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Acidic electrochemical CO₂ reduction promises efficient carbon use, but maintaining stable acidity at high current remains a major challenge. Here, the authors demonstrate a membrane-free CO₂ hydrogenation electrolyzer that stabilizes pH and enables efficient and stable formic acid production.

Zhang et al. show that the activation of RIPK1 is suppressed by acetylhypusination in a spermidine-dependent manner. Disruption of this axis contributes to RIPK1-mediated vascular pathology to promote insulin resistance and diabetic kidney pathology.

This work demonstrates superadiabatic topological pumping on photonic chips, achieving a 20-fold device miniaturization and high-efficiency operation across a 650–920 nm bandwidth, paving the way for ultracompact integrated photonic transports.

Multimodal immune profiling of ART pregnancies reveals systemic immune hyperactivation in gestational diabetes, characterized by activated CD8⁺ T cells, altered immune repertoires, and inflammatory signaling driven by FOS/JUN and KLF6.

Cutaneous tuberculosis is an infectious disease associated with extracellular matrix remodeling and granuloma-driven fibrosis. Here, the authors present an in vitro model of this disease using skin organoids infected with Mycobacterium tuberculosis, and describe infection-induced alterations in specific pathways and cell populations.

Maintaining the stability of Ru–based materials in the acidic oxygen evolution reaction remains a challenge. Here, the authors report a fluorination–induced symmetry–breaking strategy that enhances the structural stability of RuO₂, enabling over 1,440 h of continuous operation at 100–1000 mA cm⁻².

Adipocyte deposition is believed to be a primary characteristic of age-related thymic involution. Here, the authors show that MRAP is a key factor in promoting thymic MSCs adipogenesis triggered by thymosin-α1 and FoxO1 pathway, which provide a new mechanism for age-related thymic involution

Previous clinical studies suggested that Insulin-like growth factor binding-protein 7 (IGFBP7) is elevated in early stages of diabetes. Here authors showed tubule and glomerular-specific IGFBP7 promotes diabetic kidney disease.

Quantum metastability has been studied primarily in continuous-time systems. Here the authors observe it in the discrete-time evolution of a single nuclear spin in diamond via sequential Ramsey interferometry measurements of a nearby electron spin, enabling single-shot, high-fidelity nuclear spin readout.

The function and regulatory mechanism of mRNA acetylation modification in cancer progression remains largely unknown. Here the authors identify that targeting tumor N4-acetylcytidine (ac4C) RNA acetyltransferase NAT10 improves anti-tumor response via MYC/CDK2/DNMT1/dsRNA/type I IFN pathway, and show the synergic anti-tumor effect of NAT10 inhibition with aPD-1.

Here, the authors present Ediacaran fossils from the Tongshan Lagerstätte (South China), including Burgess Shale-type rangeomorphs preserved both with fronds and holdfasts. They use sedimentary and chemical evidence to suggest that fast burial and early diagenetic mineralization produced excellent preservation.

Authors converted waste ozonation catalysts into carbon-based nano-single-atom-site catalysts through in-situ carbonization of self-doped biological secretions, enabling efficient regeneration and resource reuse.

Xiang et al. use patient samples and mouse models of osteoarthritis to examine the link with muscle atrophy. They identify that, in osteoarthritis, senescent macrophages promote ferroptosis in skeletal muscle cells, and they show the therapeutic value of targeting this pathological mechanism.

Photocatalysis at 40–60 °C is shown to be able to defluorinate perfluoroalkyl substances, known as ‘forever chemicals’, allowing the recycling of fluorine in polyfluoroalkyl and perfluoroalkyl substances as inorganic fluoride salt.

Whether multimorbidity accelerates brain Aβ deposition in humans remains largely unknown. Here, the authors demonstrate that higher self-reported multimorbidity burden predicts increased brain Aβ accumulation rates in the ADNI cohort.

Trained and validated on multimodal data from 14.5 million images from multicountry datasets, a foundation model is shown to increase diagnostic and referral accuracy of clinicians when used as an assistant in a trial involving 16 ophthalmologists and 668 patients.

An in-built fluoropolyether-based quasi-solid-state polymer electrolyte enables high-capacity lithium-rich manganese-based layered oxide cathodes with stable interfaces, achieving 604 Wh kg⁻¹ pouch-cell energy density.

The antiangiogenic agent apatinib has been shown to clinically improve responses to immune checkpoint inhibitors in several cancer types. Here the authors report the results of a phase II clinical trial of camrelizumab (anti-PD1) and apatinib plus induction chemotherapy and concurrent chemoradiotherapy in stage N3 nasopharyngeal carcinoma.

The positive electrode/electrolyte interface is crucial for the performance of all-solid-state lithium batteries. Here, authors use a sintering technique to form a conformal interface between high-entropy disordered rock salt electrodes and garnet-type electrolytes to reduce interfacial resistance.

Wang et al. analyzed data from a large population-based cohort study in China to examine the relationship between blood cell biomarkers and the risk of depression.

Familial spastic paraplegia (SPG) is a rare heritable neurodegenerative disorders. Here, the authors show SPG80-associated protein UBAP1 deficiency disrupts lysosomal and mTORC1 signal, indicating rapamycin could potentially benefit SPG80 patients.

Low-frequency quasiperiodic oscillations in X-ray data are thought to trace the accretion flow in X-ray binaries. Here, the detection of 200 keV oscillations probes the innermost regions of MAXI J1820+070, revealing the precession of a small-scale jet.

Viruses such as EBV use various mechanisms to avoid antiviral responses. Here the authors propose that the EBV protein BRRF2 is secreted via extracellular vesicles from NPC cells, disrupts the cGAS-STING pathway, reduces cGAS-DNA phase separation and the subsequent antiviral response.

Maturation of functional eggs in mammalian follicles is crucial for ovarian physiology. Here, Biswas et al. report that compressive stress by contractile theca cells or extrinsic perturbations can impact overall follicle mechanics, somatic cell signalling and functional growth of follicles, revealing insights into follicle mechanosensing and biophysical control of ovarian biology.

Visible light-induced glycosylation reactions are achieved by either photoactivating a photosensitizer or using a stoichiometric activator, while glycosylation via a photoactive glycosyl donor was so far not reported. In this study, the authors develop a photosensitizer free visible-light-mediated glycosylation approach using photoactive 2-glycosyloxy tropone as the donor, obtaining a wide range of O-glycosides or oligosaccharides.

Natural products often contain complex N-fused polycyclic structures with multiple substituents and stereocentres. Here, the authors developed a bifunctional organocatalyst that is instrumental in obtaining such structures and applied it to the total synthesis of naucleofficine I and II in 6 steps.

Early and accurate clinical assessment of disease severity in COVID-19 patients is essential for planning the allocation of scarce hospital resources. An explainable machine learning tool trained on blood sample data from 485 patients from Wuhan selected three biomarkers for predicting mortality of individual patients with high accuracy.

The Einstein Probe has discovered a fast X-ray transient, EP240414a, associated with a broad-lined type Ic supernova. Its unusually soft spectrum and weak jet add to the diversity of stellar deaths and suggest a previously unknown Wolf–Rayet star explosion mechanism.

This study shows how a dirigent protein and an aldo-keto reductase derail the gossypol pathway in cotton, producing hemigossypolone and heliocides in green organs and enhancing plant defense, revealing insights into plant specialized metabolism.

Achieving generality in asymmetric catalysis with highly reactive radicals is a challenge. Now it is shown that a sequential copper-catalysed approach enables the efficient, enantioselective cross-coupling of over 50 diverse radicals, providing unified access to C-, P- and S-chiral products and advancing the asymmetric synthesis of challenging molecular architectures.

In this clinical trial, the authors demonstrate that recombinant gE-Fc Fusion Protein Vaccine LZ901 for herpes zoster induces superior cellular immunogenicity and exhibits a better safety profile than HZ/su in adults ≥50 years, supporting its potential as vaccine candidate.

Photocatalytic water splitting is an attractive route to hydrogen production, but safely isolating hydrogen and oxygen products remains a challenge. Here, the authors propose a carbon nitride/grapheme (GR)-based sandwich structure, providing safe and effective photocatalytic hydrogen generation and capsule storage.

The gamma-ray burst GRB 060614 was an unusual astrophysical event whose origins are still unclear. This study re-examines the burst’s afterglow data and finds an excess in the spectrum that appears to be consistent with a weak macronova, suggesting that GRB 060614 originated from a compact binary merger.