Search

Solid-state organic optical limiters for laser protection suffer from aggregation quenching. Here, the authors use coordination-bond anchoring strategy to overcome this and achieve an enhancement of nonlinear absorption coefficient.

While cheese is enjoyed globally, most of the known physiochemical and microbial characteristics are from western cheeses. Here, the authors expand the global catalogue of cheeses by investigating 235 Chinese samples and compiling over 3000 metagenomic datasets.

AI is transforming protein engineering, but the immobilization of enzymes often impairs their activity. Here, the authors present a machine-learning-based workflow that can be used to identify optimal nanohybrids with high activity recovery across diverse enzymes.

Presence of higher soil pH and calcium in limestone promote free-living nitrogen fixation activity in soils by fostering beneficial microbial associations, whereas lithology has no significant effect on the activity in litter, according to sampling analysis conducted in the southwest China.

Lithium dendrites are a major barrier to the use of high-energy lithium metal batteries. Now, a highly adhesive polymer electrolyte is designed to suppress lithium dendrites by confining lithium in a continuous nucleation state through strong interfacial binding interactions.

A two-dimensional/two-dimensional contact of metallic Nb_0.3W_0.7Se₂ and tungsten diselenide can be used to make p-type transistors with channel lengths of 100 nm and on-currents of over 1.1 mA µm⁻¹.

A solar-powered methodology facilitated by the rational design of a photocatalyst enables efficient defluorination of structurally diverse per- and polyfluoroalkyl substances, thereby establishing a sustainable strategy for the environmental remediation of these recalcitrant contaminants.

Lin et al. identify a mechanism by which swimming exercise attenuates cognitive decline in Alzheimer’s disease mice, via induction of skeletal muscle-derived vesicles containing miR-378a-3p, taken up by microglia to regulate metabolism and enhance plaque clearance.

Merlin, a vision–language foundation model trained on a large dataset of paired CT scans, patient record data and radiology reports, demonstrates strong performance across model architectures, diagnostic and prognostic tasks, and external sites.

He et al. report a lanthanide-doping strategy for dual-halogen-alloyed perovskite microplates, which promotes phase segregation and facilitates ion migration in the alloyed case, while suppressing it in the phase-segregated state, resulting in dual-wavelength lasing in visible spectral region.

A benchmark to evaluate spatial alignment methods for spatial transcriptomics shows that the best approach is dataset dependent and offers actionable guidance for the future development of methods.

Transcriptomic and clinical data analyses from multiple cohorts of patients with cancer receiving immunotherapy find that PD-1 blockade potentiates tumor-specific IgG1 plasma cell responses that complement cellular immunity and contribute to clinical benefit.

Proteolysis-targeting chimeras (PROTACs) hold therapeutic promise but face challenges of high molecular weight, polarity, and poor drug-like properties. Here, authors develop PLA-based SM-PROTACs that achieve efficient target degradation and superior low-dose, long-term tumor inhibition in vivo

A nanoimprint technique exploiting capillary forces in nanohole arrays enables patterning CdSe-based quantum-dot LEDs with a resolution of nearly 170,000 pixels per inch while maintaining high average external quantum efficiencies of 17.0%, 10.5% and 5.7% for red-, green- and blue-emitting pixels, respectively.

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

The study identifies PLUM, a uORF-encoded microprotein from Lin28b, as a key regulator that drives deterministic induction of naïve pluripotency through coordinated RNA regulation and metabolic remodeling.

Medullary thyroid carcinoma (MTC) is a rare and aggressive neuroendocrine tumor with limited risk stratification. Here, the authors perform multi-omic analysis of MTC samples from 452 patients across 10 Chinese clinical centers, identify molecular subtypes and develop a prediction model.

Soil viruses may impact soil carbon cycle. Here, the authors use metagenomic analysis of contaminated soil and 13 C labeled microcosm incubation to show that the DNA viral community enhances microbial carbon fixation capacity via auxiliary metabolic genes.

Methods for direct incorporation of tri- and di-fluoroethanol units in molecules are relatively limited. Here, the authors report two organosilicon reagents which are applied to allylation, alkylation and alkenylation reactions as tri- and di-fluoroethanol transfer reagents.

Monodisperse biaxial colloidal particles are used as model systems to understand the phase behavior of biaxial molecules but high-quality biaxial colloids are limited. Here the authors describe gram-scale synthesis of uniform biaxial colloidal cuboids and their assembly into mesophasic structures.

The growth of artificial intelligence requires better computation at lower energy. Semiconductors remain the more prolific materials platform driving practical improvements to device hardware. Here, the authors outline a critical pathway for accelerating the transfer of early findings in material science into manufactural processes for faster scale-up and technology applications.

Dense mapping of DNase I cleavage sites across the whole yeast genome by next-generation sequencing reveals a global view of the binding of regulatory proteins to genomic DNA. The high resolution allows the identification of new binding sites for known factors as well as the de novo derivation of factor binding motifs.

Post-translational modifications are critical to protein structure and function. Mass spectrometry, antibody pulldowns and other lines of evidence now establish the presence of lysine succinylation across numerous proteins and species.

Achieving high output-power-density in Gallium-nitride transistors is challenging due to high thermal resistances and thick nitride layers. Here, the authors propose ion-implantation on silicon-carbide substrates, achieving high performance and reduced thermal resistance.

Quality control for epigenomic datasets requires robust ground truths. Here, authors generate genome-wide quantitative methylation reference datasets from the publicly available Quartet DNA reference materials, which could serve as a resource for the standardised benchmarking of emerging technologies.

The hydrogenation of multisubstituted allenes presents a long-standing challenge due to the difficulty in simultaneously controlling multiple selectivity parameters. Now a class of pincer cobalt catalysts featuring multiple metal–ligand cooperation functionalities has been developed that enables the regio- and stereodivergent hydrogenation of allenes to provide all possible multisubstituted alkene products.

Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder characterized by the functional loss of the tumor suppressor gene neurofibromin, that can lead to the development of benign and malignant tumors. Here the authors describe the development of an adeno-associated virus vector for NF1 gene replacement therapy of NF1 related tumors, showing tropism and anti-tumor activity in preclinical models

H₂O₂ photosynthesis offers a green alternative to traditional methods, but challenges remain in charge separation and reaction selectivity. Here, the authors report Z-scheme photocatalysts where sulfur vacancy regulates O₂ adsorption configuration, enhancing H₂O₂ production with high selectivity.

Microglia play essential roles in sculpting synaptic connections during brain development but their role in the adult brain is less clear. Here the authors show that activated microglia can prophylactically protect the adult rodent brain from injury by migrating to and displacing inhibitory synapses from cortical neurons.

Pilcher et al. present a single-cell transcriptomics-based immune atlas of participants with newly diagnosed multiple myeloma, reporting on the association of cell types, gene expression and intercellular interactions with disease progression phenotypes.

It is extremely difficult to separate tritium from radioactively contaminated water. Here the authors introduce catalytic hydrogen isotope exchange to water distillation, realizing excellent detritiation performance.

Detailed knowledge of COVID-19 epidemiology is needed to inform public health responses. Here, the authors use large-scale contact tracing data to provide empirical estimates of key parameters, and show that susceptibility increases with age but transmissibility does not vary significantly.

A recombinant vaccine that targets the receptor-binding domain of the spike protein of SARS-CoV-2 induces a potent antibody response in immunized mice, rabbits and non-human primates, and protects primates from infection with the virus.

Papillary thyroid carcinoma has a heterogenous outcome, particularly in paediatric patients. Here, the authors utilise machine learning to create a protein-based prognostic model to predict recurrence risk.

RNA-binding proteins (RBPs) modulate all aspects of RNA metabolism. Here the authors introduce a method named HARD-AP that effectively isolates RBPs and their closely associated RNA regulatory complexes from both cultured cells and fresh tissues.

The role of stem Leydig cells in restoration of male fertility after acute injury is not clear. In an acute injury mouse model of testicular torsion, the authors show that Stem Leydig cells can restore testicular immunological homeostasis by mitochondria transfer to macrophages in a TRPM7-mediated manner.

Studying tumour heterogeneity and tumour evolution remains a challenging task. Here, the authors propose a supercontinuum-tailoring two-photon microscope to enable the imaging of multiple fluorophores with a single light beam. They use this tool to monitor the dynamics of heterogeneous tumour evolution.

Here the authors report two structures of human PTH1R-Gs complex bound to ligands PTH and ABL, providing insight into the molecular mechanism of ligand duration.

Osteolytic bone disease is a complication that affects 80% of patients with multiple myeloma. Here, authors show that inhibition of EMP1 due to EZH2 activation results in increased proliferation of myeloma cells and up-regulation of osteoclastogenic cytokines that promote bone lesions.

Here, by performing multi-omics microbiome analyses in a cohort of children with new-onset T1D, the authors characterize altered microbial functional and metabolic traits involved in T1D, which they validate in animal experiments, together providing potential avenues for microbiome-based interventions.

Root-associated microbiota confers benefits to plant in responding to environmental stress. Here, the authors show that wild soybean secretes purines under salt stress, reshapes the microbiota and recruits Pseudomonas.

Myeloid cells are the predominant cell type in the tumor microenvironment of human and murine glioblastoma (GBM). By generating a mouse model deficient for all monocyte chemoattractant proteins, here the authors show that blocking monocyte recruitment promotes a compensatory neutrophil influx and that concomitant neutrophil inhibition is required to improve survival in GBM preclinical models.