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Magnetic toroidal invariance generates transverse electromagnetic effects in materials with broken symmetries. Now a distinct magnetic response is shown to emerge in ferro-rotational systems in which both inversion and time-reversal symmetries are preserved.

In single-particle cryo-EM, datasets often contain molecules that exist in a heterogeneous mix of states. Here, the authors compare different computational tools to study this heterogeneity and derive metrics to quantitatively compare their results.

Using single broadband X-ray pulses from a free-electron laser on a gaseous neon target, coherent, nonlinear four-photon interactions with core–shell electrons is demonstrated, representing a strategy for multidimensional correlation spectroscopy at the atomic scale.

Quantifying ecosystem dynamics is critical in the face of rapid environmental change. This study uses airborne eDNA to quantify changes in organism abundances across the tree of life and reveal a regional decline in biodiversity over three decades.

Picks include a quantum pioneer, a co-discoverer of Ebola and a bioethicist-turned-activist.

Manipulating the chemical composition of proteins and peptides has been central to the development of polypeptide-based therapeutics and to help address fundamental biological questions. This Review describes how nature-inspired protein ligation strategies have been repurposed as chemical biology tools.

Using circularly polarized inelastic X-ray scattering, the authors map spin-wave (magnon) excitations in the altermagnet CrSb and detect a reversible chiral signal for the first time, establishing a practical method to probe altermagnetic magnons.

Direct measurement of edge transport in the quantum anomalous Hall effect can be made difficult due to the presence of parallel conductive paths. Here, Mahoney et al. report features associated with chiral edge plasmons, a signature of robust edge states, by probing the zero-field microwave response of a magnetised disk of Cr-(Bi,Sb)₂Te₃.

Exercise has considerable health benefit, including modulation of the immune system. Here the authors compare the molecular make-up of peripheral blood immune cells at resting state and upon a single bout of two different aerobic exercise modes by proteomics and show that although both exercise modes trigger similar changes, the effect is more pronounced after high intensity interval training.

This study reports highly selective Li⁺Mg²⁺ separation via concentration gradient-driven transport using negatively charged membranes with high charge content. The separation mechanism involves selective partitioning of Li⁺ ions into the membrane and uphill transport of Mg²⁺ ions. Bench-scale diffusion dialysis experiments with model brine solutions demonstrate effective monovalent/divalent ion separation.

Sivanandan, Leitmann, and colleagues present the CellPaint-POSH platform, which combines pooled CRISPR screening with Cell Painting. Using self-supervised deep learning on cell images, the method enables discovery of gene function and biological networks.

In this multicenter phase 1 trial of patients with advanced solid tumors resistant to anti-PD-1 therapy, treatment with the anti-latent TGFβ1 antibody linavonkibart with or without pembrolizumab was safe, and encouraging clinical response rates were associated with T cell infiltration and immune activation.

New hominin fossils from the Grotte à Hominidés at Thomas Quarry I (ThI-GH) in Casablanca, Morocco, dated to around 773 thousand years ago are similar in age to Homo antecessor, yet are morphologically distinct.

NbN/AlN/NbN qubits prepared by atomic layer deposition allow for precise control of the tunnelling barrier and stable operation beyond the temperature limit of aluminium-based devices.

Chronic stress disrupts the brain vasculature and contributes to mood disorders, but mechanisms of resilience remain unclear. Here, the authors show that enriched environments increase astrocytic Fgf2 to prevent stress-induced vascular alterations and depressive behavior with relevance to human depression.

Here, the authors present archaeology of the Namorotukunan site in Kenya’s Turkana Basin that demonstrates adaptive shifts in hominin tool-making behaviour spanning 300,000 years and increasing environmental variability. They contextualize these findings with paleoenvironmental proxies, dating, and geological descriptions.

Achieving nonlinear optical response of free-space planar solid devices in the few-photon regime will provide several technological advances. Here, the authors demonstrate a self-hybridised perovskite metasurface with strong nonlinear absorption at record low incident powers, by means of cavity critical coupling engineering

Hepatocyte organoids derived directly from human tissue enable long-term hepatocyte expansion and can be combined with portal mesenchyme and cholangiocyte organoids to form a donor-specific periportal liver assembloid system.

Reported detections of gases in exoplanet atmospheres, including claims of biosignatures on K2-18 b, disappear when broader models are tested, revealing that such detections often reflect modelling limits rather than real signals.

Here, as part of the Sherlock-Lung study, the authors profile the microbiomes of 940 lung cancers in never smokers finding no significant associations with demographic and clinical features, suggesting lung bacteria are unlikely to have a sizable role in lung cancer.

A multi-institute, multi-platform initiative generates standard metrics and best practices for spatial transcriptomics analysis.

Synapse dysfunction contributes to cognitive decline with age. Here, the authors show that aging-related changes in microglia and the extracellular matrix are associated with synapse abundance, extracellular matrix buildup, and cognitive deficits in aging mice.

Tree longevity is thought to increase in harsh environments, but global evidence of drivers is lacking. Here, the authors find two different pathways for tree longevity: slow growth in resource limited environments and increasing tree stature and/or slow growth in competitive environments.

Here authors identify GluN2D-containing NMDA receptors on interneurons as a specific target for rapid antidepressant action. Blocking GluN2D restores stress-impaired plasticity and mimics the effects of ketamine with fewer side effects.

The study finds coherent spin waves, generated by ultrafast laser pulses, drive antiferromagnetic domain walls (DWs) in Sr₂Cu₃O₄Cl₂ at a record  ~50 km/s. DW propagation direction is controllable via laser helicity and DW winding number, explained by in-plane magnon mode-induced dynamics unique to easy-plane anisotropy magnets.

China’s crowded coasts must balance seafood demand with conserving migratory shorebirds that rely on tidal flats along the East Asian–Australasian Flyway. This study suggests that well-managed mariculture feeds shorebirds and limits overharvest, benefiting seafood production and biodiversity.

ADGRL4 is a cancer-implicated adhesion GPCR whose ability to couple to G proteins had been unclear. Here, authors show that ADGRL4 weakly engages Gq and determine its 3.1 Å active-state structure, revealing its mechanism of activation.

Data collected from zoos and aquariums worldwide show that hormonal contraception or permanent surgical sterilization in mammals increase life expectancy, with different mechanisms in males and females.

VRACs are ubiquitously expressed osmosensitive ion channels assembled from LRRC8A-E subunits. Here, the authors determine the structures of a LRRC8A:D VRAC using cryo-EM and identified that these channels are gated by lipids inside the channel pore.

Drawing on the largest dataset of its kind, this Article shows that, rather than improving performance, serial dependence makes perceptual decisions more uncertain. These results challenge the prevailing view and call for a rethinking of the role of serial dependence in human behaviour.

A greater diversity of crops at the national level increases the temporal stability of total national harvest, reflecting markedly lower frequencies of years with sharp harvest losses.

Combining high-resolution mapping of foliar and herbivore faecal sodium concentrations across Africa, the authors show that plant-derived sodium availability constrains megaherbivore densities at a continental scale.

Mapping of the neutrophil compartment using single-cell transcriptional data from multiple physiological and patological states reveals its organizational architecture and how cell state dynamics and trajectories vary during health, inflammation and cancer.

Methods for the systematic synthesis and evaluation of large numbers of transition metal complexes at a time are still limited. Here, the authors report a high-throughput method to create and test hundreds of metal complexes, revealing potent new metalloantibiotics and a highly active iridium catalyst.

This study demonstrates that 16p11.2 hemideletion, a genetic deletion linked to neurodevelopmental disorders, affects male and female mice differently, altering specific striatal neuronal circuits and driving sex-specific behavioral changes.

Multidrug efflux pumps help bacteria survive stress and promote antibiotic resistance. Here, authors define the molecular detail of an anaerobic-connected pump MdtF uncovering acid-responsive activity which may enable toxin control in certain niches.

There is a trade-off between achieving fast qubit control and preserving long qubit lifetimes. In this work, the authors demonstrate single qubit gates by driving a transmon qubit parametrically at 1/3 of its frequency, creating fast, high-fidelity gates while protecting the qubit lifetime and mitigating heating.

Increased ocean acidification could accelerate the decay of underwater historical stone materials, posing a threat to cultural heritage, according to combined field and laboratory experimentation on stone samples.

Differential isoform usage is identified with high statistical power from spatial transcriptomics data.

By performing a CAR-adapted base-editing screen of phosphatidylinositol-3-kinase delta (PI3Kδ, PIK3CD), Bucher et al. identify mutations affecting endogenous PI3K–AKT signaling that enhances CAR T cell antitumor potency.

This study associates p53 loss and brain metastasis in breast cancer. Mechanistically, p53-null tumors recruit astrocytes that provide substrates for enhanced fatty acid synthesis via upregulated SCD1 expression, representing a targetable axis in the disease.

An interferometer design allows systematic investigation of the anyonic statistics of bulk fractional quantum Hall states.

Water-vapor interfaces have been studied with many techniques, yet open questions persist about their electronic and molecular structure. Here, the authors demonstrate the application of soft x-ray second harmonic generation to study the water surface by leveraging attosecond pulses at the LCLS and a flat liquid sheet microjet, providing insights on the H-bond structure.