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There has been a recent interest in control of magnetism via ionic transport. The appeal of such magneto-ionic control lies in its extent, non-volatility and potential energy-efficiency, however, the number of systems showing such behaviour is limited. Here, Tan, Ma, and coauthors demonstrate magneto-ionic control through Carbon transport.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Disease course and pathology an infection may cause can change owing to the structural and functional physiological changes that accumulate with age, but therapy can be tailored accordingly; disease tolerance genes show antagonistic pleiotropy.

This work presents a global wind power simulation tool that uses high-resolution data and extensive validation to improve accuracy. It corrects wind speed biases and validates against real-world data, enhancing reliability for wind energy assessments across various scales and regions.

CELSR1 is a core component of the tissue/planar cell polarity pathway. Here, the authors report a CELSR1-related disorder featuring brain malformations, neurodevelopmental delay and epilepsy, and use mice to explore the pathophysiological mechanisms.

Systematic screening of transcription factors reveals conserved mechanisms governing cortical radial glia lineage progression across primates and provides a framework for functional dissection of gene regulatory networks in human cortical neurogenesis.

The MOUNTAINEER phase 2 trial demonstrated the efficacy and safety of tucatinib (HER2-targeted TKI) and trastuzumab (anti-HER2 antibody) in patients with HER2 + , RAS wildtype unresectable or metastatic colorectal cancer that had progressed on chemotherapy, resulting in the approval of the regimen. Here, the authors report the updated analysis of the MOUNTAINEER trial.

A protein biomarker, the NOTCH3 extracellular domain, identifies individuals with idiopathic pulmonary hypertension, correlates with disease progression, improves mortality risk prediction and provides a readily implementable, noninvasive blood test for this disease.

De novo and inherited dominant variants in genes encoding U4 and U6 small nuclear RNAs are identified in individuals with retinitis pigmentosa. The variants cluster at nucleotide positions distinct from those implicated in neurodevelopmental disorders.

During development of eutherian females, one of the X-chromosomes is silenced. Here, authors show that alleles on the inactive X-chromosome are dynamically expressed along neural differentiation enhancing resilience of female neural tissue.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

This study demonstrates the capability of deep learning protein design models in generating functionally validated β-strand pairing interfaces, expanding the structural diversity of de novo binding proteins and accessible target surfaces.

How the complex interplay between multiple nutrients within the microenvironment dictates potential sites of metastatic cancer growth is explored.

By performing a CAR-adapted base-editing screen of phosphatidylinositol-3-kinase delta (PI3Kδ, PIK3CD), Bucher et al. identify mutations affecting endogenous PI3K–AKT signaling that enhances CAR T cell antitumor potency.

Here Pachicano et al. uncover sublaminar gene expression patterns across the mouse hippocampal CA1 pyramidal layer, revealing distinct molecular architectures within CA1 subregions.

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

Vicente Puig et al. develop a volumetric electrocardiographic imaging approach that estimates cardiac sources to reconstruct three-dimensional myocardial activation. They show improved localization of arrhythmia origins, including septal and intramural sites, with higher accuracy in simulations and concordance with invasive maps in clinical data.

Landscapes of microbial community function inferred statistically from a broad range of datasets can predict community function on the basis on presence and absence data, without the need for abundance dynamics or interaction data.

Modern neutrino experiments require precise tuning of energy response parameters, a task complicated by the parameters’ nonlinear behavior and strong correlations. The authors present neural density estimators using normalizing flows and transformers integrating them with Bayesian nested sampling to achieve near-zero systematic biases and uncertainties limited only by statistics, offering a flexible framework for particle physics applications

Systematic analysis and machine learning coupled with in vitro and in vivo validation link gut microbiome-mediated transformation of dietary phytonutrients to health outcomes.

The quark structure of the f₀(980) hadron is still unknown after 50 years of its discovery. Here, the CMS Collaboration reports a measurement of the elliptic flow of the f₀(980) state in proton-lead collisions at a nucleon-nucleon centre-of-mass energy of 8.16 TeV, providing strong evidence that the state is an ordinary meson.

Mapping of the neutrophil compartment using single-cell transcriptional data from multiple physiological and patological states reveals its organizational architecture and how cell state dynamics and trajectories vary during health, inflammation and cancer.

Oat is an important food crop, but the genetic diversity within the gene pool remains unclear. Here, the authors report the analyses of worldwide diversity and population structure of hexaploid oat, and identify signatures of structural rearrangements within the germplasm collection.

Cell type deconvolution is crucial for studying disease and development. Here, the authors present SCCAF-D, a workflow that reduces batch effects and achieves high correlation across tissues, offering key insights into cell proportion changes in non-alcoholic fatty liver disease.

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Here the authors show that gut metagenomes of Indigenous Australian infants living remotely, display greater diversity and abundance of bacteria, viruses and fungi, compared to non-Indigenous infants living in urban Australia, suggesting that while having access to Western foods, the infants start life with a gut microbiome that retains key features of pre-industrialized societies.

Insulin-mediated FOXO nuclear translocation is a key step in the stress response. Here, the authors show that C. elegans DAF-16/FOXO translocates in stochastic pulses. These pulses are synchronized throughout the body and coincide with bouts of growth arrest.

Cannabis exposure is a critical concern, particularly during adolescence. This study shows that tetrahydrocannabinol-induced cognitive deficits are mediated by a specific astrocytic ensemble in the nucleus accumbens whose manipulation prevents and reverses these effects.

Targeting individual DNA secondary structures in the genome with small molecules is challenging. Here, the authors develop ATENA, a CRISPR-based platform for targeting specific DNA structures in cells with high precision, helping to elucidate their biological roles and guide therapeutic design.

UCP1 is involved in regulating thermogenesis, and the Ucp1-Cre mouse line has been widely used for studying brown fat. Here they show that this mouse line carries an extra copy of the Ucp1 gene and displays unexpected changes in fat tissue function. Researchers should be cautious when interpreting studies using this model.

Quintana and colleagues describe the engineering of oncolytic viruses armed with multiple immunomodulators and with targeted tropism for tumor cells for glioblastoma immunotherapy.

Here the authors apply machine learning approaches to Alzheimer’s genetics, confirm known associations and suggest novel risk loci. These methods demonstrate predictive power comparable to traditional approaches, while also offering potential new insights beyond standard genetic analyses.

Multiferroic materials that exhibit coupled ferromagnetic and ferroelectric characteristics could be useful in the development of non-volatile digital storage. Evans et al. report a single-phase multiferroic material whose room-temperature magnetoelectric coupling appears to be unusually strong.

Experimental evidence shows that hydrogen–silicate reactions can generate abundant water in sub-Neptunes, suggesting hydrogen-rich planets have the potential to reach water-rich compositions.

Triadic interactions, where one node regulates the interaction between two others, are a ubiquitous form of higher-order interaction. Here, the authors show that triadic interactions modulate mutual information between linked nodes and propose an algorithm to mine them in real biological data.

CAR T cell therapies have been developed to treat paediatric diffuse intrinsic pontine glioma (DIPG), however, clinical efficacy remains limited. Here, the authors report that engineering B7-H3-targeting CAR T cells to express the chemokine receptor CXCR3-A enhances their trafficking and efficacy in DIPG preclinical models.

Protons and neutrons in nuclei form shell structures with energy gaps at magic numbers. These numbers vanish in neutron rich isotopes, creating “Islands of Inversion”. Studies of 84Mo and 86Mo reveal a shift, defining an “Isospin-Symmetric Island of Inversion” influenced by three-nucleon forces.