Search

Natural rubber is a widely used biopolymer and further improving its resistance to crack growth will extend its service life. Here the authors show a strategy to amplify the resistance to crack growth in natural rubber by forming a tanglemer.

Solar-driven production of H₂O₂ and chemicals from O₂ and biomass is promising but hindered by inefficient photocatalysts. Here, the authors report composite photocatalysts of atomically dispersed Ta sites for broad-spectrum light absorption and selective biomass conversion in a three-phase system.

Although N₂O emissions from wastewater treatment plants have been studied extensively, emissions of NH₃ have been largely considered irrelevant. Analysis of such emissions from a sludge drying pan, a commonly used method, shows that NH₃ emissions are in fact substantial and should not be overlooked.

The function of serotonin receptors and the neuroimmune relationship in psoriasis is not fully understood. Here, the authors find HTR2A antagonistic drugs worsened psoriasis outcomes in a study population, and that HTR2A modulation reduced psoriasis severity in imiquimod mouse models and that this involved HTR2A-expressing monocyte-derived Langerhans cells.

Integrating functional materials with microfibers for optical tuning remains challenging. Here, the authors present a conformal strategy to integrate homogeneous and inhomogeneous nanomembranes—including metals, oxides, semiconductors and polymers—onto microfibers, which are further developed into on-fiber sensors, modulators, filters, and photodetectors.

Systems with strong photon-photon interactions enable advanced quantum optical applications as well as the study of highly correlated light-matter states. Here the authors report strong coupling between single- and two-photon states in a superconducting circuit, enabling a new regime of nonlinear quantum optics.

The relationship between interacting sites and catalytic mechanisms in single-atom catalysts remains unclear. Here a support engineering strategy is used to tune the binding strength between single-metal atoms and the support, optimizing active Cu sites and enhancing CH₄ formation.

The ρ-type GABAA receptors are potential therapeutic targets in several neurological conditions. Here, authors elucidate interactions of it with three therapeutic drugs, offering mechanistic insights and a prospective basis for further pharmaceutical development.

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

An approach that integrates electrochemical CO₂ reduction and biological denitrification provides a new solution for nitrogen removal, where the formate obtained from CO₂ is used directly as the carbon source in the denitrification process in wastewater treatment.

Through the sonochemical exfoliation of grown black phosphorus crystals, high-quality, narrow and clean black phosphorus nanoribbons with smooth edges and defined edge chirality are achieved, enabling the realization of high-performance transistors and photodetectors.

A screen for protein degraders discovers hits by imaging cell survival.

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

Anti-TSLP biologics have shown promise for the clinical treatment of type 2 respiratory disease. Here the authors present a clinical trial of CM326, a monoclonal antibody against TSLP, and show the clinical effects in patients with eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP), who present with type 2-dominant inflammation.

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

Parity-time symmetry breaking and related non-Hermitian phenomena, such as high-order exceptional points, have attracted significant interest across various experimental platforms. Here the authors demonstrate a third-order exceptional point induced by parity-time symmetry breaking in a dissipative trapped ion.

An ex vivo model and pre-clinical study in a brain-dead recipient provide enzyme-converted O organs to avoid hyperacute rejection in ABO-incompatible kidney transplant patients.

‘Ultrathin’ gold interlayers are shown to form nanoparticles that balance optical losses and electrical contact, enabling efficient perovskite–perovskite integration for scalable and durable triple-junction photovoltaics.

In advancing the design of electronic devices, the dielectric tunability of barium strontium titanate is enhanced by an order of magnitude relative to the previously reported values through the manipulation of polar domain characteristics.

This study proposes a contact-dominated, field-enhanced design for capacitive sensors, achieving high response, strong linearity, and high sensitivity over a broad range, demonstrating great potential for functionalized flexible electronics and artificial intelligence robotic applications

The development of moderate magnetic hyperthermia (MH) for tumor ablation while concurrently restoring bone homeostasis shows potential for osteosarcoma (OS) therapy. Here this group combines magnetothermal nanoparticles with MH temperature-controlled borosilicate bioactive glass achieving OS cell impair while activating TNF signaling pathway for therapeutic purpose.

Monkeypox or Mpox represents a worldwide health emergency, and efficient vaccines are urgently needed. Here authors present a modified vaccinia virus as vaccine candidate, generated from the Tiantan strain by targeted gene deletion to make it replication-deficient, which elicits robust immune response in both mouse and macaque models, with favourable safety and long-lasting protection profiles in the non-human primates.

In vitro transcribed circular RNAs (ivcRNAs) offer a stable and efficient platform for protein replacement therapy. Here, the authors show that localized ivcRNA delivery restores MSI2 and SOX5 expression in chondrocytes, mitigating osteoarthritis progression in mice.

Genetic mutations causing hereditary deafness, including autosomal dominant non-syndromic deafness 15 (DFNA15), currently have no effective treatment. Here, authors establish a Pou4f3^WT/Q113* mutant mouse model and engineer and deliver an adenine base editor for near-complete hearing recovery.

Temporal processing and robustness to noise are challenges in current spiking neural networks. Drawing on principles of neural oscillations, the authors introduce Rhythm-SNN, which enhances temporal processing and robustness while significantly reducing energy consumption.

Here the authors show that crotonate and H3K14cr levels are increased in regenerating crypts. Treatment with sodium crotonate (NaCr) significantly alleviates dextran sulfate sodium induced colitis, an effect largely dependent on HBO1-mediated H3K14cr.

Basalt clasts returned by Chang’e-6 suggest a lunar farside mantle potential temperature that is approximately 100 °C cooler than the nearside mantle, according to a petrologic study combined with thermobarometric modelling and remote sensing data.

Primary angle-closure glaucoma is a leading cause of blindness. Here, the authors identify rare deleterious variants in UBOX5 as risk factors and implicate BIP ubiquitination as a potential disease mechanism.

Cardiovascular diseases often co-occur. Here the authors conduct cross-disease genome wide association studies using multi-trait analyses to uncover shared genetic mechanisms contributing to overlapping risk profiles.

The continuous dilute CO₂ electrolysis is promising for industrial applications but limited by high resistance of mass transport. Here, the authors report a localized mass transport channels coupling CO₂ concentrating and converting process to synthesize highly selective and stable C₂₊ products.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

In a phase 3 trial for Huntington’s disease, pridopidine did not meet its primary endpoints but was safe and favored in some prespecified subgroup analyses.

The use of Cu catalysts for the CO₂ reduction reaction is hindered by their poor stability. The authors find that traces dissolved oxygen in the electrolyte results in Cu dissolution/reconstruction and report an in-situ passivation strategy to prevent oxygen adsorption in high stability.

The growth of wafer-scale single-crystalline 2D semiconductors on sapphire is important for their electronic applications, but the underlying mechanisms are not yet fully understood. Here, the authors study the influence of air-induced sapphire surface hydrolysis on the growth process of 2D WS₂ and propose an ultraviolet light healing method to repair the degraded substrates.

Near-edge plasma treatment of Hf0.5Zr0.5O2 capacitors results in dielectric permittivity of 921, stored charge density of 349 μC/cm2, and energy density of 584 J/cm3 when the material’s ferroelectricity abruptly disappears after polarization fatigue.

Trained and validated on multimodal data from 14.5 million images from multicountry datasets, a foundation model is shown to increase diagnostic and referral accuracy of clinicians when used as an assistant in a trial involving 16 ophthalmologists and 668 patients.

IP6 is a critical host cofactor for HIV-1 assembly and infectivity. In this study, the authors uncover the structural basis by which HIV-1 adapts to a deficiency in IP6 packaging through a G225R mutation at the C-terminus of the capsid protein.

A combination of mouse model data and data from a randomized phase 2 trial in patients with breast cancer in remission demonstrates feasibility, safety and a reduction in residual tumor cells following treatment with hydroxychloroquine and/or everolimus.

Single-cell RNA sequencing, whole-exome sequencing and spatial transcriptome sequencing of gallbladder adenocarcinomas from 75 patients stratifies the disease into groups with distinct clinical outcomes.

A coherent 909-Hz quasi-periodic oscillation was potentially detected in GRB 230307A, the second brightest gamma-ray burst to date, indicating that a millisecond magnetar formed after the merger powered the burst.

Mitochondrial fatty acid β-oxidation is essential for cellular energy production. Here the authors show that mutations in Testis-Expressed Protein 44 (TEX44) are associated with misregulated fatty acid β-oxidation and male infertility.

In this Stage 2 Registered Report, Buchanan et al. show evidence confirming the phenomenon of semantic priming across speakers of 19 diverse languages.

This study develops a liquid-gating topological gradient microfluidics device that generates finely tuned microbubbles in a functional liquid in a high-throughput manner for air purification in different scenarios.

Disorder has emerged as a promising tool to manipulate properties of superconducting circuits. Here the authors demonstrate the use of disordered spinodal superconductor for fluxonium qubit fabrication and reveal an interesting correlation between the material disorder and the 1/f-type flux noise.

The authors experimentally realize the control of the topological charge of magnetic skyrmionic structures at room temperature in a Dzyaloshinskii-Moriya interaction (DMI) platform with spatially alternating signs. By modifying the DMI energy landscape through chemisorbed oxygen, a magnetic topological transition is realized.

Materials with low dielectric constant and low dielectric loss over a wide temperature range are needed to produce complex and miniaturized integrated circuits. Here, the authors report covalent organic framework films showing ultralow dielectric constant and dielectric loss, low thermal expansion coefficient, and improved mechanical properties. At the same time, the films exhibit prominent thermal conductivity, which is one order of magnitude higher than that of other typical porous dielectric materials.

HIV infection is associated with increased risk of more severe Mpox, yet the underlying mechanisms aren’t well understood. Here, the authors reveal increased MPXV replication and immune dysfunction in SIV-MPXV co-infected rhesus macaques and, using proteomics and phosphoproteomics from multiple organs, identify involved pathways.