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Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

The flammability of the Li electrode impedes its safe application in a battery. Here, the authors develop a layered Li electrode design to eliminate corrosion between Li metal and fire retardant, and smart release fire retardant against Li combustion during heating conditions, enabling a safe Li metal battery.

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

Researchers identified a previously unrecognized progeroid neuropathy caused by mutations in IVNS1ABP. Patient-derived fibroblasts, induced pluripotent stem cells, and neural progenitor cells exhibited disrupted dynamics, resulting in defective cytokinesis, DNA damage, and cellular senescence, which in turn led to premature neurogenesis in cerebral organoids.

C-14 hydroxyl group is critical for the function of ent-kaurane diterpenoids (ent-KTs). Here, the authors report discovery and engineering of bacterial P450s for C-14 hydroxylation in ent-KTs.

Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme conditions. Here, the authors show that the natural product P57 induces hypothermia by targeting pyridoxal kinase and has a potential application in therapeutic hypothermia.

Using sunlight to turn carbon dioxide into fuels is appealing, but reactions are often inefficient. This study shows a photothermal catalyst that lets hydrogen move between sites, enabling selective conversion of carbon dioxide to methane.

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

Using a regioirregular polymerization strategy, diverse polymer structures containing urethane, carbonate and urea linkages are synthesized from a single tetramethylene urethane monomer. Mixed polymers can be depolymerized to the starting monomer in a closed-loop manner.

A platinum(II) azido complex (complex 1) that releases platinonitrene upon X-ray exposure induces DNA damage and enhances immune checkpoint blockade outcomes via the abscopal effect.

An evaluation across 193 countries for the 2026 Global Action Plan update showed that countries with strong multisectoral governance and early surveillance adoption achieved long-term improvements in reducing antimicrobial resistance.

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

Newly emerging SARS-CoV-2 variants underscore the need for broad-spectrum antiviral solutions. This study shows a macrocyclic peptide inhibitor that locks the SARS-CoV-2 spike trimer into a “closed” conformation by engaging a conserved region, and demonstrates that intranasal administration of the peptide inhibitor protects against Omicron variants.

Here they show that NONO collaborates with HOXA1 to modulate gene expression during early cardiomyocyte differentiation. This interaction facilitates activation of the Wnt signaling pathway, establishing the NONO-HOXA1-Wnt axis as a key mechanism in cardiac development.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

STAARpipeline is a comprehensive framework for flexible and scalable rare-variant association analysis using whole-genome sequencing data and annotation information.

A self-regulated photothermal superhydrophobic film with strong solar modulation, energy storage, and durability is reported, switching between black and white as temperature changes, enabling winter anti-/deicing and summer overheating prevention.

The authors make a bimodal network polyacrylate dielectric elastomer featuring high driving frequency like silicones and thereby a high power density of 154 W kg⁻¹@20 MV m⁻¹, 200 Hz. Their rotary motor realizes a maximum rotating speed of 1245 rpm@ 19.6 MV m⁻¹.

Cystine levels in pancreatic ductal adenocarcinoma (PDAC) tumour microenvironment are deficient, despite its crucial role for cancer cell maintenance. Here, the authors show that adaptation to cystine limitation stress promotes PDAC growth through induces metabolic reprogramming to promote PDAC tumor growth, while conferring a vulnerability in lipid metabolism targetable by lomitapide.

Here the authors perform an epigenome-wide DNAm study in 472 AD brains, identifying 5,478 regional methylation associations, mainly with tau. Replication and integration analyses reveal 93 regions and 535 genes enriched in oligodendrocyte genes, a subset of which were consistent across tauopathies.

A self-powered symbiotic transcatheter pacemaker that regenerates energy via electromagnetic induction from the cardiac motion demonstrates a month-long operation in a porcine model of arrhythmia and surpasses the critical energy condition for lifelong service.

meta-Cyclophane synthesis is often restricted to unstrained systems owing to unfavourable energetic constraints. Now the preparation of strained analogues is shown via sequential aryne insertion into cyclic sulfoxides and an anionic [4,5]-sigmatropic rearrangement. This strategy enables the use of meta-cyclophane-based aryne precursors and the orthogonal assembly of double cyclophanes.

The rigid-to-soft transformation and imperceptible, morphology-adaptable nature of a hydrogel–elastomer adhesive bilayer based on ionic–electronic conductive nanomembranes enable the real-time stable monitoring of electrophysiological signals in vivo.

Optical aberrations can hinder fluorescence imaging of thick samples, reducing image signal, contrast, and resolution. Here, the authors introduce a deep learning-based strategy for aberration compensation, improving image quality without slowing image acquisition or introducing more optics.

Global Burden of Disease estimates show that between 1990 and 2023, the prevalence and burden of drug use disorders, inclusive of amphetamine, cannabis, cocaine and opioid use, have been increasing in high-income countries, particularly in the USA.

Here authors show loss of AKAP11, a strong genetic risk factor for bipolar disorder and schizophrenia, disrupts PKA proteostasis and signaling, leading to widespread transcriptomic alterations across the brain, particularly in striatal neurons, as well as altered behavior.

Here, the authors sample air and surfaces in hospital rooms of COVID-19 patients, detect SARS-CoV-2 RNA in air samples of two of three tested airborne infection isolation rooms, and find surface contamination in 66.7% of tested rooms during the first week of illness and 20% beyond the first week of illness.

Light-sheet fluorescence microscopy enables high resolution imaging of biological samples. Here the authors use reflective coverslips to obtain multiple sample views simultaneously, improving the speed of acquisition and resolution compared to dual-view selective plane illumination microscopy.

Rebuilding cities after conflict often prioritizes political or economic interests at the expense of long-term resilience, equity and inclusion. Post-war recovery must break away from traditional, interest-driven patterns. Instead, reconstruction should be redefined through a science-driven, multidisciplinary lens that has people and communities, social justice, and sustainability at its heart.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

DNA in many bacteriophages contains unusual chemical modifications. Here, the authors discover that carboxymethylcytosine is a natural DNA base and reveal its role as an intermediate enabling further DNA hypermodification.

Seismic refraction profiling indicates that subduction initiation of the Caroline Plateau into the Mariana Trench has involved intense faulting and mantle serpentinization at the leading edge of the subducting oceanic plateau

Artificial muscles composed of carbon nanotube yarns have previously demonstrated fast, large-angle rotations. Here, the authors infiltrate carbon nanotube yarns with a paraffin wax and polystyrene-based copolymer mixture, achieving stable 9,800 r.p.m. rotation without apparent oscillation.

Mitochondrial fatty acid β-oxidation is essential for cellular energy production. Here the authors show that mutations in Testis-Expressed Protein 44 (TEX44) are associated with misregulated fatty acid β-oxidation and male infertility.

Some thiamine diphosphate-dependent enzymes are powerful biocatalysts, forming carbon–carbon bonds between two α-keto acids, but their catalytic properties have been poorly understood. Now the substrate selectivity and catalytic stereoselectivity of two representative enzymes, CsmA and BbmA, have been fully characterized. Enzymatic total synthesis using these enzymes generates diverse carboligation products.

Dielectric elastomer actuators (DEAs) with large electrically actuated strain can be used in non-magnetic motors, but high stiffness, poor strength and slow response currently limit the application of DEAs. Here, the authors optimize the crosslinking network in a polyacrylate elastomer to enable a DEA with high toughness and actuation strain and use the polyacrylate to build a motor which can be driven under low electric field.

Non-reciprocal charge transport has potential for applications but is usually weak. Here the authors report a room-temperature divergent non-reciprocal Hall effect in devices made of Pt deposited on Si substrates.

Garnet-type LLZO electrolytes are considered among the most promising solid-state electrolytes for all-solid-state batteries; however, numerous challenges need to be addressed before they are integrated into a cell. By precipitating amorphous zirconium oxide onto grain boundaries, increased ionic conductivity is observed and dendrite growth is suppressed.

Limited therapeutic options are available for pulmonary fibrosis because its molecular pathogenesis remains unclear. Here, the authors show that the CCL20– integrin α5β1–TGF β signaling cascade could be a potential therapeutic target for pulmonary fibrosis.

ACE2 and TMPRSS2 have received recent attention as entry factors for SARS-CoV-2. Here the authors analyze nasal airway transcriptome data from 695 children determining ACE2 and TMPRSS2 expression is induced by viral and type2 inflammation, respectively, and both exhibit eQTLs that vary across world populations.

Atomic force microscopy is used to investigate the adsorption and organization of ions on charged surfaces. Trivalent ions adopt complex networks, clusters and layers associated with overcharging, whereas divalent ions follow classical predictions.

Wireless modules within self-powered Internet of Things devices are affected by external interference. Here, authors reported a moist-electromagnetic coupling effect by polymer diodes for synergistic moist energy harvesting and electromagnetic protection.

SpaceX’s Inspiration4 mission sent an all-civilian crew into orbit to study physiological, neurovestibular and neurocognitive changes in the astronauts and found that short-duration civilian space missions do not pose a major health risk.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

How synovial fibroblasts activate cartilage degradation in arthritis is not well understood. Here, the authors identify an O-glycosylation program and glycosylated Calnexin in synovium’s edge fibroblasts as drivers of extracellular matrix degradation, highlighting potential therapeutic targets.

Multiblock copolymers (MBCPs) comprising polyester and polyacrylate segments offer an efficient strategy for enhancing the performance of polyester and polyolefin blends but synthesis and structural modification of these MBCPs remains challenging. Here, the authors propose a method for synthesizing MBCPs via the switchable polymerization of epoxides, cyclic anhydrides, and acrylates using a dinuclear Co-complex.

Band topology of Weyl semimetals is usually predetermined by material parameters and can hardly be manipulated, and their transport properties appear at low temperature. Here, the authors modify the topology via a weak magnetic field and observe a giant anomalous Hall effect at room temperature.