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Understanding microwave emission from resonating spin spirals is key for on-chip magnonics. Now, real-time spin precession modes with distinct microwave patterns are captured in a helimagnet/ferromagnet heterostructure.

Temporal metamaterials enable wave control through timevarying properties, but achieving broadband antireflection remains challenging. Here, the authors experimentally realize a “temporal taper” metamaterial that provides near-full-band antireflection, eliminating the need for spatial matching components and enabling agile impedance matching.

NiPS3 is a van der Waals antiferromagnet with a rich optical response including an exciton of very narrow linewidth, the origin of which is still a topic of active discussion. Herein, Song, Lv and coauthors study the response of the Zhang-Rice exciton to applied magnetic fields.

Fibers derived from non-silk proteins hold potential for various biomedical applications, but mechanically-balanced and highly-biocompatible regenerated protein fibers are elusive. Here, the authors report an entanglement-reinforced strategy to fabricate keratin/albumin bio-fibers that show high strength and toughness, along with favorable biocompatibility, degradability and immunocompatibility.

MnBi₂Te₄ has an appealing combination of topological bands and magnetic ordering. While chemical doping with Sb can be used to tune these properties, it typically comes with an increase in defect density. Here, Chen, Wang, Li, Duan, and coauthors demonstrate a defect engineering approach that preserves the topological and magnetic properties of Mn(Bi_1-xSb_x)₂Te₄.

Photonic time crystals provide a time equivalent to standard spatial crystals. Here, authors observe wave amplification induced by the time modulation and provide experimental proof of a nontrivial temporal topology in the middle of a momentum bandgap.

Z-DNA forms at highly active genes, but its function is unclear. Here, the authors show that MYC recruits FACT to promote Z-DNA formation within nucleosomes, enabling RNA Polymerase II loading and enhancing transcription, revealing a mechanistic role for Z-DNA in MYC-driven regulation.

Simultaneously capturing polarization and frequency is challenging. This work develops a metasurface-based intelligent photodetector, which can detect arbitrary polarization and frequency within 0.3-1.1 THz with a total error smaller than 5.1%.

The authors show that bichromatic moiré superlattices formed by two mismatched moiré patterns in van der Waals semiconductor heterotrilayers stabilize quadrupolar moiré trions and enable electric-field tuning of excitonic and electronic ground states.

Ferroptotic propagation aggravates kidney ischemia-reperfusion injury and causes delayed graft function. Here, the authors show that inhibiting lactate shuttle and AARS1-mediated NPM1 lactylation protects graft function by blocking ferroptotic waves.

Type 2 diabetes is an established risk factor for dementia. Here, the authors use data from 33,136 older Chinese adults to show that polygenic risk for type 2 diabetes was associated with vascular dementia but not Alzheimer’s disease.

Foundation models trained on DNA sequences have the potential to transform genomics, but systematic evaluations are scarce. Here, the authors benchmark five DNA foundation models across diverse genomic tasks, revealing key factors influencing their performance and practical application.

Batch effects in MS-based proteomics pose important challenges in protein quantification, and the optimal stage for batch-effect correction remains elusive and crucial. Here, the authors, through benchmarking using reference standards and simulated data, demonstrate that protein-level batch correction is most robust in MS-based proteomics.

Excitation-dependent multicolour emission is desirable, but hard to obtain. Here, the authors report the development of a molecular symmetry breaking strategy to all excitation-dependent multicolour emissions from one chemical entity.

While the ligand coordination microenvironment surrounding catalytic centres influences reactivity, dynamic oxygen reconstruction during water oxidation electrocatalysis complicates structure-based mechanistic insights. Now the in situ formation of lattice O–O ligands has been shown to activate Fe centres in metal oxides and hydroxides, thereby enhancing their oxygen evolution reaction activity.

Boron-stereogenic and C–B axially chiral compounds featuring boron-based chirality represent a rarely explored class of chiral scaffolds. Here, the authors report an asymmetric access to boron-stereogenic and C–B axially chiral (hetero)cycles via rhodium-catalyzed C–H activation of (hetero)arenes en route to [4 + 2] or [3 + 2] annulation with two classes of boron-functionalized alkynes.

The authors propose a stepwise dual-site entropy increase strategy to simultaneously modulate relaxor behavior and enhance the breakdown strength of Bi0.5Na0.5TiO3-based capacitors.

The pilot phase of PigGTEx, re-analyzing 5,457 published RNA-seq samples, presents a pan-tissue catalog of molecular quantitative trait loci. Cross-species comparisons identify traits with shared genetic regulation in humans.

Heavy noise and missing wedge effect hamper the efficient visualization and analysis in cryo-ET. Here, authors present a deep learning-based method for directly visualizing and revealing the dynamic states of target molecules.

Here, the authors evaluate the neutralization susceptibilities of BA.2.86 and JN.1 and determine the structural basis for binding to the ACE2 receptor and monoclonal neutralizing antibodies, revealing their evolution and antibody evasion mechanism.

Here the authors show that σ^I factors encompass a unique, hitherto-unknown recognition mode of bacterial transcriptional promoters and represent a new distinctive class of σ⁷⁰-family σ factors for bacterial transcription.

Manipulating the internal interactions within biological fibers to tune macroscopic properties is important but challenging, and can limit applications. Here, the authors report the use of dynamic imine chemistry for engineering molecular interactions and forming strong and tough protein fibers.

Treating myocardial reperfusion injury via nanotherapy is challenging due to clearance by the mononuclear phagocyte system. Here, the authors target the spleen to reduce acute heart injury and improve long-term cardiac function via transient IRF7 inhibition.

By mimicking antigen processing and presentation during the rejection of xenotransplanted tissue, xenogeneic cell membrane-derived vesicles encapsulating peptide antigens or mRNA-encoded antigens function as vaccines targeted to dendritic cells.

In this work, the authors report the full-length structure of the attachment glycoprotein from Langya Henipavirus, which could enhance the understanding of emerging Henipavirus and provide important clues for vaccine development in the future.

The crystal structure of the full-length human glucagon receptor reveals the essential role of the 12-residue ‘stalk’ segment and an extracellular loop in the regulation of ligand binding and receptor activation.

Venous thromboembolism is a serious condition influenced by genetics, but current protein-based analyses often miss complex patterns. Here, the authors show that a new non-linear analysis method reveals 43 associated proteins, including eight missed by traditional models, offering deeper insight into disease mechanisms.

Cryoprotectants are needed for the storage of lipid nanoparticles (LNPs). Here, the authors report on a study which shows that freezing can be harnessed to reformulate LNPs in a way that both preserves their integrity and boosts mRNA delivery after sub-zero storage by increasing endosomal escape.

Bi₂O₂Se is a promising 2D semiconductor with high electron mobility and native high-k dielectric layers, but its p-type doping remains challenging. Here, the authors report a low-temperature substitutional doping method to fabricate 2D Bi₂O₂Se p-n junctions and p-type transistors

The authors develop overtone photothermal microscopy that leverages a pump-probe detection of second overtone vibrations within the shortwave-infrared (SWIR) window. This technique complements existing large-scale SWIR imaging approaches, offering enhanced resolution and sensitivity for bioimaging applications.

The presence of breast cancer stem cells is associated with therapy resistance in patients with triple-negative breast cancer (TNBC). Here, the authors identify KK-LC-1-mediated YAP signaling as a driver of TNBC stemness and develop a therapeutic molecule to target this axis in preclinical models of TNBC.

The good adhesion of scales is crucial for safe service of alloys. This study reveals that trace sulfur impurities can cause severe interface segregation and premature cracking, and such a detrimental effect can be prevented by micro alloying.

Stimulated Raman scattering (SRS) microscopy enables label-free chemical imaging at high speed, but has been limited by low sensitivity. Here, the authors demonstrate plasmon-enhanced SRS microscopy and achieve single molecule detection sensitivity.

Weak interaction of light with matter makes its tunable control notoriously challenging, resulting in bulky and inefficient devices. Now, a study demonstrates that van der Waals antiferromagnets featuring strong spin-charge induced anisotropy could offer excellent control of light polarization selectivity.