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Scholl et al. show that PopZ forms filamentous condensates driven by its helical domain and inhibited by its disordered region. Phase-dependent conformations modulate client interactions and disruption of filamentation or condensation impairs cellular function and growth.

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

Nylon-11 is a common and durable polymer but possess low piezoelectric properties. Here, the authors use mechanical accelerations and strong electric fields to induce crystallization, hydrogen-bonding and dipole alignment in Nylon-11 films, achieving high piezoelectricity.

Mass-wasting deposits that accumulated against mid-ocean ridge faults have high porosity in which calcium carbonate precipitated, storing seawater carbon dioxide, as revealed by cores of a 61-million-year-old seafloor talus deposit.

ALMA has captured exquisitely detailed images of bowshock shells in the outflow of an outbursting protostar. These provide important insights into the variable nature of the ejections from protostars, which play a key role in star and planet formation.

Tan and colleagues present “cycling molecular assemblies” that borrow cellular lipidation machinery to build nanostructures inside the Golgi apparatus. These tools enable rapid organelle imaging and selective destruction of cancer cells.

The STAR experiment at the Relativistic Heavy Ion Collider at Brookhaven National Laboratory demonstrates evidence of spin correlations in \(\Lambda \bar{\Lambda }\) hyperon pairs inherited from virtual spin-correlated strange quark–antiquark pairs during QCD confinement.

Here the authors use Ramsey interferometry to study Tan’s contact in uniform two-dimensional Bose gas of 87Rb atoms across the Berezinskii–Kosterlitz–Thouless superfluid transition. They find that the two-body contact is continuous across the critical point.

Adaptive microwave surfaces can dynamically adjust their electromagnetic transmission to meet specific needs, being potentially useful in reconfigurable communication systems. Here, the authors use temperature induced break and reconstruction of hydrogen bonds to drive the orientational motion and charge mobility of an ionic liquid in a polymer leading to the controllable modulation of dielectric properties at microwave frequencies.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

The genetic basis underlying resistance to Sclerotinia stem rot (SSR) in oilseed rape remains elusive. Here, the authors identify BnaA07.MKK9 as a pivotal regulator of SSR resistance in oilseed rape by GWAS, providing new insights into plant defense mechanisms against necrotrophic pathogens.

Genome-wide association meta-analysis identifies 58 independent risk loci for major anxiety disorders among individuals of European ancestry and implicates GABAergic signaling as a potential mechanism underlying genetic risk for these disorders.

Droplet impacts shape technologies from erosion to bioprinting. Here, authors show a scaling crossover in peak impact force on soft substrates, from inertial to Hertzian, unified by a similarity parameter. The proposed stress tomography provides a practical map to design impact-resistant processes.

A CRISPR screen reveals that loss of structural components of the SAGA complex derails hematopoiesis by decoupling epigenetic control. This halts stem cell maturation, triggers a pathogenic interferon program and boosts human MDS-L cell growth.

A comprehensive atlas platform integrating transcriptional and epigenetic data enables more precise engineering of T cell states, accelerating the rational design of more effective cellular immunotherapies.

The Yamaji effect is a modulation of the electronic transport as the angle of an applied magnetic field is changed. This has been observed in a model cuprate and sheds light on the geometry of the Fermi surface and the nature of the pseudogap.

A M5 earthquake triggered the 2018 Sierra Negra eruption after 10 hours. Subsequent microseismicity revealed a cryptic fluid phase facilitated magma intrusion, highlighting that cascading processes are potentially essential for eruption initiations.

Findings from a tectonically active mountain range show that soil production is driven by bottom-up rock weakening rather than by soil thickness, challenging long-held top-down models.

Tanycytic insulin receptors allow insulin access to the hypothalamic arcuate nucleus and are relevant for driving AgRP neuronal activity in response to feeding.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Vortex dynamics and mutual friction in quantum fluids are intimately connected to the fundamental properties of superfluids. Here, the authors reveal previously unexplored mechanisms underlying the mutual friction coefficients in ultracold Fermi superfluids in the unitary limit, suggesting bound quasiparticles within the vortex core play a significant role.

Chromosomes are coated in proteins and RNA called the mitotic chromosome periphery. Here, broadband microrheology analysis has shown that this coat has dynamic, liquid-like properties and provides an external structural constraint.

Rathmell and colleagues show that metabolic reprograming of regulatory T cells is associated with severity of critical illness in patients with and without sepsis.

Macrocyclization typically proceeds via thioesterase mediation in type I polyketide synthases. Now, using genome mining and crystallographic analysis, an alternative mechanism for stereoselective macrocyclization in the akaeolide biosynthetic pathway is reported. The mechanism is proposed to proceed via an iminium-catalysed tandem Michael addition and Knoevenagel condensation, using nuclear transport factor 2-like enzymes.

Bacterial biofilms include viscous extracellular polymeric matrices such as extracellular DNA (eDNA). Here, Mugunthan et al. show that protein RecA generates three-stranded nucleic acid structures known as R-loops, which contribute to formation of the viscoelastic eDNA matrix as part of bacterial stress responses.

The authors report an experimental study of the Hall effect measuring electrical quantities in ultracold fermionic quantum simulators. This provides a way forward in measuring transport properties in these platforms and verifying long-standing theoretical predictions.

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

Cavity-mediated interactions lead to collective effects and ordering in ultracold atomic systems. Here, the authors demonstrate the interplay of different ordered states of ultracold Fermi gases in a cavity, resulting from an intriguing coexistence of photon coupling with both atoms and atom-pairs.

Combining gas permeability and self-adaptive compliance in breathable, on-skin electronics is challenging. Here, the authors overcome this by using coaxial electrospinning to create an ionic nanomesh which encapsulates a self-compliant liquid crystal elastomer core within a permeable ionic sheath.

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

We present a sustainably sourced adhesive system, with performance comparable to that of current industrial products, made from epoxidized soy oil, malic acid and tannic acid, all biomass derived, low cost and readily available.

Global Burden of Disease estimates show that between 1990 and 2023, the prevalence and burden of drug use disorders, inclusive of amphetamine, cannabis, cocaine and opioid use, have been increasing in high-income countries, particularly in the USA.

Polyamines prevent the action of kinases on acidic phosphorylatable motifs in spliceosomal proteins, thus providing a mechanism for metabolite-mediated regulation of alternative splicing in cells.

Gravitational lens modelling of a million-solar-mass dark object reveals that it cannot be a free-floating black hole or dark-matter halo as predicted by cold dark matter, instead indicating a peculiar and highly concentrated mass distribution.

De novo domestication was performed on the brassica Thlaspi arvense (pennycress) by identifying and stacking CRISPR-induced mutations to create a new intermediate oilseed crop that can be grown in the off-season, with seed compositions similar to canola (low erucic acid and reduced glucosinolate).

Atomic force microscopy is used to investigate the adsorption and organization of ions on charged surfaces. Trivalent ions adopt complex networks, clusters and layers associated with overcharging, whereas divalent ions follow classical predictions.

dSHERLOCK is a nucleic acid platform for the quantification of double-stranded DNA targets using CRISPR/Cas and isothermal amplification and is applied to quantify pathogen C. auris in clinical surveillance swab samples.

Nitrogen-rich Ruddlesden–Popper nitrides are notoriously difficult to stabilize. Now a high-pressure high-temperature synthesis method has enabled the preparation of Pr₂ReN₄, Nd₂ReN₄ and Ce₂TaN₄. Neutron diffraction analysis reveals fully nitrided materials and intricate magnetic structures.

TGF-β stimulated tumor-associated neutrophils (TANs) can exert pro-tumoral functions. Here the authors show that Smad3 activation in TANs is associated with an N2-like polarization state and poor outcome in patients with non-small cell lung carcinoma and that Smad3 targeting reprograms TANs to an antitumor state suppressing tumor growth in preclinical lung cancer models.

High-pressure measurements of the electrical conductivity of (Mg,Fe)O, used as an analogue for basal magma ocean material, indicate that the conductivity is high enough to produce a dynamo much stronger than a core-driven dynamo for super-Earths larger than 3–6 Earth masses.

MARSIS attenuation and thermal data confirm that liquid brines are the most plausible source for the bright reflections at the base of the South Polar Layered Deposits. Such results also justify why SHARAD does not penetrate to the base of the ice.

The mechanical reliability and scalability of flexible perovskite solar cells remain challenging. Mingzhu He et al. design β-cyclodextrin derivatives to reinforce grain boundaries, enhancing both the efficiency and stability of cells and modules.

Conventional lithography methods involve the transfer of patterns through resist templating. Here, the authors explore a concept based on the Moiré interference of molecular beams to directly write complex 3D surfaces and self-aligned superlattices.

How do low-mass binaries age? Astronomers have constrained a tight, circular orbit of a close-in companion around a dying giant star, raising new questions about how tidal forces shape binary orbits in the final phases of stellar evolution.

Mapping of the neutrophil compartment using single-cell transcriptional data from multiple physiological and patological states reveals its organizational architecture and how cell state dynamics and trajectories vary during health, inflammation and cancer.

This work proposes multivariate frequency-dispersion regulation approximation under the protection of an oxide layer to overcome the challenge of HT broadband EM wave absorption of monomer ceramics, allowing wide-band absorption from RT up to 1473 K.

Here the authors show that persistent antigen stimulation drives the generation of CD8⁺ tissue-resident exhausted T cells with distinct developmental origins, function and therapeutic responsiveness when compared to CD8⁺ tissue-resident memory T cells.

Measurement-induced quantum phases provide prime examples of non-trivial many-body dynamics and collective phenomena, but their experimental detection is difficult due to the post-selection barrier. Here, the authors provide a spin-wave-based approach to monitored quantum dynamics in long-range interacting systems, overcoming this challenge.

Dimorphos ejecta plume properties were revealed by the observations from the LICIACube cube satellite, which was deployed 15  days in advance of the impact of DART.