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Achieving directional ion transport in thin membranes is desirable yet challenging. Here, authors demonstrate an ultrathin ferroelectric single-pore membrane that enables polarization-driven ion rectification and hysteretic responses under pH stimuli.

This study applies generalized linear mixed models (GLMM) and advanced transcriptome wide association study (TWAS) methods to improve the discovery of colorectal cancer risk transcription factors and genes, including potential druggable targets.

Organic molecular crystals with controllable bending angles are crucial interconnectors in integrated optoelectronic chips but current methods of tailoring bent geometric features in molecular crystals without fracturing remain limited. Here the authors proposing a molecular cocrystal strategy that introduces directional non-covalent interactions into molecular systems to weaken the original interactions triggering the spontaneous deformation.

In this work, the authors demonstrate nonlinearity-engineered dissipative quadratic solitons (DQS) for the first time. Moreover, they achieve an in-situ sign reversal of the effective nonlinearity, enabling a transition from bright DQS to platicon generation without requiring any dispersion engineering.

The development of sustainable water oxidation catalysts is crucial for hydrogen production, yet cobalt-based materials often suffer from instability. Here, the authors report that co-doping LiCoO₂ with nickel, iron, and palladium yields a durable electrode with stability of over 2,000 hours.

The Taiwan Precision Medicine Initiative (TPMI) has built a cohort of more than half a million individuals with Han Chinese ancestry, providing a rich resource of genetic and medical data for this group.

The Taiwan Precision Medicine Initiative recruited and genotyped more than half a million Taiwanese participants, almost all of Han Chinese ancestry, and performed comprehensive genomic analyses and developed polygenic risk score prediction models for numerous health conditions.

LncRNA P4HA2-AS1 drives renal fibrosis by stabilizing TRIM32 to promote K63-linked ubiquitination of ULK1.

Global Burden of Disease estimates show that between 1990 and 2023, the prevalence and burden of drug use disorders, inclusive of amphetamine, cannabis, cocaine and opioid use, have been increasing in high-income countries, particularly in the USA.

This work uncovers why traditional methods underestimate active site density in fuel cell catalysts. The researchers developed a novel in-situ acid-assisted method coupled with infrared spectroscopy to accurately quantify sites and elucidate their structure, validated across multiple catalysts.

Mitochondrial damage is a central pathological mechanism of cerebral ischemia-reperfusion injury. This study develops a bioengineered nanolamellar system to sequentially restore neuronal cell mitochondrial function and modulate microglial polarization to mitigate ischemia-reperfusion injury.

Here the authors reveal a study of 486,956 Han Chinese individuals showing that most people with genetic variants affecting drug response do not have the predicted adverse events, highlighting the challenges of implementing pharmacogenetics in clinical practice.

A virus-mimicking micelle selectively delivers drugs to diseased chondrocytes in osteoarthritis, significantly alleviating disease progression in mouse and sheep models.

Circadian rhythms shape epidermal stem cell fate by regulating rhythmic gene expression in human EPSCs. ZFP42 maintains stemness by sustaining CRY1 expression, promoting proliferation and restraining differentiation to preserve epidermal homeostasis.

Bronchiectasis and asthma can co-exist in the same patient, and the characteristics may be different from bronchiectasis alone. Here the authors characterise the function of ILC3 cells and how IL-17C potentiates IL-17A expression promoting a neutrophil dominated asthma endotype in mouse bronchiectasis-asthma models.

Direct and site-selective C–H functionalization of alkenes under environmentally benign conditions represents a useful and attractive yet challenging transformation to access value-added molecules. Here, the authors report a protocol for a variety of intermolecular Heck-type functionalization of C(sp2)–H bond of alkenes by thianthrenation.

Phonon engineering with anisotropic Lorentz-type dielectric oscillations enables the creation of hyperbolic asymptotic line polaritons, achieving broadband diffraction-free propagation.

Gut microbiota influence bone health, but the genetic and metabolic mechanisms are unclear. Here, the authors show that specific bifidobacterial taxa causally reduce bone mineral density, partly via n-3 fatty acid metabolism, highlighting host-microbe interactions with potential therapeutic implications.

Atmospheric chemistry models and observation networks in China may underestimate particulate dry nitrogen deposition due to inadequate representation of the particle size distribution and dry deposition mechanisms, impacting nitrogen deposition modelling used for public health decisions and climate change projections.

Advancements in spin-orbit-torque magnetic random-access memory require solutions for achieving high density and low power consumption. Here, the authors achieve a significant and simultaneous enhancement of perpendicular magnetic anisotropy and spin-orbit-torque conductivity by inserting an ultrathin gadolinium layer at the β-W/CoFeB interface, positioning rare-earth elements as key multifunctional regulators for efficient spintronic devices.

This study defines a two-receptor entry mechanism for coxsackievirus A6: heparan sulfate for initial attachment and KRM1 for uncoating. Protective antibodies that block KRM1 binding were identified, offering a path for therapeutic development.

To fully realize LLMs’ potential value in clinical applications, effective methods to enhance their quality and credibility are required. Here, the authors present LINS, a framework to enhance medical LLM responses by integrating up-to-date evidence and supporting clinical tasks, and validate it through new physician-curated datasets and large-scale user trials.

Authors in this study discover a CCKBR agonist MF-8 with β-arrestin bias. This biased agonist can reduce other CCKBR signaling pathways, including Gαs-induced cAMP and Gαq/11-induced calcium signaling, thereby inhibiting the CCKBR-LTP. This discovery provides us with new ideas for developing drugs targeting CCKBR.

Tetrahydropyridines are vital scaffolds, yet regio- and site-selective assembly is hard. This work delivers a mild CoH-mediated reductive hydroarylation of pyridinium salts, enabling site-divergent arylation to access diverse tetrahydropyridines.

Enantioenriched α-arylated dialkyl ketones with acidic proton are ubiquitous subunits in organic molecules and serve as synthetic precursors for other value-added chiral blocks. Here, the authors report a synthetic strategy of enantioenriched α-arylated dialkyl ketones enabled by nickel-catalyzed iterative cross-hydrocarbonylation of two alkenes.

Compared to the oxygenation of Earth’s atmosphere, little is known about the build up of dissolved oxygen in the oceans. Vanadium isotopes in shales suggest shallow oceans equilibrated with a newly oxygenated atmosphere in just a few million years.

Neurovascular interaction is critical for normal brain vascular development. Here, the authors show that neuronal NMDARs regulate brain vascular development via VEGF-induced global Ca2+ activities of endothelial tip cells.

Liquid crystals on silicon (LCoS) devices are limited by the polarization sensitivity and reliance on complex architectures for full-color integration. Here, the authors demonstrate a metasurface-integrated LCoS device for polarisation-insensitive, full-color amplitude modulation on a single chip.

2D memtransistors are promising candidates for energy-efficient neuromorphic computing, but their scalability remains challenging. Here, the authors report the fabrication of 2D MoS₂ memtransistor arrays with controllable Schottky barrier, demonstrating device-to-device variation <6.8% and high performance for image recognition tasks.

Here, the authors perform large trans-ancestry fine-mapping analyses identifying large numbers of association signals and putative target genes for colorectal cancer risk, advancing our understanding of the genetic and biological basis of this cancer.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Zhang, Jiang and colleagues demonstrate that, independent of its role in innate immunity, STING can target and inhibit HK2 activity, thereby blocking tumour aerobic glycolysis and enhancing antitumour immune responses.

Many physical and mental disorders share common risk factors captured by a general disease factor. Here, the authors identify the neural, genetic, and environmental bases of this factor, linking environmental deprivation to brain structure and multimorbidity risk.

The Duf4243 dioxygenases GedK and BTG13 are known to catalyze the aromatic cleavage of bulky tricyclic hydroquinone. Here, the authors discover a distinct Duf4243 dioxygenase PaD that favors small monocyclic hydroquinones from the penicillic-acid biosynthetic pathway and determine the structural basis for its changed substrate specificity.

C-H activation is a powerful method to form functionalised molecules, but is particularly challenging for unactivated sp³sites. Here the authors report a directing-group-free radical cascade process for converting vinyl azides and carboxylic acids to tetralone derivatives in high diastereoselectivity.

Achieving selective and precise modification of macromolecules under biocompatible conditions (such as aqueous solutions, mild temperatures, and neutral pH) remains a significant technical challenge. Here, the authors develop a photoinduced coupling reaction based on N-hydroxy naphthalimide esters, which is effective in biologically relevant conditions.

Here authors show that dangling-bond-induced surface states are critical in governing Fermi level pinning at the metal-semiconductor interfaces. The reconstruction-induced self-passivation of dangling bonds leads to Si having a weaker pinning than Ge, which prefers non-reconstruction.

Tao et al. show that SCRN1 acts as a scaffold to facilitate GPX4 phosphorylation by STK38, thereby preventing chaperone-mediated autophagy of GPX4 and subsequent ferroptosis in patient-derived organoids and mouse models for hepatocellular carcinoma.

The methods for systematically profiling RNA composition of processing bodies (PBs) are limited. Here, the authors present PB-TRIBE-STAMP and LSM14A-TRIBE-ID, two RNA editing-based methods enabling systematic characterization of dynamic PB-RNAs association.