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The authors report that Ta-doped PbTiO₃ films with a p-i-n structure can generate a high photovoltaic current, offering the opportunity to advanced optoelectronic and imaging devices.

This work develops DJX-A-KM, a small-molecule KRASG12C degrader that recruits E3 ligase FBXO28 via dual covalent binding, inducing potent degradation. This strategy can possibly be extended to pan-KRAS degraders against a broader spectrum of KRAS mutations.

Elevated exposure to 4-hydroxyphenanthrene (4-OHPhe) is positively associated with obesity risk. Here, the authors show that exposure to 4-OHPhe downregulates expression of hydroxylamine reductase genes in Bacteroides uniformis, leading to altered gut microbiota-bile acid-FXR axis and suppression of adipose thermogenesis.

Zanubrutinib is a second-generation BTK inhibitor, reported to have fewer off-target toxicities while maintaining comparable efficacy to previous BTK inhibitors. Here, the authors report the phase II CHESS trial evaluating frontline Zanubrutinib (second-generation BTK inhibitor) plus rituximab (anti-CD20) induction, followed by chemoimmunotherapy in patients with mantle cell lymphoma.

Maternal obesity is known to cause systemic lipid dysregulation, yet its effect on lipid reprogramming during the maternal-to-zygotic transition (MZT) remains unknown. Here, they show that obesity disrupts very-long-chain fatty acids (VLCFAs) storage in oocytes, impairing peroxisomal protein import in 2-cell embryos.

Cancer stem cells contribute to cancer evasion and relapse by suppressing the immune response. Here, the authors identify sterol O-acyltransferase 1 (SOAT1) as a cancer stem cell immune checkpoint and propose that SOAT1 inhibition results in oxysterol-mediated reprogramming of intratumoral regulatory T cells via a trans-cellular 20SOHC-GPR132, ultimately enhancing anti-tumor immunity in various preclinical mouse models.

Here, the authors report the fabrication of broadband flexible photodetectors based on composite graphene-copper phthalocyanine heterojunctions, showing that a moderate external pressure can enhance the performance of the devices. The detectors were also applied for simultaneous contact sensing and non-contact perception as electronic skin sensors.

Treatment failure exists in Induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) patients. Here this group reports a phase 2 randomized trial evaluating the efficacy and safety of adding nimotuzumab, to CCRT on 246 patients with untreated, non-keratinising, stage II–IVA LA-NPC.

Protein engineering is often hindered by the gap between modelling and experiment. Here, authors present ORI, a closed-loop computational framework to iteratively optimize proteins, achieving 100-fold higher activity, enhanced thermal stability, and the design of multifunctional enzymes.

Photocured materials with room temperature phosphorescence are potentially useful but can be challenging to prepare. Here, the authors report the development of such materials by use of naphthalimide as both a chromophore and photoinitiator.

Han et al. report a highly conductive composite electrode with low equivalent sheet resistance of 1.5 Ω sq-1. A self-masking method is developed to prevent shunting caused by uneven grid surfaces, enabling flexible organic solar cells with efficiencies of 15.20% (4 cm² devices) and 14.24% (16 cm² devices).

The flammability of the Li electrode impedes its safe application in a battery. Here, the authors develop a layered Li electrode design to eliminate corrosion between Li metal and fire retardant, and smart release fire retardant against Li combustion during heating conditions, enabling a safe Li metal battery.

The authors identify Npr1 as a nucleophagy receptor in fission yeast that acts redundantly with Epr1 to degrade nuclear components. Tethering chromatin to the inner nuclear membrane blocks nucleophagy, suggesting a genome protection mechanism.

The authors reveal intrinsic long-range-order noncollinear electric dipole order in the van der Waals crystal WO₂Br₂, enabling pressure-driven 90° polarization rotation via multiple transition pathways and distinctive ultrafast phonon dynamics.

In C. elegans, a p38 MAPK–ATF-7 pathway upregulates hypodermal CATP-3 during potassium scarcity, integrating neuronal signals to maintain homeostasis, enhance survival, and link potassium regulation to lifespan and immunity. This conserved mechanism is distinct from osmotic stress responses.

Template-directed covalent polymerization that proceeds without sacrificing non-covalent order of the precursor during alignment remains a formidable challenge. Here the authors report a supramolecular-templating strategy for photopolymerization of triphenylamine-based diyne assemblies.

The mid-infrared (MIR) range of the electromagnetic spectrum can be indirectly accessed by frequency upconversion. Here, authors propose a phase-matching-free scheme for broadband and efficient upconversion, covering wavelengths from MIR to ultraviolet with high-order harmonics generated from a NbOI₂ crystal. MIR imaging is demonstrated with a standard silicon camera.

Photosystem I drives photosynthesis by harvesting light through antennas. Here, the authors resolve the cryoEM structure of the Euglena gracilis PSI– LHCI–LHCII supercomplex, revealing its antenna organization and pigment arrangement that support efficient energy transfer in a secondary plastid.

Biomass-derived hard carbon negative electrodes can cut cost, but properties vary by feedstock. Here, authors use data-driven intelligent carbonization to unify performance across diverse biomass, yielding high-capacity, long-life negative electrodes with lower footprints.

Efforts to generate H₂O₂ through mechanical activation are hampered by poor charge control and low efficiency. Herein, a tailored catalyst strengthens internal fields and speeds reactions, markedly improving production and pollutant cleanup.

This study reveals that Amphotericin B activates glucocerebrosidase to remodel late endosomal lipid and protein composition, promoting respiratory viral entry. This highlights a risk of secondary viral infections during antifungal therapy.

A dual-symmetry-guided strategy is used to assemble a broad class of complex Archimedean lattices and two-dimensional quasicrystalline structures, providing a general and experimentally accessible route to complex-symmetry materials.

Drug discovery often lacks complete multimodal molecular data. Here, the authors introduce M2UMol, a framework that transfers multimodal knowledge into 2D structures, enabling accurate predictions with missing modalities across diverse tasks.

In a prospective multi-centre cohort in China, people living in areas of high soil selenium had a 35% increased risk of incident diabetes over a 3-year study period, with a stronger effect seen for men.

You, Hu et al. discover a population of COTL1^high NK cells regulated by GITRL⁺ macrophages and demonstrate their functional importance in mediating anti-tumour immunity in cancer with impaired tumour-specific MHC-I expression.

Imaging genetics links genetic variations to brain structures and functions, however the computational challenges posed by high-dimensional imaging and genetic data are significant. Here, the authors develop a scalable genome-wide association analysis framework for imaging data.

Reconfigurable chip-to-free-space interfaces based on thin-film lithium niobate microrings generate on-demand nonlinear structured light, including tunable optical vortices, optical skyrmions and spatiotemporal vortex pulses.

The Taiwan Precision Medicine Initiative recruited and genotyped more than half a million Taiwanese participants, almost all of Han Chinese ancestry, and performed comprehensive genomic analyses and developed polygenic risk score prediction models for numerous health conditions.

The Taiwan Precision Medicine Initiative (TPMI) has built a cohort of more than half a million individuals with Han Chinese ancestry, providing a rich resource of genetic and medical data for this group.

The flow of water between rivers and floodplains—surface water connectivity—showed a net global increase from 1984 to 2019 driven by climate and anthropogenic changes and shaping sediment transport, according to a study of satellite observations.

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

Here the authors reveal a study of 486,956 Han Chinese individuals showing that most people with genetic variants affecting drug response do not have the predicted adverse events, highlighting the challenges of implementing pharmacogenetics in clinical practice.

mRNA vaccines hold promise as cancer therapeutics. However, production complexity and prohibitive manufacturing costs limit the applicability of these vaccine platforms. Here, the authors present an engineered linear Cap-independent mRNA vaccine design that achieves stable in vivo expression and elicits robust anti-tumor immune responses in preclinical mouse models.

Li, Li, Yang and Huang et al. show that ultraviolet-induced ribotoxic stress activates ZAK signaling to phosphorylate the Integrator subunit INTS12, thus promoting Integrator recruitment to CSB-bound, stalled RNA polymerase II (Pol II) and facilitating Pol II removal during efficient transcription-coupled nucleotide excision repair.

Researchers identify FOXJ3 variants in focal epilepsy and cortical dysplasia and show that FOXJ3 regulates neuronal migration and cortical layer formation by controlling the PTEN–mTOR pathway; disruption of this process leads to abnormal brain development.

Fracto-mechanoluminescence is the emission of light from fracturing solids. Here, the authors show that this emission in Mn halides arises from elastic stiffness, electromechanical coupling, and trap states that activate Mn²⁺ d−d transitions.

This work identifies ERECTA–EPFL genes as major regulators of maize meristem activity and the development of maize shoots and ears. The findings highlight genetic targets that influence kernel row number and plant architecture to increase maize yield.

CRISPR-based diagnostics are often limited by complex workflows and poor validation. Here the authors develop and validate a one-pot asymmetric CRISPR assay, which permits rapid and sensitive diagnosis of tuberculosis in a format which is suitable for resource-limited settings.