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This study presents an HDB (horizontal diagonal band) – mPFC (medial prefrontal cortex) – thalamus circuit and the cholinergic signaling in mPFC Foxp2⁺ neurons in modulating sensory and affective pain in male mice.

Newly emerging SARS-CoV-2 variants underscore the need for broad-spectrum antiviral solutions. This study shows a macrocyclic peptide inhibitor that locks the SARS-CoV-2 spike trimer into a “closed” conformation by engaging a conserved region, and demonstrates that intranasal administration of the peptide inhibitor protects against Omicron variants.

B7H3 is an immune checkpoint overexpressed in many cancers and associated with tumor immune evasion. Here, the authors discover that in colorectal cancer, particularly microsatellite-stable tumors, palmitic acid promotes ZDHHC24- mediated B7H3 palmitoylation, regulating CD8⁺ T cell antitumor activity.

NIID is a neurodegenerative disease caused by GGC repeat expansions within NOTCH2NLC gene. Here, authors develop a precise gene-editing therapy that effectively treats the disease in multiple models.

Sealing of puncture points after interventional surgeries is a vital requirement, but large diameter sheaths and transapical punctures present a significant challenge for wound closure. Here, the authors present a water-activated tissue adhesive patch designed for quick and strong adhesion to blood vessel and heart tissue surfaces after surgery.

The scaffold protein AXIN can promote the formation of two opposing complexes: the Wnt signalosome and a degradation complex that inhibits Wnt. Here, the authors show that mechanical compression and the presence/absence of Wnt ligand are inputs in a circuit that acts as a logic gate to control which complex is formed.

Spin transport properties of magnetically ordered materials have been well studied. Here, the authors report an anomalous spin signal exhibiting spin transport over 480 microns in the frustrated hyperkagome magnetic insulator Gd₃Ga₅O₁₂.

Defect formation and phase instability remain critical challenges for perovskite/organic tandem solar cells. Jiang et al. address this by designing an additive to modulate the crystallization thermodynamics of wide-bandgap perovskite, achieving a record efficiency of 22.1% in a flexible cell.

Mechanistic modeling of the MAT2A–SRF–PARN axis reveals a SAM-independent pathway that stabilizes SRF, drives glycolysis through PI3K/AKT activation, and promotes osteosarcoma progression, highlighting MAT2A as a therapeutic target.

Low glume coverage is the preferred for easy threshing in grain production, but the genetic basis remains unclear. Here, the authors report the gene GC1, which encodes an atypical G protein γ subunit, negatively regulates sorghum glume coverage and the naturally truncated alleles can be useful in the naked grain breeding.

Wastewater treatment plants harbour extensive but poorly characterized microbial genetic diversity. Using 828 metagenomes from wastewater treatement plants globally, this study reconstructs >24,000 metagenome-assembled genomes, including >12,000 new species, providing a genome-resolved framework for understanding and engineering activated sludge functions.

A soft, biodegradable, wireless sensing device can monitor pressure, temperature and strain over long distances (up to 16 cm), maintaining accuracy across varying positions and angles.

Plants utilize anion channels to adapt to environmental stresses. Here, authors elucidate the coordinated regulatory mechanisms within the SLAH family and demonstrate that tRNA molecules directly bind to and inhibit the SLAH1 anion channel.

While phytoplankton are well studied and understood at the global scale, floating macroalgae are not. This study presents a comprehensive picture of the global distributions of floating macroalgae and phytoplankton surface scums, both showing expanding trends from 2003 to 2022.

The regulatory roles of structural variations (SVs) in transcriptional networks and agronomic traits of tea plants are largely unexplored. Here, the authors assemble the pangnome from 22 representative tea accessions and their wild relative and reveal SVs driving gene expression alteration and agronomic traits diversification.

Single-cell multi-omics analysis reveals the transcriptional signatures of dermal papilla cells in yak hair follicles, providing insights into adaptation of yaks to cold climates.

The study finds that seasonal marsquake patterns may indicate active near-surface brines on Mars today. By connecting seismicity changes to ice-to-brine melting, it infers that shallow liquid water continues to operate beneath the surface and influence Martian fault activity.

Colorectal cancer has high recurrence and metastasis rates making treatment difficult. Here, the authors report on peptide modified cell membrane coated cobalt based metal-organic frameworks which degrades and forms, in situ, photothermal materials with H₂S, allowing for immune-photothermal therapy.

The mitochondrial membranes present a formidable barrier to the delivery of exogenous genes. Here, the authors report on the development of fluorinated lipid nanoparticles to efficiently introduce therapeutic genes into mitochondria, for the correction of mitochondrial genomic defects.

Population genomics has primarily focused on sequence polymorphisms rather than gene expression diversity. Here, the conduct RNA-seq for 328 common wheat lines to investigate the role of gene expression variation in shaping agronomic traits and their contributions to modern wheat improvement.

In mitochondria transplantation, the limited activity and yield of mitochondria constrain their clinical application for mitochondrial diseases. Here, authors develop a method for producing mitochondria-enriched extracellular vesicles, which offer high-quality, abundant mitochondrial material for transplantation.

Piezoionic materials are integrated into sensors, though many piezoionic materials have unfavorable mechanical properties. Here the authors report a piezoionic eutectogel, optimizing mechanical properties and piezoionic response.

Coherence is widely seen as essential for quantum source quality. Here, authors demonstrate on-chip photon states with increased brightness and purity using incoherent light. It reveals the mechanism of pump coherence and lowers the barrier for the generation of high-quality quantum states.

PCBP2 is elevated in AD and forms condensates that sequester mitochondrial proteins and RBPs, disrupting mitochondrial function and the NMD of BACE1 mRNA, alongside amyloid deposition. The small molecule, CN-0928 mitigates AD pathology by inhibiting PCBP2 condensation.

Current CO₂ utilization relies on high-purity CO₂, requiring energy-intensive capture and purification. This study developed a solar-powered heterojunction catalytic system that directly converts atmospheric CO₂ with ammonia into urea.

Genomic, transcriptomic and metabolomic analyses from a population of 295 diverse sweet-corn inbred lines provide insights into kernel quality formation mechanisms and the divergence of sweet corn and field corn.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

It is essential to test the neutralization of approved vaccines against SARSCoV-2 Omicron sublineages. Kurhade et al. find that sera from people with three doses of BNT162b2 neutralize Omicron BA.1, BA.2, and BA.3 to a lesser extent than the original strain USAWA1/2020.

vdW assembly of low-dimensional materials has proven the capability of creating structures with on-demand properties. Here, the authors report on the structural collapse of CNTs in conjunction with a metal-semiconductor junction induced by the VdW encapsulation.

Dong and colleagues describe how T_FH cells initially interact with dendritic cells in colonic lymphoid follicles and further differentiate into long-lived pathogenic T_H1 cells, promoting the progression of colitis.

The RNA-binding protein SAIR1 forms phosphorylation-regulated condensates in guard cells, which link PAMP–MPK3/6 signalling to stomatal immunity. This finding reveals how biomolecular condensates regulate spatially specific immune responses in plants.

Tools for precisely manipulating phase-separated condensates remain limited. Here authors present an engineered system based on the androgen receptor, where clinically used drugs can be used to control the formation and dissolution of synthetic condensates, subsequently allowing control over various cellular processes.

Multiplexed DNA imaging uncovers promoter−enhancer interaction dynamics and effects of epigenetic modifications.

An operando method combining stopped-flow technique and rapid-scan infrared spectroscopy has been developed to monitor, in real time, the lifetime of Fe-oxo species formed during heterogeneous Fenton-like reactions.

This work presents MAPIT-seq, an antibody-guided RNA editing method that enables co-profiling of RBP-RNA interactions and gene expression at single-cell resolution and in tissue contexts.