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High yield and wide adaptation rice are crucial for grain supply and food security. Here the authors report OsPI4Kγ7 which contributes to different “adaptability-yield” trade-offs in japonica and indica, and provides an alternative breeding strategy for raising grain yield in different latitudes.

Using volatile vanadium oxide and non-volatile tantalum oxide/hafnium oxide memristor arrays, a first-principles Fourier transform system can be created that can outperform conventional Fourier transform hardware in terms of throughput and reduce memory cost.

To address non-uniform sintering caused by Gaussian laser beams, the authors use adaptive inkjet printing to form curved circuits that match the light profile, thereby enhancing the electrical and optical performance of metal and semiconductor films.

Papaya is a trioecious species with XX females, XY males, and XY^h hermaphrodites, and the combination of Y and Y^h chromosomes is lethal. Here, the authors identify the degeneration of the YY lethality gene on the Y chromosome as the causal balancing lethal factor that reenforces dioecy and stabilizes balanced sex ratios.

Significant amounts of food waste are generated, and although composting is a useful route for such waste, the process is long. Here, the authors report the development of a microwave-assisted method for the rapid humification of waste potato, resulting in a fluvic acid-like fertiliser.

Soil life relies on microbial nutrient exchange to maintain ecosystem balance. This study shows that cobamide-producing microbes act as essential connectors in soil food webs, supporting host health and highlighting cross-kingdom links central to One Health.

Downsizing into the strong confinement regime can improve single-photon purity in quantum dot emitters, but often at the expense of optical stability. Here, the authors present an alternative approach leveraging electron–phonon coupling to achieve stable, room-temperature single-photon emission with enhanced purity in colloidal hybrid lead halide perovskite quantum dots.

The cellular makeup of the primate cochlea, crucial for hearing, remains poorly understood. Here, authors show a detailed map of primate cochlear cells, revealing both conserved and species-specific features.

The current unbalance between the performance of n-type and p-type 2D transistors limits their applications for next-generation electronics. Here, the authors report the realization of high-performance 2D MoTe₂ p-type transistors by depositing metallic tellurium contacts via thermal evaporation.

Altermagnets combine spin-split electronic bands with zero net magnetization, making them ideal for integration into spin-based information processing devices. Here Guo, Chen, Zeng, and coauthors demonstrate a magnetic memory making use of the altermagnetic spin splitting torque in a three terminal MRAM device.

Here, the authors document the evolutionary dynamics of angiosperm pollen, using pollen morphology and time calibrated phylogeny. They identify two surges in pollen disparity in the mid-Cretaceous and Paleogene that are associated with environmental changes and important pollen adaptations.

Aqueous zinc-ion batteries are safe and affordable but limited by incompatible electrode kinetics. Here, authors present a machine learning framework that resolves this mismatch, enabling the rational design of durable and stretchable zinc-ion batteries.

CDK4/6 inhibitors are promising treatments for ER+ breast cancer, however resistance remains a challenge. Here, the authors analyse the NeoPalANA cohort and indicate that a 33 gene signature was predictive of response to neoadjuvant anastrozole and palbociclib.

Multimodal immune profiling of ART pregnancies reveals systemic immune hyperactivation in gestational diabetes, characterized by activated CD8⁺ T cells, altered immune repertoires, and inflammatory signaling driven by FOS/JUN and KLF6.

The mechanisms underlying the improved survival in HPV-positive penile squamous cell carcinoma (PSCC) compared to HPV-negative counterparts remain to be explored. Here, single-cell sequencing highlights the role of the B cell-IgA-PIGR axis in enhancing antitumor immunity and improving clinical outcomes in HPV-positive PSCC.

A model, trained to generate synthetic, patient-specific angiography images, reduced radiation exposure to patients and clinicians by two-thirds in a multicenter randomized controlled trial involving 1,068 patients.

Dysregulation in proteolysis contributes to brain tumorigenesis. Here the authors report that USP10 deubiquitinase is enriched in glioma stem cells (GSCs), which antagonizes DTX3L-mediated ubiquitination of SATB2, a major driver of GSC proliferation and self-renewal.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

Probing, understanding, and manipulating nontrivial excitonic transport in atomically thin transition metal dichalcogenides (TMDCs) is a long-standing challenge. Here, the authors report the observation of ultrafast spatial hole burning of excitonic emission in monolayer WS₂ and reveal the underlying mechanism, showcasing the peculiar excitonic transportation in monolayer TMDCs.

Whether amorphous-amorphous interfaces constitute separate phases requires clarification. This study reports a Pd₄₀Ni₄₀P₂₀ bulk granular nanostructured glass with an interfacial structural-compositional rearrangement.

The authors develop textile electronic substrates with tailored stiffness and interfacial affinities by selective and controllable laser-matter interaction, addressing the mechanical mismatch between hybrid electronics and elastic textiles.

A cobalt-catalysed asymmetric radical hydroalkylation of 1,1-dialkyl-substituted alkenes with unactivated alkyl electrophiles is reported. This approach avoids the need for heteroatom- or aryl-functionalized substrates, enabling a concise and efficient route to traditionally inaccessible fully alkyl-substituted chiral tertiary carbon centres.

Wang, Chu, Chen, Wei and colleagues discover a subset of tumour-associated macrophages expressing SLC2A1 whose spatial proximity to CD8⁺ T cells drives resistance to anti-PD-L1 treatment in non-small-cell lung cancer.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Wu and colleagues present the efficacy and safety results from the phase 3 SCORES trial evaluating suvemcitug plus chemotherapy in persons with platinum-refractory or resistant recurrent ovarian cancer.

α-Chiral amines are ubiquitous in natural products, pharmaceuticals, and other biologically active molecules, making their enantioselective synthesis a critical and enduring pursuit in synthetic chemistry. Here, the authors report a dinickel complex-enabled, enantioselective reductive alkenylation reaction of N-Ts imines with vinyl chlorides to form α-chiral allylic amines.

The reactivity and ligandability of arginine within the human proteome have been largely unexplored despite it being involved in various biological functions. Now, arginine reactivity and ligandability have been mapped across the proteome, revealing hyper-reactive sites and identifying residues that control liquid–liquid phase separation, protein activity and protein–protein interactions.

The authors find that O-GalNAc transferase 2 (GALNT2) restricts viral infection, probably through the regulation of the proteolytic processing of viral glycoproteins via its O-linked glycosylation activity, impairing virus–cell fusion.

SCOPE-DTI introduces a large semi-inductive DTI dataset and optimized deep learning framework for drug-target interaction prediction. It integrates 3D structural modeling and bilinear attention, with experimental validation of drug targets and open access tools for broad research use.

The regulatory roles of structural variations (SVs) in transcriptional networks and agronomic traits of tea plants are largely unexplored. Here, the authors assemble the pangnome from 22 representative tea accessions and their wild relative and reveal SVs driving gene expression alteration and agronomic traits diversification.

Glioblastoma multiforme (GBM) recurrence driven by residual glioma-initiating cells (GICs) and immunosuppressive microenvironment presents a significant clinical challenge. Here, they report an injectable therapeutic platform that targets remaining GICs and reverses the immunosuppressive microenvironment after postoperative resection to prevent the recurrence of GBM.

This study shows that pesticide pollution reduces the diversity and functions of plant-beneficial bacteria in soils worldwide, threatening soil health and crop yields. The authors find that nutrient supplementation could be a potential strategy for recovery.

To establish metastasis, cancer cells need to adapt in order to navigate through confined spaces. Here, the authors discover that compression force-induced CSK23-mediated NF-κB activation regulates ALDH1B1 expression, ultimately modulating ferroptosis and tumor cell survival in confining capillaries.

Regulated cell death and its dysregulation may contribute to chemoresistance. Here, the authors show that Ferroptosis Suppressor Protein 1 (FSP1) promotes chemoresistance in gastric cancer in part by suppressing ferroptosis.

Powering single organic electrochemical transistor (OECT) device is challenging as power reductions can cause unstable device outputs. Wu et al. report a wearable, self-powered biosensor with a dual-OECT amplifier powered by an organic solar cell for monitoring physiological signals under varying light conditions.

All-solid-state batteries face significant performance challenges with conventional anodes under high currents. Here, the authors design an In₀.₃₈Sn₀.₃₃Bi₀.₂₉ alloy anode that forms a robust mixed ionic–electronic network, enabling high-rate capability and durable solid-state cells.

The study finds that seasonal marsquake patterns may indicate active near-surface brines on Mars today. By connecting seismicity changes to ice-to-brine melting, it infers that shallow liquid water continues to operate beneath the surface and influence Martian fault activity.

Stacking perovskite LEDs in tandem structures to combine the luminance of individual units yielded efficiencies greater than the summed efficiencies of equivalent single-unit devices, suggested to result from photon recycling between individual light-emitting elements.

Field experiments and network data show that the witchcraft label ‘zhu’ influences labour-sharing and intermarriage in a large network of southwest Chinese villages. Zhu is not an indicator of pro-sociality, but may function to spite or damage rivals.

Constructing C(sp³)–C(sp³) bonds using non-prefunctionalized substrates as radical precursors is challenging. Now an ene-reductase and an organophotoredox catalyst work together to enable the enantiodivergent hydroalkylation of electron-deficient C(sp³)–H bonds via radical intermediates generated from carbanions.

Mineral carbonation could enable gigatonne-scale CO₂ removal. Here, the authors use molecular simulations to map a full CO₂ mineralization pathway at a wetting surface, revealing key reactive sites and optimal pH conditions for efficient carbonation.