Nature Search

Naturally Occurring Alpha-Activity of Drinking Waters

R. C. TURNER
J. M. RADLEY
W. V. MAYNEORD
Research04 Feb 1961
Nature

Volume: 189, P: 348-352
Microseisms at Scott Base

T. HATHERTON
R. H. ORR
Research20 Jun 1959
Nature

Volume: 183, P: 1760-1761
De novo variants in the splicing factor gene SF3B1 are associated with neurodevelopmental disorders

This study reports that de novo germline missense variants in SF3B1, distinct from the somatic variants frequently observed in cancer, cause a neurodevelopmental disorder and disrupt global RNA splicing.

Kevin Uguen
Tiffany Bergot
Delphine G. Bernard
ResearchOpen Access23 Jan 2026
Nature Communications

P: 1-17
Nature of the Lepidopteron Sensing Mechanism: Possible Photochemical Response

W. C. LEVENGOOD
I. I. ELDUMIATI
R. FREELING
Research23 Feb 1973
Nature

Volume: 241, P: 545-547
Nature of the Variation in Flower Colour in Vicia

R. C. PECKET
Research25 Mar 1967
Nature

Volume: 213, P: 1240-1241
Nature of the Transition in Carbon Tetrabromide

J. G. MARSHALL
K. R. HART
L. A. K. STAVELEY
Research22 Sept 1951
Nature

Volume: 168, P: 519-520
The size and shape of Jupiter

Juno radio occultations precisely redefine Jupiter’s shape, measuring a polar diameter of 66,842 km and an equatorial diameter of 71,488 km, both smaller than long-used values, bringing models of the planet’s interior into better agreement with observations.

Eli Galanti
Maria Smirnova
Yohai Kaspi
Research02 Feb 2026
Nature Astronomy

P: 1-9
Follow-up usage of the Scott-Craig Orthosis in paraplegia

William E O'Daniel
Harry R Hahn
Research01 Dec 1981
Spinal Cord

Volume: 19, P: 373-378
Natural selection of hemi- and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria

C. Ruwende
S. C. Khoo
A. V. S. Hill
Research20 Jul 1995
Nature

Volume: 376, P: 246-249
Fecal microbiota transplantation plus immunotherapy in non-small cell lung cancer and melanoma: the phase 2 FMT-LUMINate trial

In a phase 2 trial evaluating healthy donor fecal microbial transplantation plus either anti-PD-1 in patients with non-small cell lung cancer or anti-PD-1 and anti-CTLA-4 in patients with melanoma, encouraging efficacy was seen in both cohorts, with responses linked to significantly greater loss of baseline bacterial species.

Sreya Duttagupta
Meriem Messaoudene
Arielle Elkrief
ResearchOpen Access28 Jan 2026
Nature Medicine

P: 1-14
cellSTAAR: incorporating single-cell-sequencing-based functional data to boost power in rare variant association testing of noncoding regions

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

Eric Van Buren
Yi Zhang
Xihong Lin
Research31 Dec 2025
Nature Methods

P: 1-12
Natural calcite in cathodoluminescence: crystal growth during diagenesis

G. M. Walkden
J. R. Berry
Research05 Apr 1984
Nature

Volume: 308, P: 525-527
Global burden of amphetamine, cannabis, cocaine and opioid use in 204 countries, 1990–2023: a Global Burden of Disease Study

Global Burden of Disease estimates show that between 1990 and 2023, the prevalence and burden of drug use disorders, inclusive of amphetamine, cannabis, cocaine and opioid use, have been increasing in high-income countries, particularly in the USA.

Jiseung Kang
Hyeon Jin Kim
Dong Keon Yon
Research16 Jan 2026
Nature Medicine

P: 1-18
Natural Reactivity and the Origin of Species

AXEL R. OLSON
GILBERT N. LEWIS
Research28 Apr 1928
Nature

Volume: 121, P: 673-674
The Scott Polar Research Institute¹

H. R. MILL
News01 Sept 1928
Nature

Volume: 122, P: 332-333
National hydrologic connectivity classification links wetlands with stream water quality

A national classification system of wetland hydrologic connectivity to streams, which could be applied globally, demonstrates and advances current understanding of how wetland connectivity affects surface water quality.

Scott G. Leibowitz
Ryan A. Hill
Charles R. Lane
ResearchOpen Access06 Apr 2023
Nature Water

Volume: 1, P: 370-380
Structure and immunogenicity of an engineered soluble prefusion-stabilized EBV gB antigen

Epstein–Barr virus (EBV) is a widespread herpesvirus linked to cancer and autoimmune disease. The authors in this work design and characterize a stabilized prefusion form of gB, an essential viral fusion protein, advancing EBV vaccine and therapeutic development.

Ryan S. McCool
Cory M. Acreman
Jason S. McLellan
ResearchOpen Access03 Jan 2026
Nature Communications

Volume: 17, P: 1-13
The global extent of the grassland biome and implications for the terrestrial carbon sink

By combining satellite observations with ground-based data and expert validation, this analysis demonstrates considerable misestimation of grassland extent and thereby carbon stock estimates in previous global assessments based on remote sensing.

A. S. MacDougall
B. Vanzant
M. B. Siewert
Research27 Jan 2026
Nature Ecology & Evolution

P: 1-12
Fibroblastic reticular cells direct the initiation of T cell responses via CD44

CD44 expressed by fibroblastic reticular cells in secondary lymphoid organs regulates trafficking of dendritic cells, and thus has an essential role in the priming of T cells and the adaptive immune response.

Xavier Y. X. Sng
Valentina Voigt
Mariapia A. Degli-Esposti
ResearchOpen Access21 Jan 2026
Nature

P: 1-11
Integrative spatial omics reveals distinct tumor-promoting multicellular niches and immunosuppressive mechanisms in Black American and White American patients with TNBC

Cellular niches are highly heterogenous in triple negative breast cancer. Here, the authors utilise imaging mass cytometry and spatial transcriptomics to characterise the microenvironment in Black American and White American patients.

Qian Zhu
Akhila Balasubramanian
Arun Sreekumar
ResearchOpen Access17 Jul 2025
Nature Communications

Volume: 16, P: 1-23
Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Jiyeon Oh
Soeun Kim
Dong Keon Yon
Research06 Jan 2026
Nature Medicine

Volume: 32, P: 197-223
Phosphoproteomics of aged insulin-resistant bone identifies P70S6K phosphorylation of AFF4 as a gene-specific transcriptional regulator

Insulin signaling plays a crucial role in coordinating skeletal development with whole‑body energy metabolism. Here, the authors use phosphoproteomics to show insulin-signaling rewiring in aged, insulin-resistant bone and identify defective phosphorylation of AFF4 as a key mechanism for regulating gene-specific transcriptional activation.

Mriga Dutt
Luoping Liao
Benjamin L. Parker
ResearchOpen Access31 Dec 2025
Nature Communications

P: 1-23
Genetics and environment distinctively shape the human immune cell epigenome

A single-cell epigenomic atlas of human immune cells highlights cell-type-specific features associated with genetic or environmental exposures.

Wenliang Wang
Manoj Hariharan
Joseph R. Ecker
ResearchOpen Access27 Jan 2026
Nature Genetics

P: 1-12
Quantum spin resonance in engineered proteins for multimodal sensing

A recently developed class of magneto-sensitive fluorescent proteins are engineered to alter the properties of their response to magnetic fields and radio frequencies, enabling multimodal sensing of biological systems.

Gabriel Abrahams
Ana Štuhec
Harrison Steel
ResearchOpen Access21 Jan 2026
Nature

Volume: 649, P: 1172-1179
Large-scale testing of antimicrobial lethality at single-cell resolution predicts mycobacterial infection outcomes

Via high-throughput imaging and tracking over 140 million single mycobacteria, the authors show that drug- and strain-specific killing predict treatment outcomes, with potential to improve drug development and personalized therapy.

Alexander Jovanovic
Frederick K. Bright
Lucas Boeck
ResearchOpen Access09 Jan 2026
Nature Microbiology

Volume: 11, P: 566-583
A benchmark of expert-level academic questions to assess AI capabilities

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Long Phan
Alice Gatti
Davide Scaramuzza
ResearchOpen Access28 Jan 2026
Nature

Volume: 649, P: 1139-1146
Resurrected nitrogenases recapitulate canonical N-isotope biosignatures over two billion years

The study shows that nitrogenase enzymes have maintained stable isotope signatures over billions of years, revealing how ancient microbes shaped Earth’s nitrogen cycle and offering a new experimental framework for probing early life.

Holly R. Rucker
Kunmanee Bubphamanee
Betül Kaçar
ResearchOpen Access22 Jan 2026
Nature Communications

Volume: 17, P: 1-9
Biomimetic model of corticostriatal micro-assemblies discovers a neural code

How neuron-level interactions produce complex cognitive behavior remains unclear. Here, the authors develop a brain circuit mechanistic model based on physiological computation, that uncovers an unexpected neural code, subsequently validated by empirical data.

Anand Pathak
Scott L. Brincat
Richard Granger
ResearchOpen Access29 Dec 2025
Nature Communications

Volume: 17, P: 1-21
Native American gene flow into Polynesia predating Easter Island settlement

Genomic analyses of DNA from modern individuals show that, about 800 years ago, pre-European contact occurred between Polynesian individuals and Native American individuals from near present-day Colombia, while remote Pacific islands were still being settled.

Alexander G. Ioannidis
Javier Blanco-Portillo
Andrés Moreno-Estrada
Research08 Jul 2020
Nature

Volume: 583, P: 572-577
Thickness of the Earth's Crust in Antarctica

F. F. EVISON
C. E. INGHAM
R. H. ORR
Research31 Jan 1959
Nature

Volume: 183, P: 306-308
Recent Changes in the Stocks of Tilapia in Lake Victoria

R. L. WELCOMME
Research01 Oct 1966
Nature

Volume: 212, P: 52-54
Cosmic Numbers

E. R. HARRISON
Research30 Mar 1963
Nature

Volume: 197, P: 1257-1259
Mapping the genetic landscape across 14 psychiatric disorders

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

Andrew D. Grotzinger
Josefin Werme
Jordan W. Smoller
ResearchOpen Access10 Dec 2025
Nature

Volume: 649, P: 406-415
Changes in phenology mediate vertebrate population responses to temperature globally

Climate change can alter when and how animals grow, breed, and migrate, but it is unclear whether this allows populations to persist. This global study shows that shifts in seasonal timing are key to helping vertebrate species maintain population growth under global warming.

Viktoriia Radchuk
Carys V. Jones
Martijn van de Pol
ResearchOpen Access12 Jan 2026
Nature Communications

Volume: 17, P: 1-14
Experiments with Diving Seals

R. J. HARRISON
Research24 Dec 1960
Nature

Volume: 188, P: 1068-1070
Natural history of long-COVID in a nationwide, population cohort study

The long-term natural history of long-COVID is not well understood. In this population-based cohort study from Scotland, the authors describe symptom prevalence and health-related quality of life up to 18 months after a positive SARS-CoV-2 test and compare with matched test-negative controls.

Claire E. Hastie
David J. Lowe
Jill P. Pell
ResearchOpen Access13 Jun 2023
Nature Communications

Volume: 14, P: 1-10
Enantioselective protein affinity selection mass spectrometry (E-ASMS)

High-throughput chemical ligand discovery is challenged by false positives. Here, authors introduce a scalable enantioselective affinity-selection mass spectrometry approach for proteome-wide ligand discovery with high sensitivity and selectivity

Xiaoyun Wang
Jianxian Sun
Levon Halabelian
ResearchOpen Access17 Dec 2025
Nature Communications

Volume: 17, P: 1-10
New Phases in the System Al₂O₃–SO₃–H₂O at Temperatures above 100° C

N. F. DYSON
T. R. SCOTT
Research01 Jan 1965
Nature

Volume: 205, P: 358-359
Past, present and future perspectives on the science of aging

As Nature Aging celebrates its fifth anniversary, the journal asks some of the researchers who contributed to the journal early on to reflect on the past and the future of aging and age-related disease research, the impact of the field on human health now and in the future, and what challenges need to be addressed to ensure sustained progress.

Fabrisia Ambrosio
Maxim N. Artyomov
Sebastien Thuault
Comments & Opinion21 Jan 2026
Nature Aging

Volume: 6, P: 6-22
Sunyaev–Zeldovich detection of hot intracluster gas at redshift 4.3

Detection of hot intracluster gas in SPT2349−56 with the Atacama Large Millimeter/submillimeter Array provides new insights into early cluster formation.

Dazhi Zhou
Scott C. Chapman
Axel Weiß
Research05 Jan 2026
Nature

Volume: 649, P: 1130-1133
Microbial biomining from asteroidal material onboard the international space station

Rosa Santomartino
Giovanny Rodriguez Blanco
Charles S. Cockell
ResearchOpen Access30 Jan 2026
npj Microgravity

P: 1-15
A niche-dependent redox rheostat regulates epithelial stem cell fate

Intracellular redox state orchestrates a self-reinforcing circuit connecting hypoxia inducible factor 1α-dependent signalling with post-translational regulation of the metabolic enzyme isocitrate dehydrogenase 1 to govern intestinal stem cell fate.

Xi Chen
Krishnan Raghunathan
Jay R. Thiagarajah
ResearchOpen Access28 Nov 2025
Nature Communications

Volume: 16, P: 1-20
HTRA1/lncRNA HTRA1-AS1 dominates in age-related macular degeneration reticular pseudodrusen genetic risk with no complement involvement

Age-related macular degeneration (AMD) is a common cause of vision loss with a large genetic risk in older individuals. Here, for a high-risk AMD subtype, the authors identify an association with a chromosome 10 risk region containing a long non-coding RNA.

Samaneh Farashi
Carla J. Abbott
Anneke I. den Hollander
ResearchOpen Access08 Dec 2025
Nature Communications

Volume: 16, P: 1-16
Antigen reactivity defines tissue-resident memory and exhausted T cells in tumors

Here the authors show that tissue-resident memory and exhausted T cells in tumors are distinct populations that are shaped by relative presence or absence of TCR signals, suggesting that a tailored therapeutic strategy is needed to target each subset.

Thomas N. Burn
Jan Schröder
Laura K. Mackay
ResearchOpen Access29 Dec 2025
Nature Immunology

Volume: 27, P: 98-109
Early genetic evolution of driver mutations in uveal melanoma

The early genetic evolution of uveal melanoma (UM) remains poorly understood. Here, the authors perform genetic profiling of 1140 primary UMs, including 131 small early-stage tumours, finding that most genetic driver aberrations have occurred by the time small tumours are biopsied; in addition, the15-gene expression profile discriminant score can predict the transition from low- to high-risk tumours.

James J. Dollar
Christina L. Decatur
J. William Harbour
ResearchOpen Access12 Dec 2025
Nature Communications

Volume: 16, P: 1-12
Small Earthquakes in Victoria Land, Antarctica

R. D. ADAMS
Research18 Oct 1969
Nature

Volume: 224, P: 255-256
Sm—Nd systematics of Lewisian gneisses: implications for the origin of granulites

P. J. Hamilton
N. M. Evensen
J. Tarney
Research04 Jan 1979
Nature

Volume: 277, P: 25-28
Genome-scale spatial mapping of the Hodgkin lymphoma microenvironment identifies tumor cell survival factors

Hodgkin Reed Sternberg (HRS) cells and their surrounding microenvironment in Hodgkin lymphoma remain poorly characterized. Here, the authors perform genome-wide transcriptional profiling with spatial and single-cell resolution to explore the cellular and molecular composition of the Hodgkin lymphoma microenvironment and used machine learning to identify IL13 as a potential HRS cell survival factor.

Vignesh Shanmugam
Neriman Tokcan
Todd R. Golub
ResearchOpen Access20 Dec 2025
Nature Communications

Volume: 17, P: 1-17
Determining accurate conformational ensembles of intrinsically disordered proteins at atomic resolution

This study demonstrates how to combine molecular dynamics computer simulations with experimental biophysical data to determine accurate atomic-resolution ensembles of intrinsically disordered proteins.

Kaushik Borthakur
Thomas R. Sisk
Paul Robustelli
ResearchOpen Access10 Oct 2025
Nature Communications

Volume: 16, P: 1-13
Natural Phenolic Compounds

R. A. MORTON
Books & Arts17 Mar 1962
Nature

Volume: 193, P: 1015

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