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A pangenome of the Rosa subgenus constructed from genomes of 26 Rosa accessions, including 23 newly assembled, highlights widespread structural variations and key genes associated with ornamental traits for rose breeding.

This study identifies shared and distinct brain patterns underlying reappraisal and acceptance, showing how emotion regulation operates in dynamic naturalistic contexts and highlighting potential clinical markers.

Cobalt intercalated TaS2 has recently been found to host 3Q antiferromagnetic order. This 3Q state occurs coexists with a very large anomalous hall effect, and shows strong sensitivity to Cobalt concentration. Here, Luo and coauthors perform doping dependent angular resolved photoemission experiments on Co1/3TaS2, finding clearly fingerprints of 3Q magnetic order in the electronic band structure.

The crystal structure of the CHS-CHIL complex reveals a gating mechanism that enhances CHS activity and specificity. This conserved regulatory paradigm, validated by engineering a CHIL variant, offers strategies to improve flavonoid production in plants.

Cancer and cardiometabolic disease (CMD) multi-morbidity is a major health concern. Here, the authors report transition patterns as well as shared and distinct multiomics signatures in the developmental trajectories of CMD and cancer.

The catalytic enantioselective synthesis of sulfinimidate esters remains a formidable challenge in organic chemistry. Here the authors report an enantioselective oxidative esterification of sulfenamides to form sulfinimidate esters by using anionic stereogenic-at-Co(III) complexes as catalysts.

Euglenophytes evolved via secondary endosymbiosis, exemplifying plastid evolution. Here, the authors solve Euglena gracilis’ photosystem I structure, revealing specific protein organizations and structural features for far-red light absorption. This work informs the engineering of photosystem.

Anti-TSLP biologics have shown promise for the clinical treatment of type 2 respiratory disease. Here the authors present a clinical trial of CM326, a monoclonal antibody against TSLP, and show the clinical effects in patients with eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP), who present with type 2-dominant inflammation.

Femtosecond X-ray solution scattering reveals how solvent environments direct the outcome of ultrafast roaming reactions in bromoform, determining whether transient hot isomers undergo rapid solvolysis or rearrange into long-lived isomeric products.

Direct seawater electrolysis could enable hydrogen production using abundant seawater and offshore renewables, but its deployment is limited by the complex and variable composition and dynamic of seawater. This Perspective discusses scaling challenges through four key strategies: catalyst engineering, asymmetric electrolysis, aperture screening and phase-transition migration.

Generation of mature oocytes requires tight regulation of a discontinuous meiotic cell cycle. Here they show that the acetyltransferase Nat10 mediates modification of RNAs targeted for degradation and find that this process is essential for female oocyte meiosis and maturation.

How metabolic changes regulate human endoderm differentiation remains unclear. Here, the authors show that a TGFβ-driven metabolic switch reduces lactate production and enhances the TCA cycle, which controls ATP-dependent BAF complex activity to promote definitive endoderm differentiation.

Bioresorbable piezoelectric materials are key for bioelectronic–tissue integration but remain challenging to realize. Here, the authors develop flexible Rochelle salt/PLLA nanofibers that enable effective nerve regeneration and wireless monitoring of intestinal motility.

The molecular heterogeneity of brain metastases (BrMs) poses challenges for their treatment. Here, the authors generate a multi-omic, single cell, and spatially resolved atlas of 1,032 pan-cancer BrMs and identify four molecular subtypes with distinct biological and clinical features.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Arctic sea ice loss is reshaping the ocean’s carbon pump. Satellite data show an early boost, then stagnation, while models warn of future weakening under ice-free conditions, threatening carbon storage and ecosystems.

The de novo construction of enantioenriched 3-hydroxyindolenines and 3-oxindoles from easily available starting materials is highly desired. Here, the authors demonstrate an enantioselectively intermolecular direct [3 + 2] annulation of aryl amine with 2,3-diketoesters to construct 3-hydroxyindolenines with a chiral tertiary alcohol.

Reforming 3d-metal-based visible light catalytic platforms for inert bulk chemical activation is highly desirable. Herein, the authors report the use of a Brønsted acid to unlock robust and practical iron ligand-to-metal charge transfer photocatalysis for the activation of multifarious inert haloalkylcarboxylates to produce halogencontaining alkyl radicals.

Conventional battery electrodes exhibit high tortuosity, impeding ion transport. Here, authors report the use of a temporally shaped ultraviolet femtosecond laser to create an array of high-density through-holes, reducing tortuosity in thick electrodes with low material loss (> 1%) in up to 280 μm-thick LiFePO4 electrodes, improving gravimetric energy density and power capabilities.

The high performance of two-dimensional (2D) channel membranes is generally achieved by preparing ultrathin or forming short channels with less tortuous transport through self-assembly of small flakes. Here, the authors report the construction of vertical channels in graphene oxide membranes based on a substrate template with asymmetric pores demonstrating high flux and metal ion rejection.

Cardiometabolic disease and depression often co-occur, but their multi-organ basis was unclear. Here, the authors analyse UK Biobank imaging and genetics, identifying abdomen-heart-brain networks and 43 shared loci, improving multimorbidity prediction

Modifying the light-absorbing or catalytic properties of a photocatalyst typically requires tedious preparation, resulting in a lengthy development process. Here, the authors address this limitation by achieving manganese-based low-energy photoredox catalysis through the in-situ assembly of simple Mn salts with inexpensive coordinating chemicals.

Computational spectrometers are normally constrained by limited bandwidth and low light throughput of spectral encoders. Here, the authors report the realization of broadband snapshot spectrometers based on high-transparency transition metal dichalcogenides spectral encoders integrated with InGaAs photodetectors.

A soft, biodegradable, wireless sensing device can monitor pressure, temperature and strain over long distances (up to 16 cm), maintaining accuracy across varying positions and angles.

Perovskite solar cells suffer from reverse-bias degradation due to inevitable migration of iodide ions. Here, the authors incorporate tetrabenzenesulfonic acid molecules at the perovskite interface to create an electrostatic repulsion with iodide ions, achieving maximum device efficiency of 26.21%

Ultrafast electron diffraction can probe structural dynamics of photochemical reactions in real space and real time. Here the authors study the ring-opening of cyclohexadiene with sub-100 fs temporal resolution and sub-angstrom spatial resolution.

Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Lan et al. demonstrate the high performance of plasma p-tau217 in detecting and tracking multiple aspects of Alzheimer’s disease pathology, outperforming other plasma tau biomarkers across two Chinese cohorts (GHABS and Huashan) and the North American ADNI cohort.

Allele-specific expression of LINC02449 at rs149707223 in monozygotic twins with psychiatric disorders drives social deficits and repetitive behaviors in mice via CPLX1-mediated excitatory transmission, underscoring ASE as a key regulatory mechanism.

Pei et al. overcome desorption of passivating molecules under photothermal stress in wide-bandgap perovskites and achieve perovskite/Cu(In,Ga)Se₂ tandem solar cells with a certified efficiency of 27.35%.

An asymmetric self-assembled monolayer improves the efficiency of perovskite/silicon tandem solar cells compared with symmetric self-assembled monolayers, resulting in a certified power conversion efficiency of up to 34.58%.

Fullerene cages that break the isolated pentagon rule are rare and often unstable. Now a range of fullerenes that feature three sequentially fused pentagons of carbon have been stabilized by chlorination.

Bringing chiral molecules in contact with metal nanoparticles enables interfacial charge transfer. Here the authors show that when optically resonant, such complexes can show collective chiroptical responses beyond traditional plasmon-exciton coupling.

SOX2 is known to be oncogenic in squamous cell carcinomas. Here, the authors demonstrate that SOX2 promotes global histone acetylation and reprograms lipid metabolism in esophageal squamous cell carcinoma cells.

Here, the authors show that mechanical loading promotes subchondral bone osteocytes to secrete extracellular vesicles containing miR-23b-3p, which accelerates osteoarthritis progression by inhibiting mitophagy and disrupting cartilage metabolism.

Serotonin (5-HT) and its derivative melatonin are versatile physiological regulators. Here, the authors report that abscisic acid induces 5-HT biosynthesis via the ABI5 transcription factor in rice.

The additive molecule DHHB enables UV shielding, chemical passivation and strain regulation at the buried interface of perovskite solar cells. Small-area devices achieve a power conversion efficiency of 26.47%, 96% of which is maintained after 1,132 h of continuous operation.

This study reports that the gene SMPED1, located in a previously identified dichogamy-determining region in Alpinia species, controls the timing of sex-organ synchrony, improving our understanding of the evolutionary mechanisms of plant sexual diversity.

Hydrogels are essential for stem cell-based tissue regeneration but struggle with hard tissue repair. The authors report a shell-hardened macroporous hydrogel with spatiotemporally programmed mechanics to enhance stem cell-driven bone regeneration.

Traditional electrorefining process is limited by deposition potential of the metal itself. Here, the authors explore an in-situ anodic precipitation process based on different solubility of target metal chlorides that can efficiently separate components of aluminum alloys.

Stable, dissipative optomechanical solitons are realized using optical fields in a whispering gallery mode resonator by balancing the optomechanical nonlinearities with a tailored modal dispersion.