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This work reports the discovery of a giant in-plane Hall effect in a nonmagnetic half Heusler compound, demonstrating magneto-cubic behavior over a wide temperature range and identifying extrinsic mechanisms as the dominant origin.

Maternal obesity is known to cause systemic lipid dysregulation, yet its effect on lipid reprogramming during the maternal-to-zygotic transition (MZT) remains unknown. Here, they show that obesity disrupts very-long-chain fatty acids (VLCFAs) storage in oocytes, impairing peroxisomal protein import in 2-cell embryos.

Wolbachia-driven host miRNAs influence reproduction in the spider mite Tetranychus truncatus, with effects associated with Wolbachia density.

Survival requires prioritizing threats over pain. The authors identify a brain circuit in male mice, where fear signals from the cortex block pain-associated activation in the thalamus, revealing how fear suppresses pain and offering a potential target for therapies.

Multi-trait genetic analysis in East Asians identifies a novel gastric cancer risk locus shared with cardiovascular traits and shows that this variant modulates regulation of nearby genes, including VEZT, with functional effects on gastric cancer cell behaviour.

The authors propose a new mechanism for non-reciprocal magneto-transport that results from the cooperative action of skew scattering and Lorentz force and does not require spin-orbit coupling. The mechanism is strongly enhanced by topological band features near the Fermi level and is expected to dominate in highly-conductive systems.

Authors show that mapping waterbird activity entropy has the potential for identifying hotspots of avian influenza risk. The framework reveals substantial surveillance gaps, particularly across sub-Saharan Africa.

Identifying and classifying chiral phonons has been challenging, limiting their use in quantum and thermal technologies. Now, a symmetry-based framework and database describe phonon chirality across space groups and reveal promising material candidates.

Copper iodide clusters, known for their exceptional X-ray luminescence and low toxicity, face challenges in stability and radiation hardness, limiting their practical applications. Here, the authors introduce a non-conjugated bridging macrocyclic ligand with aggregation-induced emission properties to enhance the radiation hardness of a copper iodine cluster framework, achieving high-performance X-ray imaging and offering a strategy for scintillator development.

LHAASO has detected γ-ray emission with a spectrum extending to 2 PeV from the pulsar wind nebula (PWN) powered by PSR J1849-0001, indicating an extreme particle acceleration efficiency and challenging the current particle acceleration theories.

Farnesyl pyrophosphate—a mevalonate pathway metabolic intermediate—is an endogenous alarmin that enhances IgG antibody responses through keratinocyte-derived IL-6 and CCL20.

Euglenophytes evolved via secondary endosymbiosis, exemplifying plastid evolution. Here, the authors solve Euglena gracilis’ photosystem I structure, revealing specific protein organizations and structural features for far-red light absorption. This work informs the engineering of photosystem.

HorusEye is a foundation model for universal X-ray tomography restoration that learns realistic degradation directly from data. It supports imaging at substantially lower doses and reduces hardware requirements while improving expert analysis and downstream AI performance.

Labdane derived hapmnioide-type diterpenoids, which have been identified as chemical markers for Haplomitrium liverwort, show potent anti-inflammatory and allelopathic activities. Here, the authors report the total synthesis of seven typical Haplomitrium diterpenoids through late-stage biomimetic skeletal reorganization.

TRIP6 phosphorylation triggers a signalling cascade that promotes glycolysis in KRAS-mutant colorectal cancer cells. The resulting lactate accumulation drives extracellular lactylation of CD44 on CD8⁺ T cells, thereby compromising their anti-tumour activity.

Zhang, Han, Tan, Lu, Ma et al. report that kynurenine derived from peritumoural adipose tissue is hijacked by cancer cells to mediate ferroptosis resistance, a process that could potentially be targeted with immunotherapy to inhibit tumour growth.

Fibre integrated circuits created by first preparing circuitry on extremely thin and flexible substrates and then mechanically rolling them up demonstrate microdevice density reaching 100,000 transistors per centimetre and excellent stability under harsh service conditions.

In vivo base editing of a causative mutation that leads to the neurodevelopmental disorder Snijders Blok–Campeau syndrome restores protein dosage and ameliorates molecular and behavioural deficits in a humanized mouse model of the condition.

Robotic grippers struggle to handle fragile and varied objects across environments. Here, the authors introduce a liquid metal gripper that adapts its shape and stiffness for gentle, multiscale grasping and active release.

Exemplified by Bi_0.4Sb_1.6Te₃, the authors reveal the reason for low thermal conductivity induced by compositional inhomogeneity lies in randomly aligned edge dislocations induced by random composition distribution.

Wolbachia affects host reproduction and nutrition, but the underlying mechanisms are unclear. This study suggests Wolbachia enhances ovarian development in Laodelphax striatellus via riboflavin synthesis, driving ATP production and ovarian maturation.

The ophthalmic video foundation model learns the spatiotemporal motion features of ophthalmic procedures, improving surgical performance in cataract surgeries on wet-lab porcine eyes in real time.

Aerogel fibers face intrinsic trade-offs between mechanical robustness and thermal insulation. Here, the authors report ion-mediated, attenuated Coulombic assembly of recyclable heterocyclic aramid nanofibers to programmatically control hierarchical pore structure achieving high tensile strength and ultralow thermal conductivity.

In a prospective observational study, symptoms of anxiety and/or depression were associated with worse response to first-line treatment with immunotherapy in patients with advanced non-small-cell lung cancer.

The extreme hot and dry conditions of 2023 reduced soil respiration and enhanced net forest carbon sequestration in Canada, offsetting wildfire emissions, according to satellite-based and in situ observations of CO₂ fluxes.

This study identifies GCN5, a histone acetyltransferase, as a driver of metabolic dysfunction-associated steatotic liver disease progression via LXRα/SREBP1c-mediated lipogenesis, and demonstrates that pharmacological inhibition of GCN5 alleviates disease in a study with male mice.

The functionalization of carbon–carbon bonds in amines remains an important challenge in organic synthesis. Now a borane-catalysed method has been developed that enables the insertion of alkynes into the alkyl C–C bonds of amines, providing a versatile approach for the ring expansion of cyclic amines and chain elongation of acyclic amines.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

It remains unclear whether and how endometrial dysfunction leads to infertility in polycystic ovary syndrome (PCOS), independent of the ovary. Here, the authors show that elevated ERα and histone lactylation impair endometrial receptivity in PCOS and serve as potential therapeutic targets.

Bronchiectasis and asthma can co-exist in the same patient, and the characteristics may be different from bronchiectasis alone. Here the authors characterise the function of ILC3 cells and how IL-17C potentiates IL-17A expression promoting a neutrophil dominated asthma endotype in mouse bronchiectasis-asthma models.

Minimally invasive oral vaccine delivery is a desired approach. Here, the authors report on an engineered probiotic-based oral vaccine system that enables controlled mucosal delivery of ferritin-displayed dual antigens, eliciting robust mucosal and systemic antitumor immune responses.

The authors conducted a genome-wide association study of bipolar disorder (BD) in Han Chinese and integrated PGC4 East Asian and European datasets, discovering 23 novel loci, prioritizing 39 credible risk genes and implicating BD-related cell types and druggable targets.