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Unlike animals, plant possess mitochondria and chloroplasts and exhibit a unique defensive adaptation to stress. Here, the authors demonstrate the feasibility of restoring organelle interaction network homeostasis in animal cells by introducing plant-derived photosynthetic systems.

Here, they develop optimized mouse testicular organoids that recapitulate key testicular functions and generate functional haploid germ cells, enabling the generation of normal fertile F2 offspring. These organoids can be used to model male infertility and screen for drugs that may prevent germ cell loss after chemotherapy.

Conversion-type batteries face performance decay under high loading due to shuttle effects and sluggish kinetics. Here, authors introduce an f-d orbital tag-team catalysis mechanism using cerium single-atom catalysts, achieving a competitive iodine loading of 44.7 mg cm⁻² and an areal capacity of 10.2 mAh cm⁻² in zinc–iodine batteries.

A few anisotropic van der Waals materials have been shown to host hyperbolic polaritons in the visible and infrared ranges. Here, the authors characterize the complex dielectric function of hexagonal boron nitride in the deep-ultraviolet regime, supporting a natural hyperbolic dispersion and predicting hyperbolic exciton polaritons.

Treatment failure exists in Induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) patients. Here this group reports a phase 2 randomized trial evaluating the efficacy and safety of adding nimotuzumab, to CCRT on 246 patients with untreated, non-keratinising, stage II–IVA LA-NPC.

Despite rapid development of model algorithms, more evidence is needed on the widespread clinical implementation of auto-segmentation tools. In this prospective, multicenter, observational trial, the authors find that AI-assisted delineation performs better than manual delineation while improving time efficiency and reducing performance metrics variability across centers and physicians with varying expertise.

The role of gut microbiota–metabolism crosstalk in polycystic ovary syndrome (PCOS) remains unclear. Here, the authors revealed that sialic acid exacerbates PCOS pathogenesis by remodeling gut microbial bile acid metabolism and FXR activation.

Hygroscopic gels can harvest atmospheric water but face efficiency challenges. Here, authors developed a heterogeneous gel with a pectin shell and graphene oxide core, enhancing water uptake and release. This design achieves high water yield and rapid desorption, outperforming existing systems.

Chen et al. report a crystal regulation strategy for 3D perovskites by using functional molecule to adsorb to specific perovskite facets and diminish random crystal facet-correlated defects, yielding pure-blue LEDs with emission peak at 473 nm, linewidth of only 14 nm, and efficiency of 14%.

Persistent luminescence is promising for photodynamic therapy in deep-seated tumors, but the uncontrollability of light within the body complicates precise spatiotemporal regulation. Here, the authors report X-ray preactivated elimusertib-loaded tumor-targeted photodynamic nanoparticles with controllable “on-off-on” afterglow properties for the treatment of deep-seated tumors.

The COMPASSION16 trial showed survival benefits of cadonilimab plus standard therapy in advanced cervical cancer. Here, subgroup analysis confirms consistent progression-free and overall survival improvements across diverse patient profiles.

The immune mechanism of radioresistance in cancer patients remains to be explored. The authors here show that CXCL13 is upregulated in tumor regions upon radiation, which recruits immune suppressive CXCR5⁺ monocytes. Blocking CXCR5/CXCL13 interactions facilitate tumor control following radiation.

High-latitude soils are future soil organic carbon loss hotspots, with losses dominated by particulate organic carbon (POC). The fraction of POC in total SOC (f_POC) is a key indicator, emphasizing the climate importance of preserving POC.

Delivery to the eye can be complex. Here, the authors report on eyedrop based delivery using zwitterionic nanocages to deliver catalase and superoxide dismutase for enzymatic cascade therapy to treat geographic atrophy, which outperforms intravitreal injection and current clinical antioxidants and supplements.

Controlling plant metabolism to improve growth and disease resistance has huge potential. Here, the authors find a conserved pathway which promotes antiviral resistance and promotes plant growth and develop polyglutamate-loaded chitosan nanogels to manipulate this pathway.

Researchers identify FOXJ3 variants in focal epilepsy and cortical dysplasia and show that FOXJ3 regulates neuronal migration and cortical layer formation by controlling the PTEN–mTOR pathway; disruption of this process leads to abnormal brain development.

Removing trace acetylene from ethylene is vital for plastic production, yet catalysts often overreact and waste the product. This work reveals that palladium dual-atom catalyst on carbon greatly speeds the reaction while keeping ethylene intact.

This study introduces a total atmospheric energy proxy into precipitation forecasts, improving extreme precipitation prediction at sub-seasonal and longer timescales. Moreover, it shows that the predictive value added by total energy has grown substantially in recent years.

This work reports the discovery of a giant in-plane Hall effect in a nonmagnetic half Heusler compound, demonstrating magneto-cubic behavior over a wide temperature range and identifying extrinsic mechanisms as the dominant origin.

Abdominal aortic aneurysm (AAA) is a life-threatening degenerative vascular disease in which macrophage-driven inflammation plays a central role. Here the authors show that macrophage Gsα promotes AAA by stabilizing NLRP3 inflammasome activity, while Gsα silencing via lipid nanoparticles suppresses inflammation and disease progression.

Self-aggregation in self-assembled monolayers adversely affects on hole transport performance in inverted perovskite solar cells. To address this issue, Shen et al. propose an indole/carbazole co-adsorption strategy to construct phase-homogeneous monolayers featuring alternating molecular arrangements.

Pulmonary arterial hypertension (PAH) is a fatal disease involving disrupted metabolic and mitochondrial regulation. Here the authors show that REV-ERBα protects against PAH by repressing BNIP3-driven mitophagy in pulmonary vascular smooth muscle cells, revealing a potential circadian-based therapeutic target.

CBP phosphorylation keeps intestinal homeostasis by restraining CBP–p53 binding to allow sufficient versican expression. Its impairment suppresses versican, disrupting the stem cell niche to drive UC and highlighting versican as a therapeutic target.

RNA editing influences gene regulation in cancer. Here, the authors show that EZH2 regulates RNA editing by ADAR1 through remodeling its interactome and nuclear transport, thereby promoting MDM2 expression and prostate cancer progression.

Nanostructure fragility limits applications. The authors develop a tribochemical surface reconstruction strategy to build single-crystal nanostructures on sapphire, which retain bulk-level wear resistance and improve triboelectric device performance.

Natural variation in the promoter of OsTPS8 contributes to differences in grain chalkiness and seed vigor between indica and japonica rice subspecies by altering trehalose-6-phosphate biosynthesis and α-amylase levels.

Hormone receptor-positive, HER2-negative advanced breast cancer lacks defined treatment options following CDK4/6 inhibitor (CDK4/6i) failure. Here, the authors present a phase Ib clinical trial where the CDK4/6i dalpiciclib is combined with the histone deacetylase inhibitor chidamide in this setting.

Women with diminished ovarian reserve face persistently low success rates during in vitro fertilization. Here, the authors show that a modified letrozole protocol yields cumulative clinical pregnancy rates and cumulative live birth rates comparable to those of the GnRH antagonist protocol.

Protein oligomerization can regulate cellular functions. Here, authors identify a small molecule that selectively induces WDR5 oligomerization using nanopore screening and show it disrupts cancer-driving interactions, highlighting a potential anti-tumor strategy.

High-nickel layered positive electrodes suffer from lattice oxygen loss and inherent lattice strain. Here, authors report a self-derived subtractive strategy to form a coherent spinel-phase shell with tunable thickness to confine active oxygen intermediates and suppresses interfacial side reactions.

Current thermal wax refining methods are energy intensive. Here, the authors report a photothermal process using a nanoscale zero-valent iron catalyst and sunlight to refine low-grade waxes into high-grade waxes with narrow distributions.

Mechanical computing is promising for environment-adaptive information processing, however existing methods have limited scalability. Here the authors report a polyaniline composite film enabling scalable logical operations.

This study reveals how the Vip1-Vip2 binary toxin assembles and enables protein translocation into target cells, providing structural insights into binary toxin action and suggesting strategies for developing next-generation bioinsecticides.

In maize, ZmDapF1 suppresses the activity of ZmMDH6 in chloroplasts, exacerbating oxidative damage under drought. Knocking out ZmDapF1 or using its favourable allele with lower gene expression enhances drought resilience without yield penalty.

Epitaxial CuO thin films exhibit crystal-symmetry-dependent orbital Rashba–Edelstein effects, enabling anisotropic orbital torque generation. The work reveals how crystal symmetry governs orbital angular momentum transport in oxide spintronic systems.

Maternal obesity is known to cause systemic lipid dysregulation, yet its effect on lipid reprogramming during the maternal-to-zygotic transition (MZT) remains unknown. Here, they show that obesity disrupts very-long-chain fatty acids (VLCFAs) storage in oocytes, impairing peroxisomal protein import in 2-cell embryos.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

Ca²⁺ concentration-mediated, seesawed interactions between IRE1α and two chaperones, CALR and BIP, were discovered to drive IRE1α activity fluctuation that was observed under chronic endoplasmic reticulum stress and physiological circadian conditions.

Here, the authors establish 1,3-propanediol, a low-cost biomass-derived bulk chemical, as an efficient, green, and sustainable C1 source for the mono-N-methylation of primary amines, via chelation-free C(sp3)−C(sp3) bond cleavage.

Telomere length varies across chromosome arms, but most studies measure only averages. Here, the authors use long‑read sequencing in >2,500 participants to map chromosome‑specific lengths, showing arm‑level variation, strong individual differences, and associations with aging and disease.

Whether mammalian adult stem cells possess asymmetric histone inheritance in vivo remains poorly understood. Here, the authors show that asymmetric histone inheritance in mouse olfactory stem cells coordinates transcription reinitiation, p63 distribution, and cell fate priming, and is required for tissue regeneration and smell behavior recovery.

Researchers demonstrate a minimalist terahertz wireless transceiver in integrated photonics. They break the longstanding constraint between source purity and DSP complexity, realizing 144 Gbps high-speed transmission at subterahertz frequency.

In this study, the authors identify an Aurka–Bhlhe41 axis, which prevents microglia from aging-like dysfunction by limiting CD22 upregulation, preserving myelin debris clearance and remyelination, and highlighting a potential therapy target for neurodegeneration.

By constructing tailored donor-acceptor structures in 3D COFs via artificial defects and electronic tuning, researchers overcame inherent limitations in conjugation and light absorption, achieving stable and efficient photocatalytic H₂O₂ production.

Han et al. report a highly conductive composite electrode with low equivalent sheet resistance of 1.5 Ω sq-1. A self-masking method is developed to prevent shunting caused by uneven grid surfaces, enabling flexible organic solar cells with efficiencies of 15.20% (4 cm² devices) and 14.24% (16 cm² devices).

The flammability of the Li electrode impedes its safe application in a battery. Here, the authors develop a layered Li electrode design to eliminate corrosion between Li metal and fire retardant, and smart release fire retardant against Li combustion during heating conditions, enabling a safe Li metal battery.

Neutrophils are known to be important in COPD pathogenesis and calcium signaling is involved in this process. Here the authors examine the function of Na⁺Ca²⁺ exchanger 1 (NCX1) in neutrophil function in mouse models of chronic cigarette smoke exposure and show that inhibition of NCX1 reduces neutrophil accumulation in the lungs and formation of neutrophil extracellular traps (NETs).

High cost and aggregation of single-component fullerenes hinder inverted perovskite solar cell development. The authors synthesize a fullerene composite in high yield that cross-links during annealing, improving stability and efficiency while maintaining performance in various device formats.

Researchers report a metal-organic framework with “gate-channel-cavity” for the energy-efficient separation of propylene. By combining sieving gates with a large diffusion channel, the material achieves record-fast diffusion and high capacity for industrial use.