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This study reports that the gene SMPED1, located in a previously identified dichogamy-determining region in Alpinia species, controls the timing of sex-organ synchrony, improving our understanding of the evolutionary mechanisms of plant sexual diversity.

Simultaneous profiling of spatial transcriptomics (ST) and metabolomics (SM) offers a novel way to decode tissue microenvironment heterogeneity. Here, the authors present SpatialMETA, a conditional variational autoencoder-based framework designed for the integration of ST and SM data.

A super-pangenome analysis incorporating 123 newly sequenced bryophyte genomes reveals that bryophytes exhibit a larger number of unique and lineage-specific gene families than vascular plants.

An in-built fluoropolyether-based quasi-solid-state polymer electrolyte enables high-capacity lithium-rich manganese-based layered oxide cathodes with stable interfaces, achieving 604 Wh kg⁻¹ pouch-cell energy density.

An asymmetric self-assembled monolayer improves the efficiency of perovskite/silicon tandem solar cells compared with symmetric self-assembled monolayers, resulting in a certified power conversion efficiency of up to 34.58%.

(Hetero)aryl sulfoximines are useful bioisosteres of (hetero)aryl sulfones in medicinal chemistry as they have improved aqueous solubility and metabolic stability. Here, the authors report a synthesis of (hetero)aryl sulfoximines via copper-catalysed coupling of (hetero)aryl iodides and sulfenamides.

Epstein-Barr virus is associated with increased cancer risk. Here, the authors analysed two population-based prospective cohorts in Southern China to examine the association between increased seropositivity and the risk of multiple cancer types.

The Einstein Probe has discovered a fast X-ray transient, EP240414a, associated with a broad-lined type Ic supernova. Its unusually soft spectrum and weak jet add to the diversity of stellar deaths and suggest a previously unknown Wolf–Rayet star explosion mechanism.

In this work, authors show that deletion of FprB enhances the antibacterial activity of gallium against Pseudomonas aeruginosa, revealing a combination strategy and demonstrating the utility of CRISPRi-seq for therapeutic target discovery.

Catalytic atroposelective construction of axially chiral aryl-fused medium-sized rings, such as nine-membered rings is challenging. Here the authors describe a catalytic asymmetric (4 + 5) cycloaddition to achieve the challenging transformations.

Vaginal infections influence about 75% of adult women worldwide each year. Here, the authors report a strategy to treat vaginal infection by restoring the homeostasis of the vaginal mucosal barrier through in situ formation of a living-synthetic therapeutic coating.

Small peptide tags (like ALFA) cause minimal disruption of proteins, but they typically lack fluorescence, which would enable knockin screening. Now, antigen-stabilizing fluorescent protein-fused nanobodies called ANGEL have been developed, which enable endogenous labeling guided by ALFA nanobodies. ANGEL fluorescence increased with genomic ALFA in-frame insertion, which enables fluorescence-activated cell sorting screening for knockins, endogenous protein labeling, imaging, degradation and interactome analysis in native cellular contexts.

The primary entry route of vanilloid ligands to the vanilloid-binding site in transient receptor potential vanilloid 1 (TRPV1) is found to be a distinct and targetable hydrophobic pathway at the TRPV1–cell membrane interface rather than through direct membrane penetration.

Usually, each refrigerant has a limited refrigeration temperature span. In this work, the authors observe refrigeration with barocaloric effect in a region from 77.5 to 300 K and potentially down to 4 K.

The acetyltransferase cysE is involved in mitigating oxidative stress, which modulates the virulence and drug resistance of M. tuberculosis.

Semiconductor quantum dots that simultaneously support blue and yellow emission offer a route to realizing efficient white light-emitting diodes.

Selective CO₂-to-liquid conversion remains a major challenge due to inertness of CO₂. This work designs Pd nanoneedles with bent Pd–Pd bonds, enabling >99% selective formic acid production under mild conditions by enhancing CO₂ activation.

The mechanism of HIV-1 latency reversal remains unclear. The authors suggest that PRMT3 drives the reversal by enhancing chromatin accessibility to form a transcriptional hub containing TEAD4 and P-TEFb at the viral promoter.

Understanding past warming events is essential to project the consequences of anthropogenic carbon emissions. Here, carbon and hydrological cycle changes of the Carnian Pluvial Episode are revealed, offering insights into Earth System functioning.

Here, the authors report that SARS-CoV-2 M protein interacts with host ARF1 to facilitate viral assembly at the ER-Golgi intermediate compartment and demonstrate that targeting ARF1 or its interaction with the M protein disrupts virus production in vitro and in vivo, proposing a potential broad-spectrum therapeutic approach.

First-instar orchid mantis nymphs avoid predators by mimicking black-red assassin bugs, whereas those in later instars avoid predators and attract prey by camouflaging themselves as lighter-coloured flowers. Here the authors use developmental transcriptomics, evolutionary genomics and predation experiments to reveal that this ontogenetic colour change is regulated by a pigment transporter called Redboy that emerged in Polyneoptera 284–197 million years ago.

The death of massive stars has traditionally been discovered by explosive events in the gamma-ray band. Liu et al. show that the sensitive wide-field monitor on board Einstein Probe can reveal a weak soft-X-ray signal much earlier than gamma rays.

Worldwide, the number of only-child families is increasing. This research examines how growing up without siblings affects adult brain structure, function and connectivity, cognition, personality and mental health.

Renal cell carcinoma consists of several subtypes, and recurrence is highly dependent on subtype. Here, the authors develop a multi-classifier using imaging, lncRNA and clinical data to predict recurrence in papillary renal cell carcinoma.

Extreme Sr–Nd depletion in 2.8-billion-year-old basalt fragments from the lunar farside South Pole–Aitken basin suggests an ultra-depleted mantle source resulting from lunar magma ocean crystallization and/or later impact-related melt extraction.

The characterization of the surface structure and binding sites of materials is crucial for designing advanced materials for adsorption processes. Here, the authors use ¹⁷O solid-state nuclear magnetic resonance spectroscopy to identify specific CO₂ adsorption sites on MgO nanosheets.

Proton transfer plays a key role in nature, yet its ultrafast dynamics remain elusive. Here the authors use coincidence spectroscopy and theoretical simulations to show that radiolytic doubly-ionized pyrrole triggers proton transfer to water within 60 fs.

Steroid resistant asthma can be combatted with antibody therapy, but delivery and off-target effects are a concern. Here, the authors report on the co-delivery of thymic stromal lymphopoietin nanobody mRNA and budesonide in budesonide-incorporated inhalable lipid nanoparticles to treat steroid resistant asthma.

Activation of brown adipose tissue thermogenesis increases energy expenditure and promotes weight loss in mice. Here the authors identify neurotrophic factor neurotrophin 3 (NT-3) as an adipokine that regulates sympathetic nervous system growth and innervation in adipose tissue and increases white adipose beiging.

Song et al. developed a computational tool to profile binding pairs between tumor-derived antigens and antibodies from high-throughput B cell receptor sequencing data, predicting response to immune-checkpoint inhibitor therapy and risk of adverse events.

Nanoscale circularly polarized light sources are an important building block for future integrated photonics. Here the authors demonstrate circularly polarized light emission from a thin organic single crystal light-emitting diode.

Low-frequency quasiperiodic oscillations in X-ray data are thought to trace the accretion flow in X-ray binaries. Here, the detection of 200 keV oscillations probes the innermost regions of MAXI J1820+070, revealing the precession of a small-scale jet.

In magnetic materials, geometry-defined competing interactions between spins combined with quantum fluctuations can present the possibility of quantum liquid states which do not order even as 0K is approached. Here, the authors present an analogue built from electric dipoles on a triangular lattice.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.