Search

Each valley of the mini-Brillouin zone ("mini valley") of twisted bilayer graphene (TBG) contains two Dirac cones that hybridize to form flat bands. Theory predicts that these two Dirac cones have the same chirality, leading to topological obstruction. Here, the authors confirm this prediction experimentally.

A van der Waals crystal, niobium oxide dichloride, with vanishing interlayer electronic coupling and considerable monolayer-like excitonic behaviour in the bulk, as well as strong and scalable second-order optical nonlinearity, is discovered, which enables a high-performance quantum light source.

Analysis of nuclear and mitochondrial genomes from archaeological canid remains found across Europe and Anatolia shows that a genetically homogeneous dog population was already widely distributed across the region by 15,000 years ago.

This study highlights the role of van der Waals interactions between hydrophobic aliphatic alkyl chains and hydrophilic ZnO surfaces in mitigating catalyst deactivation during aliphatic aldehyde electrical sensing.

Fe₃GeTe₂, known as FGT, is a van der Waals magnetic material that was recently shown to host magnetic skyrmions. Here, Birch et al using both X-ray and electron microscopy to study the stability of skyrmions in FGT, revealing how the sample history can influence skyrmion formation

Longitudinal metatranscriptomics in a prospective cohort of 1,164 adults hospitalized for COVID-19 reveals that azithromycin offered no apparent anti-inflammatory benefit but enriched the respiratory microbiome with potential pathogens and antimicrobial resistance genes.

Van der Waals heterostructures made of 2D materials offer a rich platform for the study of novel proximity effects. Here, by means of Hall effect measurements, the authors show a proximity-induced ferromagnetic/ferrovalley ground state with spontaneous spin-valley polarization in a V₅Se₈/NbSe₂ heterostructure.

Frank et al. introduce Euclidean fast attention, a linear-scaling framework for 3D data. By leveraging Euclidean rotary encodings, the method overcomes the quadratic cost of standard attention to accurately capture long-range effects in physical systems.

The authors observe strong coupling between valley excitons in a monolayer WS2 and intrinsically chiral photons shaped by a metasurface. The polaritons display enhanced chiral emission with their spin configuration controlled by the light source.

A magneto-transport study of twisted bilayer graphene near the magic angle further reveals its rich physics.

Element-element bonded multiply charged cationic species are well known as dimers or small cyclic oligomers in the condensed phase but the smallest acyclic version, a trinuclear unit possessing greater than a monocationic charge, has remained elusive. Here the authors report a bis(phosphine) supported low valent triantimony-based tricationic compound.

This study applies machine learning to fMRI data to map developmental variations in functional connectivity, uncovering heterogeneity across individuals and cortical regions that predicts neurocognitive maturation in youth.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

Artificial intelligence (AI) could help improve risk predictions in acute leukaemia and reduce systemic health disparities in the diagnostic process. Here, the authors assemble a diverse, international cohort of 6,206 patients with acute leukaemias and deploy an AI tool to support diagnosis based on standard laboratory results, with refinements for both adult and peadiatric leukaemias.

B cell receptors (BCR) are the membrane-bound counterparts of antibodies, and the role of N-linked glycans in their functions are much less known than that of circulating immunoglobulins. Here authors study the site-specific glycosylation profiles of all 4 N-linked glycosylation sites of human Igµ BCRs expressed in naïve and memory B cells and conclude that these show high level of conservation across development and don’t contribute to differences in their expression and function.

Heterostructures of graphene and hexagonal boron nitride have great potential for high-mobility electronics, yet little is known about the electronic interaction between these two atomically thin materials. Here, the authors perform angle-resolved reflected-electron spectroscopy to unveil their interplay.

Genome-wide association meta-analysis identifies 58 independent risk loci for major anxiety disorders among individuals of European ancestry and implicates GABAergic signaling as a potential mechanism underlying genetic risk for these disorders.

This umbrella review of 56 meta-analyses and 296 effect sizes examines the risk factors, protective factors and consequences of cyberbullying. The authors also examine interventions to mitigate cyberbullying victimization.

Hexagonal boron nitride is a common component of 2D heterostructures. Defects implanted in boron nitride crystals can be used to perform spatially resolved sensing of properties, including temperature, magnetism and current.

The use of antimicrobial agents can exacerbate the proliferation of antimicrobial resistance genes, which can put public health at risk; evaluating this risk requires proper monitoring. An extensive investigation of Australian wastewater reveals a distinct correlation between the type of antimicrobial used and the socioeconomic status of the population.

A molecular-level understanding of structural evolution upon electrochemical doping in organic mixed ionic-electronic conductors is required. A pronounced reduction in mass and thickness is observed in an n-type ladder polymer upon doping with protic cations owing to water expulsion.

The magnetic anisotropy of the van der Waals ferromagnet Fe₅GeTe₂ can be continuously tuned—from an initial out-of-plane orientation to a canted orientation and then finally to an in-plane orientation—using electrical gating.

This study of magic-angle twisted trilayer graphene moiré superconductors using scanning tunnelling microscopy and spectroscopy identifies two energy gaps that develop from many-body resonance in this highly tunable class of materials.

Using ARPES, this work identifies dice-lattice flat bands in the electride material YCl. The authors show that anionic electrons act as lattice sites to create this rare electronic structure.

Boron-dipyrromethenes (BODIPYs) are fluorophores applicable for imaging and sensing, though are sensitive to acidic deboronation. Here the authors design macrocyclic BODIPYs resistant to acid, and have stable photophysical properties.

Covalent polymers with helical conformations offer an adaptive scaffold for smart materials, but polymer-to-monomer deconstruction is inhibited by the covalent backbone. Now it has been shown that poly(disulfide)s can be folded into helices driven by side-chain hydrogen-bonding self-assembly, resulting in a synthetic helical polymer that can be fully recycled.

The atomic displacements that generate ferroelectricity in materials commonly fit a double-well potential energy surface. Here, ferroelectricity in two-dimensional CuInP₂S₆ is shown to fit a quadruple well due to the van der Waals gap between layers of this material.

Terahertz microspectroscopic imaging at subgap millielectronvolt energies of a two-dimensional superfluid plasmon in few-layer Bi₂Sr₂CaCu₂O_8+x is demonstrated, allowing the spatial resolution of its deeply subdiffractive terahertz electrodynamics.

89ZED88082A is a zirconium-89-labeled one-armed anti-CD8α antibody for the non-invasive whole-body visualization of CD8 + T-cells by positron emission tomography (PET). Here the authors report the results of a phase 2 study of 89ZED88082A for whole-body CD8 + T-cell PET imaging in patients with large B-cell lymphoma before and during CD19-directed CAR T-cell therapy.

Hahn et al. use a diverse clinical cohort to test for associations of clinical variables with SARS-CoV-2 kinetics. They find minimal associations with known clinical variables but do find that different viral strains are associated with different viral kinetics.

Single-crystal 2D metals are stabilized at the interface between epitaxial graphene and silicon carbide, with strong internal gradients in bonding character. The confined 2D metals demonstrate compelling superconducting properties.

Global Burden of Disease estimates show that between 1990 and 2023, the prevalence and burden of drug use disorders, inclusive of amphetamine, cannabis, cocaine and opioid use, have been increasing in high-income countries, particularly in the USA.

In this Consensus Statement, Iasiello et al. outline key dimensions of positive mental health and propose a taxonomy to standardize concepts across disciplines, strengthening measurement, intervention design and policy development.

Ultrathin and flat crystals of bismuth are grown between the atomically flat layers of a van der Waals material. These crystals exhibit outstanding electronic properties, including gate-tunable quantum oscillations of the magnetoresistance.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

Van der Waals magnetic materials are composed of atomically thin magnetically ordered layers stacked together. Here, aiming to control magnetism locally, Klein et al use an electron beam to create small regions where van der Waals layers are orientated perpendicular to the rest of the sample.

The APOE-ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease, but it is not deterministic. Here, the authors show that common genetic variation changes how APOE-ε4 influences cognition.

Revealing the structural features governing ergodicity breaking is critical to understanding glass formation. Here, the authors synthesise a family of hybrid metal halide glasses, and show that the molecular shape and polarity determine rotational disorder, enabling diverse glass-forming abilities.

Rathmell and colleagues show that metabolic reprograming of regulatory T cells is associated with severity of critical illness in patients with and without sepsis.

Homarine is a ubiquitous, phytoplankton-derived metabolite that is broken down by widely distributed and diverse marine bacteria containing a conserved homABCDER operon.

During carrier multiplication, high-energy free carriers in a given material relax by generation of additional electron-hole pairs. Here, the authors report evidence of carrier multiplication in multilayer MoTe₂ and WSe₂ films with up to 99% conversation efficiency.

The authors report an enhancement of the superconducting onset temperature in nanometer-thin YBa₂Cu₃O₇-δ films grown on substrates with nanofaceted surfaces. They theoretically show that the enhancement is mainly driven by electronic nematicity and unidirectional charge density waves, and further suggest that the nanofacets themselves may promote these effects.

The dense desmoplastic stroma and insufficient infiltrating T cells limit effective immunotherapy in pancreatic ductal adenocarcinoma (PDAC). The authors here administer an autologous dendritic cell (DC) vaccine (MesoPher) with an agonistic CD40-specific antibody (mitazalimab) to patients with metastatic PDAC after (m)FOLFIRINOX standard-of-care treatment and find MesoPher/mitazalimab combination therapy is safe and tolerable, accompanied with enhanced systemic and local immune responses.

The orientation of a rotating para-xylene molecule in the nanochannel of a zeolite framework can be visualised by electron microscopy to determine the host–guest van der Waals interaction inside the channel.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Gestational exposure of mice to the obesogen tributyltin alters 3-D chromatin interactions in primordial germ cells leading to stable reduction of hepatic Ide expression and predisposing male descendants to insulin dysregulation and obesity.

This study shows that CrSBr hosts Frenkel-like and Wannier-Mott-like excitons whose distinct spatial character explains their contrasting sensitivity to magnetic order and lattice vibrations, challenging the standard dichotomy in describing excitons.

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

While boreal forest fires in Alaska tend to induce net warming through high fuel consumption and permafrost thaw, those in Canada generally lead to net cooling by increasing snow albedo, according to a multi-data analysis over 2001–2019.

Keratinicyclins are recently discovered glycopeptide antibiotics. Now, the mechanism of action of keratinicyclin B has been uncovered. Keratinicyclin B displays narrow-spectrum inhibitory activity against Clostridioides difficile by binding a species-specific wall teichoic acid, disrupting cell wall protein localization and peptidoglycan remodeling.