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This randomized open-label trial shows that hemoadsorption combined with hemodialysis reduces all-cause and cardiovascular mortality, and cardiovascular events in patients with end-stage kidney disease compared to hemodialysis (mainly low-flux hemodialysis plus intermittent hemodiafiltration) alone.

Authors reconstruct the molecular evolution of severe fever with thrombocytopenia syndrome virus (SFTSV) in East Asia. SFTSV splits into two lineages with diversity driven by segment-specific reassortment; transmission occurs via distinct networks.

Achieving high power scaling in ultrawide bandgap electronics remains challenging. Here, the authors present a Ga₂O₃ module using a high permittivity interface that enables fast megawatt pulsed switching with improved thermal performance.

The authors propose an asynchronous sublattice distortion mechanism to elucidate the complex phase transitions in HfO₂-based materials. The phase transitions among the orthorhombic, tetragonal, and monoclinic phases are governed by the orientation of the orthorhombic phase.

The study presents NMR-Solver, an automated framework that determines small-molecule structures from NMR spectra by combining large-scale spectral matching with physics-guided optimization, enabling accurate and interpretable structure elucidation.

Here, the authors show that the PLA2G6 protein is a component of the IP3R1–GRP75–VDAC1 complex at the mitochondria-associated endoplasmic reticulum (ER) membrane, maintaining the integrity and function of ER–mitochondria contacts.

Han et al. report a highly conductive composite electrode with low equivalent sheet resistance of 1.5 Ω sq-1. A self-masking method is developed to prevent shunting caused by uneven grid surfaces, enabling flexible organic solar cells with efficiencies of 15.20% (4 cm² devices) and 14.24% (16 cm² devices).

Tuning selectivity on metal nano catalysts is challenging. In CO₂ hydrogenation, carbon reshapes cobalt on manganese oxide, shifting products from methane to CO and lifting the CO-to-methane ratio 15-fold.

Lithium-metal batteries promise high energy but dendrites limit life. Here, authors introduce a 90 wt.% lithium multicomponent solid solution alloy negative electrode that drives lithium into the bulk, enabling 3100 mAh g − 1 capacity and a 385 Wh kg−1 pouch cell that retains 82% capacity after 600 cycles.

In this study, the authors report the structure of a human astrovirus spike protein bound to the FcRn receptor and show that clinically approved FcRn inhibitors potently inhibit virus infection via competing with viral spike proteins for receptor binding.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

Zhang et al. show that the activation of RIPK1 is suppressed by acetylhypusination in a spermidine-dependent manner. Disruption of this axis contributes to RIPK1-mediated vascular pathology to promote insulin resistance and diabetic kidney pathology.

Cultivated banana is threatened by Fusarium oxysporum f. sp. cubense tropical race 4 (TR4). In this study, the authors assemble the genome of Musa cheesmanii, a wild banana species that is highly resistant to TR4, and use it in crossbreeding with two cultivars to enhance disease resistance.

Zheng et al. show that extending the guide RNA restores the reduced activity of a high-fidelity CRISPR–Cas9 enzyme while preserving accuracy, revealing how strengthened PAM-distal interactions can improve genome-editing performance.

Efficient low temperature oxygen activation is essential but hard to achieve with accessible metal sites. This work shows that zero-valent single Pt atoms on cobalt oxide donate electrons to oxygen, enabling low-temperature toluene oxidation.

Farnesyl pyrophosphate—a mevalonate pathway metabolic intermediate—is an endogenous alarmin that enhances IgG antibody responses through keratinocyte-derived IL-6 and CCL20.

Dong and colleagues report that blockade of T cell-expressed cytotoxic and regulatory T cell molecule results in selective mitigation of immune-related toxicities without affecting antitumor efficacy of immune checkpoint inhibitors.

Studying the intrinsic shear properties of Ti₃C₂T_x under in-plane shear loading is crucial for the stability of 2D flexible electronics. This work reports a high in-plane shear modulus of 0.279 ± 0.007 TPa, along with stable wrinkle resistance

ProTact, an SE(3)-invariant geometric GNN, enhances protein-protein contact prediction and docking by integrating physics-informed constraints. It surpasses existing methods in low MSA scenarios and enhances AlphaFold3’s confidence scores.

Metabolic reprogramming of immune cells can modulate their response to and ability to respond in infective contexts. Here the authors show phosphoglycerate dehydrogenase mediated serine reprogramming in macrophage is linked to hyper inflammatory responses in murine models of Pseudomonas aeruginosa pneumonia.

Conventional carbon synthesis is energy intensive. Here, the authors introduce an energy-autonomous pathway using polyaniline-HClO₄ composites. This rapid reaction yields carbon nanosheets with tunable active sites for electrocatalysis.

P-(H)-m@EMLN mRNA nanovaccine for hepatocellular cancer immunotherapy was developed using hydrogen bonding between poly T-PLGA polymer and the poly(A) tail of GPC3 mRNA followed by an endoplasmic reticulum membrane coating.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

This study reports on a hydrogen-molecule-mediated proton-exchange membrane. The design leverages hydrogen evolution and oxidation reactions on gas diffusion electrodes to overcome the typical trade-off between selectivity and conductivity, with demonstrations in a pH-decoupled rechargeable battery and an electrochemical stack for efficient acid and base generation.

While EGFR mutations are drivers of cancer, the function of extracellular domain mutations remains poorly defined. Here, the authors show that the R252C extracellular mutation induces conformational change of EGFR to directly activate ERK and promote cancer growth, which can be targeted by afatinib.

Phenotypic mutations, such as mistranscription and mistranslation, are widely impactful. Here, the authors reveal in five eukaryotes that mistranslation suppresses mistranscription. This appears to be a result of the negative epistasis that renders proteins with both errors unexpectedly deleterious.

p97-UFD1L-NPLOC4 unfolds proteins for proteasomal degradation, but whether it suffices to extract proteins from lipid bilayers is unclear. We show that the UBH-UBX module in FAF2 and its homologs double p97’s ATPase and unfolding activity, and drives membrane protein extraction.

Yang et al. compare neoadjuvant triple therapy versus direct hepatectomy in patients with resectable intermediate or advanced hepatocellular carcinoma. The findings indicate that the neoadjuvant regimen improves overall and event-free survival but is associated with a higher risk of serious adverse events and postoperative complications.

Tissue resident donor CD4 T cells contribute to chronic graft-versus-host disease (GVHD). To date, how these cells are maintained and the mechanism of pathogenesis remain undefined. Here, the authors perform transcriptomics and epigenomic analyses, they analyze memory CD4 T cell heterogeneity and differentiation pathways in tissues of mice with chronic GVHD and propose the selective targeting of stem-like memory T cell stemness or differentiation as a strategy to alleviate chronic tissue inflammation

DBiTplus represents an integrated experimental and computational workflow that unifies sequencing-based and imaging-based spatial omics, demonstrated by combining transcriptomic profiling and multiplexed protein imaging on the same tissue section.

Controllable and scalable phase transition of transition metal chalcogenides is challenging. Using in situ microscopic analysis, a non-stoichiometric phase transition from PdTe₂ to PdTe is observed on the atomic scale, providing mechanistic insights into the scalable phase engineering of transition metal chalcogenide films and heterostructures.

Dai and colleagues implicate defective dendritic cell migration in impaired vaccine responses in aged mice. Oral delivery of yeast-derived nanoparticles promotes migration of dendritic cells from the gut to lymph nodes and restores vaccine efficacy in aged mice.

ENSO’s mid-century strengthening and post-2100 weakening under strong warming is driven mainly by changing tropical Pacific stratification, which produces contrasting adjustments in the feedbacks that regulate ENSO variability.

The authors identify AMsh glia, expressing both cold and heat receptors, function as a dual-mode thermosensory hub, bidirectionally modulating neural circuits to regulate various thermal behaviors in C. elegans.

Circulating tumor cell (CTC) clusters are key drivers of metastasis, yet their formation in tumors lacking classical adhesion molecules is unclear. Here, the authors discover that hyaluronic acid promotes homotypic and heterotypic CTC clustering by initiating early cell contacts and stabilizing mature interactions.

Loss of TDP-43 induces a pathogenic cryptic splicing event in the PKN1 gene. The resulting stable, neurotoxic N207 peptide is detected in Alzheimer’s disease brains and drives cognitive deficits in mice, revealing a new mechanism in TDP-43 proteinopathy.

Researchers developed a simple, industry-compatible method using an indium buffer layer between cobalt and 2D materials to form vdWs tunnel contacts. This achieved high spin injection efficiency in both graphene and MoS2, enabling future large-scale spintronic devices.

Cell-cell adhesion plays critical roles in maintaining and regulating cellular functions. Here, authors present a diffusive N-cadherin functionalized hydrogel that provides cell-cell adhesion cues to modulate intercellular communication to promote neural regeneration for treatment of traumatic brain injury.

A martensitic alloy with a tensile strength exceeding 3 GPa and a fracture elongation of 5.13% is developed. These mechanical properties arise from interface complexes interacting with dense dislocation networks, which is a mechanism shown to be applicable to other compositions.