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Ferroptotic propagation aggravates kidney ischemia-reperfusion injury and causes delayed graft function. Here, the authors show that inhibiting lactate shuttle and AARS1-mediated NPM1 lactylation protects graft function by blocking ferroptotic waves.

Shape-changing substrates are pivotal for advancing minimally invasive, conformable bioelectronics, yet their implantation is hindered by inaccessible triggering mechanisms and complex geometric fabrication. Here, the authors report a digital 4D printing technique for fabricating customized shape memory hydrogel substrates enabling trigger-free shapeshifting with predefined onset periods.

β-thalassemia mutations show striking population differences, but their evolutionary origins are unclear. Here, the authors trace multiple independent origins of common β-thalassemia mutations in southern China, shaped by agricultural expansion, migration, and local selection.

Realizing robust ferromagnetic order in two dimensions is challenging as an underlying crystalline framework is normally required. Now room-temperature ferromagnetism is demonstrated in a two-dimensional honeycomb self-assembly of confined molecules.

This study identifies four distinct polycystic ovary syndrome (PCOS) subtypes using unsupervised clustering analysis on data from 11,908 women and validated across five diverse cohorts. The subtypes show unique clinical features and suggest that subtype-specific management could enhance treatment precision for PCOS.

High-fidelity personalized anatomical models can offer invaluable support for precision medicine. Here, the authors show the 3D printing of self-healing liver models, which can be resected in a trial and-error manner for surgical training to enhance the safety of hepatic surgery.

Constructing ultraviolet lasing is of great significance for basic research and medical use. Here the authors present a strategy for generating ultraviolet lasing through a tandem upconversion process with ultralarge anti-Stokes shift (1260 nm).

Identifying intermediates during phase transitions is critical for our understanding of correlated materials, but difficult to achieve experimentally. Here, the authors report a surface coordination route to stabilize and directly image a phase-transition intermediate during the metal-insulator transition in vanadium dioxide.

Limited improvement of systemic therapy has been achieved in first line treatment for advanced Biliary tract cancer (BTC). In this randomized phase 2 trial on BTC, the combination of sintilimab, anlotinib, and gemcitabine/cisplatin demonstrated an improvement in progression - free survival (PFS) and objective response rate (ORR) while reducing the risk of disease progression compared to chemotherapy monotherapy.

Here, the authors control concentration quenching in a stoichiometric Er3+ compound using a core−shell nanostructured host and an integrated optical waveguide circuit excitation platform. The efficient telecom to ultraviolet upconversion allows for exploration of photonic applications involving upconversion nanomaterials.

Zhu, Fu, Zhu, Li and colleagues found that the key DNA repair enzyme poly(ADP-ribose) polymerase 1 promotes transcriptional restart after DNA damage through PARylating and stabilizing AFF1 by preventing its ubiquitylation by the E3 ligase Siah1.

This randomized trial assessed the effectiveness and safety of single blastocyst transfer vs single cleavage-stage embryo transfer among women with good prognosis. Here, the authors show improved cumulative live birth rates and relatively unfavorable perinatal outcomes after blastocyst transfer.

Spirocycles are traditionally difficult structures to synthesize due to the congested nature of the central atom. Here the authors show a method to synthesize quaternary carbon spirocycles in one step from 1,3-enynes and pyrazolidine-type heterocycles, both relatively unactivated structures, proceeding via palladium catalysis.

The mechanism of HIV-1 latency reversal remains unclear. The authors suggest that PRMT3 drives the reversal by enhancing chromatin accessibility to form a transcriptional hub containing TEAD4 and P-TEFb at the viral promoter.

Here, the authors present scRICA-seq, which is capable of profiling isoforms and chromatin accessibility for up to 10,000 single cells in a single run. By applying this method to human retinal organoids, they construct a multi-omic cell atlas.

The development and deployment of clean technologies requires high-precision sensing, which quantum sensors can provide. This Review explores the development of quantum sensing technologies for emerging energy generation, transmission and storage applications.

Enantiodivergent methods, which to access both enantiomers of the same compound, are of importance in drug synthesis. Here, the authors show that by simply changing a NiBu- to a NMe-group in readily available amine organocatalysts, high stereocontrol and broad scope are achieved in eight asymmetric reactions.

The burden of herpes simplex virus (HSV) infection is exacerbated due to the emergence of antiviral drug resistance and a lack of effective antibodies. Here the authors construct a bispecific nanobody that blocks receptor binding and prevents gD-gH/gL interaction, and show that it protects against HSV-1 and HSV-2 infection in mice.

Fu et al. describe a pathogen effector, HaRxL10 that suppresses plant immunity and interferes with plant development by hijacking the clock component CHE to perturb its function in transcriptional regulation.

Polysulfide-air redox flow batteries are an appealing energy storage technology but suffer from polysulfide crossover and the use of costly catalysts. Here, the authors report a cell structure that enables battery operation using a cost-effective catalyst while mitigating polysulfide crossover.

Simultaneous inhibition of LSD1 and GSK3 kinase promotes cell differentiation, providing a therapeutic strategy for treating acute myeloid leukaemia.

Urate oxidase (Uox) lost its function during evolution. Here the authors propose an atavistic strategy to treat hyperuricemia by using a proprietary lipid nanoparticle to load Uox mRNA, which reduced the serum uric acid levels effectively in two animal models.

The development of the fruiting body (perithecium) in ascomycete fungi involves sexual differentiation processes. Here, the authors show that a non-pheromone receptor, Gip1, regulates two early stages of sexual differentiation in the wheat scab fungus Fusarium graminearum by activating cAMP signaling and Gpmk1 pathways.

Ionic-junction devices are difficult to integrate with fiber-shaped tissues like nerves and muscles for applications in implantable bioelectronics due to their large size and bulk structure. Authors realize here easy to implant fiber-shaped iontronics through an integrated opposite charge grafting process, enabling the construction of ionic logic gates and artificial neural pathways.

A high-quality genome assembly of pea cultivar ZW6 and pan-genome analyses provide insights into pea genome evolution and domestication as well as genomic resources for pea improvement.

Differences in timescales of electron transfer reactions limit the efficiency of electrochemiluminescence. Here, the authors coordinate the timescales using shallow trap states in carbon nitride to achieve high efficiencies applied in nitrite sensing.

Dysregulation of mitochondrial reactive oxygen species (mtROS) contributes to intestinal tumorigenesis. Here the authors report that excessive mtROS induces the release of mitochondrial PGAM5 into cytoplasm and subsequent dephosphorylation of MST3 kinase, promoting colorectal cancer progression.

ctDNA is a promising method to monitor tumor burden in triple negative breast cancer. Here, the authors show that ctDNA detection correlated with prognosis after neoadjuvant chemotherapy but not at baseline.

Allelopathy—the chemical competition between neighbouring plants—has been observed for centuries. This study identifies a sensor of phenolic allelochemicals and reveals translational control as a key mechanism.