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Dissipative many body systems provide quantum-enhanced sensitivity to external near gap-closing points. Here, the authors demonstrate record sensitivity in a Rydberg-atomic platform in correspondence of folded hysteresis trajectories under external microwave driving

Chang and Yu review recent knowledge of how lncRNAs regulate immune cell specification and function.

A majority methylammonium and iodine edge termination is observed by electron ptychography in the perovskite methylammonium lead iodide, and the stability of its edges and internal defects depends on the concentration and type of vacancies present.

Colourful patterns in two-dimensional lead halide perovskites are created by letting them self-etch into tiny squares that can template epitaxial growth.

Kumazawa, Xu, Wang and colleagues identify nuclear egress as the mechanism by which cytoplasmic chromatin fragments relocate from the nucleus to the cytoplasm in senescence. They link inflammation to metabolism by showing this egress is regulated by AMPK and metformin.

Two-dimensional metal halide perovskites exhibit diverse structures, but tuning their intralayer structure is challenging. Now, ammonium-terminated bidentate linkers have been used to develop 2D perovskites. These materials exhibit superior thermal resistance and improved photovoltaic performance compared with their Ruddlesden–Popper and Dion–Jacobson counterparts.

Subtle changes in molecular backbone geometry impact intermolecular interactions and performance of organic solar cells. Here, authors show how fused-ring configurations dictate the packing of isomeric small-molecule acceptors and achieve an efficiency of 20.07% for non-halogenated ternary devices.

The authors demonstrate that a cell’s external environment can physically control its genes. Osmotic pressure alters intranuclear crowding, shifting the equilibrium of proteins binding to dCas9-SunTag complex and thereby regulating gene expression.

Manganese-based oxides are promising cathodes for sodium-ion batteries. Here, authors design a titanium substituted oxide cathode with an optimized structure, achieving long cycle life, good air/water stability, and validation in pouch cells, supported by theory and experiments.

Ionic liquid additives increase the power conversion efficiency of perovskite solar cells, but their effect on perovskite crystallization remains unclear. Xu et al. provide mechanistic insights and demonstrate improved operational stability under continous illumination and 90 °C thermal stress.

Insulin resistance contributes to cardiometabolic disease, but its genetic basis remains incompletely defined. Here, the authors identify 217 associated loci and highlight potential therapeutic targets, linking insulin resistance to multiple diseases and aging traits.

Bulk superconductivity has been observed up to 96 K in pressurized bilayer nickelate single crystals which were synthesized under ambient pressure.

Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

The authors conducted a genome-wide association study of bipolar disorder (BD) in Han Chinese and integrated PGC4 East Asian and European datasets, discovering 23 novel loci, prioritizing 39 credible risk genes and implicating BD-related cell types and druggable targets.

Triggering the natural repair processes in the body has huge potential in tissue regeneration. Here, the authors develop a bone-targeted nanoparticle that selectively eliminates osteoclasts and generates pro-regenerative apoptotic bodies, restoring bone density and treating osteoporosis.

Heart development and function rely on communication among diverse cardiac cells. Here, the authors show that RNF20 safeguards endothelial cell identity and orchestrates heart morphogenesis and contractility by restraining TGF-β signaling and modulating angiocrine communication.

This Perspective examines the development of thermal interface materials, exploring material and design strategies that balance thermal conductivity, mechanical compliance, thickness and electrical insulation, and proposes an integrated engineering framework for the future development of the materials.

Dou, Xiao, Shen, Wang et al. show that RBFOX2 recognizes m⁶A on chromatin-associated RNAs and recruits RBM15, YTHDC1 and PRC2 to facilitate transcription suppression. Inhibition of the axis exerts anti-leukaemic effects.

Diabetes can contribute to pancreatic cancer development as well as be a consequence of it. Here, the authors report that diabetes-induced senescence of endothelial cells promotes pancreatic cancer progression.

Understanding the atomic arrangement and binding nature of 2D materials with substrates is crucial to understand their properties and utilize their functions. Here, authors report that at high temperature graphene and α-Al₂O₃ substrate form a C-O-Al bond, having strong interactions, while interfacial structural relaxations of sapphire remain suppressed.

Structural and functional understanding of the afferent inputs to histaminergic neurons remains incomplete and lacks systematic characterization. Herein, the authors establish a comprehensive and precise whole-brain atlas of long-range inputs to mouse histaminergic neurons and investigate the representative upstream histaminergic neural circuits in regulating the sleep-wake cycle.

Here the authors construct an artificial pathogen cell with tunable rigidity and find crosstalk between these and macrophages. Macrophages probe the artificial pathogen surface, and increasing rigidity of the artificial pathogen promotes proinflammatory polarization of macrophages.

Authors use a high-entropy engineering approach to produce fully amorphous BiTO films by exfoliation and annealing, creating crystalline regions, leading to flexible ceramics with dielectric properties.

Single-cell transcriptomic profiling of immune cells in the blood and liver of a human decedent receiving a pig liver xenograft reveals impaired adaptive immunity and monocyte features that may induce T cell exhaustion and contribute to platelet activation.

Wang and colleagues show that specific DNA methylation profiles mark the ILC progenitors (ILCP) that would differentiate into ILC1, ILC2 or ILC3 subsets.

An industry-compatible disorder-to-disorder synthesis produces wafer-scale, ultraclean monolayer amorphous carbon in seconds that can be used as a membrane for generating high-precision proton beams.

Yu et al. developed AIPatient, a virtual patient that uses a large language model-based AI in curating a medical knowledge base that holds realistic and personality-aware clinical conversations. The system shows high accuracy in answering questions and medical-term recognition, with readable, reliable, and consistent outputs for medical training.

An asymmetric self-assembled monolayer improves the efficiency of perovskite/silicon tandem solar cells compared with symmetric self-assembled monolayers, resulting in a certified power conversion efficiency of up to 34.58%.

The synthesis of two-dimensional (2D) organic lateral heterostructures with desirable properties from organic single crystals remains challenging. Now, 2D organic lateral heterostructures have been produced by using a liquid-phase growth approach and vapour-phase growth method, enabling the structural inversion of organic lateral heterostructures via a two-step strategy.

The transcription factor CREM is a pivotal regulator of NK cell function, making CREM a valuable target to increase the efficacy of anticancer immunotherapies based on this cell population and chimeric antigen receptors.

This study presents a comprehensive pipeline to profile transmembrane receptors involved in macrophage-driven inflammation in pancreatic islets during the onset of diabetes. The authors identify GPR132 as a mediator of macrophage-driven inflammation and find compounds that reduce inflammation and improve glycaemic control.

Ye et al. find a positive causal effect of mental well-being on healthy aging, independent of socioeconomic status. This work underscores the imperative to prioritize mental well-being in health policies geared to fostering healthy aging.

E. coli is common in humans, animals and the environment but the extent of circulation between ecological niches is unclear. Here, the authors sample ~1,000 E. coli strains from different urban aquatic ecosystems in Hong Kong and describe genomic relatedness of markers of antimicrobial resistance.

Confining high-entropy nanoparticles in molecular sieves enhances catalytic performance but lacks scalable synthesis methods. This study presents a versatile quenching strategy, producing uniform HE-NPs@MSs with high propane dehydrogenation activity.

Chromatin-associated retrotransposon RNA 5-methylcytosine can be recognized by the methyl-CpG-binding-domain protein MBD6, which guides deubiquitination of nearby monoubiquitinated Lys119 of histone H2A to promote an open chromatin state in TET2-deficient cells.

Long-range interactions in many-body quantum systems may induce dissipation channels described by non-Hermitian dynamics. Here, the authors report the observation of higher-order exceptional points, a hallmark of non-Hermitian physics, in a Rydberg atom gas. This enables design of quantum dynamics around these points, providing insight into phase transitions.

The authors used Mendelian randomization to investigate how various dimensions of socio-economic status causally affect longevity. They found a positive independent causal effect of education on longevity but no evidence for independent effects from income or occupation.

During chronic but not acute inflammation, chromatin remodelling is influenced by nuclear autophagy through WSTF interaction with ATG8 in the nucleus, leading to WSTF nuclear export and its subsequent degradation.