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Lipid Nanoparticles (LNPs) effectively deliver mRNA to cells but suffer have low levels of endosomal release. Here the authors report on core-shell LNPs with ionizable lipid–coated gold nanoparticle cores with enhanced pH-responsive membrane disruption, endosomal escape, and cytosolic mRNA delivery improving therapeutic efficiency.

Applying concepts from non-Hermitian physics to diffusive systems enables the static control of heat transport. Now, this notion is expanded to dynamic control, including a demonstration of programmed thermal transport in a metamaterial.

The precise brain circuits underlying drug reward memory remain unclear. Here, authors show that the interconnected wirings between medial prefrontal cortex and claustrum contribute to the encoding and retrieval of methamphetamine reward memory in a pathway-specific manner.

A soft, biodegradable, wireless sensing device can monitor pressure, temperature and strain over long distances (up to 16 cm), maintaining accuracy across varying positions and angles.

Here the authors present NCATS-SM0225, a small molecule that inhibits ERAD and selectively kills cancer cells by binding VDACs, disrupting calcium homeostasis, and triggering the PERK-STIM1 pathway to degrade ERAD regulators.

Nitrogen-fixing bacteria offer a promising route to reduce reliance on synthetic fertilizers, but their effectiveness is hindered by environmental stresses that limit survival on leaf surfaces. This study introduces a nanocoating strategy that enables robust foliar colonization of Klebsiella variicola, enhancing nitrogen fixation and improving rice yield under low-fertilizer conditions.

A new winter-rotation oilseed crop has been generated from a freeze-tolerant wild field pennycress by de novo domestication, reducing its glucosinolate and erucic acid contents, as well as its weediness, without a growth and yield penalty. Commercialization has resulted in a low-carbon-intensity intermediate crop, demonstrating a great potential for de novo domestication to create a new crop rotation paradigm for the optimized utilization of agricultural resources.

In this work, authors present their goal-directed subgroup identification (GD-SI) framework, reconciling biological heterogeneity with clinical actionability, and offering a scalable infrastructure for precision trial design and personalized sepsis management.

Insulin resistance contributes to cardiometabolic disease, but its genetic basis remains incompletely defined. Here, the authors identify 217 associated loci and highlight potential therapeutic targets, linking insulin resistance to multiple diseases and aging traits.

Oncogenic driver mutations can influence the tumour biology of lung adenocarcinomas. Here, authors analyse 157 LUAD samples using imaging mass cytometry to reveal how these mutations impact the tumour microenvironment and clinical outcomes.

The catalytic activation of alkyl amines as α-nitrogen carbanions is challenging. Now the activation of N-arylidene-protected alkyl amines as carbanions by chiral ammonium organocatalysis for asymmetric conjugate addition and the Mannich reaction is reported, affording chiral α,α-dialkyl amines.

The 64-plex fluorescence imaging of RNA in tissues is achieved in one imaging cycle

Tropical Pacific hydrology affects the global climate through the strength of the Pacific Walker Circulation. Yanet al. reconstruct variations in the Pacific Walker Circulation in the South China Sea over the last millennium and find that less precipitation fell during warmer and more rainfall during cool periods.

The molecular characterisation of soft tissue sarcomas (STSs) across diverse populations remains crucial. Here, the authors perform a proteomics and phosphoproteomics analysis of 272 Chinese STS patients across 12 subtypes, and obtain insights related to progression, metastasis, and immune signatures.

Ancient genomes from Neolithic rice-farming populations at Baligang reveal a demographic shift around 4,200 years ago and a 5,000-year-old patrilineal social structure, providing insights into the population history of East Asia.

Coating additive solutions onto wet perovskite films in situ enables flexible all-perovskite tandem solar cells with a certified power conversion efficiency of 23.0% for a module with an aperture area of 20.26 cm². The modules maintain 97% of their initial efficiency after 10,000 bending cycles with a 10 mm radius.

Hydroformylation of 1,2-disubstituted alkenes usually occurs at the α position of the directing heteroatom. Here, the authors report the asymmetric rhodium-catalyzed hydroformylation of 1,2-disubstituted alkenylsilanes with excellent regioselectivity at the β position (relative to the silicon heteroatom) and enantioselectivity.

Precipitation patterns in the western Pacific changed at the onset of the Little Ice Age. A synthesis of precipitation reconstructions suggests that this change resulted from a contraction of the intertropical convergence zone.

The spatial architecture of the lung cancer microenvironment could influence the survival outlook and therapeutic options of patients. Here the authors find distinct patterns and composition of immune cells when comparing lung adenocarcinomas and lung squamous cell carcinomas, paving way for precision immune therapy according to histological subtype.

Topsoil nitrogen stocks declined over a ten-year field warming experiment in a permafrost ecosystem due to enhanced plant nitrogen uptake, nitrogen leaching and gaseous losses, suggesting that permafrost soil nitrogen stocks are vulnerable to warming.

Non-uniform noise introduces bias in multivariate analysis of mass spectrometry data. Here, the authors study the noise structure of the widely used Orbitrap to develop a data scaling method that reduces this bias resulting in clearer separation of chemical information from noise in biological data.

Transfer of faecal microbiota from hepatocellular carcinoma patients to mice promotes carcinogenesis via live gut pathogenic Klebsiella pneumoniae translocating to the liver.

Traditional cultured meat scaffolds employ animal-derived biomaterials or intricate manufacturing, but plant-based scaffolds offer an appealing alternative. Here the authors present a simple shortcut method to transform common vegetables into edible bioscaffolds via autoclaving, which mimics meat stiffness and microstructure.

A fuzzy sequencer can exceed the current limit of information efficiency of DNA sequencers for resequencing applications.

Muons are conventionally produced from cosmic rays or with a proton accelerator. Now a proof-of-principle experiment demonstrates the feasibility of muon production with a laser-driven electron beam with gigaelectronvolt energy in a lead converter target.

Analysis of ancient DNA, stable isotope data and archaeological evidence from the Fujia archaeological site in eastern China suggests it was populated by a matrilineal Neolithic community between 2750 and 2500 bc.

Ligand detection is an essential component of pre-clinical drug development. Here, the authors develop an assay directly coupling protein ligand binding to the luminescence intensity of NanoLuc luciferase; enabling a compound discovery strategy for a broad spectrum of potential drug targets.

Dielectric materials with high energy storage performance are desirable for power electronic devices. Here, the authors achieve high energy density and efficiency simultaneously in multilayer ceramic capacitors with a strain engineering strategy.

LKB1-mut has been shown as a major genetic driver of primary resistance to immune checkpoint inhibitors. Here this group reports the identification of the LKB1-IAP-JAK dynamic complex as a molecular determinant for immune response of LKB1-mut lung cancer cells.

EGFR amplification can affect temozolomide sensitivity in glioblastomas (GBM). Here the authors show that EGFR signalling mediates lysine methylation of NFAT5 which contributes to reduced efficacy of temozolomide in GBM.

Researchers report a sustainable nanofluidic osmotic energy harvester made from natural montmorillonite clay nanosheets and recycled cellulose. Scaled-up films of 700 cm² show power output of 8 W m⁻² with stability over 30 days

Analysis of 5hmC in tumor tissues and cfDNA reveals concordant cancer signatures that show potential for tissue origin prediction via liquid biopsy

The search for lunar polycyclic aromatics is challenging. Here abundance, aromatic structures and carbon isotope composition of polycyclic aromatics in Chang’E 5 lunar soils are reported, shedding light on the fate of polycyclic aromatics and accretion of organic carbon on the Moon.

The authors highlight the role of acyl coenzyme A binding protein (encoded by DBI) in Cushing’s syndrome by using six different inhibition methods and mapping the physiological effects.