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Integrative analyses that link molecular data to treatment sensitivity are essential for precision medicine. Here the authors introduce WON-PARAFAC to integrate multiple genomics data to identify sparse and interpretable factors.

In a long-term follow-up of the FAME 2 trial, fractional flow reserve-guided percutaneous coronary intervention plus medical therapy in patients with stable coronary artery disease reduced cardiovascular events compared to medical therapy alone, primarily due to a decrease in urgent revascularization events.

Governments must focus on solutions that are already working, even when they aren’t glamorous or supported by powerful lobbyists.

Global Burden of Disease estimates show that between 1990 and 2023, the prevalence and burden of drug use disorders, inclusive of amphetamine, cannabis, cocaine and opioid use, have been increasing in high-income countries, particularly in the USA.

To meet ambitious emissions targets will require systems thinking and massive breakthroughs in technology and fuels, says Jane C. S. Long.

For the celebration of our tenth anniversary, Nature Microbiology asks the former editors to reflect on their time at the journal.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Celebrate our new astronomical insight into the ultimate fate of the Universe.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Actionable goals are needed to guide the world towards what needs to happen most quickly: shifting economies to clean energy sources.

Sleep is known to promote memory consolidation, but the extent to which this is dependent on the memory’s relevance remains unclear. Here, the authors use a brain decoding approach to show that neural representations of rewarded experiences undergo a privileged reactivation during sleep, favouring their consolidation.

Peripartum cardiomyopathy (PPCM) is a potentially fatal heart condition with poorly understood molecular causes. Here, the authors show that loss of the protein PTRH2 in female mice leads to postpartum heart failure, identifying it as a potential therapeutic target.

Researchers use adaptive optics to correct distortions from digital micromirror devices in Hadamard single-pixel microscopy. The sensorless method restores sharp detail, nears diffraction-limited resolution, while correcting sample-induced aberrations.

Kumazawa, Xu, Wang and colleagues identify nuclear egress as the mechanism by which cytoplasmic chromatin fragments relocate from the nucleus to the cytoplasm in senescence. They link inflammation to metabolism by showing this egress is regulated by AMPK and metformin.

The authors developed a highly sensitive skin-conformal NIR organic photodetector with fast photoresponse speed that achieves MHz-speed, angle-free, and long-range (100 m) wireless optical communication with stable performance under mechanical deformation.

While the emergence of immune checkpoint inhibitors has improved outcomes in patients with small cell lung cancer (SCLC), tumour that develop means of immune evasion become resistant. Here, the authors report that ERBB2 signalling induces loss of MHC Class I expression and subsequently immune evasion in preclinical models of SCLC.

Tests of the Bell-Kochen-Specker theorem aim at showing that the measurement statistics of a single qutrit are incompatible with noncontextual realism. Here, the authors use a superconducting qutrit with deterministic readouts to violate a noncontextuality inequality, ruling out several loopholes.

The study presents a CMOS-compatible memristor-based bio-to-electrical transducer with built-in threshold-sensing functionality, demonstrated for electrochemical biosensor applications.

The ocean carbon sink strengthened in previous warm El Niño years due to reduced CO₂ outgassing in the tropics. Here the authors show that the ocean carbon sink declined in 2023 despite record-high sea surface temperatures (SSTs), primarily due to SST-driven outgassing of CO₂ in the subtropics.

Current single-cell RNA sequencing methods struggle to comprehensively profile transcriptomes, with many lowly expressed transcripts remaining undetected. Here authors present a workflow for enhancing the detection of both transcripts and regions of interest in combination with a standard transcriptome profile.

The carrier envelope offset phase (CEP) of a short laser pulse is tuned to control electrons on attosecond timescales, while rotational states are associated with much longer nanosecond timescales. Here, the authors introduce CEP control in rotational air lasing, unveiling nontrivial contribution from rotational states.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Mitochondrial DNA heteroplasmy associates with context-specific nuclear CpG methylation, supported by a cell model. Heteroplasmy–CpG scores relate to mortality and cardiovascular risk, though direction and mechanisms remain unclear.

The interactions of CAR-T cells and solid tumors are modeled on a chip.

Climate change is a politically polarized subject, and changing peoples’ beliefs is challenging. This study shows that participation in a climate prediction market by betting on future climate outcomes may be an effective way to change both attitudes and behaviour around climate change.

In Chinese residential buildings sector, avoid, shift and improve measures in demand-side solution will mitigate 47% of cumulative CO2 emissions and 16% of cost before 2060, and reduce the uncertainty of achieving carbon neutrality target.

Magnetic domain patterns and the capability to control them is important for applications such as information storage. Here, Kronseder and colleagues find a metastable magnetic domain state with a domain width larger than the thermodynamically stable one as a result of reduced thermal fluctuations.

Researchers analyzed 5,279 plasma proteins in 40 people undergoing feminizing gender-affirming hormone therapy over 6 months, revealing significant changes in 299 proteins. Such changes could have implications for reproductive capacity, immune regulation and long-term health.

The alignment of heterogeneous spatial samples has become a growing challenge. Here, authors present a multi-scale, multi-context, and interpretable mapping strategy to map cells across space, time, and disease.

A genetic variation in the horsemyostatingene is found at a very high frequency in the best Thoroughbred sprinters. This study shows, using molecular and pedigree data from modern and historic horses, that a single introduction of the variant occurred at the foundation stages of the Thoroughbred from a British native mare.

In the field of tissue engineering, achieving precise spatiotemporal control over engineered cells is critical for sculpting functional 2D cell cultures into intricate morphological shapes. Here the authors introduce μPatternScope (μPS), a modular system for precise, automated light-based control of cell patterning in 2D cultures.

This study uses a natural experiment with game console lotteries to identify the causal effect of video gaming on mental well-being in Japan (2020–2022). Results show that video gaming reduced psychological distress and improved life satisfaction.

A new model merges behavioural science and machine learning to predict choice under risk and uncertainty. Tested on multiple large datasets, it outperforms top psychological and AI models, enabling accurate, interpretable forecasts of human decisions.

In this Review, the authors discuss guideline-directed medical therapy for diabetic kidney disease and the evolving clinical evidence for next-generation therapies, including incretin-based therapies, endothelin receptor antagonists, aldosterone synthase inhibitors, soluble guanylate cyclase agonists and anti-inflammatory therapies.

Crystal structures of human CB₁ bound to two cannabinoid agonists reveal key features, including a twin toggle switch and binding pocket reduction, advancing understanding of receptor dynamics and guiding cannabinoid drug design.

This online study with 3,371 participants from 13 societies found that perceived societal honour norms predicted both greater competition and greater cooperation at both societal and individual levels.

In the randomized phase 3 AMPLITUDE trial, patients with HRR-deficient mCSPC experienced longer progression-free survival when they were treated with niraparib and AAP compared to placebo and AAP.