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The ring-opening polymerization of CO2-derived EVP, a cyclic lactone, struggles with poor thermodynamics and kinetics. Here, the authors convert EVP to a thionolactone and demonstrate that S/O and vinyl isomerization enhances the polymerization activity and enables the rapid synthesis of high-molecular-weight CO2-based polythioesters.

Here, the authors show that an Entamoeba histolytica protein, KERP2, binds parasite DNA to regulate virulence genes and then enters human gut cells, disrupting actin and weakening the epithelial barrier during infection.

A 64-kb non-volatile digital compute-in-memory macro that is based on 40-nm spin-transfer torque magnetic random-access memory technology can achieve a software-equivalent inference accuracy for a residual network at 8-bit precision and physics-informed neural networks at 16-bit precision.

The ALICE Collaboration provides details on the microscopic mechanism that ends up creating antideuteron in high-energy proton–proton collisions at the Large Hadron Collider.

Vertically assembled graphene devices have received less attention than the typical two dimensional arrangements. Chen et al. show that an Au/graphene/Au assembly exhibits a large magnetoresistance ratio of up to 400%, while a Co/graphene/Co device displays a spin valve effect at room temperature.

Through integrated multi-omics and experimental validation, this study reveals that altered gut microbiota and bile acid metabolism activate TLR3 to induce urothelial injury in interstitial cystitis, identifying a pathway with therapeutic potential.

Postsynthetic modification of rigid MOFs with photoswitchable azobenzene molecules enables tunable interlayer spacing in stacked 2D MOF membranes, greatly expanding the fabrication of 2D MOF membranes with dynamic interlayer spacing.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Thin-film perovskites are excellent semiconductors for optoelectronics. This Review discusses their device design principles and film requirements, with a focus on how secondary bonds regulate crystallization to achieve high-quality films for high-performance devices.

A chiral copper catalyst, generated in situ from commercially available components, can be used to achieve photoinduced deracemization of alkyl halides through carbon–halogen bond cleavage.

Bacterial cellulose (BC) possesses excellent biocompatibility and mechanical strength but lacks the bioactivity needed for many biomedical applications. Here the authors use glycoengineering–click chemistry to incorporate azide groups into BC in situ, and show enhanced BC-mediated wound healing.

Insights to elucidate the composition–behaviour relationship in organic photovoltaic materials are required. Here the phase behaviour of disordered polymer:small-molecule acceptor blends is studied and an extended model is invoked to understand the temperature–composition diagrams.

A strategy using simple one-step spin-coating to form 3D/2D vertically oriented perovskite heterojunctions is described, allowing the fabrication of perovskite light-emitting diodes with record-high green emission efficiencies of 42.9% (certified 42.3%).

This work introduces an accurate liquid identification strategy by integrating droplet mechanics and solid–liquid interface contact electrification in a ZnO–PDMS superhydrophobic solid–liquid sensor.

The electroluminescence emitted from lanthanide fluoride nanocrystals functionalized with ligands is shown to be tunable, providing a method for exciton control in insulating nanocrystal systems and offering a pathway for spectrally precise electroluminescent materials.

N-Glycosylated heterocycles play important roles in biological systems and drug development, but the synthesis heavily relies on ionic N-glycosylation. Herein, the authors report a dehydroxylative radical method for synthesizing N-glycosides by leveraging copper metallaphotoredox catalysis.

Two-dimensional perovskite phases at the bottom interfaces of solar cells improve performance, but their formation is challenging. To address this, Zhao et al. graft the 2D perovskite-phase precursor onto a functionalized SnO₂ electrode substrate.

It is highly desired to explore cheap, non-toxic transition metals catalysts for semihydrogenation of acetylene. Here, isolated Cu atoms anchored onto a defective nanodiamond-graphene support exhibit robust catalytic performance in acetylene semihydrogenation in comparison with supported Cu clusters.

Direct meta-selective C–H functionalization of pyridines is of paramount importance, but such reactions remain limited and highly challenging. Here, the authors report an electrochemical methodology in which nucleophilic sulfinates allow meta-sulfonylation of pyridines through a redox-neutral dearomatization-rearomatization strategy.

A thin-film engineering method is employed to preserve high pressure solids in diamond capsules at ambient conditions, enabling tunable preserved pressures, controllable particle size, atomic-scale characterization, and potential large-scale uses.

p97-UFD1L-NPLOC4 unfolds proteins for proteasomal degradation, but whether it suffices to extract proteins from lipid bilayers is unclear. We show that the UBH-UBX module in FAF2 and its homologs double p97’s ATPase and unfolding activity, and drives membrane protein extraction.

Although having potentially useful applications, development of organogels that absorb nonpolar liquids is challenging. Here, the authors report the development of organogels with a nanowire-polymer networks, capable of absorbing and gelating nonpolar organic liquids.

Down’s syndrome is characterized by intellectual disability and other neuropathological symptoms. Here, the authors show that astroglia derived from induced pluripotent stem cells from Down’s syndrome patients impair the development of neurons, and that this can be attenuated with the drug minocycline.

Reactive capture bypasses CO₂ regeneration, enabling efficient CO production but with low Faradaic efficiency. The authors report a Ni–N₃ molecular catalyst that resists amino acid adsorption and promotes efficient CO production in amino-acid systems.

The creation of protective barriers around cells is of interest for a range of applications. Here, the authors report on the creation of DNA templated alginate-polylysine biomimetic cell walls for encapsulating and shielding cells, demonstrating protection against physical assaults and immune reactions.

The unconventional hexagonal phase CuCo PBA with open structure, large pore size, and high specific surface area is synthesized, and it delivers much better small molecular gas adsorption performance than the traditional cubic counterpart.

Electrochemical C–N coupling of 5-hydroxymethylfurfural with methylamine offers a sustainable route to produce value-added amines. Here, the authors present a facet-controlled Ag catalyst that tunes the substrate adsorption geometry and hydrogenation propensity for promoted selectivity.

Limited delivery of therapeutic cells to diseased tissue hampers the effective application of mesenchymal stromal cells (MSCs). Here, authors modify the cell surface with polyvalent antibodies using DNA-templated assembly, and show that polyvalent interactions can be used to improve the targeting efficiency of MSCs.

Methods for asymmetric alkyl–alkyl bond formation between sp³-hybridized carbon atoms, C(sp³)–C(sp³), are limited yet highly desirable. Now an approach for asymmetric alkyl–alkyl bond formation by Ni-catalysed cross-coupling between alkenes has been developed to construct tertiary stereogenic carbon centres with head-to-tail regioselectivity and excellent chemo- and enantioselectivity.

Perovskite solar cells suffer from reverse-bias degradation due to inevitable migration of iodide ions. Here, the authors incorporate tetrabenzenesulfonic acid molecules at the perovskite interface to create an electrostatic repulsion with iodide ions, achieving maximum device efficiency of 26.21%

The authors report the synthesis and characterization of samarium-based superconducting infinite layer nickelate thin films, along with co-doped variants incorporating europium and calcium. The co doped compounds achieve a record-small c-axis parameter and display superconducting transition temperatures up to 32.5 K.

Understanding electrochemical corrosion mechanism is essential for developing the fundaments of electrochemistry in catalysis. Here, the authors study the electrochemical corrosion of Pd-Pt core-shell catalysts by connecting structure evolution with the in-situ electrochemical cyclic voltammetry.

The electro-oxidative synthesis of valued chemicals offers to enhance the overall efficiency and economic viability of renewable electrosynthesis systems. Here, the authors use dopant-tuned catalysts to promote the electrosynthesis of dimethyl carbonate from CO and methanol via oxidative carbonylation.

High-throughput chemical ligand discovery is challenged by false positives. Here, authors introduce a scalable enantioselective affinity-selection mass spectrometry approach for proteome-wide ligand discovery with high sensitivity and selectivity

Improving catalysts for producing carbonates remains a challenge due to limited activity and durability. This study shows a bismuth–ceria catalyst that enhances reaction steps through remote electronic effects and can be easily regenerated.

Allylic alcohols and ethers are key functional motifs widely found in various bioactive molecules, pharmaceuticals, and natural products. Here, the authors report the synthesis of (E)-allyl ethers from internal alkenes and alcohols or phenols via copper catalyzed selective allylic C–H oxidation.

Arginine methyltransferases (PRMTs) are involved in the regulation of various physiological and pathological conditions. Using proteomics, the authors here profile the methylation substrates of PRMTs 4, 5 and 7 and characterize the roles of these enzymes in cancer-associated splicing regulation.

Manganese complexes have long been utilized by nature to catalyze the oxygen evolution reaction (OER) but mirroring their efficiency in artificial electrochemical systems has proven difficult. This study centers on alpha-manganese dioxide (α-MnO₂), which closely mimics natural Mn^IV-O-Mn^III-H_xO motifs, presenting a novel method for manipulating proton coupling within the OER process using an external electric field.

Hepatic fibrosis causes blood ammonia accumulation, which leads to hepatic encephalopathy. Here, a biocompatible water-powered Zn micromotor is developed for chemotactic migration towards and targeted clearance of ammonia for the treatment of hepatic encephalopathy.

Catalytic syngas conversion is an essential part of sustainable chemical production but is hindered by the trade-off between conversion activity and product selectivity. Here the authors address this challenge by developing a catalytic shunt strategy.

Crossover of CO₂, in the form of carbonate, from the cathode to the anodic compartment places a major limitation on carbon efficiency in traditional CO₂ electrolysis cells. Here, the authors place a porous solid electrolyte layer between the compartments, where protonation of carbonate during CO₂ electrolysis allows recovery of over 90% of the lost CO₂ gas.

A reference-quality genome assembly of hexaploid oat variety ‘Sanfensan’ and genome assemblies of its diploid and tetraploid Avena ancestors provide insights into the evolutionary history of allohexaploid oat.

Zinc-bromine flow batteries face challenges from corrosive Br₂, which limits their lifespan and environmental safety. Here, the authors introduce sodium sulfamate as a Br₂ scavenger, enabling a more durable and higher-energy-density Zn/Br flow battery suitable for large-scale operation.

An intratumoural vaccination chimera reprograms tumour cells into an antigen-presenting state with restored anti-tumour immunity.

Combination of p- and n-doped graphene is important in optoelectronic applications, but spatially selective doping of graphene is challenging. This work reports large-scale growth of graphene monolayers with spatially modulation doping and built-in single-crystalline p–n junctions.

Perovskite solar cells have been limited by the use of relatively expensive organic compounds as hole-transporting materials. Here, Qin et al.use an inorganic hole conductor, CuSCN, in a lead halide perovskite solar cell and achieve power conversion efficiencies as high as 12.4%.

Inspired from bimetallic active sites in both enzymes and heterogeneous catalysts, the development of binuclear catalysis can offer the potential to induce novel intermediates, reactivity, and selectivity. Here the authors report a dimerization-hydrocarbofunctionalization of internal alkynes via dinickel catalysis, leading to the formation of pentasubstituted 1,3-dienes.

The ATLAS Collaboration reports a measurement of the ratio of the decay rates of W bosons to τ leptons and muons, in agreement with universal lepton couplings as postulated in the standard model of particle physics.