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A ZnO/CuO catalyst featuring dual-site cooperative framework for polymerization-based wastewater treatment. Zn sites preferentially adsorb/activate organics, whereas Cu sites predominantly activate the oxidant, showcasing atomic-scale design to reactor-scale implementation.

Skeletal muscle fiber type is key to metabolic health. Zhou et al. reveal that the protein BRD4 dictates muscle fiber identity, blocking it promotes energy-burning slow fibers and prevents obesity in mice, offering a new target for metabolic disease.

Treatment failure exists in Induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) patients. Here this group reports a phase 2 randomized trial evaluating the efficacy and safety of adding nimotuzumab, to CCRT on 246 patients with untreated, non-keratinising, stage II–IVA LA-NPC.

High blood pressure is regulated by natriuretic peptide signaling through the GC-A receptor. Here, authors show that antibodies can activate GC-A, and that XX16 locks an active state without hormone and lowers blood pressure in obese mice.

Decoding skin gases can reveal a lot about our health. Here, the authors introduce a monolithic AI-powered wearable ring designed to non-invasively monitor dermal volatile-organic-compounds associated with diet-related metabolism.

In this study, the authors present two distinct neuronal subpopulations, sharing a speed encoding model, in the mouse dorsal periaqueductal grey, controlling running and backing away behaviors, respectively.

This study presents an oral CRISPR–Cas9 delivery system that precisely disrupts the TRAP1 gene in colorectal cancer, enhancing chemo-immunotherapy with robust antitumour effects.

How do avian eyes fulfill the intense metabolic activity of thick, high-acuity retinas in the absence of direct vascular support? The study finds that birds’ rapid, oscillating saccadic eye movements pump glucose from the pecten to the avascular retina, sustaining nutrient supply and boosting visual responses in the brain; especially when driven by dynamic visual stimuli.

Cultivated banana is threatened by Fusarium oxysporum f. sp. cubense tropical race 4 (TR4). In this study, the authors assemble the genome of Musa cheesmanii, a wild banana species that is highly resistant to TR4, and use it in crossbreeding with two cultivars to enhance disease resistance.

Converting light alkanes into useful olefins is hard because strong bonds and heat drive overoxidation. This study uses a copper-doped titanium dioxide photocatalyst to steer bond breaking, yielding ethylene and hydrogen.

The CMS experiment at CERN reports one of the highest-precision measurements of the W boson mass, finding it in line with standard model predictions and at odds with recent anomalous measurements.

Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme conditions. Here, the authors show that the natural product P57 induces hypothermia by targeting pyridoxal kinase and has a potential application in therapeutic hypothermia.

Short-lived halogens have a substantial indirect cooling effect on climate and this cooling effect has increased since pre-industrial times owing to anthropogenic amplification of natural halogen emissions.

A short peptide derived from a commensal-fungal-secreted protein promotes repair in models of colon epithelial damage when delivered directly or via probiotic microbes.

Farnesyl pyrophosphate—a mevalonate pathway metabolic intermediate—is an endogenous alarmin that enhances IgG antibody responses through keratinocyte-derived IL-6 and CCL20.

Zheng et al. generate and utilize a biobank of colorectal cancer PDOs to find that high LGR4 is linked to chemoresistance. They develop a monoclonal antibody against LGR4 that activates ferroptosis and is therapeutically beneficial.

An evaluation across 193 countries for the 2026 Global Action Plan update showed that countries with strong multisectoral governance and early surveillance adoption achieved long-term improvements in reducing antimicrobial resistance.

In patients with hypopharyngeal squamous cell carcinoma (HPSCC), resistance to the standard-of-care induction chemotherapy often occurs. Here, using longitudinal single-cell transcriptomic profiling of HPSCC samples from patients receiving induction chemotherapy, the authors identify a ZNF683-high natural killer (NK) cell population as a predictor of chemotherapy response.

The authors mapped the continental-scale fraction of age-dependent leaf area index and revealed a widespread increase in the fraction of photosynthetically efficient young leaves across the majority of Amazon rainforests over the past decades.

Crystallizing the perovskite layer on thin tunnel oxide passivated contact silicon cells is challenging due to rapid heat transfer. Zhou et al. address this issue using a 2-mercaptobenzothiazole additive, achieving a tandem cell efficiency of 32.76%.

Methods for asymmetric alkyl–alkyl bond formation between sp³-hybridized carbon atoms, C(sp³)–C(sp³), are limited yet highly desirable. Now an approach for asymmetric alkyl–alkyl bond formation by Ni-catalysed cross-coupling between alkenes has been developed to construct tertiary stereogenic carbon centres with head-to-tail regioselectivity and excellent chemo- and enantioselectivity.

Strong nonlinear optical response of most thin layered materials is often narrowband, especially in the mid-infrared spectral range. Here, authors experimentally observe second harmonic generation in the range of 1.2-5.0 μm from Weyl semiconductor tellurium nanoflakes. The generation efficiency is shown to be two orders of magnitude larger than that of GaSe.

Endothelial cells (ECs) and bone marrow stromal cells (BMSCs) support hematopoiesis and hematopoietic regeneration. Whether ECs are a source of BMSCs remains unclear. Here, using lineage tracing models the authors show that ECs are not a source of BMSCs during homeostasis and regeneration.

Zhang, Han, Tan, Lu, Ma et al. report that kynurenine derived from peritumoural adipose tissue is hijacked by cancer cells to mediate ferroptosis resistance, a process that could potentially be targeted with immunotherapy to inhibit tumour growth.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

Inhibitor of differentiation 1 (ID1) has been described as a cancer-promoting factor and also involved in the formation of an immunosuppressive tumor microenvironment. Here the authors report that ID1-expressing tumor associated macrophages favor colorectal cancer progression by promoting cancer cell stemness and CD8⁺ T cell exclusion.

Increased glycolysis in pancreatic cancer promotes immune escape by altering the tumor microenvironment. Here, the authors show that lactate-driven histone lactylation via PCAF increases CXCL1 expression, recruiting neutrophils and enabling immunosuppression, and PCAF inhibition improves anti-PD-1 therapy in pancreatic cancer mouse models.