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Inflammatory skin diseases are characterized by immune dysregulation often underpinned by metabolic dysregulation. Here the authors show that in human psoriasis and mouse skin inflammation models, adenosine-mediated crosstalk between fibroblasts and keratinocytes drive mitochondrial dysfunction and pro-inflammatory mediator release in keratinocytes, leading to epidermal inflammation.

The yeast ceramide synthase assembles into a 4:4 complex through a Lac1 helix interface. This interface physically occludes the active site yet is essential for proper ceramide regulation, revealing sophisticated control beyond simple autoinhibition.

The thermoelectric performance of rhombohedral GeTe-based material is boosted by the TiB₂ nanoparticle-induced interfacial constraint effect that results in reduced equivalent deformation potential and substantial interfacial thermal resistance.

Here, the authors present a machine-learning assisted single-molecule sensor that can precisely quantify the structurally diverse per- and polyfluoroalkyl carboxylic acids in the absence of standards, together with state-of-the-art detection limits.

SLCO4C1 is known for regulating kidney diseases. This study showed SLCO4C1 regulates hepatic cAMP uptake to suppress lipogenesis in MASLD. Targeting this pathway by FGF21 or forskolin suppressed lipogenesis.

High cost and aggregation of single-component fullerenes hinder inverted perovskite solar cell development. The authors synthesize a fullerene composite in high yield that cross-links during annealing, improving stability and efficiency while maintaining performance in various device formats.

Here, the authors design a self-optimizing experimental system for the automatic discovery of lightweight and high‑strength plate‑lattice metamaterials, integrating a robotic platform with a machine learning framework.

Cu catalysts show promise for converting CO₂ into valuable products, but achieving high selectivity and long-term stability remains challenging. Here, modifying Cu cubes with a nitrogen-rich organic network enables a Faradaic Efficiency of 71.2% for C₂H₄ production with greatly enhanced durability.

Xie et al. identify a distinct subset of CD4⁺ helper T cells expressing EOMES and granzyme K in both mice and human models of colitis.

Mesenchymal stromal cells (MSC) contribute to tissue repair and regeneration by activating pro-repair macrophages. However, the precise signaling governing this crosstalk upon injury is elusive. Here, using a mouse model of endovascular injury and single-cell RNA sequencing, the authors identify an IL-33–ST2–OPN axis that orchestrates the functional interaction between MSCs and reparative ST2+ macrophages, stimulating vascular smooth muscle cell and vascular repair.

Pangenome analyses of 28 representative Gossypium hirsutum accessions, including a telomere-to-telomere genome for NDM13, and transcriptomic profiling across 15 tissues highlight structural variations associated with breeding traits.

NIID is a neurodegenerative disease caused by GGC repeat expansions within NOTCH2NLC gene. Here, authors develop a precise gene-editing therapy that effectively treats the disease in multiple models.

Psychedelics and their non-hallucinogenic analogues were compared, revealing that serotonin 2A receptor (5-HT_2AR)-mediated G_i signalling is essential for hallucinogenic effect, with the functional mechanisms underlying this providing insights for designing therapeutic drugs without hallucinogenic effects.

The severity of climate change impacts calls for low-carbon thermal management solutions. This work presents a chameleon-inspired electronic skin for adaptive electrochromic thermal regulation with minimal energy input and scalability potential.

A donor–π–acceptor carbon nitride photocatalyst with enhanced charge separation enables efficient hydrogen production from natural seawater under ambient pressure and sunlight, advancing scalable green hydrogen generation.

Next-generation autonomous systems call for robust perception capabilities in diverse environments. Dun et al. report an ultraviolet-to-mid-infrared photosynapse array with 65,536 pixels and efficient in situ processing capabilities for dynamic trajectory recognition under challenging conditions.

Dai and colleagues implicate defective dendritic cell migration in impaired vaccine responses in aged mice. Oral delivery of yeast-derived nanoparticles promotes migration of dendritic cells from the gut to lymph nodes and restores vaccine efficacy in aged mice.

Anti-HER2 resistance causes treatment failure in HER2-positive breast cancers. Here the authors identify FGFR4 as one of the vulnerabilities of anti-HER2 resistant breast cancer and show that FGRR4 inhibition enhances sensitivity to anti-HER2 treatment in these resistant cells by triggering ferroptosis.

Sulfur fluoride exchange has wide applications, but chiral sulfonimidoyl transfer remains highly challenging due to the crowded three-dimensional environment. Now, using chiral pyridine-N-oxides as organocatalysts, the catalytic asymmetric sulfonimidoyl transfer reaction has been achieved with racemic sulfonimidoyl chlorides as the reactant, enabling the construction of optically active sulfonimidoyl fluorides and related derivatives.

The methods for systematically profiling RNA composition of processing bodies (PBs) are limited. Here, the authors present PB-TRIBE-STAMP and LSM14A-TRIBE-ID, two RNA editing-based methods enabling systematic characterization of dynamic PB-RNAs association.

The authors reconcile the conflict between polarization and hysteresis by confining polarization response of non-polar nanoclusters in high-entropy relaxors, thus improving the energy storage properties of multilayer ceramic capacitors.

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

The antibody Fab5 cross-neutralizes gammaherpesviruses by binding to a conserved region in the membrane fusion protein gB on the virus; this region could form the basis for a herpesvirus vaccine.

Regulation of alveolar macrophage function requires further investigation. The authors here show that EI24, elicited by commensal microbiota, decreases alveolar macrophage phagocytosis and inflammatory responses against lung infection and tumor metastasis, whereas targeting EI24 enhances anti-viral and anti-tumor effects of macrophages.

In this study analyzing data from 8,690,286 individuals in the Netherlands, autism significantly increased the risks for various cardiometabolic conditions. Cox proportional hazards models demonstrated heightened hazard ratios, emphasizing the importance of monitoring these health issues in people with autism.

The tunable enantioselective functionalization of alkene feedstocks represents a highly desirable yet predominantly unresolved tactic for generating high-value scaffolds. Herein, the authors report a tunable enantioselective electrolytic system for dehydrogenative allylation, dehydrogenative alkenylation, and hydroalkylation reactions to afford structurally diverse products.

The recent global mpox outbreaks underscore the critical need for antiviral development, hindered by the complexity of the MPXV genome. Using yeast TAR cloning, CRISPR-Cas9, and Lambda Red recombination to engineer replication-defective MPXV, the authors offer a platform for therapeutic research and identify G243-1720, a compound with a tecovirimat-like mechanism, as a promising anti-poxvirus compound.

Incorporating CO₂ into propane dehydrogenation (PDH) offers great potential for propylene production while simultaneously utilizing greenhouse gases; however, a key challenge is suppressing the undesired dry reforming of propane. Here, the authors present a coupled strategy that combines PDH with the reverse water–gas shift reaction through a tandem catalytic system.

Type 2 diabetes is an established risk factor for dementia. Here, the authors use data from 33,136 older Chinese adults to show that polygenic risk for type 2 diabetes was associated with vascular dementia but not Alzheimer’s disease.

Minimally invasive medical procedures are widely used in clinical practice. This Review discusses recent advances in bioelectronic devices that can be implanted using minimally invasive technologies, highlighting innovations in the materials and design to engineer personalized bioelectronic systems.

This study establishes MPXV clade IIb-infected SCID mouse models presenting with pneumonia, lesions, and localized inflammation that recapitulate key clinical manifestations observed in high-risk populations, and demonstrates that the timing of treatment initiation and the stage of disease progression critically influence the anti-MPXV efficacy of both tecovirimat and cidofovir.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

Radical ligand transfer is a common reactive pathway in 3d transition metals. Here the authors describe it for 5d transition metals in dinuclear gold complexes, for the formal addition of unactivated C(sp³)–Cl bond in gem-dichloroalkanes and Freon-22 to different kinds of alkenes.

Under sustained high greenhouse-gas emissions, the stratospheric quasi-biennial oscillation (QBO) may weaken and eventually disappear, potentially reducing short-term climate predictability, highlighting the risks of continued emissions for the middle and upper atmosphere.

Magnetoelectric composites of magnetic and ferroelectric components are promising for their use in applications such as information storage. Here, the authors find that magnetic quasiparticles embedded in a ferroelectric film matrix show promising properties compared to the usual thin-film architectures.

We fabricated silicon heterojunction back-contact solar cells using laser patterning, producing cells that exceeded 27% power-conversion efficiency.

Breakthrough metasurfaces generate “perfect” optical vortices with an unchanging size over distance, charge, and wavelength—a key benefit for robust optical communications and imaging systems.

Air flowing out from the Antarctic continent largely determines where summer atmospheric mercury depletion events (AMDEs) occur around Antarctica, making them most common in areas where Antarctic cold, downslope winds meet.