efficient, stable inverted perovskite devices with scalable potential.

Antimicrobial resistance genes that have been mobilized between bacterial species represent a subset of the naturally occurring resistome. Here, the authors compare the abundance, diversity and geographical patterns of acquired resistance genes with latent resistance genes in global sewage metagenomes.

Chronic pain severity is influenced by genetics and brain structure, but mechanisms remain unclear. Here, the authors identify genetic loci linked to pain intensity and show that specific brain imaging traits mediate and causally influence chronic pain.

Extracting rare earth elements (REEs) from wastewater is essential for the growth of an eco-friendly sustainable economy but separating individual rare earth elements remains challenging. Here, the authors report a REE nanotrap that features dense uncoordinated carboxyl groups and triazole N atoms in a two-fold interpenetrated metalorganic framework which is highly responsive to the size variation of rareearth ions.

Monolithic Sn-Pb perovskite NIR imager with Sn(SCN)₂ passivation achieves low dark current, high detectivity and material recognition for advanced sensing and imaging.

This study explores the genomic and transcriptomic landscapes of triple-negative breast cancer in African American women. The authors show that the mutational profile is broadly similar to that observed in European and East Asian ancestry women while highlighting some interesting differences.

Intrinsic anomalous Hall effect has been observed in twisted graphene multilayers, but these structures are typically not energetically favorable. This study extends these observations to Bernal-stacked tetralayer graphene, which is the most stable configuration of four-layer graphene.

The emission of entangled photon pairs from layered materials is attractive for quantum applications, but its observation in monolayers has remained elusive. Here, the authors report co- and counter-propagating photon pair emission in the telecom range from monolayer GaSe and the observation of high-fidelity Bell states in the counterpropagating configuration.

Atroposelective synthesis of C–N axially chiral anilides typically requires preformed aromatic ring systems. Now, a cobalt-catalysed atroposelective C–H activation and annulation method to construct isoquinolinones from benzamides, with C–N axially chirality, is reported. Using a chiral salicyl-oxazoline ligand and O₂ as an oxidant, the method yields isoquinolines in excellent yields and enantioselectivities.

Here, the authors investigate the Raman spectra of few-layered WS₂ when the excitation energy is in resonance with the dark exciton, and observe a Fano resonance between dark excitonsand zone-edge acoustic phonons.

Proton transfer plays a key role in fuel-producing reactions, but directly monitoring these processes in heterogeneous electrocatalysts is challenging. Now it has been shown that shifts in the Tafel slope in protic versus deuteric electrolytes can elucidate the rate-determining step during water splitting and reveal pH- and structure-dependent proton transfer behaviours.

Here, the authors integrate genomic and transcriptomic data obtained from African-ancestry female participants and identify six genes associated with breast cancer risk which provides biological insights into this common cancer in an underrepresented population.

A combination of adenovirus-vectored and subunit protein intranasal vaccine enhances immune response against SARS-CoV-2 variants in animal models and humans.

The authors demonstrate that the response of the flexural vibrations of twisted bilayer graphene can be hysteretic depending on the angle between the lattices of the layers, finding that the quality factors of the vibrations are enhanced compared to untwisted bilayers.

Here, the authors demonstrate a re-programmable metasurface that can produce arbitrary holographic images for optical encryption. The encrypted information is divided into two matrices and defined to the incident laser to produce arbitrary holographic images.