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Lipid Nanoparticles (LNPs) effectively deliver mRNA to cells but suffer have low levels of endosomal release. Here the authors report on core-shell LNPs with ionizable lipid–coated gold nanoparticle cores with enhanced pH-responsive membrane disruption, endosomal escape, and cytosolic mRNA delivery improving therapeutic efficiency.

Distributed multiparameter quantum metrology allows to probe multiple spatially distributed parameters across networked quantum systems. Here, the authors demonstrate distributed multiparameter quantum metrology in a modular superconducting quantum processor network.

The spatial organisation of the tumour microenvironment (TME) can affect immune responses that control tumour growth. Here, the authors use single-cell transcriptomics and spatial transcriptomics to identify a lymphocyte aggregated region (LAR) in gastric cancer and compare its cellular and molecular composition with the neighbouring TME.

Sealing of puncture points after interventional surgeries is a vital requirement, but large diameter sheaths and transapical punctures present a significant challenge for wound closure. Here, the authors present a water-activated tissue adhesive patch designed for quick and strong adhesion to blood vessel and heart tissue surfaces after surgery.

Psychedelics and their non-hallucinogenic analogues were compared, revealing that serotonin 2A receptor (5-HT_2AR)-mediated G_i signalling is essential for hallucinogenic effect, with the functional mechanisms underlying this providing insights for designing therapeutic drugs without hallucinogenic effects.

An in situ multistep edge-contact process is developed for MoS₂ transistors, achieving quasi-non-volatile capacitorless two-transistor dynamic random-access memory with 5-bit accuracy and nanosecond write speeds.

Arterial walls are vital for vascular function and disease, but their complex mechanics are not fully understood. Using broadband optical coherence elastography, the authors find that tissue viscoelasticity decreases with stretch, and collagen fibers are key for the adventitia’s nonlinear stiffening and overall nonlinear viscoelasticity.

Wearable silent speech systems hold potential for restoring communication in patients suffering from speech impairments. Tang et al. report an AI-driven silent speech system for dysarthria patients, which enables zero-time-delay expression and context-aware emotion decoding-based sentence expansion.

Chen et al. report the design and characterization of a systemically injectable oncolytic virus with tumor-targeting and low-immunogenic properties, engineered to induce tumor cell pyroptosis under local mild hyperthermia.

Highly ionically conductive and flexible solid-state composite battery electrolytes are engineered by alternately stacking inorganic Li_xM_yPS₃ (M = Cd or Mn) nanosheets with lithium-containing organic polymers in a perpendicular orientation to the surface of the electrodes.

Pressure injuries (PI) are prevalent clinical complications arising from excessive normal and shear stresses. Here, the authors present a skin-interface tri-axial stress sensing system to offer full-area coverage for PI prevention and quantitatively optimize intraoperative skin-interface stress.

Here they show that ATF7IP/SETDB1-mediated epigenetic programming governs T lymphoid progenitor trafficking and differentiation, providing important insights into the pathogenesis of human T lymphoid diseases.

Here, authors experimentally demonstrate broadband far-field phonon coupling in a valley metamaterial integrated with a Dirac-strip, achieving coupling at a five-wavelength distance.

Polymeric nanofiber membranes are hindered by low mechanical strength and stability, especially under harsh conditions. Here, the authors report an approach to simultaneously enhance the tensile strength, stability and hydrophilicity by sequentially crystallizing covalent organic frameworks and poly(ether-etherketone).

The authors developed a 5.82 g magnetically inner-actuated millirobot capable of carrying over 300 times its own weight. The high thrust and payload capability enable it to navigate tough terrains, such as sand, viscous oil, and confined spaces.

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

Analysis of the longest-lived mammal, the bowhead whale, reveals an improved ability to repair DNA breaks, mediated by high levels of cold-inducible RNA-binding protein.   

Direct epitaxial growth of vertically stacked layered materials is a promising route towards scalable fabrication of van der Waals heterostructures. Here, the authors demonstrate molecular beam epitaxy of semiconducting MoSe₂on a hBN/Ru(0001) substrate.

Type 2 diabetes is an established risk factor for dementia. Here, the authors use data from 33,136 older Chinese adults to show that polygenic risk for type 2 diabetes was associated with vascular dementia but not Alzheimer’s disease.

HIV-1 integrase is critical for viral DNA integration and RNA packaging at distinct stages of the replication cycle. Here, authors report structures of integrase assemblies, revealing how structural plasticity imparts the protein with dual functionality.

LGR4, RSPO and ZNRF3 are key regulators of the Wnt/β-catenin signaling pathway. Here, the authors reveal cryo-EM structures of human LGR4, the LGR4-RSPO2 and LGR4-RSPO2-ZNRF3 complexes, thereby providing structural insights for their regulatory mechanism of Wnt/β-catenin signaling.

In this study, the heterodimeric GABA_B receptor, a class C G protein-coupled receptor for the neurotransmitter GABA, is found to be allosterically activated by mechanical forces in a GABA independent manner through a direct interaction with integrin.

Heterojunctions of two-dimensional materials are used to design electronic and optoelectronic devices. Here, the authors show that zigzag terraces between monolayers and bilayers form atomically sharp type-I heterojunctions, resulting in a wire-like interface both in WSe₂ and in MoSe₂.

Commercial live attenuated influenza vaccines (LAIVs), usually contain a high proportion of defective interfering particles (DIPs), are not sufficiently protective. With mice models, the authors here reveal that LAIV with low DIPs replicates better, enhances immune response and facilitates cross-neutralization protection against lethal challenge of influenza strains.

Using globally consistent measurements and high-resolution modelling, this study finds that black carbon emissions are generally underestimated in the Global South.

This investigation pioneers in situ capacitance experimentation in BaTiO₃-based multilayer ceramic capacitors, and reports three radiation response mechanisms: total ionizing dose effect, enhanced low dose rate sensitivity effect, and self-recovery effect.

Noise-induced synchronization is known in classical systems and has recently been proposed in quantum many-body settings. Here, the authors experimentally demonstrate stable and entangled synchronized oscillations at the ends of a superconducting qubit chain by applying Gaussian noise to a single qubit.

The rational design and optimization of plasmonic photocatalysts depends on uncovering how light influences reactions. Here, the authors reveal a previously overlooked effect where light mimics pressure by increasing the coverage of key intermediates, thereby boosting catalytic performance.

The Dark sectioning algorithm removes the background and provides single-frame optical sectioning in fluorescence microscopy. It offers improved quantitative analysis and deep-tissue segmentation accuracy and is compatible to diverse modalities.

Low-loss superconducting aluminium cables and on-chip impedance transformers can be used to link qubit modules and create superconducting quantum computing networks with high-fidelity intermodule state transfer.

China’s cropland soil experienced acidification between the 1980s and about 2013 correlating with nitrogen fertilizer application patterns, followed by heterogeneous soil pH recovery, according to combined regional surveys and machine learning.

By mimicking antigen processing and presentation during the rejection of xenotransplanted tissue, xenogeneic cell membrane-derived vesicles encapsulating peptide antigens or mRNA-encoded antigens function as vaccines targeted to dendritic cells.

Controlled synthesis of supramolecular structures within lysosomes holds promise for cancer imaging and treatment. The authors introduce a programmable assembly strategy to generate fluorescent nanofibres in tumour cell lysosomes, enabling targeted tumour accumulation and inducing pyroptosis for precise cancer imaging and immunotherapy.

Ultrafast electron microscopy imaging of near-field spatiotemporal evolution unveils the microscopic mechanism of light transformation in chiral metasurfaces.

Fluorescence microscopy can be exploited to visualize and study T cell mediated cytotoxicity. Here the authors describe a high-throughput Bessel oblique plane microscopy platform for 3D imaging and phenotyping of cytotoxic CAR-T cells in co-culture with cancer cells.

Zero-dimensional hybrid copper halides show symmetry-dependent luminescence, enabling selective chiral recognition by coupling structural transformations with distinct optical responses.

Thermogenic proteins like PGC1α are downregulated under thermal stress, but the underlying mechanisms are unclear. Here, the authors show that chaperone-mediated autophagy, regulated by PARK7, controls PGC1α stability and BAT function at thermoneutrality.