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In patients with hypopharyngeal squamous cell carcinoma (HPSCC), resistance to the standard-of-care induction chemotherapy often occurs. Here, using longitudinal single-cell transcriptomic profiling of HPSCC samples from patients receiving induction chemotherapy, the authors identify a ZNF683-high natural killer (NK) cell population as a predictor of chemotherapy response.

Controllable and scalable phase transition of transition metal chalcogenides is challenging. Using in situ microscopic analysis, a non-stoichiometric phase transition from PdTe₂ to PdTe is observed on the atomic scale, providing mechanistic insights into the scalable phase engineering of transition metal chalcogenide films and heterostructures.

Ultra-low-temperature magnetic refrigeration is strongly dependent on the performances of refrigerants. Here the authors provide a frustrated magnet Gd₂B₂MoO₉ with excellent magnetocaloric performances and a minimum temperature of 0.16 K is achieved.

The authors reveal that the ferroelectric to antiferroelectric phase transition in Pb(Zr_0.97Ti_0.03)O₃-1wt%Nb₂O₅ at low temperatures is an irreversible process exhibiting relaxation behavior and diffusional kinetics.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

A model, trained to generate synthetic, patient-specific angiography images, reduced radiation exposure to patients and clinicians by two-thirds in a multicenter randomized controlled trial involving 1,068 patients.

The structure of transthyretin fibrils from skin of a living patient with a rare F64S mutation is determined. This structure reveals a conserved fold observed in other genetic variants and tissues, supporting skin biopsy as a non-invasive diagnostic tool.

Targeted multielement substitution of a lead-free relaxor ferroelectric perovskite distorts the lattice structure and induces strong polar disorder, leading to high-polar-entropy ferroelectric oxides with a high electrocaloric effect and long lifetime.

Fe-cyclopentadienone complexes have been widely utilized in various hydrogenation and dehydrogenation catalytic processes, yet their applications have largely been restricted to non-asymmetric versions. Herein, the authors report the synthesis of a chiral Fe- cyclopentadienone complex and its application in the catalytic asymmetric hydrogenation of acylsilanes.

Designing two-dimensional membranes to achieve tailored channels while ensuring stability remains challenging. Here, the authors use multifunctional intercalants to create stable, selective subnanochannels in MoS₂ membranes, demonstrating their potential in wastewater treatment.

AIaided diagnosis is an exciting area of cancer research, however, large scale training is limited by the availability of imaging datasets. Here, the authors develop FreeTumor as a generative AI framework to develop realistic tumor images for clinical application.

Uranium recovery from spent nuclear fuel reprocessing in ultra-acidic and radiation-intensive environments is challenging. Here, we present a pyrophosphate-g-C₃N₄ polymer with high resistance to HNO₃ and radiation, achieving a uranium adsorption capacity of 75.3 mg g⁻¹ and 79.1% recovery efficiency.

Despite pressure to improve the circularity of polysulfone plastic waste, upcycling polysulfones remains technically challenging. This study presents a photocatalytic method that can upcycle various polysulfones into valuable chemicals at ambient conditions.

The authors report diode-like resistance in a non-magnetic topological insulator in the quantum Hall regime.

Authors demonstrate a strategy to reduce power loss in FeSiAl-based soft magnetic composites by coating the particles with SnO and subsequently substituting Sn for Al via annealing to form an Al₂O₃ insulating layer. This achieves reduced power loss with stable permeability for high-frequency applications.

The introduction of chiral sulfur(VI) into polyaromatic hydrocarbons has been a formidable challenge due to the intricate enantioselective discrimination and embedded linkages with the heteroatoms in the polyaromatic systems. Herein, the authors report an enantioselective palladium-catalyzed desymmetrization of diaryl sulfoximines and sulfondiimines to access chiral SVI=N-doped heterocycles in high yields and enantioselectivities.

The crystallisation of semiconducting polymers is hindered by their rigid conjugated structures and π-π stacking, reducing their electrical performance. Here, the authors use a low-temperature plasma-driven evaporation process to prepare high crystallinity poly(aniline) films, leading to high Seebeck coefficient and power factor.

Here, Zhang et al. succeed in creating a heavily distorted oxygen deficient film of lanthanum cobaltite. The new phase of LaCoO_2.5 has several unique properties, most notably, a Curie temperature of 284 K, significantly larger than the films from which it was derived.

The topological surface states usually appear in pairs in a topological insulator, with one on the top surface and the other on the bottom surface. Here, Zhang et al. utilize Co cluster to induce a Zeeman gap on one surface through antiferromagnetic exchange coupling, and observe a quasi-half-integer plateau, suggesting the parity anomaly of Dirac fermions.

In a prespecified interim analysis of the randomized, double-blind phase 3 COMPASSION-15 trial, patients with advanced HER2-negative gastric/GEJ cancer treated with the anti-PD-L1/CTLA-4 bispecific Ab cadonilimab plus chemotherapy showed significantly improved overall survival compared with patients treated with placebo plus chemotherapy as first-line treatment.

Here, in a study of over 6,000 women across China, the authors show that Mycoplasma hominis infection strongly influences vaginal microbiota and is linked to higher risk of cervical lesions, highlighting its importance in women’s reproductive health.

Regulatory T (Treg) cells are important modulators of the tumor microenvironment. Here the authors perform transcriptome profiling of immune cells from patients with renal clear cell carcinoma to find a Treg signature that correlates with poorer prognosis, with CD177 being implicated as the main mediator for related alterations in Treg activity and tumor outcome.

Conventional silicon-based transistors, which sit at the heart of every computer, are fast approaching the limit of miniaturisation. Here, Meng et al demonstrate a field-effect transistor composed of a single rutheniumdiarylethene molecule with large on/off ratio.

Conventional solid-state electrolyte design is limited by dopant–lattice compatibility. This work introduces solid dissociation, using halide van der Waals materials to dissolve salts and create amorphous conductors with high ionic conductivity and potential for use in devices.

CO₂ hydrogenation on Cu/Al₂O₃ is limited by low activity. Herein, high-velocity gas collisions create transient distorted Cu sites, tripling CO₂ conversion, boosting methanol selectivity to 95 % and increasing the space-time-yield six times.

The SEED study is a phase 3 clinical trial demonstrating a beneficial effect on glycemic control of dorzagliatin, a glucokinase activator, in drug-naive patients with newly diagnosed type 2 diabetes.

Impedance mismatch between acoustic metamaterials and a surrounding medium hinders efficient applications, especially for zero-index materials. Here, Duboiset al. utilize the Dirac-like dispersion in a double-zero-index material to overcome this problem and to collimate sound.

Nie et al. report a multi-site binding ligand to suppress the formation of defects and increase the structural and water stability of perovskites. Solar cells fabricated fully in air achieves an efficiency of 25.03% and retain 98.98% of the performance after aging in air for 1,584 h without encapsulation.

Individual zinc oxide nanoparticles are shown to be intrinsically ferromagnetic when they are doped with cobalt, which should prove useful in spintronics and other applications.

Stable, dissipative optomechanical solitons are realized using optical fields in a whispering gallery mode resonator by balancing the optomechanical nonlinearities with a tailored modal dispersion.

High-voltage sodium solid-state batteries often suffer from capacity loss due to harmful internal reactions. By adding a uniform protective layer to the cathode, this study greatly improves their stability—retaining 77.9% capacity after 1,500 cycles—and shows promise for developing longer-lasting, high-energy batteries.

Hydroformylation of 1,2-disubstituted alkenes usually occurs at the α position of the directing heteroatom. Here, the authors report the asymmetric rhodium-catalyzed hydroformylation of 1,2-disubstituted alkenylsilanes with excellent regioselectivity at the β position (relative to the silicon heteroatom) and enantioselectivity.

Clinical diagnosis of temporomandibular joint (TMJ) disorders is complex and requires evaluation by a qualified physician. Here, Yan et al. develop a hydrogel electronic sensor to detect TMJ movement, able to accurately detect and classify disc displacement with reduction, a common TMJ disorder.

Geospatial estimates of the prevalence of anemia in women of reproductive age across 82 low-income and middle-income countries reveals considerable heterogeneity and inequality at national and subnational levels, with few countries on track to meet the WHO Global Nutrition Targets by 2030.

Evolution of accretion disk and corona during outbursts in black hole binary systems is still unclear. Here, the authors show spectral analysis of MAXI J1820+070 and propose a scenario of a dynamical corona to explain the evolution of the reflection fraction observed by Insight-HXMT.

A graph-based pan-genome constructed from 30 genome assemblies covering Malus domestica ‘Golden Delicious’ and 29 wild diploid or polyploid Malus species highlights structural variation and genome evolution in the Malus genus.

Noble metallic subnanometre clusters exhibit superior catalytic activities, but their stability remains a problem. Zhang et al. report that single niobium atoms can be stabilized in graphitic layers and the resulting carbide complex exhibits higher activity compared with commercial platinum nanoclusters.

Structures of human cholecystokinin receptors in complex with various ligands or G-proteins reveal how different ligand types are recognized and the basis of peptide selectivity in this receptor family, and suggest a stepwise activation mechanism.

Effectiveness of the hepatitis E vaccine HEV 239 amongst high-risk groups isn’t well studied. Here, Zhuang et al. analyse a decade of surveillance data (2007–2017) from Dongtai, China, and estimate HEV 239 effectiveness of 72% amongst hepatitis B virus infected people.

Available intrinsic magnetic topological insulators are rare. Here, the authors study the electronic and magnetic properties of Mn(Sb_xBi_(1-x))₂Te₄ bulks and thin flakes, revealing intrinsic magnetic topological insulator phase in the phase diagram.

Zhao et al. report bilateral Geiger mode avalanche in 2D graphene/InSe/Cr asymmetrical Schottky junction. The asymmetrical Schottky junction benefits to initiate impact ionization and multiplication for the injected majority carriers, leading to a multiplication factor up to 10 ^ 7 and a breakdown voltage of 1.4 V.