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Modifying the light-absorbing or catalytic properties of a photocatalyst typically requires tedious preparation, resulting in a lengthy development process. Here, the authors address this limitation by achieving manganese-based low-energy photoredox catalysis through the in-situ assembly of simple Mn salts with inexpensive coordinating chemicals.

Intrauterine adhesions (IUA) are a leading cause of female infertility. Here, authors engineer a Tβ4-releasing ECM hydrogel that mimics decidualization to promote endometrial regeneration as a therapeutic strategy for treatment of IUA.

Metal-cation-free CO₂ electroreduction in strong acid minimizes reactant loss and salt precipitation yet struggles with CO₂ activation and hydrogen evolution competition. Here, the authors report bioinspired sharp gold triangles with a proton-blocking layer that polarize CO₂ and suppress hydrogen evolution.

Psychological stress-mediated dysregulation of catecholamine signalling rewires the hepatic kynurenine pathway, which in turn impairs liver CD8⁺ T cell function and promotes liver cancer progression.

A non-coplanar axially chiral molecular contact favours the crystalline growth of perovskite film and improves interfacial stability in perovskite solar cells. Small-area devices yield a certified power conversion efficiency of 26.44% and maintain 98% of it after 2,000 hours of operation.

The genetic basis underlying resistance to Sclerotinia stem rot (SSR) in oilseed rape remains elusive. Here, the authors identify BnaA07.MKK9 as a pivotal regulator of SSR resistance in oilseed rape by GWAS, providing new insights into plant defense mechanisms against necrotrophic pathogens.

LncRNA P4HA2-AS1 drives renal fibrosis by stabilizing TRIM32 to promote K63-linked ubiquitination of ULK1.

Here the authors present NCATS-SM0225, a small molecule that inhibits ERAD and selectively kills cancer cells by binding VDACs, disrupting calcium homeostasis, and triggering the PERK-STIM1 pathway to degrade ERAD regulators.

The regulation of ferroelectric photovoltaic properties has been challenging. Here, authors substitute the p-site of cations with halogen for tuning distortion degree of inorganic layer and electric dipole moment of aromatic spacer, achieving ferroelectric anomalous photovoltaic effect of 38.2 V.

Chromosome-level genome assemblies of migratory and desert locusts, coupled with epigenomic profiling of migratory locusts, reveal chromatin dynamics underlying polyphenism and X-linked dosage compensation following autosomal gene translocation.

How did amphibious plants evolve the convergent strategy to escape submergence by fast shoot elongation? Yang et al. reveal the pivotal role of a cis-regulatory element in the PHYA promoter in promoting submergence-induced plastic growth of amphibious plants.

As single-cell datasets scale to millions of cells, analyzing cell-cell communication becomes computationally challenging. Here, authors present FastCCC, a fast, permutation-free framework that enables scalable CCC analysis and provides a comprehensive human CCC reference panel.

SARS-CoV-2 continues to evolve, necessitating updated vaccines and therapeutics. Here the authors identify three broadly binding antibodies from vaccinated or infected individuals, characterize their conserved non-overlapping RBD epitopes by structural analysis and demonstrate protective effects in a hamster model.

Vertical transistors based on 2D semiconductors have the potential to reduce the footprint of electronic circuits, but their high-density integration remains challenging. Here, the authors report a vertical lamination approach for realizing high-density MoS₂ vertical sidewall transistors.

The discovery of chemosynthesis-based benthic communities at depths of 5,800 m to 9,533 m in the Kuril–Kamchatka and western Aleutian trenches challenges traditional perspectives on the energy sources sustaining hadal fauna.

Molybdenum disulfide vertical transistors with channel lengths down to one atomic layer can be made with metal electrodes using a mechanical van der Waals transfer process that leads to a high-quality metal–semiconductor interface.

Here, the authors report a linear antimicrobial peptide (AMP) that exhibits antimicrobial activity in vitro and in a murine model of bacterial pneumonia and is able to alleviate bacterial resistance and restore antibiotic sensitivity.

Wild relatives of wheat provide a valuable source of genes and allelic variants for wheat improvement. Here, the authors identify a type-B response regulator (RR) AcRR1 from Agropyron cristatum and show its potential of boosting wheat yield by increasing the grain number per spike and promoting early heading.

Achieving versatile, tunable, real-time topological photonic system is challenging. Now this is accomplished by designing superlattices of WS₂ and a polymer embedded in a microcavity.

Vascular calcification, a key risk factor of cardiovascular diseases, involves smooth muscle cells shifting to osteogenic phenotype. Here, the authors show that NEXN inhibits this process and protects against calcification by stabilizing SERCA2.

The authors develop a molecular dopant to avoid the dimerization of the electron-selective material phenyl-C₆₁-butyric acid methyl ester, resulting in enhanced stability and efficiency in inverted perovskite solar cells.

An endohedral metallofullerene–polymer layer, which features ultrafast electron extraction and in situ encapsulation, improves the efficiency and stability of perovskite solar cells.

Net CO₂ budget by chemical weathering in the Tibetan Plateau is long-debated. Here, river geochemistry is used to quantify significant sulfuric acid disturbance on the net weathering CO₂ budget.

Gene implication methods (GIMs) are crucial tools for analyzing genome-wide association studies, but are often ambiguous. We present the LocusCompare2 platform to incorporate six popular GIMs and hundreds of quantitative trait loci datasets, enabling validation across several GIMs and window settings to improve accuracy and reproducibility.

Although Bernal stacked trilayer graphene is believed to be the stable packing type, at temperatures below 1,000 °C the transformation from rhombohedral packing does not occur. Zhang et al.show that rhombohedral stacking can be converted to Bernal type by evaporating triazine onto graphene at 150 °C.

CRISPR-Cas12e systems exhibit robust genome editing capabilities, yet their phylogenetic diversity remains underexplored. Here, authors elucidate the biochemical diversity and structural variations of newly identified Cas12e proteins, offering critical insights into structure-activity relationships.

Gasdermin E (GSDME) is abundantly expressed, but its physiological function remains unclear. Here, the authors show a non-pyroptotic function of GSDME in limiting renal inflammation during cisplatin nephrotoxicity by regulating O-GlcNAcylation and STAT3-S100A7A-RAGE signaling.

Materials with opposite signs of permittivity along the two orthogonal directions can support hyperbolic polaritons. Here, the authors demonstrate tunable broadband near-infrared hyperbolic plasmon polaritons in MoOCl₂.

Chen et al. report a lattice-matched molecule, tris(4-methoxyphenyl) phosphine oxide, to anchor multi-site defects and stabilise the lattice of perovskite quantum dots, enabling deep-red LEDs with efficiency up to 26.91% at 693 nm. The air-processed devices can still maintain an efficiency of 26.28%.

Weakly space-confined, large-grained crystals of all-inorganic perovskite were used to fabricate light-emitting diodes with a high external quantum efficiency and operational stability.

Ionic or molecular transport in conventional polymeric membranes often suffers from a trade-off between permeability and selectivity. The authors report on an interfacial polymer cross-linking strategy to produce a robust, permeable and selective 3-µm-thick ultrathin polymeric membrane containing quasi-ordered reticular cross-linking structures.

The SsCm1 effector of the pathogenic fungus Sclerotinia sclerotiorum, despite the lack of canonical chorismate mutase activity, inhibits chloroplast immunity and alleviates photoinhibition in host cells via stabilizing chloroplast protein MORF2.

Genomic analyses of 2,191 global common wheat accessions and over 47,000 yellow rust (YR) response data points across several environments and pathogen races provide a genome-wide landscape of YR resistance genes and effective alleles.