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Treatment failure exists in Induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) patients. Here this group reports a phase 2 randomized trial evaluating the efficacy and safety of adding nimotuzumab, to CCRT on 246 patients with untreated, non-keratinising, stage II–IVA LA-NPC.

Li et al. identify small spherical vesicles budding from plant multivesicular bodies as likely retrograde carriers and demonstrate that SNX proteins drive their formation, revealing a distinct mechanism for protein recycling during plant development.

This study demonstrates a sustainable strategy to co-upcycle spent lithium-ion batteries and plastic waste into carbon nanotube composites with microwave absorption, enabling efficient metal recovery while reducing environmental and carbon impacts.

‘Desalination of hypersaline waters is challenging for conventional methods. Here, authors enhance MOF-801 membranes by regulating missing linkers, improving water transport and achieving high salt rejection, offering an efficient solution for water purification.’

A short peptide derived from a commensal-fungal-secreted protein promotes repair in models of colon epithelial damage when delivered directly or via probiotic microbes.

Yang et al. compare neoadjuvant triple therapy versus direct hepatectomy in patients with resectable intermediate or advanced hepatocellular carcinoma. The findings indicate that the neoadjuvant regimen improves overall and event-free survival but is associated with a higher risk of serious adverse events and postoperative complications.

Pseudouridine is prevalent modification in cellular RNA. Here, the authors show that the PUS7-mediated pseudouridylation of 7SK RNA regulates Pol II elongation and affects colorectal cancer cell survival and response to 5-FU treatment.

P-(H)-m@EMLN mRNA nanovaccine for hepatocellular cancer immunotherapy was developed using hydrogen bonding between poly T-PLGA polymer and the poly(A) tail of GPC3 mRNA followed by an endoplasmic reticulum membrane coating.

The performance of 2D photodetectors in the near-infrared range is usually constrained by fundamental limits. Here, the authors report hybrid photodetectors based on 2D MoS₂/WSe₂ heterostructures integrated with plasmonic metasurfaces, exploiting anapole states to enhance the responsivity and improve their chiral discrimination ratio in the telecommunication range.

A global synthesis of >600 studies finds that across agro-ecosystems, grasslands and forests in temperate and tropical zones, increasing plant diversity has a consistently positive effect on plant performance and the suppression of antagonists.

Thymine DNA glycosylase (TDG) was identified as a synthetic-lethal target in p53-deficient cancers through alterations in double-stranded RNA accumulation. A covalent small-molecule inhibitor of TDG exhibited potent efficacy against p53-deficient tumors.

This study identifies shared genetic mechanisms between gestational diabetes mellitus (GDM) and type 2 diabetes (T2D), highlighting 5 genes linked to GDM and 97 genes associated with T2D. Four genes (COBLL1, NRBP1, IFT172, TRIM54) are shared, offering potential targets for treatment.

Due to the complexity of controlling factors and the diversity of reaction components, accurately delineating the bond formation mechanisms for copper-catalyzed radical transformations poses a challenge. Here, the authors reveal the linear free energy relationships for the C–C bond formation of Cu-catalyzed radical transformations.

Decadal changes in land surface wind speed are well known, but their ecosystem impacts remain unclear. This study suggests that wind speed changes significantly affect vegetation productivity by altering water availability and stomatal conductance.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Aberrant activation of Wnt/β-catenin signaling contributes to colorectal cancer (CRC) pathogenesis. Here the authors find that the cytoplasmic distribution of TRIM24 E3 ubiquitin ligase triggers ubiquitination and degradation of von Hippel-Lindau, resulting in the accumulation of β-catenin protein in CRC cells.

The understanding of the vector order parameter for Cu_0.3Bi₂Se₃ topological superconductor remains unclear. Here, Kawai et al. report a surprising disappearance of the in-plane upper critical field anisotropy for Cu_xBi₂Se₃ single crystals with more carriers, indicating a transition from nematic to chiral superconducting gap symmetry.

Here the authors report that genetic or pharmacological inhibition of phosphoglycerate kinase 1, an enzyme involved in glycolysis, attenuates acute kidney injury in mouse models of acute kidney injury via inhibition of ferroptosis.

The methyltransferase OsPRMT6b is found to act as an ABA responsive factor to finely turn down ABA signaling via methylation of ABA receptor, thus facilitating growth recovery as high-temperature stress subsides.

Here the authors report a phase 3 clinical trial showing that Ecnoglutide, designed as a cAMP-biased GLP-1R agonist, improved glycaemic control versus placebo in adults with type 2 diabetes inadequately controlled with diet and exercise alone or with a single oral hypoglycaemic agent.

The construction of dynamic protein–DNA nano-assemblies suitable for modulating protein proximities and activities has now been demonstrated. This approach uses DNA strand displacement and can enable control of enzyme activity to be programmed using logic gates. As a demonstration, a split enzyme capable of activating a prodrug is triggered is by cancer-specific miRNAs.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

Poly(vinylidene fluoride) typically exhibits a negligible electrocaloric effect, while the derived ferroelectric terpolymers are expensive and have a narrow temperature window. Here, the authors report that poly(vinylidene fluoride) films prepared by solid-phase pressure forming show a giant electrocaloric effect over a wide temperature window.

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

The ability to form complex molecular architectures from simpler precursors is important for drug discovery and medicinal chemistry. Here, the authors report a cascade reaction giving access to tricyclic products and apply it in the total synthesis of two natural products.

In this work, the authors build on the high-resolution structural characterization of the tubulin-binding site and show that the microtubule inhibitor KY216 blocks NSCLC metastasis by prompting α-tubulin detyrosination and inhibiting the miR429/VASH2/ZEB1 axis.

R. Khasanov et al. report thermodynamic and muon-spin-rotation measurements on the Mo₅Si_3−xP_x superconducting family. They find that a flat band reaches the Fermi level at x ≃ 1.3, leading to enhancement of electronic correlations and an abrupt change of the superconducting properties.

Though metamaterials enhance nonlinear light-matter interactions due to their resonant features, these materials typically show a narrow spectral bandwidth. Here, the authors report broadband enhanced second-harmonic generation in patterned multilayer hyperbolic metamaterial arrays.

Atropisomers with a chiral C-N axis are useful for natural products synthesis and as ligands in asymmetric catalysis. Here, the authors reportt a π-π interaction and dual H-bond concerted control strategy in enantioselective C-H amination affording configurationally stable N-C atropisomers.

(‒)-Morphine is an essential medicine selected by the World Health Organization, however its catalytic asymmetric syntheses have been rarely reported. Here, the authors developed an intramolecular enantioselective Michael addition leading to (‒)-morphine in a longest linear sequence of 16 steps.

Clear cell renal cell carcinoma (ccRCC) usually metastasizes to the lungs. Here, the authors discover that SWI/SNF ATPase subunit SMARCA4 silencing of HLF regulates ccRCC lung metastasis by modulating the integration of collagen's mechanical cues with the actin cytoskeleton through leupaxin.

A cross-ancestry GWAS meta-analyses of brainstem structures identify 713 associations. It reveals shared/distinct genetic architectures across ancestries/substructures and overlaps with neuropsychiatric disorders and physiological functions.

The phytohormone abscisic acid (ABA) regulates a variety of physiological processes in plants. A molecule involved in chlorophyll biosynthesis, the H-subunit of Mg-chelatase functions as an ABA receptor. This interaction controls seed germination and stomatal movement.

Germano-silicate used as a building material for integrated photonics circuits substantially reduces optical losses, approaching levels comparable to those in optical fibres.

This study elucidates the underlying cell death mechanism of NECSO (Necrosis by sodium overload). TRPM4-mediated sodium influx activates mitochondrial sodium–calcium exchange, which impairs mitochondrial energy production. This energy deficit inactivates the Na/K-ATPase, ultimately leading to cellular swelling and lysis.