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The maternal effector NLRP14 regulates two E3 ubiquitin ligases via distinct mechanisms to prevent excessive ubiquitination and maintain protein homeostasis during the oocyte-to-embryo transition, thereby supporting successful early embryonic development.

IgG bivalency enhances neutralization against enveloped viruses, but its on-virion structural details remain unclear. Here, authors use cryo-ET to reveal that two anti-RBD IgGs, P17 and S309, form diverse S-IgG bivalent binding modes, distinct higher-order assemblies, and inter-virion cross-linking on SARS-CoV-2 S protein.

The authors develop a Physical-Knowledge-Undergirded Transfer Learning (PKU-TL) approach to overcome data scarcity in polymer design. The method enables the design of high-performance, low-voltage electrochemical transistors.

Here, in mouse models of GMPPB dystroglycanopathy, the authors show that impaired glycosylation disrupts muscle integrity and triggers broader cellular stress. They identify actionable pathways that improve muscle function, suggesting therapeutic strategies.

Elucidation of fundamental pancreatic-targeted mechanisms enables the development of lipid nanoparticles for the precise delivery of nucleic acid therapeutics to the pancreas, highlighting their promising potential in the treatment of pancreatic diseases.

Pancreatic ductal adenocarcinoma carries a poor prognosis, with pancreatectomy as the only potentially curative option. This Phase II trial assessed distant metastasis-free survival in locally advanced disease using GVAX vaccine, pembrolizumab, and SBRT following chemotherapy.

The switching behavior of oxide-based memristors is governed by uncontrolled formation and rupture of conductive filaments. Here Li et al. report a device with ultrathin elemental oxygen reservoir layer to regulate the random migration of oxygen vacancy, enabling switching speed of ~10 ns and high energy efficiency.

Single-cell transcriptome profiling has been reported for human thymi, but high-resolution spatial information is still lacking. Here the authors use Stereo-seq to report spatial transcriptomic and proteomic information from human fetal and pediatric thymi to provide a useful resource, and to define transcription factor networks regulating rare thymic cell types.

This paper reports the mechanism by which phytochrome B integrates JA and warm temperature signals in regulating chloroplast development through the HY5-MYCs transcriptional regulatory network.

Here the authors identify a tumor immunoevasion mechanism in which tumor cells release branched-chain amino acid metabolites that can bind and activate Notch on tumor-associated macrophages, reprogramming these cells to be immunosuppressive.

Self-assembled hole-selective molecules can enable high performance in perovskite solar cells, but controlling the hole extraction efficiency is challenging. Tianyu Li et al. address this by designing molecules that adopt a quasi-random orientation on the substrate.

Chen et al. engineer TRANSFER (trogocytosis-inspired receptor transfer and functional effector release), a method to deliver functional cargos from donor to recipient cells in a specific manner via direct cell–cell contact.

Chiral quantum optics is a prerequisite for communication protocols in quantum networks, but current methods are limited to the single-photon regime. The authors demonstrate that multiple giant emitters coupled to a nonlinear waveguide enable tunable multiphoton directional emission via interference, establishing a configurable building block for multiphoton cascaded quantum networks.

Sulcal morphometric remodeling during childhood and adolescence, characterized by cortical thinning and widening, predicts cognitive gains in working memory and attention, with gene enrichment linking these changes to synaptic processes.

Dynamic multi-omics profiling reveals coordinated immune, epithelial and microbiome reprogramming in the gut during sepsis progression.

Traditional iterative catalysis in RiPP biosynthesis typically modifies linear peptides. Here the authors discover GNAT enzymes that iteratively modify fully folded lasso peptides and engineer them to create lipolasso peptides with expanded chemical diversity.

In mice, a circuit between the spinal cord and various regions of the brain, centring on spinal-cord-projecting neurons in the rostral ventromedial medulla, has a key role in driving chronic pain.

An in situ computational spectrometer, implemented on a fully integrated 576-Kb memristor chip, can reconstruct a single spectrum in 125.0 ns and consumes only 6.7 nJ of energy, achieving software-equivalent accuracy.

Zhang, Han, Tan, Lu, Ma et al. report that kynurenine derived from peritumoural adipose tissue is hijacked by cancer cells to mediate ferroptosis resistance, a process that could potentially be targeted with immunotherapy to inhibit tumour growth.

Urban parks enhance microbial functionality but reduce genomic diversity compared with forests due to nutrient enrichment and pH changes. Urbanization drives short-term functional gains at the cost of long-term evolutionary flexibility.

Determining structures of small proteins ( < 50 kDa) is a major challenge in cryo-EM. Here, authors introduce Trimbody, a simple AI-designed rigid scaffold that enables atomic-resolution structures of diverse proteins, including membrane targets

Bioresorbable piezoelectric materials are key for bioelectronic–tissue integration but remain challenging to realize. Here, the authors develop flexible Rochelle salt/PLLA nanofibers that enable effective nerve regeneration and wireless monitoring of intestinal motility.

The susceptibility of mouse and human T cells to ferroptosis is determined by the balance of systemic polyunsaturated and monounsaturated fatty acids, highlighting a key role for lipid metabolism and dietary composition in regulating T cell function.

Imprinting by influenza viruses can cause a deleterious shift of nearly the entire memory recall response against key, conserved epitopes.

Here, Li, Lu, Xia and colleagues identify the maternal complex MPU (PADI6–UHRF1–UBE2D), determine its cryo-electron microscopy structure and show that PADI6 maintains oocyte proteostasis by sequestering UBE2D with the assistance of UHRF1, thereby inhibiting protein ubiquitination. The study, thus, provides a molecular mechanism underlying PADI6-associated female infertility.

Hong-Xuan Lin, Ji-Ping Gao, Jun-Xiang Shan and colleagues show that natural variation in a proteasome α2 subunit gene contributes to thermotolerance in African rice. Their follow-up studies suggest that the variant allele protects cells from heat stress by enhancing the elimination of cytotoxic denatured proteins and maintaining heat-response processes.

The fluorescence-based protein assembly platform GEMINI is able to record the history of individual cells by leveraging a computationally designed protein assembly as an intracellular memory device.

Copper nanoclusters are promising photothermal heaters, but their conversion efficiency is limited efficiency. Here, the authors present a rotor-stator ligand architecture that enables enhanced photothermal conversion efficiency of copper nanoclusters.

Bacterial phosphate transporter PstSCAB is essential for survival and virulence. Here, authors reveal cryo-EM structures of PstSCAB in multiple states, uncovering how conformational changes drive phosphate import and providing insights for antibiotic development.

Axially chiral arylpyrroles hold significant promise in catalysis, medicinal chemistry and materials science. Here, the authors report a copper-catalyzed dynamic kinetic asymmetric (4 + 1) cyclization enabling atroposelective synthesis of arylpyrroles with single stereogenic axes or 1,2-diaxes from 1,3- enynes and amines.

Wan, Li, Cao and colleagues report a feedback crosstalk between THY1⁺ cancer stem cells and neutrophils via migrasome-mediated release of mitochondria, which induces a pseudohypoxic state and promotes metastasis.

This work demonstrates superadiabatic topological pumping on photonic chips, achieving a 20-fold device miniaturization and high-efficiency operation across a 650–920 nm bandwidth, paving the way for ultracompact integrated photonic transports.

The inter-system crossing induced by selenium may undesirably enhance formation of triplet excitons in non-fullerene acceptors, leading to increased non-radiative losses. Here, the authors introduce achiral N-alkyl substituents, achieving maximum efficiency of 20.4% for ternary organic solar cells.

Researchers report a solid that is amorphous in two dimensions but crystalline in the third, made of stacked disordered atomic layers. This shows that crystalline and amorphous order can coexist within a single material depending on direction.

Selective functionalization of polyfluoroalkyl compounds is vital for advancing pharmaceuticals, agrochemicals, and high-performance materials but is hindered by the stability of C(sp³)–F bonds. Here, the authors report a dual photoredox/cobalt catalytic strategy enabling redox-driven defluoroallylation of perfluoroalkylarenes and polyfluorinated aliphatic amides.

In this Review, Zhu et al. outline the various CRISPR-based tools recently built for dynamic DNA and RNA imaging, which have provided insights into various molecular mechanisms. The authors also discuss the important parameters to consider when using these tools, and how to approach the quantitative image analysis.

Colorectal cancer has high recurrence and metastasis rates making treatment difficult. Here, the authors report on peptide modified cell membrane coated cobalt based metal-organic frameworks which degrades and forms, in situ, photothermal materials with H₂S, allowing for immune-photothermal therapy.

Eye tracking relies on ocular features, that are susceptible to interference from light and individual variations. Here, Zhu et. al. present eye movement feature enhanced cosmetic contact lenses, enabling accurate, natural, and homogenized eye tracking.

Transition metal dichalcogenide nanotubes possess symmetry-breaking properties promising for fundamental physics research. Here, the authors report a direct synthesis of crystalline MoS₂ nanotubes exhibiting strong polarization and bulk photovoltaic effects.

The scaffold protein AXIN can promote the formation of two opposing complexes: the Wnt signalosome and a degradation complex that inhibits Wnt. Here, the authors show that mechanical compression and the presence/absence of Wnt ligand are inputs in a circuit that acts as a logic gate to control which complex is formed.

Constructing two-dimensional (2D) polymers with complex tessellation patterns is important for the fabrication of advanced materials but achieving such complexity is a great challenge. Here the authors report a tessellated 2D covalent organic framework with increased structural complexity as well as different pore structures.

In mitochondria transplantation, the limited activity and yield of mitochondria constrain their clinical application for mitochondrial diseases. Here, authors develop a method for producing mitochondria-enriched extracellular vesicles, which offer high-quality, abundant mitochondrial material for transplantation.

Visualizing mechanical stress distribution in soft and live biomaterials is key to understand biological processes and improve material design. Here, the authors design a biosensor to visualize the stress distribution in soft biomaterials and living tissues.

Arctic sea ice loss is reshaping the ocean’s carbon pump. Satellite data show an early boost, then stagnation, while models warn of future weakening under ice-free conditions, threatening carbon storage and ecosystems.