Nature Search

Neuroprotective potential of eugenol against acrylamide-induced brain toxicity by regulating Nrf2/NQO1/HO-1 and NLRP3/NF-κB/IL-1β signaling cascades

Sara M. Baraka
Yosra A. Hussien
Dalia O. Saleh
ResearchOpen Access23 Jan 2026
Scientific Reports

Volume: 16, P: 1-16
A HO-1 gene knockout using a NanoCRISPR scaffold suppresses metastasis in mouse models

A gene-editing-based nanoplatform for knockout of HO-1 in tumours is combined with photodynamic therapy, triggering immunogenic cell death.

Ning Wang
Zichao Luo
Changyang Gong
Research22 Oct 2025
Nature Biomedical Engineering

P: 1-17
Systemic engineering and global regulation enabling high-level bilirubin biosynthesis

The large-scale production of bilirubin has long been a challenge. Here, the authors engineered an in vitro enzymatic cascade through systems-level design, enabling gram-scale synthesis of bilirubin.

Zhentao Jiang
Jingxin Rao
Rongzhen Zhang
ResearchOpen Access23 Dec 2025
Nature Communications

Volume: 17, P: 1-14
Nature of the Photoreactivable Ultra-Violet Lesion in Deoxyribonucleic Acid

JANE K. SETLOW
RICHARD B. SETLOW
Research09 Feb 1963
Nature

Volume: 197, P: 560-562
Preparation and characterization of holmium doped ZIF-8 nanocrystals for white light emitting phosphors

Mariam Sh. Gohr
Hanan Ali
Alaa E. Giba
ResearchOpen Access30 Jan 2026
Scientific Reports

Volume: 16, P: 1-12
Absence of a spin-signature from a single Ho adatom as probed by spin-sensitive tunneling

Magnetic stability of holmium atoms on a platinum(111) surface has recently been reported, raising prospects for atomic-scale spintronics, however contradictory results have since emerged. Here, Steinbrecher et al.find evidence for an invisibility of the holmium spin to scanning tunnelling spectroscopy techniques which challenges recent results.

M. Steinbrecher
A. Sonntag
A. A. Khajetoorians
ResearchOpen Access03 Feb 2016
Nature Communications

Volume: 7, P: 1-6
CFAP20 salvages arrested RNAPII from the path of co-directional replisomes

CFAP20 has a key role in rescuing RNA polymerase II complexes that have arrested during DNA transcription, limiting the accumulation of R-loops and preventing collisions between the transcription and replication machinery.

Sidrit Uruci
Daphne E. C. Boer
Martijn S. Luijsterburg
ResearchOpen Access14 Jan 2026
Nature

P: 1-10
Thrombospondin 1 and 2 regulate mesenchymal progenitor cell fate and matrix organization

Madysen K. Hunter
Sneha Korlakunta
Benjamin Levi
ResearchOpen Access19 Jan 2026
Bone Research

Volume: 14, P: 1-11
Vitisin A inhibits liver fibrosis by promoting Nrf2/HO-1 pathway and inhibiting Cuproptosis

Siwen Ding
Dishuang Hu
Liankui Wang
ResearchOpen Access19 Dec 2025
Scientific Reports

Volume: 15, P: 1-10
Isoprene chemistry under upper-tropospheric conditions

Experiments under upper-tropospheric conditions map the chemical formation of isoprene oxygenated organic molecules (important molecules for new particle formation) and reveal that relative radical ratios control their composition

Douglas M. Russell
Felix Kunkler
Joachim Curtius
ResearchOpen Access29 Sept 2025
Nature Communications

Volume: 16, P: 1-14
Nature of Electron Equilibrium in Heterogeneous Solids and the Proposed Electron Energy Distribution in Degenerate p-n Junctions

M. A. MELEHY
Research01 Jan 1965
Nature

Volume: 205, P: 456-464
Nature of the Unreactive Sulphydryl Groups in Human Haemoglobin

R. CECIL
M. A. W. THOMAS
Research26 Jun 1965
Nature

Volume: 206, P: 1317-1320
Heme reduces corpus cavernosum smooth muscle contraction via the HO-CO-sGC-cGMP pathway: implications for priapism in sickle cell disease

Dalila Andrade Pereira
Tammyris Helena Rebecchi Silveira
Fábio Henrique Silva
Research25 Sept 2025
International Journal of Impotence Research

P: 1-7
Machine-learning-guided tungsten single atoms promote oxyhydroxides for noble-metal-free water electrolysis

Sustainable hydrogen production requires efficient oxygen evolution catalysts. Here, the authors identify non-noble single-atom catalysts via machine learning-assisted computational screening and reveal their active-site mechanisms for high-performance anion exchange membrane water electrolysis.

Jaehyun Kim
Ik Seon Kwon
Ho Won Jang
ResearchOpen Access29 Jan 2026
Nature Communications

P: 1-13
Modulation of Nudt21 levels reveals dose-dependent roles of alternative polyadenylation in tissue regeneration

Nudt21-mediated 3′UTR regulation orchestrates tissue regeneration through dose-dependent control of stem cell differentiation and multiprotein complex assembly, revealing alternative polyadenylation as essential for organismal survival.

Nikolaos Tsopoulidis
Masaki Yagi
Konrad Hochedlinger
ResearchOpen Access24 Jan 2026
Nature Communications

P: 1-24
Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Jiyeon Oh
Soeun Kim
Dong Keon Yon
Research06 Jan 2026
Nature Medicine

Volume: 32, P: 197-223
Global burden of amphetamine, cannabis, cocaine and opioid use in 204 countries, 1990–2023: a Global Burden of Disease Study

Global Burden of Disease estimates show that between 1990 and 2023, the prevalence and burden of drug use disorders, inclusive of amphetamine, cannabis, cocaine and opioid use, have been increasing in high-income countries, particularly in the USA.

Jiseung Kang
Hyeon Jin Kim
Dong Keon Yon
Research16 Jan 2026
Nature Medicine

P: 1-18
Using the linear references from the pangenome to discover missing autism variants

Large-effect variants in autism remain elusive. Here, the authors use long-read sequencing to assemble phased genomes for 189 individuals, identifying pathogenic variants in TBL1XR1, MECP2, and SYNGAP1, plus nine candidate structural variants missed by short-read methods.

Yang Sui
Jiadong Lin
Evan E. Eichler
ResearchOpen Access23 Jan 2026
Nature Communications

P: 1-16
Nature and Infectivity of Granular Forms of the Bovine Tubercle Bacillus

E. M. BRIEGER
J. A. R. MILES
R. W. HORNE
Research21 Jul 1951
Nature

Volume: 168, P: 96-98
Evidence for spin selectivity of triplet pairs in superconducting spin valves

Ferromagnets are an integral part of spintronics because of their spin selectivity, but in combination with superconductors selectivity between different Cooper pairs is required. Here, the authors find evidence for this selectivity in a ferromagnet–superconductor–ferromagnet spin valve.

N. Banerjee
C. B. Smiet
J. W. A. Robinson
Research09 Jan 2014
Nature Communications

Volume: 5, P: 1-6
Nature of a Group in Papain Essential to its Activity*

A. K. BALLS
HANS LINEWEAVER
Research16 Sept 1939
Nature

Volume: 144, P: 513
Multicolor cathodoluminescence imaging of single lanthanide nanoparticles

Electron-induced light, cathodoluminescence, enables nanoscale optical analysis across disciplines. Here, the authors achieve multicolor cathodoluminescence imaging of sub-15-nm lanthanide nanoparticles and demonstrate its application for bioimaging.

Sohaib Abdul Rehman
Jeremy B. Conway
Maxim B. Prigozhin
ResearchOpen Access31 Oct 2025
Nature Communications

Volume: 16, P: 1-13
Expression of heme oxygenase-1 can determine cardiac xenograft survival

M.P. Soares
Y. Lin
F.H. Bach
Research01 Sept 1998
Nature Medicine

Volume: 4, P: 1073-1077
Redox-driven ADAR1 activation promotes Okazaki fragment maturation and DNA replication integrity

Chen et al. show that redox signals activate ADAR1 to fix faulty RNA pieces during DNA copying, ensuring smooth replication and protecting genome stability.

Bin Chen
Guangchao Sun
Zhenkun Lou
Research08 Jan 2026
Nature Structural & Molecular Biology

P: 1-11
Rates of reaction of HO₂ with HO and O studied by laser magnetic resonance

J. P. BURROWS
G. W. HARRIS
B. A. THRUSH
Research19 May 1977
Nature

Volume: 267, P: 233-234
A benchmark of expert-level academic questions to assess AI capabilities

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Long Phan
Alice Gatti
Davide Scaramuzza
ResearchOpen Access28 Jan 2026
Nature

Volume: 649, P: 1139-1146
The Yang-tse, the Yellow River, and the Pei-ho

A. WOEIKOF
Research04 Nov 1880
Nature

Volume: 23, P: 9
Dihydroartemisinin ameliorates renal tubulointerstitial fibrosis in diabetic nephropathy via restoring mitochondrial function via HIF-1α/HO-1 pathway

Yuan Yang
Dan Fei
Lingling Qian
ResearchOpen Access30 Sept 2025
Scientific Reports

Volume: 15, P: 1-14
Global functional shifts in trees driven by alien naturalization and native extinction

This study finds that native tree extinctions and alien naturalizations are pushing forests towards fast-growing, resource-demanding species. This global shift could affect carbon storage and ecosystem stability, highlighting the need to protect slow-growing trees.

Wen-Yong Guo
Josep M. Serra-Diaz
Jens-Christian Svenning
Research28 Jan 2026
Nature Plants

P: 1-11
Odoribacter splanchnicus rescues aging-related intestinal P-glycoprotein damage via GDP-L-fucose secretion

Here, with multi-omics analyses of human cohorts and murine models, the authors identify Odoribacter splanchnicus depletion to impair intestinal P-glycoprotein function via loss of microbial, GDP-L-fucose, which in turn promotes eIF4E phosphorylation and c-Jun–driven ABCB1 expression, maintaining xenobiotic efflux.

Cheng Cui
Lu Fang
Dongyang Liu
ResearchOpen Access27 Nov 2025
Nature Communications

Volume: 16, P: 1-17
The protective role of nuclear Heme oxygenase-1 in blood-spinal cord barrier after hypoxia in vitro

Jian Wang
Hui Wang
Tengbo Yu
ResearchOpen Access02 Dec 2025
Scientific Reports

Volume: 16, P: 1-9
Heme oxygenase: A novel target for the modulation of inflammatory response

D. Willis
A.R. Moore
D.A. Willoughby
Research01 Jan 1996
Nature Medicine

Volume: 2, P: 87-90
Targeting local lymphatics to ameliorate heterotopic ossification via FGFR3-BMPR1a pathway

Different types of mesenchymal progenitors participate in ectopic bone formation. Here, the authors show Col2⁺ lineage cells adopt a lymphatic endothelium cell fate, which regulates local inflammatory microenvironment after trauma, thus influencing heterotopic ossification (HO) development via a FGFR3-BMPR1a pathway.

Dali Zhang
Junlan Huang
Yangli Xie
ResearchOpen Access19 Jul 2021
Nature Communications

Volume: 12, P: 1-16
Ephemeral collision complexes mediate chemically termolecular transformations that affect system chemistry

Chemically termolecular reactions — arising from the collision of ephemeral collision complexes with other chemically reactive species — have been neglected in current gas-phase chemical mechanisms of combustion and planetary atmospheres. First-principles calculations reveal that such chemically termolecular reactions constitute major pathways affecting macroscopic observables.

Michael P. Burke
Stephen J. Klippenstein
Research14 Aug 2017
Nature Chemistry

Volume: 9, P: 1078-1082
Garetosmab in fibrodysplasia ossificans progressiva: a randomized, double-blind, placebo-controlled phase 2 trial

In the LUMINA-1 trial for fibrodysplasia ossificans progressiva, garetosmab, an activin A monoclonal antibody, did not lead to significant changes in heterotopic ossification lesion activity in pre-existing lesions in period 1. Garetosmab prevented the formation of new lesions in both periods 1 and 2.

Maja Di Rocco
Eduardo Forleo-Neto
Frederick S. Kaplan
ResearchOpen Access28 Sept 2023
Nature Medicine

Volume: 29, P: 2615-2624
Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes

Wayne W. Hancock
Roland Buelow
Laurence A. Turka
Research01 Dec 1998
Nature Medicine

Volume: 4, P: 1392-1396
Heme catabolism by tumor-associated macrophages controls metastasis formation

Tumor-associated macrophages (TAMs) play multifaceted roles in establishing an immunosuppressive tumor microenvironment. Sica and colleagues find that macrophage-intrinsic complement signaling initiates a pathway leading to the induction of highly tumorigenic TAMs.

Francesca Maria Consonni
Augusto Bleve
Antonio Sica
Research26 Apr 2021
Nature Immunology

Volume: 22, P: 595-606
The Taiwan Precision Medicine Initiative provides a cohort for large-scale studies

The Taiwan Precision Medicine Initiative (TPMI) has built a cohort of more than half a million individuals with Han Chinese ancestry, providing a rich resource of genetic and medical data for this group.

Hsin-Chou Yang
Pui-Yan Kwok
Jer-Yuarn Wu
ResearchOpen Access15 Oct 2025
Nature

Volume: 648, P: 117-127
Natural Selection and the Sex Ratio

A. W. F. EDWARDS
Research10 Dec 1960
Nature

Volume: 188, P: 960-961
Crocin exhibits an antihypertensive effect in a rat model of gestational hypertension and activates the Nrf-2/HO-1 signaling pathway

Xuan Chen
Jingying Huang
Jinghong Rao
Research13 Jan 2021
Hypertension Research

Volume: 44, P: 642-650
Response to Comment on: Heme reduces corpus cavernosum smooth muscle contraction via the HO-CO-sGC-cGMP pathway: implications for priapism in sickle cell disease

Dalila Andrade Pereira
Fábio Henrique Silva
Comments & Opinion17 Dec 2025
International Journal of Impotence Research

P: 1-2
Nature of Prothrombin Biosynthesis : Preprothrombinæmia in Vitamin K-deficiency

H. C. HEMKER
J. J. VELTKAMP
E. A. LOELIGER
Research09 Nov 1963
Nature

Volume: 200, P: 589-590
Nature of the Renal Lesions induced by Intravenous Injection of Carrageenan

J. C. MORARD
A. FRAY
L. ROBERT
Research25 Apr 1964
Nature

Volume: 202, P: 401-402
Natural short-lived halogens exert an indirect cooling effect on climate

Short-lived halogens have a substantial indirect cooling effect on climate and this cooling effect has increased since pre-industrial times owing to anthropogenic amplification of natural halogen emissions.

Alfonso Saiz-Lopez
Rafael P. Fernandez
Jean-François Lamarque
ResearchOpen Access28 Jun 2023
Nature

Volume: 618, P: 967-973
Nature of the Surface of the Moon

J. C. JAEGER
A. F. A. HARPER
Research16 Dec 1950
Nature

Volume: 166, P: 1026
Collective asymmetric synthesis of the Strychnos alkaloids via thiophene S,S-dioxide cycloadditions

Thiophene S,S-dioxides are excellent substrates for cycloaddition reactions, but underused in target-oriented synthesis. Here the authors show how these heterocycles enable the asymmetric synthesis of tricyclic indolines, as well as the collective synthesis of the iconic Strychnos alkaloids. Computational studies rationalize the source of asymmetry and reveal a spontaneous SO₂ extrusion pathway.

Kun Ho ‘Kenny’ Park
Jisook Park
Edward A. Anderson
ResearchOpen Access23 Jan 2026
Nature Chemistry

P: 1-8
Natural variation of YELLOW SEEDLING1 affects photosynthetic acclimation of Arabidopsis thaliana

Natural genetic variation of photosynthesis is an underexplored resource for plant genetic improvement. Here, the authors find allelic variations of YS1 affect Arabidopsis photosynthesis acclimation using genome-wide association study, reverse genetics, and quantitative complementation approaches.

Roxanne van Rooijen
Willem Kruijer
Mark G. M. Aarts
ResearchOpen Access10 Nov 2017
Nature Communications

Volume: 8, P: 1-9
Identification of an allosteric site on the E3 ligase adapter cereblon

An allosteric site on the E3 ligase adapter cereblon can be targeted to modulate the efficacy of cereblon in targeted protein degradation applications.

Vanessa N. Dippon
Zeba Rizvi
Christina M. Woo
Research21 Jan 2026
Nature

P: 1-9
Multi-trait and multi-ancestry genetic analysis of comorbid lung diseases and traits improves genetic discovery and polygenic risk prediction

Multi-trait genome-wide analyses identify variants associated with comorbid lung diseases. Polygenic scores leveraging shared components of heritable risk improve prediction of asthma, chronic obstructive pulmonary disease and lung cancer in a multi-ancestry cohort.

Yixuan He
Wenhan Lu
Alicia R. Martin
Research21 Jan 2026
Nature Genetics

P: 1-10
CD4⁺ T cells mediate CAR-T cell-associated immune-related adverse events after BCMA CAR-T cell therapy

An in-depth analysis of tissue biopsies from patients with multiple myeloma and CAR T cell therapy-associated immune-related adverse events (CirAEs) after treatment with commercial BCMA-targeted CAR T cell therapy shows that CD4⁺ CAR T cells mediate off-tumor toxicities and that high CD4:CD8 ratio at apheresis, robust early CAR T cell expansion, ICANS and ciltacabtagene autoleuce treatment are independently associated with the development of CirAEs.

Matthew Ho
Luca Paruzzo
Joseph A. Fraietta
Research15 Jan 2026
Nature Medicine

P: 1-15

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