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Multislice electron ptychography reveals that gradient-distributed ions induce progressive lattice distortions from bulk to surface, driving monoclinic γ-WO3 electrochromic materials to transform into tetragonal and cubic phases and forming the gradient-distributed colour centers.

Off-the-shelf, on-demand allogeneic CAR-T cells could represent a therapeutic alternative to autologous products for cancer therapy. Here the authors report the preclinical characterization of off-the-shelf CRISPR-Cas9– edited IL-13Rα2-specific allogeneic universal CAR-T cells and the results of a first-in-human phase I trial in patients with high-grade glioma.

Controllable and scalable phase transition of transition metal chalcogenides is challenging. Using in situ microscopic analysis, a non-stoichiometric phase transition from PdTe₂ to PdTe is observed on the atomic scale, providing mechanistic insights into the scalable phase engineering of transition metal chalcogenide films and heterostructures.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

DBiTplus represents an integrated experimental and computational workflow that unifies sequencing-based and imaging-based spatial omics, demonstrated by combining transcriptomic profiling and multiplexed protein imaging on the same tissue section.

Short-circuiting during fast charging through lithium dendrite intrusion into electrolytes is a major challenge in solid-state batteries. Here, using thermally annealed 3-nm-thick Ag coatings, lithium penetration into brittle electrolyte Li_6.6La₃Zr_1.6Ta_0.4O₁₂ is inhibited at local current densities of 250 mA cm⁻² due to an increase in surface fracture toughness.

Organoid modeling and single-cell profiling reveal TUBA4A and TUBB4B tubilin proteins-driven vascular smooth muscle cell migration and contractile-to-synthetic phenotypic switching via GJA1/PI3K/AKT/KLF4 pathway in Moyamoya disease.

An in-depth analysis of tissue biopsies from patients with multiple myeloma and CAR T cell therapy-associated immune-related adverse events (CirAEs) after treatment with commercial BCMA-targeted CAR T cell therapy shows that CD4⁺ CAR T cells mediate off-tumor toxicities and that high CD4:CD8 ratio at apheresis, robust early CAR T cell expansion, ICANS and ciltacabtagene autoleuce treatment are independently associated with the development of CirAEs.

Mitochondria that are transported from satellite glial cells in dorsal root ganglia to peripheral sensory neurons through tunneling nanotube-like structures provide protection against peripheral neuropathy.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Haobo Xu and Rong Yang discuss how scaling laws and chemical engineering fundamentals help control the geometric precision of microdomes by transforming droplets into functional surfaces inspired by nature.

The authors generate transcriptomic profiles and construct 3D genome maps for nine giant panda tissues, revealing tissue-specific 3D genome reorganization linked to gene expression and function.

The intercellular disruption leading to persistent inflammation in diabetic wounds remains unclear. Here, Lv et al. identify that the moonlighting function of MAT2A mediates the senescence-inflammation communication between pericytes and macrophages, and provide a potential biomimetic senotherapy for wound regeneration.

The regulation of ferroelectric photovoltaic properties has been challenging. Here, authors substitute the p-site of cations with halogen for tuning distortion degree of inorganic layer and electric dipole moment of aromatic spacer, achieving ferroelectric anomalous photovoltaic effect of 38.2 V.

Controlling the chain length distribution (CLD) of hydrocarbons in plastic degradation is crucial for the downstream synthesis of functional chemicals but controlling the CLD remains challenging. Herein, the authors introduce a fractionated degradation approach to tune the CLD of hydrocarbons derived from polypropylene (PP) degradation, thereby facilitating effective downstream valorization.

The authors find that O-GalNAc transferase 2 (GALNT2) restricts viral infection, probably through the regulation of the proteolytic processing of viral glycoproteins via its O-linked glycosylation activity, impairing virus–cell fusion.

High fidelity manipulation of diamond-based spin qubits is difficult at room temperature because of decoherence. Here, the authors show a universal set of logic gates in nitrogen-vacancy centres with average single-qubit and two-qubit gate fidelities of 0.999952 and 0.992, respectively.

Syt1 is a primary Ca²⁺ sensor for secretion but the function of non-Ca²⁺ -affinitive Syt11 remains unknown. Here, authors identify strong but Ca²⁺ -inhibited lipid affinity of Syt11, and a Syt11-1-11 inter-switch during excitation-coupled exo-endocytosis.

C10, a potent non-nucleoside inhibitor targeting NSP14’s SAM-binding pocket, suppresses viral translation, exhibits immunostimulatory effects, and reverses NSP14-induced transcriptome alterations, offering promise for broader coronavirus treatment.

A relatively high proportion of patients relapse following radiofrequency ablation. Here, authors show that neutrophils with high expression of CD177 and PAD4 promote progression of residual tumors after incomplete radiofrequency ablation via PPARγ-related lipid metabolism adaptation.

Modeling antibody-antigen complexes boosts biomedical research and therapeutic design. To tackle slow antibody development, the authors’ tFold System designs epitope-specific antibodies, with their nanomolar affinities experimentally confirmed.

Gut microbiota influence bone health, but the genetic and metabolic mechanisms are unclear. Here, the authors show that specific bifidobacterial taxa causally reduce bone mineral density, partly via n-3 fatty acid metabolism, highlighting host-microbe interactions with potential therapeutic implications.

Molecular property prediction is vital for drug discovery. Here, the authors introduce MotiL, an unsupervised approach that learns motif representations from molecular graphs, enabling accurate predictions for both small molecules and macromolecules.

Mercury isotopes in Northeast Asia intraplate basalts indicate that the EM1 mantle source contains recycled ancient terrigenous sediments stored in the mantle transition zone for over a billion years, recording long-term deep-Earth volatile cycling.

The synthesis of long dendralene skeletons is made possible by a copper-mediated chain-growth polymerization of strained [3]cumulenes. These extensively cross-conjugated molecules enable visible-range two-photon lithography.

Understanding brain function requires integrating neuronal structure, activity, and genes. Here, authors developed an optogenetic tool they name Pisces, to enable complete labeling of individual neurons’ morphology with functional and molecular profiling, allowing multimodal single-cell analysis in vivo in zebrafish.

Neurovascular interaction is critical for normal brain vascular development. Here, the authors show that neuronal NMDARs regulate brain vascular development via VEGF-induced global Ca2+ activities of endothelial tip cells.

In patients with metastatic osteosarcoma who have progressed on first-line chemotherapy, the prognosis is poor. Here, the authors report a phase II randomized clinical trial comparing the combination of apatinib (multi tyrosine kinase inhibitor) and chemotherapy (ifosfamide and etoposide) against chemotherapy alone in patients with relapsed or refractory metastatic osteosarcoma.

Conditional knockout of LARP4 in naive CD4⁺ T cells leads to attenuated quiescence exit and clonal expansion.

Here, the authors report immunogenicity and safety of AR-MPXV5, a penta-component mRNA vaccine, in naive and simian immunodeficiency virus infected nonhuman primates (NHPs), and demonstrate protection in naïve male NHPs after immunization with two doses of AR-MPXV5.

A tri-omic atlas of the mouse brain from postnatal day 0 to P21 reveals that layer-specific projection neurons have a role in coordinating axonogenesis and myelination.

Metabolic dysfunction-associated steatohepatitis (MASH) has an incompletely understood mechanistic basis. Here the authors use gain- and loss-of-function mouse models to show that that E3 ligase TRIM7 in hepatocyte promotes MASH pathogenesis via DUSP10 ubiquitination.

Pulmonary fibrosis involves chronic inflammation and extracellular matrix remodeling but the contribution of neutrophils is unclear. Here the authors show that reverse-migrating neutrophils anchored in the lung extracellular matrix exacerbate fibrosis via ICAM1 and macrophage derived cathepsin C.

Therapeutic options for patients with renal medullary carcinoma (RMC) are limited. Here the authors report the results of a phase II clinical trial of anti-PD1 nivolumab plus anti-CTLA4 ipilimumab in RMC, associating the activation of a myeloid mimicry program in tumor cells to the rapid disease progression and hyper-progression observed in treated patients.

m6A modification has been reported to play roles in many developmental and pathological processes, but its role in AKI remains poorly understood. Here, the authors show the role and the mechanism of the m6A demethylase, ALKBH5 on IRI induced AKI.

In this work, the authors introduce parallel symbolic enumeration (PSE), a model that discovers physical laws from data with improved accuracy and speed. By evaluating millions of expressions in parallel and reusing computations, PSE outperforms the state-of-the-art methods.

Immune checkpoint inhibitors have shown promise in tumour immunotherapy but resistance has been seen. Here using pre-treatment hepatocellular carcinoma patient biopsies from patients scheduled for immunotherapy, the authors implicate BCL9 and show that a BCL9-targeting peptide promotes anti-tumour immunity in mouse models through targeting macrophages and promoting anti-tumour T cell responses.

The oxygen evolution reaction enables many clean energy technologies, but most acid-unstable catalysts still block deployment. Here the authors report a temperature dependent mechanistic evolution in RhRu3Ox that links reaction pathways to stability, enabling durable acidic water electrolysis.