Search

The CMS experiment at CERN reports one of the highest-precision measurements of the W boson mass, finding it in line with standard model predictions and at odds with recent anomalous measurements.

The authors simulate phytoplankton macromolecular composition—proteins, carbohydrates and lipids—under present and future scenarios. They show increased protein allocation in subtropical phytoplankton but declines in high-latitude populations under warming, with implications for marine food webs.

Psychedelics have therapeutic potential, yet their underlying mechanisms remain unclear. Here, authors show that psilocin increased PVT and PVT◄CeA activity in female rats, revealing sexspecific effects on thalamo-limbic circuitry and behavior.

Allogeneic CAR T cells carry a higher risk of immune rejection, which may limit persistence and therapeutic efficacy. The authors here show that co-expression of an anti-rejection CD70 CAR with a CD19 CAR enhances persistence and activity in preclinical models of cancer and autoimmune disease.

Not all deer are equally susceptible to SARS-CoV-2. Authors show that spike mutations reshape ACE2 compatibility across cervids, providing a structural basis for variant-dependent differences in spillover potential.

Kancharla, Kelly et al. identify an acridone antimalarial potent across all major parasite life stages. Lead candidate T111 shows oral efficacy, low toxicity, and synergy with tafenoquine, providing a unique mechanism to overcome resistance.

∆9-tetrahydrocannabinol induces anxiety at high doses, but the neural mechanisms remain unclear. Here, authors show that CB1 receptor–mediated inhibition of the ACC → DMS pathway drives anxiety-like behavior and THC aversion in mice.

Microplastic-oil co-contaminants are environmentally concerning, though conventional membranes are typically designed for single pollutant removals. Here the authors design a membrane using a sodium periodate-assisted co-deposition of caffeic acid and ε-polylysine method for the removal of complex mixtures from water.

MitoCatch is a cell-type-specific mitochondrion-targeting system that links mitochondria and the cell surface by protein binders and delivers mitochondria into the target cell.

The interplay between bulk oxygen diffusion and surface reactions in reducible metal oxides is key in heterogeneous catalysts, yet direct measurements of their coupling through transient kinetics and in situ spectroscopies have been lacking. Here, the authors uncover complex H₂-driven dynamics in ceria–zirconia using transient mass spectrometry along with in-situ Raman, near-ambient pressure X-ray photoelectron spectroscopy, machine learning potential-based molecular simulations, and multiscale kinetic modeling.

A dispersive sensing technique, termed the radiofrequency electron cascade, can perform singlet-triplet readout of two exchange-coupled electron spins in a natural silicon planar metal–oxide–semiconductor quantum-dot array.

Neutrophil accumulation in the ischemic heart occurs rapidly after myocardial infarction, but their early origin has been unclear. Here, the authors show that β2-adrenergic signaling drives stress-induced demargination of vascular neutrophils, supplying the first wave of early post-MI neutrophils.

Kraus et al. report correlative real- and reciprocal-space analysis using 3D electron diffraction in a single transmission electron microscope. The technique reveals molecular texture, mosaicity, and the direct correlation between molecular packing and nanomorphology in archetypal organic blend films.

Salladay-Perez and colleagues explore senescence induction in human and mouse macrophages using multiomic profiling. They characterize a p21⁺TREM2⁺ senescent macrophage population, which they functionally implicate in inflammaging and liver disease.

How the brain supports speaking and listening during conversation of its natural form remains poorly understood. Here, by combining intracranial EEG recordings with Natural Language Processing, the authors show broadly distributed frontotemporal neural signals that encode context-dependent linguistic information during both speaking and listening..

Here, structural analysis by cryoFIB-SEM and cryoET of virus-induced cell remodeling shows how phage SPP1 takes over the bacterial cytoplasmic space to confine stepwise assembly of virions starting from procapsid formation at the cellular membrane.

Glaucoma is a common cause of vision loss. Here the authors show that elevated intraocular pressure disrupts the blood retinal barrier (BRB) and contributes to retinal ganglion cell death in mouse glaucoma models, and detect similar BRB disruption in human glaucoma donor eyes.

In-situ high-speed synchrotron X-ray imaging quantifies bubble explosion dynamics during electron beam melting, observing process sensitive melt pool instabilities and defect formation.

Developing efficient battery electrolytes is a slow and complex challenge. Here, authors create a deep active learning framework that rapidly identifies high-performance materials and transfers knowledge to new designs, tripling battery lifespan while requiring significantly fewer experiments.

A new method for performing genome-wide fine-mapping with functional annotations outperforms current methods across several metrics, including error control, mapping power, resolution, precision, replication rate and cross-ancestry phenotype prediction.

Assessment of how 16 taxonomic groups in a lowland tropical forest resist and recover from anthropogenic disturbance shows the potential of protecting naturally regenerating secondary forests to reverse biodiversity losses.

In a phase 1b trial, patients with treatment-naive metastatic pancreatic adenocarcinoma received the CD73 inhibitor quemliclustat plus gemcitabine and nabpaclitaxel with or without the anti-PD1 antibody zimberelimab, showing encouraging clinical response rates and survival in quemliclustat-treated patients.

AlphaFold’s success in protein structure predictions has led to similar attempts to predict interactomes. Here, the authors demonstrate that AI-based screens are very limited in discovering truly novel interactions compared to experimental screens, exposing open challenges in interaction prediction.

Emerging multidrug-resistant Neisseria gonorrhoeae is a global health threat in the treatment of gonorrhoea. This study reports the discovery and characterization of a promising antigonorrhoea agent that addresses antibiotic resistance.

Transmission of Plasmodium falciparum relies on the development of gametocytes, which undergo extensive cellular remodelling. Here, the authors demonstrate that the PfGID E3 ubiquitin ligase complex affects gametocyte development by regulating key proteins, producing defective cells that cannot infect mosquitoes.

Aqueous two-phase systems have potential as biomimetic materials, but often lack stability and are prone to collapse. Here, the authors use interfacial assembly of chitin nanofibres and cellulose nanocrystals to prepare a biobased system with permeability and switchable motility.

This study demonstrates spin–refractive-index locking in a microwave metamaterial, enabling frequency-controlled chiral photon–magnon coupling. This mechanism offers a route toward directional and reconfigurable microwave signal routing.

Dissociative ionization of H₂ molecules by the combination of a phase-locked attosecond laser pair and a few-cycle NIR laser shows that ion–photoelectron entanglement influences electronic coherence in H₂⁺, allowing control over the degree of entanglement by varying the delay between the pulses.

The transcription factor ATF4 is shown to regulate double-stranded DNA repair within vulnerable CUX2⁺ upper-layer 2/3 cortical neurons, enabling their survival during development.

In this study, the authors present optimization and efficacy testing of apolipoprotein-based lipid nanoparticles for delivering various nucleic acid therapeutics in vivo to immune cells and their progenitors in the bone marrow.

CryoEM structures of mitochondrial complex I reveal ubiquinol-10 binding to the reduced enzyme. Together with molecular dynamics simulations, this study maps quinone binding poses and proton-transfer pathways linking redox chemistry to proton pumping.

Hybridized modes are realized through strong tripartite coupling between a three-dimensional microwave cavity, a granular-aluminium superconducting thin-film microwave resonator circuit and an antiferromagnetic crystal, with implications for sensing and for frequency conversion between the microwave and terahertz regimes.

The Shastry-Sutherland model consists of orthogonal dimers in a two dimensional plane, and has proved a rich basis for both theoretical and experimental investigation of quantum magnetism. Here, Brassington et al show that Yb2Be2SiO7 hosts an anisotropic variant of the Shastry Sutherland model.

Odd-parity spin-triplet superconductivity remains difficult to establish experimentally. Now, several distinct magnetic-field-tuned superconducting states—including a possible topological helical phase—have been identified in YbRh₂Si₂.

Frenster et al. utilize mosaic mouse gastruloids as a model of cell fitness and competition, identifying a temporal window between primed pluripotency and early gastrulation during which cell competition occurs in mammalian embryogenesis.

Biallelic inactivation of the VHL tumour suppressor gene is a hallmark of Clear cell renal cell carcinoma (ccRCC). Here the authors perform genome-wide CRISPR/Cas9 screening to identify that loss of Core Binding Factor β (CBF-β), a component of RUNX transcription factor complexes, is synthetically lethal in VHL-deficient ccRCC tumour models.

Virtual nature exposure reduces self-reported pain and is associated with decreased brain responses linked to somatosensory and nociceptive processing, providing new insights into the underlying mechanisms of nature-induced analgesia.

Drivers of fungal metabolic diversity are incompletely understood. Here, the authors conduct a global genomics study of over 1,000 pathogenic fungi to show that geography shapes the metabolic diversity in Aspergillus flavus revealing how climate drives fungal chemical adaptive evolution.

This long-term, large-scale intervention and follow-up MRI study suggests that sustained visceral fat loss, rather than weight loss, is linked to better cognition and attenuation of brain atrophy years later, mainly via improved glycaemic control.

High-latitude soils are future soil organic carbon loss hotspots, with losses dominated by particulate organic carbon (POC). The fraction of POC in total SOC (f_POC) is a key indicator, emphasizing the climate importance of preserving POC.

Single-cell transcriptome profiling has been reported for human thymi, but high-resolution spatial information is still lacking. Here the authors use Stereo-seq to report spatial transcriptomic and proteomic information from human fetal and pediatric thymi to provide a useful resource, and to define transcription factor networks regulating rare thymic cell types.

LHAASO has detected γ-ray emission with a spectrum extending to 2 PeV from the pulsar wind nebula (PWN) powered by PSR J1849-0001, indicating an extreme particle acceleration efficiency and challenging the current particle acceleration theories.

The impact of cooling through the Eocene-Oligocene transition on the marine biosphere is not well constrained. Here the authors construct a high-resolution record of foraminiferal species richness history spanning this transition that reveals differential diversity trends depending on foraminiferal habitat and life mode.

Longitudinal tracking of mice reveals that stable, specialized social roles emerge spontaneously within groups during a foraging task, with dopaminergic activity in the ventral tegmental area driving sex-divergent patterns of specialization.

Using artificial neural networks applied to human data, Eckstein et al. show that good models of reinforcement learning require memory components that track representations of the past.

Combining quantum error correction with gauge theory concepts from many-body physics enables the design of codes with improved resource requirements for fault-tolerant quantum computation.

In vivo regulation of neuronal lipid droplet formation mediates whole-body energy homeostasis in a sex-specific manner in Drosophila and mice.

Phosphorus locked in carbonate rocks from seven global sites shows simultaneous marine phosphorus spikes during major mass extinctions. Modelling ties high marine phosphorus to eutrophication, CO2 drawdown, and global cooling.

Divergent white matter metabolic patterns reveal a mechanistic basis for cognitive resilience and enhance prediction of future cognitive decline beyond established aging and dementia biomarkers.

Consortia of anaerobic methane-oxidizing archaea and sulphate-reducing bacteria can grow with minimal amounts of free energy. Here, Guo et al. show that these consortia can oxidize carbon monoxide, which may help their survival in the absence of methane.