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This study identifies shared and distinct brain patterns underlying reappraisal and acceptance, showing how emotion regulation operates in dynamic naturalistic contexts and highlighting potential clinical markers.

Bacteria employ diverse nucleases to defend against viruses. Here, authors characterize Upx, a single-protein, dual-nuclease system, and reveal that a specific phage protein relieves auto-inhibition to activate its antiviral function.

Florets of indica rice open earlier than japonica rice, hindering utilization of the cross subspecies heterosis. Here, the authors show that an OsMYB8-OsJAR1 module regulates diurnal floret opening time divergences between the two subspecies.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

Combining metabolic theory with global datasets, Li et al. show that root water content is a stronger predictor of root growth traits than the widely considered root nitrogen, better reflecting fast acquisition strategies and leaf–root alignment.

Maternal mRNA regulation in growing oocytes is poorly understood. Here, the authors identify hnRNPM as a key splicing regulator during oogenesis. Its deletion causes severe cytoplasmic defects, meiotic arrest, and female infertility.

Quantum light sources are promising for quantum circuits, yet facing an inherent trade-off between multifunction and brightness. By leveraging a strategy based on parity-time symmetry, we demonstrate an on-chip quantum light source with programmable lifetime, achieving a 20-fold tuning range of lifetime and balanced photon-pairs generation rate.

Eggplant is a globally widely cultivated vegetable. Here, the authors report the construction of pangenome based on 11 new and six existing chromosome-scale genomes assemblies, perform population genomic analyses of 226 accessions, and reveal structural variations associated with fruit color and bacterial wilt resistance.

Artificial intelligence is transforming materials research, yet its potential for sustainability remains underexploited. Artificial intelligence can enable circular materials systems by integrating materials performance, life-cycle assessment and sustainability metrics across design, use and recycling, accelerating the transition from linear innovation to closed-loop materials economies.

The authors report the synthesis and characterization of samarium-based superconducting infinite layer nickelate thin films, along with co-doped variants incorporating europium and calcium. The co doped compounds achieve a record-small c-axis parameter and display superconducting transition temperatures up to 32.5 K.

In this study, long-read RNA sequencing achieves accurate single-nucleotide polymorphism calling, haplotype phasing and allele-specific expression analysis.

LINE-1 retrotransposons are implicated in aging, but their role in cardiac aging specifically is not well understood. Here the authors show that LINE-1 expression rises in mouse hearts with age. Genetic LINE-1 derepression is accompanied by cGAS–STING activation and cardiac dysfunction, while pharmacological inhibition of LINE-1 or STING improves cardiac function in aged mice.

The existence of a long-lived, prethermal regime in many-body systems with tunable heating rates, driven by structured random protocols, is observed using a 78-qubit superconducting quantum processor.

It remains unclear whether and how endometrial dysfunction leads to infertility in polycystic ovary syndrome (PCOS), independent of the ovary. Here, the authors show that elevated ERα and histone lactylation impair endometrial receptivity in PCOS and serve as potential therapeutic targets.

This study reveals how Tau pathology in spinal neurons contributes to early tactile deficits in Alzheimer’s disease, linking sensory dysfunction to cognitive decline. It highlights potential peripheral biomarkers and new therapeutic targets beyond the brain.

A device for rectifying supercurrents at liquid-nitrogen temperature with high efficiency is demonstrated. This is a practical step towards implementing dissipationless electronics.

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

Electrocatalytic co-reduction of CO₂ and nitrate to synthesize urea is a sustainable and promising option to the alternative conventional Bosch-Meiser. Here, the authors report a CeO_x-integrated diatomic electrocatalyst overcomes the traditional trade-off between urea yield and Faradaic efficiency.

Coherence is widely seen as essential for quantum source quality. Here, authors demonstrate on-chip photon states with increased brightness and purity using incoherent light. It reveals the mechanism of pump coherence and lowers the barrier for the generation of high-quality quantum states.

This work describes FX-Cell and its derivatives to achieve single-cell RNA sequencing from challenging and cryopreserved plant tissues, expanding the scope of single-cell genomics across field-grown samples.

Periodic marine oxygen oscillations occurred throughout the middle Ediacaran Gaskiers Glaciation, probably stemming from increased organic carbon burial destabilizing ocean redox systems, according to geochemical constraints and modelling.

Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

Molecular recognition is an important biological process where guest and host molecules interact through non-covalent bonding. Yeet al. show that this can be sensed by the dielectric and ferroelectric signals of the final complexes in a series of metal-coordination compounds with different diol molecules.

Large-effect variants in autism remain elusive. Here, the authors use long-read sequencing to assemble phased genomes for 189 individuals, identifying pathogenic variants in TBL1XR1, MECP2, and SYNGAP1, plus nine candidate structural variants missed by short-read methods.

An intratumoural vaccination chimera reprograms tumour cells into an antigen-presenting state with restored anti-tumour immunity.

MuSCs are vital for muscle renewal with unclear regulatory mechanisms. Here, the authors show that cytosolic TBC1D1 inhibits nuclear entry of the AS160-STAT3 complex and regulates MuSC proliferation. Deficiency of TBC1D1 improves muscle regeneration.

Transformations in organic chemistry are mainly limited to the incorporation of only one equivalent of the greenhouse gas CO₂ per substrate. Now, a visible-light photoredox-catalysed dicarboxylation of alkenes, allenes and arenes allows the incorporation of two CO₂ molecules into organic compounds.

The sluggish hydrogen oxidation reaction hinders the development of anion exchange membrane fuel cells. Here, the authors develop high-curvature RuIr CNCs that induce an O-down water orientation, thereby strengthening hydrogen-bond networks and reducing proton transfer barriers.

Some pathogens manipulate host ferroptosis, a type of programmed cell death, for pathogenesis. Here, the authors show that Pseudomonas aeruginosa uses a quorum sensing metabolite to induce ferroptosis in macrophages through a methylation pathway.

Soil viruses may impact soil carbon cycle. Here, the authors use metagenomic analysis of contaminated soil and 13 C labeled microcosm incubation to show that the DNA viral community enhances microbial carbon fixation capacity via auxiliary metabolic genes.

INSM1 is a key regulator of neuroendocrine differentiation and a biomarker for tumorigenesis. Here, the authors reveal the dynamic conformations of its five zinc fingers and show how INSM1 cooperates with TEAD1 and CTCF to regulate transcription by targeting specific genomic loci.

Quantum memory — with its unique ability to generate, preserve, and perform nontrivial operations on quantum states — provides powerful quantum-enhanced capabilities and is a promising platform for in-memory computing.

Electronic wound bandages have to balance conformability and wound healing properties. Here, the authors develop a smart patch (iSAFE) using biomaterials with bioelectronics to facilitate permeability with waterproofing. This achieves intelligent wound management with real-time wound monitoring and active therapy.

In this study, authors conduct a genomic analysis of 15,000 Acinetobacter baumannii isolates, revealing a dominant multidrug-resistant super-lineage (accounting for approximately 70% global isolates), with Clade 2.5.6 emerging in East Asia in 2006.

Solar-driven production of H₂O₂ and chemicals from O₂ and biomass is promising but hindered by inefficient photocatalysts. Here, the authors report composite photocatalysts of atomically dispersed Ta sites for broad-spectrum light absorption and selective biomass conversion in a three-phase system.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Cyclotelomerization of isoprene can lead to many isomers and controlling the selectivity in this reaction has been challenging for chemical methods. Now, Ni-catalysed nucleophilic cyclotelomerization of isoprene with heterocycles provides cyclic monoterpene derivatives with high selectivity.

Signet-ring cell carcinoma (SRCC) is a unique type of gastric cancer with no prognostic features. Here, the authors report a CLDN18-ARHGAP26/6 gene fusion in patients with a high signet-ring cell content, poor survival outcomes, and who experience no benefit from platinum/fluoropyrimidines-based chemotherapy.