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NAE1/UBA3-UBE2M are E1 and E2 enzymes for the URM1 modification
|
|
Small heat shock and J-domain proteins direct defense against areca palm velarivirus 1 by degrading coat protein via autophagy
|
|
Boosting immunogenic tumour cell death via nanotherapeutic targeting of the Stanniocalcin 1 phagocytosis checkpoint for enhanced cancer immunotherapy
|
|
Histone methylation defines c-Jun/Sox2/Hif1α axis that controls stemness and tumor progression in squamous cell carcinoma
|
|
Augmented prediction of multi-species protein–RNA interactions using evolutionary conservation of RNA-binding proteins
|
|
Reprogramming of bacterial virulence by lysine acetylation
|
|
Spatial predictors of response to chemo-immunotherapy in microsatellite stable metastatic colorectal cancer
|
|
2′--methylation-dependent installation of -methylguanosine in the U6 internal stem loop facilitates efficient spliceosome assembly
|
|
Single cell transcriptional evolution of myeloid leukemia of Down syndrome
|
|
Neoadjuvant toripalimab plus CapeOX in locally advanced Epstein-Barr virus-associated gastric or gastroesophageal junction adenocarcinoma: a phase Ⅱ trial
|
|
Discovery of a novel envelope protein derived from simian retrovirus 2 for pseudotyping retroviral vectors used for production of CAR immune cells
|
|
Structural basis of NSD2 degradation via targeted recruitment of SCF-FBXO22
|
|
Assessing the contribution of rare DNA states to cancer mutational signatures using sequence-specific conformational fingerprinting
|
|
Genetic determinants of fatigue up to 2 years after radiotherapy in prostate cancer patients
|
|
Highly mutagenic copying of telomeric circles promotes ALT establishment
|
|
Recurrent DNA break clusters drive replication-stress-induced copy number variants and genome diversification
|
|
T-cell mesenchymal transition represents a potential pathogenic mechanism of female cancer-related lymphedema
|
|
Engineered BCG selectively triggers trained immunity in tumor-associated macrophages and sensitizes glioblastoma to radiotherapy in mice
|
|
Disruption of the SAGA CORE triggers collateral degradation of KAT2A
|
|
Subcellular mRNA localization patterns across tissues resolved with spatial transcriptomics
|
|
Genetic landscape and functional exploration of kidney cancer predisposition in cross-ancestral populations
|
|
Hijacking innate immunity to enhance mRNA therapeutics by blocking IFN-P-body-XRN1 axis-mediated degradation
|
|
ELMO2 is a therapeutic vulnerability in mesenchymal-like and drug-resistant non-small cell lung cancer
|
|
Discovery of an Endonuclease G-inhibitory Ku80-peptide protecting against leukemogenic rearrangements at the MLL breakpoint cluster
|
|
Nonsense-mediated mRNA decay factors target short poly(A)-tailed mRNAs lacking a premature termination codon
|
|
Immune-induced TCR-like antibodies regulate specific T cell response in mice
|
|
Clonal biases dictate availability of colonic cancer driver mutations for transformation
|
|
Spliceosome induction is a druggable dependency of RAS-driven senescence and cancer
|
|
Sequential transcriptional waves and NF-κB-driven chromatin remodeling direct drug-induced dedifferentiation in cancer
|
|
Demethylation-primed tandem CD19/CD20 CAR T cells in relapsed/refractory B-cell lymphoma: a phase I/II trial
|
|
Chemical anchoring of immunotherapeutic drugs within senescent tumor cells overcomes senescence-driven immunotherapy resistance
|
|
Dissecting origin factors of lymph node metastasis in non-small cell lung cancer via multimodal omics
|
|
Differential KEAP1/NRF2 mediated signaling widens the therapeutic window of redox-targeting drugs in SCLC therapy
|
|
Allogeneic CD19 CAR T cells armed with an anti-rejection CD70 CAR overcome antigen escape and evade alloimmune responses
|
|
VGLL4-driven TEAD4 multimerization orchestrates DNA binding and YAP recruitment
|
|
Vitamin D binding protein induces skeletal muscle atrophy and contributes to cancer-associated muscle wasting independently of vitamin D status in preclinical models
|
|
Balancing the efficacy and safety of chimeric antigen receptor T-cell therapy by affinity combination
|
|
Pervasive non-triplet alternative splicing drives functional isoform diversity
|
|
Multi-layered molecular profiling informs the diagnosis and targeted therapy of desmoplastic small round cell tumor
|
|
Developing a multimodal therapy for glioblastoma using oncolytic virus delivering CD19 and EGFRvIII antigens and bi-specific CARs
|
|
CRISPR activation screens identify oncogenic lncRNAs that are susceptible to CDK4/6 inhibitor treatment
|
|
SMARCB1 missense mutants disrupt SWI/SNF complex stability and remodeling activity
|
|
Neoadjuvant palbociclib and endocrine therapy versus chemotherapy in ER + /HER2- breast cancer: a randomized phase II trial
|
|
Daratumumab in high-risk MGUS and low-risk smoldering myeloma: results of the Phase II D-PRISM study
|
|
NLRP14 modulates the activity of E3 ubiquitin ligases during the oocyte-to-embryo transition
|
|
L-RNA aptamer-based CXCL12 inhibition combined with radiotherapy and bevacizumab in newly-diagnosed glioblastoma: expansion of the phase I/II GLORIA trial
|
|
PD-1 antibody-bound progenitor-exhausted CD8+ T cells in lymph nodes boost PD-1-blockade anti-tumor immunity in gastrointestinal cancer
|
|
Influence of B cell-lineage targeted CAR-T cell therapy on humoral immunity and vaccine-induced antibody response
|
|
A live biohybrid bacterial therapy based on engineered Serratia marcescens
|
|
Ponatinib inhibits LCK and PI3K signaling and promotes CD8+ T stem cell memory cell development
|
|
Quizartinib and omacetaxine mepesuccinate combination therapy in FLT3-ITD AML: a phase II trial
|
|
In vivo CAR T cell generation using retargeted and functionalized lentiviral vectors with reduced immunogenicity
|
|
Durvalumab plus tremelimumab for the treatment of patients with progressive, refractory advanced thyroid carcinoma: the phase II GETNE-DUTHY trial
|
|
Single-cell transcriptomics reveals FXR1 as an actionable target for siRNA therapy in ovarian cancer
|
|
Genomic analysis of T Cell receptors reveals lynch syndrome specific immune signatures
|
|
Distinct mechanisms of replication stress induced by oncogenic RAS and cyclin E1 converge on R-loop-dependent fork reversal
|
|
D-π-A sensitized carbon dots as long-lived type-I/Ⅱ photosensitizers for NIR-excited hypoxia-regulated photodynamic therapy
|
|
MYC-induced USP10 stabilizes SOX4 to promote thymocyte proliferation and leukemia onset in mice
|
|
Recombinant haemostatic protein for therapeutic substitution of platelet function via tripartite haemostatic mechanisms in thrombocytopenic male mice
|
|
Loss of luminal lineage drives resistance to next-generation ERα antagonists in pretreated ER HER2 locally-advanced or metastatic breast cancer
|
|
FSHR and LHR functional compensation reveals the mechanism and treatment of Ovarian Hyperstimulation Syndrome
|
|
TFEB degradation is regulated by an IKK/β-TrCP2 phosphorylation-ubiquitination cascade
|
|
Clinicopathologic and molecular predictors of survival in -deficient tubo-ovarian high-grade serous carcinoma
|
|
Structures of ZYG11B-EloB-EloC-substrate complex reveal mechanisms of CRL2ZYG11B assembly and function
|
|
Timosaponin AIII enhances CAR-T cell potency and prevents relapse through impairing CAR-Tregs
|
|
PD-1 blockade plus tyrosine kinase inhibitor remodels the tumor microenvironment in advanced renal cell carcinoma
|
|
Lymphodepleting preconditioning impairs host antitumor immunity induced by adoptive T cell therapy in mouse models
|
|
Epitranscriptomic RNA editing resolves Mus81 DNA repair tradeoffs in heat tolerance and meiosis
|
|
HR3/RORα-mediated cholesterol sensing regulates TOR signaling
|
|
Spatial single cell transcriptomic analysis informs tumor developmental hierarchy of DICER1 syndrome related sarcoma
|
|
Phosphorylation of SF3B1 by CDK11 orchestrates spliceosome activation via SNIP1-dependent RES complex recruitment
|
|
CBP phosphorylation maintains intestinal homeostasis by supporting the stem cell niche through versican
|
|
NEK8 kinase-mediated lactate increase impairs antitumor immunity decreasing radiotherapy sensitivity in colorectal cancer
|
|
Iminium-linked hyperporphyrin covalent organic framework mediates type I photodynamic therapy via a photoredox process
|
|
Structural basis for pH-responsive amino acid transport via SLC7A4.
|
|
FOXA1 loss drives basal/squamous de-differentiation of prostate cancer and induces an immunosuppressive tumor microenvironment
|
|
Neoantigen evolution and response to checkpoint inhibitor immunotherapy in colorectal cancer
|
|
Tumor-infiltrating immature innate lymphoid cells in colorectal cancer are biased toward ILC1/tissue-resident NK cell differentiation
|
|
Structural basis for the carboxylation and epoxidation of human gamma-glutamyl carboxylase
|
|
Targeting a super-enhancer induced aldehyde dehydrogenase metabolic loop mitigates CDK4/6 inhibitor resistance in estrogen receptor-positive cancers
|
|
Bleb-based extravasation uses conserved morphodynamics but divergent calcium control
|
|
Mirvetuximab soravtansine plus pembrolizumab in recurrent folate receptor alpha-positive uterine serous carcinoma: a phase II trial
|
|
Structural and evolutionary insights into the eukaryotic RNase MRP ribonucleoprotein complex
|
|
Small-molecule degraders for oncogenic KRAS and pan-KRAS mutations
|
|
Extracellular matrix rigidity controls breast cancer metastasis via TYK2-mediated mechanotransduction
|
|
First-line Nivolumab plus FOLFOXIRI/Bevacizumab in advanced RAS/BRAF-mutated colorectal cancer: efficacy, safety and biomarker discovery from the phase II NIVACOR trial
|
|
Tazemetostat, an EZH2 inhibitor, in solid tumors harboring SWI/SNF alterations: a phase II basket study
|
|
Vascular invasion-associated gene expression is detectable in pre-surgical biopsies of stage I lung adenocarcinoma
|
|
Spatiotemporally engineered tumor-derived extracellular vesicle-based scaffold vaccine for personalized cancer immunotherapy
|
|
Maturase K forms a plastidial splicing complex with a neofunctionalized branching enzyme
|
|
Proteomic characterization of intrahepatic cholangiocarcinoma identifies risk-stratifying subgroups and EIF4A1 as a therapeutic target
|
|
X-ray preactivated reversible persistent luminescence enables photodynamic immunotherapy of deep tumors
|
|
Structural basis for prostaglandin and drug transport via SLCO2A1
|
|
A cell cycle-dependent transition of acetylation to phosphorylation regulates timely centrosome maturation
|
|
Intrinsic mechanisms and microenvironmental cues fine-tune plasticity of esophageal progenitors
|
|
Dalpiciclib plus chidamide in HR + /HER2−advanced breast cancer after CDK4/6 inhibitor failure: a phase Ib trial
|
|
AP-1 mediates cellular adaptation and memory formation
|
|
CXCR5+ monocyte emigration impairs the radiation-induced antitumor immune response
|
|
Engineering programmable CAR and antigen pairing via drug-gated light activation
|
|
Tumor-specific lncRNA IGF1R-AS1 trans-regulates chromatin interactions associated with oncogenic MYC signaling
|
|
IVNS1ABP mutation drives cellular senescence in newly identified progeroid neuropathy
|
|
Subgroup performance of a commercial digital breast tomosynthesis model for breast cancer detection
|
|
MDM2 Inhibition with Alrizomadlin (APG-115) in TP53 wild-type salivary gland cancers: a phase I clinical trial
|
|
The combination of a cancer vaccine, pembrolizumab, and stereotactic body radiation in patients with locally advanced pancreatic cancer: a single-arm, phase II study
|
|
Multimodal imaging reveals a lysosomal drug reservoir that drives heterogeneous distribution of PARP inhibitors
|
|
Inhibition of the cancer stem cell immune checkpoint SOAT1 suppresses regulatory T cell functions through a trans-cellular 20(S)-Hydroxycholesterol-GPR132 pathway in mice
|
|
Programmable nanomicelles rewire myeloid immunity for durable control of primary and metastatic breast cancer
|
|
Polar chromosomes are rescued from missegregation by spindle elongation-driven microtubule pivoting
|
|
Durvalumab and cediranib with and without olaparib in recurrent ovarian cancer: a phase II proof-of-concept study
|
|
Stepwise transcription stalling by the anti-cancer drug Actinomycin D and insights into short tandem repeat transcription inhibition
|
|
Multitrait GWAS and functional validation reveal genetic loci for gastric cancer
|
|
Both genome instability and replicative senescence stem from the shortest telomere in telomerase-negative cells
|
|
Cadonilimab plus chemotherapy with or without bevacizumab as first-line treatment for advanced cervical cancer: subgroup analyses from the COMPASSION-16 phase 3 trial
|
|
Targeting Prolyl 3-hydroxylase 1 inhibits pancreatic cancer progression and macrophage immunity
|
|
ctDNA and tumor-based biomarkers of giredestrant response in acelERA breast cancer
|
|
VHL synthetic lethality screens uncover CBF-β as a negative regulator of STING
|
|
Proteostasis failure and mitochondrial dysfunction contribute to chromosomal instability-induced microcephaly
|
|
Pan-tumor activity of olomorasib, a next-generation KRAS G12C inhibitor in G12C-mutant advanced solid tumors: a first-in-human study
|
|
Megakaryocyte and platelet thrombospondin-1 regulates matrix remodeling by stabilizing basement membrane COL6A1 in lung injury
|
|
Proteomic landscape of Ewing sarcoma primary tumors and metastases
|
|
Tumour specific HORMAD1 expression perturbs mitotic arrest and drives sensitivity to mitotic kinase inhibitors
|
|
A large-scale genome-wide association meta-analysis for nevus count provides direct insights into the genetics of melanoma
|
|
Intraoperative fluorescence-guided fresh frozen sectioning for margin control in head and neck cancer: phase 2 clinical trial
|
|
Protection of telomeres 1b safeguards the Arabidopsis genome by regulating ROS homeostasis
|
|
Sororin locks the DNA-exit gate of cohesin to preserve sister-chromatid cohesion
|
|
An ultraconserved pseudo 5’ splice site fine-tunes development by regulating alternative splicing within TOR-related pathways
|
|
DNA Repair gene alterations and efficacy from gemcitabine and nab-paclitaxel with/without durvalumab and tremelimumab in metastatic pancreatic ductal adenocarcinoma
|
|
Tumor-induced orexigenic imbalance lowers protein appetite and drives early organ wasting symptoms
|
|
Necroptosis in both tumour and stromal compartments determines responsiveness to immunogenic cell death-based immunotherapy
|
|
USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion
|
|
Clonal evolutionary analysis reveals patterns of malignant transformation of Intraductal Papillary Mucinous Neoplasms of the pancreas
|
|
A hormetic transcriptional program coregulates invasion, proliferation and dormancy to define metastatic potential
|
|
A hotspot phosphorylation site on SHP2 drives oncoprotein activation and drug resistance
|
|
Targeting leucine-rich repeat kinase 2 overcomes resistance to oncolytic herpes simplex virus-based therapies in glioblastoma
|
|
Cryo-EM structures of UBA6 reveal mechanisms of E1–E2 specificity and dual FAT10/ubiquitin thioester transfer
|
|
First-line modified FOLFOX plus/minus nivolumab and Ipilimumab or FLOT plus nivolumab in advanced gastroesophageal adenocarcinoma: a phase II multi-cohort trial
|
|
Prospective multicenter study of ctDNA versus tumor tissue guiding FGFR-targeted therapy in metastatic urothelial cancer
|
|
Prussian blue nanoparticles targeting multiple PANoptosome-mediated PANoptosis for myocardial ischemia-reperfusion injury therapy
|
|
Tumor metabolic adaptation induced by L-asparaginase reveals a vulnerability to PARP1/2 inhibitor in B-cell lymphomas
|
|
Rank signaling drives basal cell-lineage infidelity leading to mammary tumorigenesis
|
|
NR2F6 deletion revives CAR-T cell function and induces antigen-agnostic immune memory in solid tumors
|
|
Tumor-informed circulating tumor DNA stratifies recurrence risk and survival in anal squamous cell carcinoma
|
|
Laser interstitial thermal therapy and adjuvant pembrolizumab in recurrent high-grade astrocytoma: a Phase 1/randomized Phase 2b trial
|
|
The nitrogen starvation-induced inhibitor Rts3 restrains Sit4/PP6 to gate quiescence downstream of TORC1
|
|
Molecular insights into mRNA export regulation by the human TREX-2 complex
|
|
A gated hydrophobic funnel within BAX binds bioactive lipids to potentiate pro-apoptotic function
|
|
Targeting de novo pyrimidine synthesis confers vulnerability to copper-mediated ATR inactivation in PARP inhibitor-resistant ovarian cancer
|
|
The nuclease EXO1 promotes genomic instability by degrading nascent DNA in BRCA-proficient cells
|
|
Combination of PARP and KRASG12D inhibitors enhances therapeutic efficacy by exploiting vulnerabilities in PDAC
|
|
B7-H3-mediated cis-inhibition of EGFR by a tumor-selective bispecific antibody enhances anti-tumor efficacy and minimizes toxicities
|
|
Cryo-EM structures of light chain fibrils from abdominal fat biopsies of multiple myeloma patients
|
|
The N-Myc MB0-MBI region interacts specifically and dynamically with the N-lobe of Aurora kinase A
|
|
Eukaryote initiation factor 6 modulates small-cell lung carcinoma plasticity via the integrin-FAK signaling axis
|
|
Mast-cell derived nerve growth factor drives ILC2 pro-tumoral functions in bladder cancer
|
|
Immunometabolic determinants of long-term response in leukemia patients receiving CD19 CAR T cell therapy
|
|
A spatially resolved human glioblastoma atlas reveals distinct cellular and molecular patterns of anatomical niches
|
|
A neurotoxic cryptic peptide arising from TDP-43-dependent cryptic splicing of
|
|
HIF sustain a transcriptional regulatory circuit of EPAS1 expression in renal clear cell carcinoma
|
|
Composite SMG5-SMG6 PIN domain formation is essential for NMD
|
|
R-loop editing by DNA cytosine deaminase APOBEC3B modulates the activity of oestrogen receptor enhancers
|
|
Long-acting interleukin-7 improves the efficacy of oncolytic viral therapy in glioblastoma
|
|
Recruitment of BRD4 to the ASXL1 genomic targets depends on the extra-terminal domain of BRD4
|
|
LOAd703-induced tumor microenvironment gene engineering in combination with atezolizumab in metastatic malignant melanoma: a phase I/II trial
|
|
14-3-3ζ interacts with DNA-binding domain of FOXO3a and competitively dissociates DNA by dual-motif tethering
|
|
T cells engineered against Dickkopf-1-A2 complex can be used to treat HLA-A2+ solid and hematologic cancers
|
|
Machine learning-predicted insulin resistance is a risk factor for 12 types of cancer
|
|
Mithramycin alters EWS::FLI1 DNA binding and RNA polymerase II processivity to inhibit nascent transcription
|
|
Talimogene laherparepvec and atezolizumab in HER2-negative breast cancer following neoadjuvant chemotherapy: a window-of-opportunity phase II trial (SOLTI-1503 PROMETEO)
|
|
Amino acid and viral binding by the high-affinity Cationic Amino acid Transporter 1 (CAT1) from Mus musculus
|
|
cfGWAS reveal genetic basis of cell-free DNA end motifs
|
|
Amelioration of colorectal cancer-associated fibroblasts in immunosuppressive microenvironment by ferroptosis-based nanotherapy
|
|
FOXJ1 mediates taxane resistance through regulation of microtubule dynamics
|
|
Structure and mechanism of the HECT ligase HECTD3
|
|
Structural and molecular basis for allosteric regulation and catalytic coupling of human phosphoribosylformylglycinamidine synthase
|
|
Lactate derived from macrophages drives skin dermal fibroblasts phenotypic remodeling via MCT1-primed histone H3 lysine 23 lactylation in hypertrophic scar
|
|
NKG2D upregulation sensitizes tumors to combined anti-PD1 and anti-VEGF therapy and prevents hearing loss
|
|
Mutant KRAS vaccine with dual checkpoint blockade in resected pancreatic cancer: a phase I trial
|
|
Targeting NHEJ activates STING signaling through MYC degradation to boost antitumor immunity in SCLC
|
|
Phytic acid (InsP6) activates HDAC3 epigenetic axis to maintain intestinal barrier function
|
|
Histone lactylation increases CXCL1 expression for neutrophil infiltration and immune escape in pancreatic cancer
|
|
STING synergizes with TOX suppressing HO-1 expression to trigger ferroptosis in tumor-infiltrating CD8+ T cell and immunotherapy resistance
|
|
A role for condensin-mediator interaction in mitotic chromosome organization
|
|
Pan-RAF inhibitor exarafenib targets BRAF class II/III NSCLC and reveals ARAF-KSR1 resistance and combination strategies
|
|
Hepatocytes functionally reprogrammed by KIAA1199-high colorectal cancer cells favour the accumulation of pro-metastatic Egr1+ neutrophils
|
|
Combined targeted and epigenetic-based therapy enhances antitumor immunity by stabilizing GATA6-dependent MHCI expression in pancreatic ductal adenocarcinoma
|
|
Afuresertib plus fulvestrant for pretreated HR-positive, HER2-negative, advanced breast cancer: a phase Ib trial
|
|
Extracellular matrix mediates circulating tumor cell clustering in triple-negative breast cancer metastasis
|
|
Inhibition of stress resilience and adult hippocampal neurogenesis by platelet-derived LPA16:0 in anxiety
|
|
NEO-STIM advances personalized neoantigen-specific adoptive T cell therapy
|
|
Tumour-intrinsic features shape T cell differentiation through precursor to symptomatic multiple myeloma
|
|
Succinate receptor 1 restricts hematopoiesis and prevents acute myeloid leukemia progression
|
|
Early diagnosis of pancreatic ductal adenocarcinoma by signal-enhanced lateral flow immunoassay: SELFI
|
|
Indolent primary cutaneous B-cell lymphomas resemble persistent antigen reactions without signs of dedifferentiation
|
|
Enhancing CAR- and TCR-mediated targeting of cancer via an immune synapse-stabilizing receptor
|
|
Paclitaxel drives TREM2 macrophage expansion underlying its inferior therapeutic efficacy compared to Nab-paclitaxel
|
|
Splice isoform-perturbation coupled to single cell transcriptome profiling reveals functions of microexons in neurogenesis and autism-linked pathways
|
|
An interpretable AI system reduces false-positive MRI diagnoses by stratifying high-risk breast lesions
|
|
Covalent inhibitor design confers activity against both GDP- and GTP-bound forms of KRAS G12C
|
|
Neoadjuvant modified FOLFIRINOX plus nivolumab in borderline-resectable pancreatic ductal adenocarcinoma: a pilot phase 1 trial
|
|
Cancer cachexia in STK11/LKB1-mutated non-small cell lung cancer is dependent on tumor-secreted GDF15
|
|
Olutasidenib in recurrent/relapsed locally advanced or metastatic -mutated chondrosarcoma: phase 1b/2 trial
|
|
Endothelial PDLIM5 promotes tip cell filopodia formation and tumor angiogenesis by regulating ACTN1/ACTN4-dependent actin bundling
|
|
Dalpicilib combined with cetuximab in patients with HPV-negative, anti-PD-1-resistant recurrent or metastatic head and neck squamous cell carcinoma: A phase II trial
|
|
Leveraging glucan-induced trained immunity for the epigenetic and metabolic rewiring of macrophages to enhance colorectal cancer vaccine response
|
|
The functional landscape of alternative splicing in hematopoietic lineage commitment
|
|
Biomarkers of response to neoadjuvant palbociclib plus anastrozole in endocrine-resistant estrogen receptor-positive/HER2-negative breast cancer: a phase 2 trial
|
|
Stenotrophomonas promotes gastrointestinal tumor progression via STING degradation in tumour cells and mitigated immune response
|
|
Priming versus propagating: distinct immune effects of alpha- versus beta-particle emitting radiopharmaceuticals when combined with immune checkpoint inhibition in mice
|
|
CXCR4 induces memory formation over exhaustion in CAR-T cells to achieve durable leukemia targeting
|
|
Modulation of Nudt21 levels reveals dose-dependent roles of alternative polyadenylation in tissue regeneration
|
|
Structural basis of CSN-mediated SCF deneddylation
|
|
De novo variants in the splicing factor gene are associated with neurodevelopmental disorders
|
|
CDK2 inhibitor BLU-222 synergizes with CDK4/6 inhibitors in drug resistant breast cancers through p21/p27 induction
|
|
ZNF683 NK cells govern chemotherapy sensitivity in advanced HPSCC via reshaping immune microenvironment
|
|
Structures of nucleotide-bound human telomerase at several steps of its telomeric DNA repeat addition cycle
|
|
negatively regulates self-renewal of liver cancer stem cells and hepatocarcinogenesis via suppressing transcription
|
|
INCENP and CDCA8 predict neoadjuvant chemotherapy response and outcomes in esophageal squamous cell carcinoma
|
|
An alternative EGFR activation by patient-derived R252C mutation promotes cancer progression
|
|
Neoadjuvant chemoradiotherapy plus sintilimab in proficient mismatch repair locally advanced rectal cancer with intermediate/high-immunoscore (SILAR): a single-arm phase II trial
|
|
In situ self-assembled cell reservoir hydrogel for maneuvering multistage radioimmunotherapy
|
|
TET1 as a master regulator controlling GPX4-dependent and -independent ferroptosis surveillance in acute myeloid leukemia
|
|
Dextran-based T-cell expansion nanoparticles for manufacturing CAR T cells with augmented efficacy
|
|
Gemcitabine plus selinexor in selective advanced sarcomas: a phase I of the Spanish group for research on sarcoma study
|
|
Targeting the UFL1-AKT cascade suppresses triple-negative breast cancer progression
|
|
Disruption of iron homeostasis sensitizes pancreatic cancer to irreversible electroporation
|
|
Double-dose firmonertinib as first-line treatment in patients with locally advanced or metastatic non-small-cell lung cancer harboring EGFR L858R mutation: a prospective, multicenter, phase II study (FIRM)
|
|
Site-saturation functional screens identify PALB2 missense variants associated with increased breast cancer risk
|
|
Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integrity
|
|
AI-guided CAR designs and targeted pathway modulation to enhance multi-antigen CAR T cell durability and overcome antigen escape
|
|
NALIRIFOX versus gemcitabine plus nab-paclitaxel in Chinese patients with advanced pancreatic adenocarcinoma: a randomized, open-label phase II trial
|
|
Multiscale imaging on proton pump-driven acidity for assessing tumor progression and metastasis
|
|
Cryo-EM structure of the human COP1-DET1 ubiquitin ligase complex
|
|
Control of telomerase recruitment and end protection by independent shelterin components
|
|
Multi-center multi-omics integration predicts individualized prognosis in medullary thyroid carcinoma
|
|
EGFR inhibitor-resistant lung cancers exhibit collateral sensitivity to a covalent, cysteine-independent KEAP1 oligomerizing molecular bridge
|
|
Osimertinib with or without savolitinib as first-line treatment for MET-aberrant, EGFR-mutant NSCLC: randomized phase 2 trial (FLOWERS)
|
|
Hypoxia-driven remodeling of SELENOP macrophages shapes T cell dynamics and promotes ovarian cancer metastasis
|
|
RAS/MEK/PI3K pathway inhibition augments response to CD40 agonism by targeting CD11b+ Bregs thereby overcoming melanoma PD1-resistance
|
|
Tucatinib plus trastuzumab for chemotherapy-refractory, HER2 + , RAS wild-type metastatic colorectal cancer (MOUNTAINEER): final analysis
|
|
Targeting SPAK suppresses progression and averts an immune exhaustive microenvironment in hepatocellular carcinoma
|
|
Structure of SHOC2-KRAS-PP1C complex reveals RAS isoform-specific determinants and insights into targeting complex assembly by RAS inhibitors
|
|
Perioperative tislelizumab plus lenvatinib treatment for resectable hepatocellular carcinoma at high risk of recurrence: single-arm phase II trial
|
|
USP10 promotes glioma stem cell maintenance and glioblastoma growth by antagonizing DTX3L-mediated SATB2 ubiquitination
|
|
SOX2 confers tumour permissiveness in a specific skin progenitor population
|
|
Boron neutron capture therapy preserves immune cells and induces robust anti-tumour immunity in preclinical mouse model
|
|
A Mechanophenotyping chip for high-throughput detection of metastatic bacteria-infected circulating tumor cells
|
|
Loss of KDM6A-mediated genomic instability and metabolic reprogramming regulates response to therapeutic perturbations in bladder cancer
|
|
A multidimensional workflow profiling of allogeneic virus-specific T cell therapies reveals potency-linked signatures
|
|
Intrathecal CRISPR-edited allogeneic IL-13Rα2 CAR T Cells for recurrent high-grade Glioma: preclinical characterization and phase I trial
|
|
Neoadjuvant immune checkpoint blockade before chemoradiation for cervical squamous carcinoma (GINECO window-of-opportunity COLIBRI study): a phase II trial
|
|
Tight junction-high and CDH17-positive cell population is the source of colorectal cancer liver metastases
|
|
A CD8αβ co-receptor modified to contain an intracellular CD28 signaling tail enhances TCR-engineered T cell function independent of solid-tumor-associated co-stimulatory ligands
|
|
Peptide-functionalized membrane camouflage for endogenous HS-induced photothermal immunotherapy of orthotopic colorectal cancer
|
|
Anti-CSF-1R therapy with combined immuno-chemotherapy coordinate an adaptive immune response to eliminate macrophage enriched triple negative breast cancers
|
|
Binimetinib and encorafenib for the treatment of advanced solid tumors with non-V600E BRAF mutations: results from the Phase II BEAVER trial
|
|
Oxidative stress and GPX2 control pancreatic vs. non-pancreatic cell fate in human endoderm
|
|
Mechanistic insights into recruitment and regulation of the RNA helicase UPF1 in replication-dependent histone mRNA decay
|
|
WRN structural flexibility showcased through fragment-based lead discovery of inhibitors
|
|
Design of precision therapeutics for a CKD risk allele by targeting Shroom3-Rock interaction
|
|
Ribosome biogenesis as a potential therapeutic target in KRAS mutant colorectal cancer
|
|
Expression of antibody-drug conjugate targets in post-mortem samples of breast cancer metastases and normal tissue
|
|
Multi-scale classification decodes the complexity of the human E3 ligome
|
|
GPR4 promotes immune exclusion in colon cancer through LOXL2-mediated extracellular matrix remodeling
|
|
Structural dynamics of mixed-subunit CaMKIIα/β heterododecamers filmed by high-speed AFM
|
|
Intraperitoneal programming of tailored CAR macrophages via mRNA lipid nanoparticle to boost cancer immunotherapy
|
|
Induction chemo-immunotherapy followed by chemo-radiotherapy and immunotherapy maintenance in stage III NSCLC (APOLO): a phase 2 trial
|
|
Clonal evolution and transcriptional plasticity shape metastatic dissemination routes in prostate cancer
|
|
Decoding necrosome assembly: harmonizing signal amplification and attenuation through optimal RIP3 stoichiometry
|
|
Structural insights into toxicant export mediated by ABCC2 in
|
|
Deep Mutational Scanning of FDX1 Identifies Key Structural Determinants of Lipoylation and Cuproptosis
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Fruquintinib plus sintilimab in patients with advanced endometrial cancer with mismatch-repair proficient status: a multicenter, single-arm, phase Ib/II trial
|
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Neoadjuvant serplulimab combined with chemotherapy for resectable oesophageal squamous cell carcinoma: a single-arm, phase 2 trial
|
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Synovial sarcoma reprograms transcription by GBAF activation of polycomb targets and loss of CBAF enhancers
|
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Genome-scale spatial mapping of the Hodgkin lymphoma microenvironment identifies tumor cell survival factors
|
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Reconstructing the three-dimensional architecture of extrachromosomal DNA with ec3D
|
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Kinetochore mutations and histone phosphorylation pattern changes accompany holo- and macro-monocentromere evolution
|
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Harnessing multivalency and FcγRIIB engagement to augment anti-CD27 immunotherapy
|
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Determinants of sensitivity to HER2-targeted antibody drug conjugates in urothelial cancer
|
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Thrombopoietin increases susceptibility for EVI1 + KMT2A-MLLT3-driven AML expressing stem cell genes linked to poor outcome
|
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The molecular cartography of malignant and benign sebaceous tumours
|
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SPLiCR-seq: A CRISPR-Based Screening Platform for RNA splicing Identifies Novel Regulators of IRE1α-XBP1 Signaling Under ER Stress
|
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Stereotactic body radiotherapy with sintilimab and bevacizumab biosimilar in anti-PD-1 refractory hepatocellular carcinoma: the ReUNION-1 phase 2 trial
|
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Local therapeutic platform prevents postsurgical GBM recurrence by diminishing GICs and reshaping immunosuppressive microenvironment
|
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Lack of caspase 8 directs neuronal progenitor-like reprogramming and small cell lung cancer progression
|
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Structural insights into cationic amino acid transport and viral receptor engagement by CAT1
|
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Loss of ALK4 promotes cancer progression through regulating TGF-β receptor N-glycosylation
|
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Early favorable prostate-specific antigen response prediction in metastatic hormone sensitive prostate cancer
|
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AMP-activated protein kinase-driven lipid droplet dynamics govern melanoma sensitivity to polyunsaturated fatty acid and iron-induced ferroptosis
|
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Engineered antibodies that stabilize drug-modified KRASG12C neoantigens enable selective and potent cross-HLA immunotherapy
|
|
ER degradation for ER+/HER2– advanced or metastatic breast cancer: a phase 1 trial
|
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AAK1 activation-mediated iron trafficking drives ferroptotic cell death
|
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Metabolic syndrome promotes endometrial cancer by Oleic acid-mediated polyamine accumulation
|
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Polypeptide sono-adjuvant for ultrasound-activatable regulation of innate immunity and cancer vaccination therapy
|
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Cancer stage at diagnosis by duration of pre-existing chronic analgesic use and anxiety or depression
|
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Concurrent PIK3CA mutant promotes cachexia through inflammatory signaling in EGFR mutant lung cancer
|
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Mechanism of alternative splicing of yeast HEH1 through competing 5’ splice sites
|
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Transcriptional regulation of protein synthesis by mediator kinase represents a therapeutic vulnerability in MYC-driven medulloblastoma
|
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LncRNA regulates cell size in human and mouse by guiding FOSL2
|
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Structural basis for genome-wide site-specific DNA recognition by Nuclear Factor IA
|
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Chemotherapy-driven intestinal dysbiosis and indole-3-propionic acid rewire myelopoiesis to promote a metastasis-refractory state
|
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Organ-specific delivery of an mRNA-encoded bispecific T cell engager targeting glypican-3 in hepatocellular carcinoma
|
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Histone methyltransferase PRDM9 promotes survival of drug-tolerant persister cells in glioblastoma
|
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αPD-1-conjugated acid-cleavable nanodrugs overcomes cellular immunotherapy barriers in pancreatic tumors
|
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Intrinsic resistance to RAS inhibitors is driven by dysregulation of KRAS degradation
|
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PD-1/ PD-L1 bispecific antibody IBI318 combined with lenvatinib in advanced non-small cell lung cancer with acquired resistance to immune checkpoint inhibitors: a phase II trial
|
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APOBEC3 promotes squamous differentiation via IL-1A/AP-1 signaling
|
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Targeting LRBA triggers CTLA4 degradation and antitumor immunity for cancer immunotherapy
|
|
Five-year clinical outcome and immune biomarkers of durable response from the MM1636 trial on IDO/PD-L1 vaccination and PD-1 blockade in first line metastatic melanoma
|
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Inhibiting translation elongation by reducing eIF5A activity induces feedback inhibition of initiation, limiting tumour cell proliferation
|
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Prodrug nanoplatform for triggering ferroptosis to eliminate senescent cells in age-associated pathologies
|
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Targeting of the m6A eraser ALKBH5 suppresses stemness and chemoresistance of colorectal cancer
|
|
Early genetic evolution of driver mutations in uveal melanoma
|
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G-CSF/NAMPT signaling drives neutrophil dysfunction and enhances bacterial infection susceptibility in cancer patients
|
|
USP29 and SMURF1 orchestrate FSP1-mediated ferroptosis suppression to facilitate chemoresistance in gastric cancer
|
|
Histone acetylation homeodynamics navigates cell survival and apoptosis
|
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Motorized chromosome models of mitotic chromosome folding
|
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Identification of a lipid oxygen radical defense pathway and its epigenetic control
|
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Lypd6b depletion promotes CD8+ T cell-mediated anti-tumor immunity via metabolic reprogramming in colorectal cancer
|
|
BPTF regulates androgen receptor activity by enhancing chromatin accessibility and stabilizing the AR-FOXA1 interaction
|
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The PIK3CA/AKT pathway drives therapy resistance in rhabdomyosarcoma
|
|
Phosphorylation of PA28γ by CK2 kinase facilitates HNSCC tumor formation and progression
|
|
Aberrant cytoplasmic localization of MLH1 characterizes a cell population that seeds breast cancer recurrence
|
|
Ubiquitination by HRD1 is essential for TLR3 trafficking and its innate immune signaling
|
|
A recurrent pathogenic truncating variant reveals a role for BRCA2-PCAF complex in modulating NF-κB-driven transcription
|
|
SLFN11 counteracts the RFWD3-PRIMPOL DNA damage tolerance axis to restrain gapped DNA synthesis in response to replication stress
|
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Fragment-based discovery enables direct targeting of the melanoma oncogene MITF
|
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Inhibiting the formation of neutrophil extracellular traps to prevent the recurrence of post-operative glioblastoma
|
|
Circulating tumor DNA refines risk stratification of neoadjuvant therapy-resistant breast tumors
|
|
Cancer-associated USP28 missense mutations disrupt 53BP1 interaction and p53 stabilization
|
|
Precise diagnosis of small invasive pulmonary nodules driven by single-cell immune signatures in peripheral blood
|
|
Metabolic support protects mucosa from ferroptosis in radiation-induced mucositis
|
|
Inhibiting B cells enhances the efficacy of STING agonism or immune checkpoint blockade in hepatocellular carcinoma
|
|
Predictive models of melanoma metastasis based on dermatoscopy in an international retrospective human reader study
|
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Adjuvant benmelstobart plus anlotinib in patients with high-risk recurrence after resection of hepatocellular carcinoma: a phase II study (ALTER-H006)
|
|
ANKLE1 processes chromatin bridges by cleaving mechanically stressed DNA
|
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Tissue-resident microbiota impacts colorectal cancer progression and prognosis
|
|
Therapeutic 6-thio-deoxyguanosine inhibits telomere elongation in cancer cells by inducing a non-productive stalled telomerase complex
|
|
EP300 deficiency leads to chronic replication stress mediated by defective replication fork protection
|
|
INSM1 governs a neuronal progenitor state that drives glioblastoma in a human stem cell model
|
|
Actin dysregulation induces neuroendocrine plasticity and immune evasion: a vulnerability of small cell lung cancer
|
|
A JAK/STAT-Pdk1-S6K axis bypasses systemic growth restrictions to promote regeneration
|
|
Targeting TNK2/ACK1 reverses the immunosuppressive tumor microenvironment and synergizes with immunochemotherapy in pancreatic cancer
|
|
Single cell mapping identifies a distinct platelet-phenotype in psoriatic type III inflammation
|
|
KY216-tubulin complex captures VASH2 to inhibit NSCLC metastasis
|
|
Pericytes orchestrate a tumor-restraining microenvironment in glioblastoma
|
|
Hologenomic analysis of rectal mucus sampling for detection of adenomatous polyps and colorectal cancer
|
|
Glasdegib in combination with temozolomide and radiotherapy in adult patients with newly diagnosed glioblastoma: the phase Ib/II GEINO 1602 trial
|
|
Letrozole, abemaciclib and metformin in endometrial cancer: a non-randomized phase 2 trial
|
|
The E2F1-HMGCR axis promotes ferroptosis resistance in immune refractory tumor cells
|
|
Non-small cell lung cancer molecular subtypes and vulnerability to immunotherapy treatment combinations
|
|
Programmable Argonaute-mediated single-nucleotide variant sequencing of cell-free DNA for multi-cancer early detection
|
|
ctDNA detectability and representativeness in seven body liquids from patients with metastatic breast cancer
|
|
Nuclear actin and DNA replication stress regulate telomere maintenance by telomerase
|
|
CAV2-expressing nerves induce metabolic switch toward mitochondrial oxidative phosphorylation to promote cancer stemness
|
|
DDX6 undergoes phase separation to modulate metabolic plasticity and chemoresistance
|
|
Identification and characterization of binders to a cryptic and functional pocket in KRAS
|
|
Residual tumor cells after insufficient radiofrequency ablation promote lung metastasis by educating CD177PAD4 neutrophils
|
|
Constitutive activity of an atypical chemokine receptor revealed by inverse agonistic nanobodies
|
|
The fibroblast epigenome underlies SS18::SSX-mediated transformation in synovial sarcoma
|
|
MCL1 modulates mTORC1 signaling to promote bioenergetics and tumorigenesis
|
|
MYC drives left-handed Z-DNA formation to shape gene expression
|
|
Molecular mechanism of PINK1 regulation by the Hsp90 machinery
|
|
THRAP3 promotes ferroptosis resistance in acute myelocytic leukemia through SLU7-mediated alternative splicing of GIT2
|
|
Targeting leukemic stem cell biomechanics suppresses stemness and enhances NK cell-mediated immunotherapy
|
|
Multilayered regulation of TORC1 signaling by Ait1, Gcn2, and SEAC/GATOR during nitrogen limitation and starvation
|
|
Cellular reprogramming during anti-PD-1 and chemotherapy treatment in early-stage primary hormone receptor-positive breast cancer
|
|
NEK7 couples SDHB to orchestrate respiratory chain electron transport homeostasis that impedes liver fibrosis
|
|
Bipolar and schizophrenia risk gene encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission
|
|
Efficacy, safety, and predictive biomarkers of neoadjuvant nab-paclitaxel and pembrolizumab in hormone receptor-positive breast cancer: A randomized pilot trial
|
|
Cathepsin L as a dual-target to mitigate muscle wasting while enhancing anti-tumor efficacy of anti-PD-L1
|
|
Chromatin accessibility in stem cells unveils progressive transcriptional alterations in myelodysplastic syndrome
|
|
Deciphering the role of complement system genes in pancreatic cancer susceptibility and prognosis
|
|
The CTLH ubiquitin ligase substrates ZMYND19 and MKLN1 negatively regulate mTORC1 at the lysosomal membrane
|
|
IFN-γ-driven UBE2D3 upregulation impairs antigen presentation pathways and anti-tumor immunity in pancreatic cancer
|
|
REACtiVe-2: phase I evaluation of dendritic cell vaccination and agonistic CD40 therapy following (m)FOLFIRINOX in metastatic pancreatic cancer
|
|
Targeting hepatocytic TβRI ameliorates liver metastatic outcomes by revitalizing stem-like CD8+ Tex subsets
|
|
N-terminal α-amino SUMOylation promotes phosphorylation-independent cofilin-1 translocation to the mitochondrial matrix and induces apoptosis
|
|
Aurora kinase B phosphorylates ZBP1 to drive PANoptosis following treatment with PARP and ATR inhibitors combination
|
|
Gut microbial β-glucuronidases and their role in the microbiome-metabolite axis in colorectal cancer
|
|
Uncovering the immune mechanisms underlying the emergence of immunotherapy-induced pneumonitis in lung cancer patients
|
|
Subgroup of meningiomas involving FOS and FOSB gene fusions
|
|
Allogeneic iPSC-derived iNKT cells in recurrent head and neck cancer: a phase 1 trial
|
|
Enhancer regulator MLL4 controls skeletal muscle metabolic efficiency by limiting AMPK-mediated fuel catabolism
|
|
Palbociclib and endocrine therapy diminish adaptive anti-tumor immunity in early breast cancer: The NeoRHEA phase 2 study
|
|
Nivolumab plus ipilimumab induce hyper-progression in renal medullary carcinoma: results of a phase II trial and preclinical evidence
|
|
Substrate recognition diversity and transport dynamics of ABCC1
|
|
Single-cell multi-omics identifies metabolism-linked epigenetic reprogramming as a driver of therapy-resistant medulloblastoma
|
|
Apatinib plus ifosfamide and etoposide versus ifosfamide and etoposide in patients with advanced osteosarcomas (OAIE/PKUPH-sarcoma 11): a randomized phase II study
|
|
Whole-body CD8 T-cell PET imaging in patients with large B-cell lymphoma before and during CD19-directed CAR T-cell therapy: a phase 2 study
|
|
BAF-1–VRK-1 mediated release of meiotic chromosomes from the nuclear periphery is important for genome integrity
|
|
Cancer-associated snaR-A noncoding RNA interacts with core splicing machinery and disrupts processing of mRNA subpopulations
|
|
Non-canonical roles of Keap1/Nrf2 in regulating quiescence and early activation in adult muscle stem cells
|
|
Bioorthogonal optimized virus immuno-nanomedicine (BOVIN)
|
|
The AML cellular state space unveils NPM1 immune evasion subtypes with distinct clinical outcomes
|
|
A ternary switch model governing ERα ligand binding domain conformation
|
|
TSCM-predominant allogeneic anti-BCMA CAR-T therapy for relapsed/refractory multiple myeloma: preclinical characterization and interim results from a phase 1 trial
|
|
WEE1 inhibitors trigger GCN2-mediated activation of the integrated stress response
|
|
Automated MRI system for clinically significant prostate cancer detection development validation and real-world implementation
|
|
Multiplex gene-editing strategy to engineer allogeneic EGFR-targeting CAR T-cells with improved efficacy against solid tumors
|
|
Targeting fibroblast derived thrombospondin 2 disrupts an immune-exclusionary environment at the tumor front in colorectal cancer
|
|
Allosteric regulation of BH3-in-groove interactions by tail anchors of BCL-xL complexes limits BH3 mimetic antagonism
|
|
Alternating current pre-treatment enhances multi-enzymatic activity of high-entropy alloy nanozymes that regulate metabolism for effective tumor immunotherapy
|
|
Remodeling of the immune microenvironment is linked to adverse outcome in pediatric T cell acute lymphoblastic leukemia
|
|
A hindrance-plane-hindrance molecular engineering strategy towards self-assembled nanorods for enhanced photodynamic therapy
|
|
Induction chemotherapy plus camrelizumab followed by concurrent chemoradiotherapy in unresectable locally advanced esophageal squamous cell carcinoma: a single-arm phase II trial
|
|
Cancer cell-derived IL-1β reverses chemo-immunotherapy resistance in non-small cell lung cancer
|
|
SLC45A4 encodes a peroxisomal putrescine transporter that promotes GABA de novo synthesis
|
|
Hexokinase 2-mediated histone H3K18la promotes PAI-1-dependent thrombosis in acute myeloid leukemia via tumor-endothelial crosstalk
|
|
A moonlighting function of tumoral interleukin-1β precursor promotes metastasis via RACK1-mediated actin remodeling
|
|
A multiplexed assay by self-assembled dual-target responsive DNA hydrogels for efficacy evaluation of immunotherapy
|
|
Spatial multi-omics identifies aggressive prostate cancer signatures highlighting pro-inflammatory chemokine activity in the tumor microenvironment
|
|
Anti-PD-L2 immunotherapy is efficacious against melanoma in aged hosts through IL-17 and IFNγ signalling
|
|
An inflammatory T-cell-stromal axis contributes to hematopoietic stem/progenitor cell failure and clonal evolution in human myelodysplastic syndrome
|
|
Self-driven electrical triggering system activates tunneling nanotube highways to enhance drug delivery in bladder cancer therapy
|
|
Multimodal AI and tumour microenvironment integration predicts metastasis in cutaneous melanoma
|
|
Co-delivery of sorafenib and an FSP1 inhibitor triggers dual ferroptosis in tumor cells and immunosuppressive macrophages for enhanced immunotherapy in mouse models of hepatocellular carcinoma
|
|
TBC1D1 functions as a negative regulator of satellite cells for muscle regeneration
|
|
β-adrenergic signaling blockade attenuates metastasis through activation of cytotoxic CD4 T cells
|
|
Human iPSCs-based modeling unveils SETBP1 as a driver of chromatin rewiring in GATA2 deficiency
|
|
Targeting tumor-intrinsic BCL9 reverses immunotherapy resistance by eliciting macrophage-mediated phagocytosis and antigen presentation
|
|
RAF inhibitors activate the integrated stress response by direct activation of GCN2
|
|
KLF5 enables dichotomous lineage programs in pancreatic cancer via the AAA+ ATPase coactivators RUVBL1 and RUVBL2
|
|
The /EAAT3 dicarboxylic amino acid transporter is an epigenetically dysregulated nutrient carrier that sustains oncogenic metabolic programs
|
|
A glucose kinase-independent HK2 activity prevents TNF-induced cell death by phosphorylating RIPK1
|
|
A non-canonical lymphoblast in refractory childhood T-cell leukaemia
|
|
Wild-type KRAS activation drives evasion of interferon-mediated immunity and resistance to immunotherapy in hepatocellular carcinoma
|
|
Engineered CXCR3-A expression enhances B7-H3-targeting CAR T cell migration and efficacy against diffuse intrinsic pontine glioma
|
|
CryoEM and computational modeling structural insights into the pH regulator NBCn1
|
|
Bidirectional communication between nucleotide and substrate binding sites in a type IV multidrug ABC transporter
|
|
Targeting polyamine metabolism and ferroptosis enhances the efficacy of KRAS-targeted therapy depending on KEAP1 status
|
|
LUBAC modulates CBM complex functions downstream of TRAF6 in T cells
|
|
Pathogenic variants in cause an X-linked neurodevelopmental disorder modulated by NURF complex composition
|
|
Systematic characterization of the composition and dynamics of processing body-associated mRNAs
|
|
Mutation of CMTR2 in Lung Adenocarcinoma Alters RNA Alternative Splicing and Reveals Therapeutic Vulnerabilities
|
|
PRKG1 hinders myogenic differentiation and predicts response to AKT inhibitor ipatasertib in Rhabdomyosarcoma
|
|
Targeting SUMOylation promotes cBAF complex stabilization and disruption of the SS18::SSX transcriptome in synovial sarcoma
|
|
Oncogenic DEAD-box ATPase DDX41 establishes transcript ensembles via CLK3-dependent and -independent mechanisms
|
|
Targeting TAZ-TEAD in minimal residual disease enhances the duration of targeted therapy in melanoma models
|
|
Olaparib, durvalumab, and cyclophosphamide, and a prognostic blood signature in platinum-sensitive ovarian cancer: the randomized phase 2 SOLACE2 trial
|
|
HER2DX in older patients with HER2-positive early breast cancer: extended follow-up from the RESPECT trial of trastuzumab ± chemotherapy
|
|
Targeting cancer glutamine dependency with a first-in-class inhibitor of the mitochondrial glutamine transporter SLC1A5_var
|
|
Site-specific ligase-dependent conjugation with ring-opening linker improves safety and stability of HER2-targeting ADCs
|
|
Camrelizumab plus chemotherapy versus chemoradiotherapy as neoadjuvant therapy for resectable esophageal squamous cell carcinoma: Phase 2 randomized trial (REVO)
|
|
On-target off-tumor toxicity of claudin18.2-directed CAR-T cells in preclinical models
|
|
Modeling and addressing on-target/off-tumor toxicity of claudin 18.2 targeted immunotherapies
|
|
Real-world data and clinical experience from over 100,000 multi-cancer early detection tests
|
|
Steering H2O2 lysis pathway for ROS generation in Prussian blue nanozymes via alkali cation doping
|
|
Single rate-limiting event of carcinogenesis
|
|
BRCA2 deficiency and replication stress drive APOBEC3-Mediated genomic instability
|
|
Tumor-targeted top1 inhibitor delivery with optimized parp inhibition in advanced solid tumors: a phase i trial of gapped scheduling
|
|
Structural basis for transport and inhibition of the human glucose-6-phosphate transporter G6PT
|
|
EWS::FLI1 expression in human embryonic mesenchymal stem cells leads to transcriptional reprograming, defective DNA damage repair and Ewing sarcoma
|
|
FAP+ fibroblasts orchestrate tumor microenvironment remodeling in renal cell carcinoma with tumor thrombus
|
|
Targeted degradation of endogenous YAP by nanobody bioPROTAC inhibits tumor progression
|
|
Genome-wide association study of childhood B-cell acute lymphoblastic leukemia reveals novel African ancestry-specific susceptibility loci
|
|
Chromatin looping-based CRISPR screen identifies TLK2 as chromatin loop formation regulator in cancer stemness plasticity
|
|
CENP-E initiates chromosome congression by opposing Aurora kinases to promote end-on attachments
|
|
Kinetochore-centrosome feedback linking CENP-E and Aurora kinases controls chromosome congression
|
|
Astrocytic-OTUD7B ameliorates murine experimental autoimmune encephalomyelitis by stabilizing glial fibrillary acidic protein and preventing inflammation
|
|
Mitochondrial one-carbon metabolism is required for TGF-β-induced glycine synthesis and fibrotic responses
|
|
Leveraging platinum-protein interactions to overcome chemoresistance
|
|
αTIGIT-IL2 achieves tumor regression by promoting tumor-infiltrating regulatory T cell fragility in mouse models
|
|
HIFα isoform specific activities drive cell-type specificity of VHL-associated oncogenesis
|
|
Chromatin remodeling restrains oncogenic functions in prostate cancer
|
|
Loss of BPTF restores estrogen response and suppresses metastasis of mammary tumors
|
|
VRK2 targeting potentiates anti-PD-1 immunotherapy in hepatocellular carcinoma through MYC destabilization
|
|
A next-generation anti-CTLA-4 probody mitigates toxicity and enhances anti-tumor immunity in mice
|
|
Histone lactylation promotes rheumatoid arthritis progression by increasing NFATc2 expression and the production of anti-lactylated histone autoantibodies
|
|
WEE1 inhibitors synergise with mRNA translation defects via activation of the kinase GCN2
|
|
Elucidating molecularly stratified single agent, and combination, therapeutic strategies targeting MCL1 for lethal prostate cancer
|
|
Metabolic profiling reveals channeled de novo pyrimidine and purine biosynthesis fueled by mitochondrially generated aspartic acid in cancer cells
|
|
The genomic landscape of relapsed infant and childhood KMT2A-rearranged acute leukemia
|
|
Neoadjuvant tislelizumab with afatinib for locally advanced head and neck squamous cell carcinoma (neoCHANCE-1): a phase 2 clinical trial
|
|
The Hippo terminal effector YAP boosts enterovirus replication in type 1 diabetes
|
|
Inflammation and mutational burden differentially associated with nivolumab or ipilimumab combination efficacy in colorectal cancer
|
|
Impact of steroid differentiation on tumor microenvironment revealed by single-nucleus atlas of adrenal tumors
|
|
A long-term self-driven metronomic photodynamic system for cancer therapy
|
|
Dual membrane receptor degradation via folate receptor targeting chimera
|
|
Pathogenic variants reveal candidate genes for prostate cancer germline testing for men of African ancestry
|
|
Structural insights into Wnt/β-catenin signaling regulation by LGR4, R-spondin, and ZNRF3
|
|
Diabetes reshapes pancreatic cancer-associated endothelial niche by accelerating senescence
|
|
CXCR4 mediated recognition of HIV envelope spike and inhibition by CXCL12
|
|
An active allosteric mechanism in ASAP1-mediated Arf1 GTP hydrolysis redefines PH domain function
|
|
Tumor immune dynamics and long-term clinical outcome of stage IIIA NSCLC patients treated with neoadjuvant chemoimmunotherapy
|
|
Inhibition of ICAM1 diminishes stemness and enhances antitumor immunity in glioblastoma via β-catenin/PD-L1 signaling
|
|
Direct - mRNA interaction regulates cell proliferation and cancer progression
|
|
Structural insights into chemoresistance mutants of BCL-2 and their targeting by stapled BAD BH3 helices
|
|
Development of an adeno-associated virus vector for gene replacement therapy of NF1-related tumors
|
|
Biomimetic organo-hydrogels reveal the adipose tissue local mechanical anisotropy regulates ovarian cancer invasion
|
|
Cytoplasmic TRIM24 promotes colorectal cancer cell proliferation by activating Wnt/β-catenin signaling
|
|
Interleukin-12 anchored drug conjugate (tolododekin alfa) in patients with advanced solid tumors: first-in-human Phase 1 trial
|
|
In vivo CRISPR screening in head and neck cancer reveals as an immunotherapy target
|
|
Post-resection delivery of a TLR7/8 agonist from a biodegradable scaffold achieves immune-mediated glioblastoma clearance and protection against tumor challenge in mice
|
|
CD137L promotes immune surveillance in melanoma via HLTF regulation
|
|
An injury-associated lobular microniche is associated with the classical tumor cell phenotype in pancreatic cancer
|
|
Oncogenic driver mutations underlie the spatial tumour immune landscape of non-small cell lung cancer
|
|
Three lncRNAs promote PUM protein condensation and germline differentiation
|
|
Poziotinib for EGFR exon 20-insertion NSCLC: Clinical efficacy of the phase 2 ZENITH trial and differential impact of EGFR exon 20 insertion location on sensitivity
|
|
PBK/TOPK mediates Ikaros, Aiolos and CTCF displacement from mitotic chromosomes and alters chromatin accessibility at selected C2H2-zinc finger protein binding sites
|
|
Stabilizing a mammalian RNA thermometer confers neuroprotection in subarachnoid hemorrhage
|
|
5-ALA photodynamic metabolite-powered zero-waste ferroptosis amplifier for enhanced hypertrophic scar therapy
|
|
RBM39 degrader invigorates innate immunity to eradicate neuroblastoma despite cancer cell plasticity
|
|
Modulating the PPARγ pathway upregulates NECTIN4 and enhances chimeric antigen receptor (CAR) T cell therapy in bladder cancer
|
|
Ataluren improves hematopoietic and pancreatic disorders in Shwachman-Diamond syndrome patients: a compassionate program case-series
|
|
Targeting ALDH16A1 mediated thioredoxin lysosomal degradation to enhance ferroptosis susceptibility in SMARCA4-deficient NSCLC
|
|
Selective ubiquitination of drug-like small molecules by the ubiquitin ligase HUWE1
|
|
Cryo-EM structures of CRAF/MEK1/14-3-3 complexes in autoinhibited and open-monomer states reveal features of RAF regulation
|
|
Longitudinal liquid biopsy identifies an early predictive biomarker of immune checkpoint blockade response in head and neck squamous cell carcinoma
|
|
Multiple myeloma associated long non-coding RNA confers chemoresistance by enhancing PRC2 mediated UPR pathway activation
|
|
High-fidelity Cas9-mediated targeting of KRAS driver mutations restrains lung cancer in preclinical models
|
|
Capillary constrictions prime cancer cell tumorigenicity through PIEZO1
|
|
PYM1 limits non-canonical Exon Junction Complex occupancy in a gene architecture dependent manner to tune mRNA expression
|
|
Structure and transport mechanism of the human prostaglandin transporter SLCO2A1
|
|
Deep indel mutagenesis reveals the regulatory and modulatory architecture of alternative exon splicing
|
|
Whole-genome methylation profiling of extracellular vesicle DNA in gastric cancer identifies intercellular communication features
|
|
Structural basis of adhesin Fap2 interaction with receptors on cancer and immune cells
|
|
UBE3A promotes foam cell formation and counters remyelination by targeting ABCA1 for proteasomal degradation
|
|
GD2T cells as a platform for single-dose and long-term delivery of biologics
|
|
A comparative analysis of heterogeneity in lung cancer screening effectiveness in two randomised controlled trials
|
|
Regulatory role of the N-terminal intrinsically disordered region of the DEAD-box RNA helicase DDX3X in selective RNA recognition
|
|
A strategy for challenging tumorous bone regeneration by borosilicate bioactive glass boosting moderate magnetic hyperthermia
|
|
Splicing QTL mapping in stimulated macrophages associates low-usage splice junctions with immune-mediated disease risk
|
|
Hepatitis C virus NS3 helicase contributes to (−) strand RNA synthesis
|
|
CD99-mediated immunological synapse formation potentiates CAR-T cell function
|
|
Clonal diversity shapes the tumour microenvironment leading to distinct immunotherapy responses in metastatic urothelial carcinoma
|
|
Hypoxic stress incites HIF1α-driven ribosome biogenesis that can be exploited by targeting RNA Polymerase I
|
|
A -natural antisense RNA regulates alternative polyadenylation of under Pi starvation in tomato
|
|
The balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells
|
|
ALS/FTD-linked TBK1 deficiency in microglia induces an aged-like microglial signature and drives social recognition deficits in mice
|
|
Maintenance olaparib after platinum-based chemotherapy for advanced/metastatic endometrial cancer: GINECO randomized phase IIb UTOLA trial
|
|
Multi-omics analysis identifies an M-MDSC-like immunosuppressive phenotype in lineage-switched AML with rearrangement
|
|
The HDAC inhibitor romidepsin renders liver cancer vulnerable to RTK targeting and immunologically active
|
|
Polyclonal expansion of functional tumor-reactive lymphocytes infiltrating glioblastoma for personalized cell therapy
|
|
LncRNA is altered in human cardiomyopathies and promotes stem cell-derived cardiomyogenesis via splicing regulation
|
|
Molecular landscape, subtypes, and therapeutic vulnerabilities of central nervous system solitary fibrous tumors
|
|
Mesothelin-directed protein-drug conjugates for mesothelin-low solid tumor therapy
|
|
Prolonging lung cancer response to EGFR inhibition by targeting the selective advantage of resistant cells
|
|
Centromere protection requires strict mitotic inactivation of the Bloom syndrome helicase complex
|
|
Targeting spermine metabolism to overcome immunotherapy resistance in pancreatic cancer
|
|
Patient-derived tumoroids from CIC::DUX4 rearranged sarcoma identify MCL1 as a therapeutic target
|
|
Small round cell sarcoma tumoroid biobank reveals CIC::DUX4 sarcoma vulnerability to MCL-1 inhibition
|
|
The bispecific innate cell engager AFM28 eliminates CD123 leukemic stem and progenitor cells in AML and MDS
|
|
Whole exome sequencing identifies as a susceptibility gene for estrogen-receptor-negative breast cancer in Hispanic/Latina women
|
|
STN1 facilitates metastasis by promoting transcription of EMT-activator ZEB1 in pancreatic cancer
|
|
Genome-wide in vivo CRISPR screens identify GATOR1 complex as a tumor suppressor in Myc-driven lymphoma
|
|
Tumor cell-adipocyte gap junctions activate lipolysis and contribute to breast tumorigenesis
|
|
Integrative proteogenomic characterization of Wilms tumor
|
|
modulates p53, the cell cycle, and genotoxicity to maintain its intracellular niche
|
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Integrated molecular and clinical characterization of pulmonary large cell neuroendocrine carcinoma
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Bioengineered hybrid dual-targeting nanoparticles reprogram the tumour microenvironment for deep glioblastoma photodynamic therapy
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CENcyclopedia: dynamic landscape of kinetochore architecture throughout the cell cycle
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Computational ranking identifies Plexin-B2 in circulating tumor cell clustering with monocytes in breast cancer metastasis
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Bioinspired ruthenium-manganese-oxygen complex for biocatalytic and radiosensitization therapies to eradicate primary and metastatic tumors
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Structural basis for substrate recognition mechanism of human SLC26A7
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A humanized anaplastic lymphoma kinase (ALK)-directed antibody-drug conjugate with pyrrolobenzodiazepine payload demonstrates efficacy in ALK-expressing cancers
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Respiration defects limit serine synthesis required for lung cancer growth and survival
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Chromatin retained lncRNA integrates ABA and DOG1 signalling pathways to enhance Arabidopsis seeds dormancy
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Multivalent interactions with CCR4–NOT and PABPC1 determine mRNA repression efficiency by tristetraprolin
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A hollow-tube-like hydrospongel for multimodal therapy of advanced colorectal cancer
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COUP-TFII-mediated reprogramming of the vascular endothelium counteracts tumor immune evasion
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A clonally expanded nodal T-cell population diagnosed as T-cell lymphoma after CAR-T therapy
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CRISPR screening reveals that RNA helicase DDX41 triggers ribosome biogenesis and cancer progression through R-loop-mediated RPL/RPS transcription
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Cell free RNA detection of pancreatic cancer in pre diagnostic high risk and symptomatic patients
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Opposing regulation of the K63-linked polyubiquitination of RIPK3 by SMURF1 and USP5 in necroptosis
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Nucleophilic addition promoted ring rearrangement-aromatization in aza-/thio-sesquiterpenoid biosynthesis
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Structure and function of the human apoptotic scramblase Xkr4
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Cross-species comparison reveals therapeutic vulnerabilities halting glioblastoma progression
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Functional interplay between condensin I and topoisomerase Iiα in single-molecule DNA compaction
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OFD1 inhibition induces BRCAness to create a therapeutic vulnerability to PARP inhibition in pancreatic cancer
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DDX41 resolves G-quadruplexes to maintain erythroid genome integrity and prevent cGAS-mediated cell death
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Functional avidity of anti-B7H3 CAR-T constructs predicts antigen density thresholds for triggering effector function
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Lung metastasis and recurrence is mitigated by CAR macrophages, in-situ-generated from mRNA delivered by small extracellular vesicles
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PROCR diminishes the efficacy of radiation by impairing T-cell-mediated antitumour immunity
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Neural function of Netrin-1 in precancerous lesions of the pancreas
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Chimeric exosomes-derived immunomodulator restoring lymph nodes microenvironment for sensitizing TNBC immunotherapy
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Pericytes promote metastasis by regulating tumor local vascular tone and hemodynamics
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Explainable multimodal deep learning for predicting thyroid cancer lateral lymph node metastasis using ultrasound imaging
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Tumor control and immune activation through palliative irradiation and ATR inhibition, PATRIOT Part C: a phase Ib trial
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Pre-mRNA processing factors differentially impact coordination between co-transcriptional cleavage and transcription termination
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Structure of CFTR bound to ()-BPO-27 unveils a pore-blockage mechanism
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A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas
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Mogat1 drives metabolic adaptations to evade immune surveillance
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Dynamic and structural insights into allosteric regulation on MKP5 a dual-specificity phosphatase
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De novo pyrimidine biosynthesis inhibition synergizes with BCL-XL targeting in pancreatic cancer
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Structure and mechanism of the RalGAP tumor suppressor complex
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DHRS13 suppresses differentiation and mitophagy in glioma via retinoic acid and mitochondrial reactive oxygen species
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AR+TREM2+ macrophage induced pathogenic immunosuppression promotes prostate cancer progression
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Mitochondrial inflexibility ignites tumor immunogenicity in postoperative glioblastoma
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The oncolytic adenovirus Ad-TD-nsIL12 in primary or progressive pediatric IDH wild-type diffuse intrinsic pontine glioma results of two phase I clinical trials
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Large-scale RNA-Seq mining reveals ciclopirox olamine induces TDP-43 cryptic exons
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U-rich elements drive pervasive cryptic splicing in 3’ UTR massively parallel reporter assays
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Longitudinal circulating tumor DNA analysis during treatment of locally advanced resectable gastric or gastroesophageal junction adenocarcinoma: the PLAGAST prospective biomarker study
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Metabolism archetype cancer cells induce protumor TREM2 macrophages via oxLDL-mediated metabolic interplay in hepatocellular carcinoma
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DSS1 inhibits autophagy to activate epithelial-mesenchymal transition in a pro-metastatic niche of renal cell carcinoma
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Structural insights into cholesterol sensing by the LYCHOS-mTORC1 pathway
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Specific oncogene activation of the cell of origin in mucosal melanoma
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Aberrant EZHIP expression drives tumorigenesis in osteosarcoma
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Transdifferentiation of tongue muscle cells into cancer-associated fibroblasts in response to tongue squamous cell carcinoma
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E2F activity determines mitosis versus whole-genome duplication in G2-arrested cells
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Allosteric activation of the SPRTN protease by ubiquitin maintains genome stability
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Determination of trunk neural crest cell fate and susceptibility to splicing perturbation by the DLC1-SF3B1-PHF5A splicing complex
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Constitutive inflammation and epithelial-mesenchymal transition dictate sensitivity to nivolumab in CONFIRM: a placebo-controlled, randomised phase III trial
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ST2/IL-33 axis blockade inhibits regulatory T cell cytotoxicity towards CD8 T cells in the leukemic niche
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Nanomechanical binding mechanism of ligands drives agonistic activity
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The invasion phenotypes of glioblastoma depend on plastic and reprogrammable cell states
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Cell-free DNA testing for the detection and prognosis prediction of pancreatic cancer
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The tumor-sentinel lymph node immuno-migratome reveals CCR7⁺ dendritic cells drive response to sequenced immunoradiotherapy
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Integrative spatial omics reveals distinct tumor-promoting multicellular niches and immunosuppressive mechanisms in Black American and White American patients with TNBC
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Comprehensive ovarian cancer variant analysis uncouples homologous recombination and replicative functions
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Living therapeutics of nonpathogenic bacteria as biosynthesis factory and active carriers for enhancing tumor-targeted therapy
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Marked heterogeneity in malaria infection rate in a Malian longitudinal cohort
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Immunodiagnostic plasma amino acid residue biomarkers detect cancer early and predict treatment response
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The Helicobacter pylori AI-clinician harnesses artificial intelligence to personalise H. pylori treatment recommendations
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Notch activity is modulated by the aGPCR Latrophilin binding the DSL ligand in C. elegans
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Androgen receptor promotes arachidonic acid metabolism and angiogenic microenvironment in AFP-negative hepatocellular carcinoma
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TRF1 relies on fork reversal to prevent fragility at human telomeres
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DKN-01 and tislelizumab as second-line therapy in DKK1-high gastroesophageal adenocarcinoma: DisTinGuish trial part B
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Regulation of partial endothelial-to-mesenchymal transition by circATXN1 in ischemic diseases
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Synthetic carbon-based lanthanide upconversion nanoparticles for enhanced photothermal therapy
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Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose
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Inferring chromosome segregation error stage and crossover in trisomic disorders with application to Down syndrome
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JAK2 inhibition mediates clonal selection of RAS pathway mutations in myeloproliferative neoplasms
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The PARP inhibitor talazoparib synergizes with reovirus to induce cancer killing and tumour control in vivo in mouse models
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Distinct structural mechanisms of LGR4 modulation by Norrin and RSPOs in Wnt/β-catenin signaling
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Tumor vessel-adaptable adhesive and absorbable microspheres for sustainable transarterial chemoembolization therapy
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YY1 enhances HIF-1α stability in tumor-associated macrophages to suppress anti-tumor immunity of prostate cancer in mice
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DDX1 methylation mediated MATR3 splicing regulates intervertebral disc degeneration by initiating chromatin reprogramming
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Cx43 enhances response to BRAF/MEK inhibitors by reducing DNA repair capacity
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Adipocyte CLDN5 promotes thermogenesis and energy expenditure through regulation of IL10 expression
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Immune correlates of anti-BCMA CAR-T products idecabtagene vicleucel and ciltacabtagene autoleucel in a real-world cohort of patients with multiple myeloma
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Tumor site-directed A1R expression enhances CAR T cell function and improves efficacy against solid tumors
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Suppression of multiple mouse models of refractory malignancies by reprogramming IL-18 ligand-receptor interaction
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Glucosamine activates intestinal P-glycoprotein inhibiting drug absorption
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Orchestrating intratumoral DC-T cell immunity for enhanced tumor control via radiotherapy-activated TLR7/8 prodrugs in mice
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NONO, SFPQ, and PSPC1 promote telomerase recruitment to the telomere
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Decoding polyubiquitin regulation of K7. 1 (KCNQ1) surface expression with engineered linkage-selective deubiquitinases
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Whole genome and transcriptome profiling in advanced pancreatic cancer patients on the COMPASS trial
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Adipocyte-specific Zeb1 downregulation remodels the tumor-associated adipose microenvironment to facilitate female breast cancer progression
|
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Interdependence of Pasha and Drosha for localization and function of the Microprocessor in C. elegans
|
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A heterozygous CEBPA mutation disrupting the bZIP domain in a RUNX1 and SRSF2 mutational background causes MDS disease progression
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Sintilimab and anlotinib with gemcitabine plus cisplatin in advanced biliary tract cancer: SAGC a randomized phase 2 trial
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Radiation therapy results in preferential tumor antigen-specific lymphodepletion in head and neck cancer
|
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Single-cell analysis reveals a longitudinal trajectory of meningioma evolution and heterogeneity
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Deep mutational scanning of the multi-domain phosphatase SHP2 reveals mechanisms of regulation and pathogenicity
|
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EZH2 loss promotes gastric squamous cell carcinoma
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An mRNA lipid nanoparticle-incorporated nanofiber-hydrogel composite for cancer immunotherapy
|
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O-GlcNAcylation of FOXK1 co-opts BAP1 to orchestrate the E2F pathway and promotes oncogenesis
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Single atom engineering for radiotherapy-activated immune agonist prodrugs
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Caffeine enhances antitumor T-cell activity by suppressing kynurenine pathway in colorectal cancer
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A ferritin-targeted biohybrid triggering ferroptosis immunotherapy via activating endogenous iron and replenishing exogenous iron simultaneously
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Deficits in mitochondrial dynamics and iron balance result in templated insertions
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The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI
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Dual asparagine-depriving nanoparticles against solid tumors
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Neoadjuvant ARX788 plus pyrotinib versus trastuzumab, pertuzumab, docetaxel and carboplatin for HER2-positive breast cancer: a randomised phase 2b trial
|
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Structure of a transcribing Pol II-DSIF-SPT6-U1 snRNP complex
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Structural mechanism of DDX39B regulation by human TREX-2 and a related complex in mRNP remodeling
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Human cancer-targeted immunity via transgenic hematopoietic stem cell progeny
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Intraindividual epigenetic heterogeneity underlying phenotypic subtypes of advanced prostate cancer
|
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Identification of the Notch ligand DLK1 as an immunotherapeutic target and regulator of tumor cell plasticity and chemoresistance in adrenocortical carcinoma
|
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Single-cell signaling network profiling during redox stress reveals dynamic redox regulation in immune cells
|
|
Different tumour-resident memory T-cell subsets regulate responses to anti-PD-1 and anti-CTLA-4 cancer immunotherapies
|
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CryoEM structure of the SLFN14 endoribonuclease reveals insight into RNA binding and cleavage
|
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Dual TIGIT and PD-1 blockade with domvanalimab plus zimberelimab in hepatocellular carcinoma refractory to anti-PD-1 therapies: the phase 2 LIVERTI trial
|
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Cardiomyocyte-derived USP13 protects hearts from hypertrophy via deubiquitinating and stabilizing STAT1 in male mice
|
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Aging measures and cancer in the Health and Retirement Study (HRS)
|
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Engineering STING Nanoadjuvants for spatiotemporally-tailored innate immunity stimulation and cancer vaccination therapy
|
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Role of stem-like cells in chemotherapy resistance and relapse in pediatric T-cell acute lymphoblastic leukemia
|
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Uncovering minimal pathways in melanoma initiation
|
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Constitutive expression of the transcriptional co-activator IκBζ promotes melanoma growth and immunotherapy resistance
|
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The mitochondrial methylation potential gates mitoribosome assembly
|
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Bladder cancer variants share aggressive features including a CA125+ cell state and targetable TM4SF1 expression
|
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A macrophage-predominant immunosuppressive microenvironment and therapeutic vulnerabilities in advanced salivary gland cancer
|
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Molecular patterns and mechanisms of tumorigenesis in HPV-associated and HPV-independent sinonasal squamous cell carcinoma
|
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A self-directed Trojanbot-enzymatic nanobot in neutrobot for active target therapy of glioblastoma
|
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A phase I/II trial of WT1-specific TCR gene therapy for patients with acute myeloid leukemia and active disease post-allogeneic hematopoietic cell transplantation: skewing towards NK-like phenotype impairs T cell function and persistence
|
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SWI/SNF ATPase silenced HLF potentiates lung metastasis in solid cancers
|
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The TRIP12 E3 ligase induces SWI/SNF component BRG1-β-catenin interaction to promote Wnt signaling
|
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Control of epithelial tissue organization by mRNA localization
|
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Cytoreductive surgery and hyperthermic intrathoracic chemotherapy in thymic epithelial tumors with pleural spread or recurrence: a prospective, single-arm, phase II study
|
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TIM3-blockade synergizes with IL2 in alleviating intra-tumoral CD8T cell exhaustion
|
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Polymerised superparamagnetic antigen presenting cell lymphocyte capture for enriching tumour reactive T-cells and neoantigen identification
|
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ELMO2 is an essential regulator of carotid artery development
|
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High mobility group A1 (HMGA1) promotes esophageal squamous cell carcinoma progression by inhibiting STING-mediated anti-tumor immunity
|
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Inflammatory diseases and risk of lung cancer among individuals who have never smoked
|
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Anlotinib plus toripalimab as a first-line treatment in patients with advanced gastric cancer and performance status 2: the phase II APICAL-GC trial
|
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Neoantigens combined with in situ cancer vaccination induce personalized immunity and reshape the tumor microenvironment
|
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A cowpea mosaic virus adjuvant conjugated to liposomes loaded with tumor cell lysates as an ovarian cancer vaccine
|
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Cleavage of CAD by caspase-3 determines the cancer cell fate during chemotherapy
|
|
CRISPR screen decodes SWI/SNF chromatin remodeling complex assembly
|
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Precision targeting of β-catenin induces tumor reprogramming and immunity in hepatocellular cancers
|
|
Human autoimmunity at single cell resolution in aplastic anemia before and after effective immunotherapy
|
|
CEACAM1 as a mediator of B-cell receptor signaling in mantle cell lymphoma
|
|
TEIPP-vaccination in checkpoint-resistant non-small cell lung cancer: a first-in-human phase I/II dose-escalation study
|
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Topobexin targets the Topoisomerase II ATPase domain for beta isoform-selective inhibition and anthracycline cardioprotection
|
|
BH3 mimetics targeting BCL-XL have efficacy in solid tumors with RB1 loss and replication stress
|
|
WNK1 signalling regulates amino acid transport and mTORC1 activity to sustain acute myeloid leukaemia growth
|
|
Ferroptosis-activating metabolite acrolein antagonizes necroptosis and anti-cancer therapeutics
|
|
Structural plasticity of the FOXO-DBD:p53-TAD interaction
|
|
HMGA2 and protein leucine methylation drive pancreatic cancer lineage plasticity
|
|
Provoking tumor disulfidptosis by single-atom nanozyme regulating cellular energy supply and reducing power
|
|
Structural basis of ubiquitin ligase Nedd4-2 autoinhibition and regulation by calcium and 14-3-3 proteins
|
|
FOXA2 promotes metastatic competence in small cell lung cancer
|
|
Alveolar epithelial and vascular CXCR2 mediates transcytosis of CXCL1 in inflamed lungs
|
|
Interplay of kinetochores and catalysts drives rapid assembly of the mitotic checkpoint complex
|
|
Real-time 3D temperature reconstruction in microwave cancer hyperthermia from scarce temperature measurements
|
|
hnRNPL phase separation activates PIK3CB transcription and promotes glycolysis in ovarian cancer
|
|
Durable response to CAR T is associated with elevated activation and clonotypic expansion of the cytotoxic native T cell repertoire
|
|
p53-inducible lncRNA LOC644656 causes genotoxic stress-induced stem cell maldifferentiation and cancer chemoresistance
|
|
Neoantigen enriched biomimetic nanovaccine for personalized cancer immunotherapy
|
|
Identification of human pathways acting on nuclear non-coding RNAs using the Mirror forward genetic approach
|
|
Cell trajectory modulation: rapid microfluidic biophysical profiling of CAR T cell functional phenotypes
|
|
FcRn-silencing of IL-12Fc prevents toxicity of local IL-12 therapy and prolongs survival in experimental glioblastoma
|
|
Deciphering the history of ERK activity from fixed-cell immunofluorescence measurements
|
|
APOBEC affects tumor evolution and age at onset of lung cancer in smokers
|
|
A searchable atlas of pathogen-sensitive lncRNA networks in human macrophages
|
|
CREBBP inactivation sensitizes B cell acute lymphoblastic leukemia to ferroptotic cell death upon BCL2 inhibition
|
|
In depth transcriptomic profiling defines a landscape of dysfunctional immune responses in patients with VEXAS syndrome
|
|
The clinical and molecular landscape of breast cancer in women of African and South Asian ancestry
|
|
HIV status alters immune cell infiltration and activation profile in women with breast cancer
|
|
Whole genome sequencing improves tissue-of-origin diagnosis and treatment options for cancer of unknown primary
|
|
Wnt/β-catenin activation by mutually exclusive FBXW11 and CTNNB1 hotspot mutations drives salivary basal cell adenoma
|
|
Transcriptional and epigenetic rewiring by the NUP98::KDM5A fusion oncoprotein directly activates CDK12
|
|
Dual Ribosome Profiling reveals metabolic limitations of cancer and stromal cells in the tumor microenvironment
|
|
Engineering anti-BCMA CAR T cells for enhancing myeloma killing efficacy via apoptosis regulation
|
|
Neoadjuvant with low-dose radiotherapy, tislelizumab, albumin-bound paclitaxel, and cisplatin for resectable locally advanced head and neck squamous cell carcinoma: phase II single-arm trial
|
|
ANP32E drives vulnerability to ATR inhibitors by inducing R-loops-dependent transcription replication conflicts in triple negative breast cancer
|
|
Alternative splicing across the C. elegans nervous system
|
|
Deep transcriptomics reveals cell-specific isoforms of pan-neuronal genes
|
|
Alectinib in combination with bevacizumab as first-line treatment in -rearranged non-small cell lung cancer (ALEK-B): a single-arm, phase 2 trial
|
|
Direct evaluation of antiplatelet therapy in coronary artery disease by comprehensive image-based profiling of circulating platelets
|
|
Long-Term Efficacy of Pembrolizumab and the Clinical Utility of ctDNA in Locally Advanced dMMR/MSI-H Solid Tumors
|
|
Unraveling mutagenic processes influencing the tumor mutational patterns of individuals with constitutional mismatch repair deficiency
|
|
A FAN1 point mutation associated with accelerated Huntington’s disease progression alters its PCNA-mediated assembly on DNA
|
|
Structural and molecular basis of PCNA-activated FAN1 nuclease function in DNA repair
|
|
Neoadjuvant PARP inhibitor scheduling in BRCA1 and BRCA2 related breast cancer: PARTNER, a randomized phase II/III trial
|
|
ATP functions as a pathogen-associated molecular pattern to activate the E3 ubiquitin ligase RNF213
|
|
GDF8 and activin A blockade protects against GLP-1–induced muscle loss while enhancing fat loss in obese male mice and non-human primates
|
|
Nivolumab plus low-dose ipilimumab in hypermutated HER2-negative metastatic breast cancer: a phase II trial (NIMBUS)
|
|
Clinical response to azacitidine in MDS is associated with distinct DNA methylation changes in HSPCs
|
|
Comprehensive molecular profiling of FH-deficient renal cell carcinoma identifies molecular subtypes and potential therapeutic targets
|
|
Structural proteomics defines a sequential priming mechanism for the progesterone receptor
|
|
Multi-omic analysis reveals a CAF-stemness-governed classification in HCC liver transplant recipients beyond the Milan criteria
|
|
Basal-shift transformation leads to EGFR therapy-resistance in human lung adenocarcinoma
|
|
Structural visualization of HECT-type E3 ligase Ufd4 accepting and transferring ubiquitin to form K29/K48-branched polyubiquitination
|
|
Ligand-activated EGFR/MAPK signaling but not PI3K, are key resistance mechanisms to EGFR-therapy in colorectal cancer
|
|
Capivasertib plus fulvestrant in patients with HR-positive/HER2-negative advanced breast cancer: phase 3 CAPItello-291 study extended Chinese cohort
|
|
Zanidatamab monotherapy or combined with chemotherapy in HER2-expressing gastroesophageal adenocarcinoma: a phase 1 trial
|
|
Palmitoylation prevents B7-H4 lysosomal degradation sustaining tumor immune evasion
|
|
Structure-based design of potent and selective inhibitors targeting RIPK3 for eliminating on-target toxicity in vitro
|
|
Transcriptional stochasticity reveals multiple mechanisms of long non-coding RNA regulation at the Xist–Tsix locus
|
|
MS CETSA deep functional proteomics uncovers DNA repair programs leading to gemcitabine resistance
|
|
Genomic landscape of diffuse glioma revealed by whole genome sequencing
|
|
Two-stage CD8+ CAR T-cell differentiation in patients with large B-cell lymphoma
|
|
mTORC1 cooperates with tRNA wobble modification to sustain the protein synthesis machinery
|
|
A key residue of the extracellular gate provides quality control contributing to ABCG substrate specificity
|
|
The ESCRT protein CHMP5 promotes T cell leukemia by enabling BRD4-p300-dependent transcription
|
|
Non-canonical Wnt signaling promotes epithelial fluidization in the repairing airway
|
|
Harnessing the FGFR2/NF2/YAP signaling-dependent necroptosis to develop an FGFR2/IL-8 dual blockade therapeutic strategy
|
|
Snord67 promotes breast cancer metastasis by guiding U6 modification and modulating the splicing landscape
|
|
LKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancers
|
|
Development of PVTX-405 as a potent and highly selective molecular glue degrader of IKZF2 for cancer immunotherapy
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