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The interlayer π-π stacking primarily results in irreversible dispersibility of GO, providing supramolecular view for the regulation of graphene-based materials.

Neural mechanisms underlying social behavior are not fully understood. Here authors show two lateral septum neuron types in male mice that bidirectionally regulate social memory via distinct hippocampal-hypothalamic circuits.

Systemic lupus erythematosus (SLE) is a complex autoimmune condition and treatment options have limited efficacy. Here, by analysis clinical samples and employing preclinical models, the authors show that cGAMP levels are elevated in the plasma of patients with SLE and that loss of cGAS ameliorates symptoms in an imiquimod-induced lupus model. Importantly, they identify prasugel as a cGAS inhibitor with promising therapeutic potential.

The human LRP8 protein is a receptor for yellow fever viruses (YFVs). Knockdown of the mosquito orthologue reduces YFV infection in mosquitoes, whereas overexpression of human LRP8 aggravates YFV infection in mice. Purified LRP8 protein blocks YFV infection.

Endometriosis causes pelvic pain and infertility, but how uterine development and disease are linked is unclear. Here, the authors show that TCF21 shapes uterine development and drives endometriosis by promoting epithelial–mesenchymal transition and reorganization of the cell skeleton.

A genome-wide association study in rice identifies variation in SBRR1 associated with sheath blight resistance. Introducing the SBRR1-R allele into a commercial rice variety reduces yield loss under severe exposure to sheath blight disease.

Major depressive disorder involves disrupted molecular polarity homeostasis, with conventional antidepressants hindered by delayed onset and drug resistance. Here, the authors engineered near-infrared-responsive IC@His-ICG nanomotors for photochemical polarity switching, achieving targeted hippocampal neuromodulation in rodents to restore monoamine balance and relieve depression/anxiety.

The piezoelectricity of ferroelectric oxide films is limited by substrate clamping, and their rigidity hinders their applications in flexible electronics. Herein, authors report freestanding PbZr0.52Ti0.48O3 nanoscale membranes with both high piezoelectricity and high flexibility.

Pulmonary fibrosis involves chronic inflammation and extracellular matrix remodeling but the contribution of neutrophils is unclear. Here the authors show that reverse-migrating neutrophils anchored in the lung extracellular matrix exacerbate fibrosis via ICAM1 and macrophage derived cathepsin C.

Presentation matters.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

GLT25D1 galactosylates collagen hydroxylysines and is essential for collagen maturation. Here, authors trap multiple functional states of GLT25D1 to elucidate its molecular mechanism, providing mechanistic insights into GLT25D1-related diseases.

Photons carrying orbital angular momentum inherit chirality from their twisted wavefront. Here, authors propose a twisted bilayer photonic structure - consisting of semiconductor membrane metasurfaces - where helical wavefronts are combined with non-Hermitian coupling, yielding orbital chiral lasing at telecom wavelengths.

Low glume coverage is the preferred for easy threshing in grain production, but the genetic basis remains unclear. Here, the authors report the gene GC1, which encodes an atypical G protein γ subunit, negatively regulates sorghum glume coverage and the naturally truncated alleles can be useful in the naked grain breeding.

NCR1 (nitrate concentration regulator 1) promotes root-to-shoot nitrate transport by regulating the transcription of nitrate transporter NRT2.3, thereby contributing to grain yield in maize.

Brain metastases are a common complication of advanced non-small cell lung cancer (NSCLC) and affect responses to immune checkpoint inhibitors (ICI). Here the authors perform single cell transcriptomics on samples from NSCLC and brain metastases and implicate transcriptomic signatures associated with responsiveness to ICI.

Long-lived trapped-ion entanglement over 10 km of spooled fibre reaches the threshold where establishment exceeds loss, providing a critical building block for scalable quantum repeaters.

Fang and colleagues report the safety and clinical activity of hypoxia-responsive carcinoembryonic antigen (CEA)-targeted chimeric antigen receptor T cells in CEA-positive solid tumors through intraperitoneal or intravenous infusion in a phase 1 trial.

Integrated quantum memories based on ¹⁵¹Eu³⁺:Y₂SiO₅ crystals coupled with impedance-matched optical cavities are demonstrated. Multiplexed quantum storage efficiencies of 80.3% and 69.8% are achieved for weak coherent pulses and telecom-heralded single photons, respectively.

Nonlinear optical micropolarimetry and atomistic Monte Carlo simulations of monolayer NiPS₃ evidence a Berezinskii–Kosterlitz–Thouless phase that, with decreasing temperature, gives way to long-range order consistent with a six-state clock model.

Freestanding membranes of hexagonal oxides remain difficult to obtain. In this work, a water-soluble crystalline hexagonal BaAl₂O₄ is found to serve as a sacrificial layer for obtaining freestanding membranes with six-fold or three-fold symmetry.

Hong-Xuan Lin, Ji-Ping Gao, Jun-Xiang Shan and colleagues show that natural variation in a proteasome α2 subunit gene contributes to thermotolerance in African rice. Their follow-up studies suggest that the variant allele protects cells from heat stress by enhancing the elimination of cytotoxic denatured proteins and maintaining heat-response processes.

Understanding interfaces at sub-nanometer scales is vital for complex chemical reactions. Here, the authors advance Pattern-enhanced Resonant Soft X-ray Scattering, enabling efficient operando probing of chemical and structural dynamics at solid-liquid interfaces.

Engineered bacteria sense gut bleeding and secrete repair materials.

Bacterial cellulose (BC) possesses excellent biocompatibility and mechanical strength but lacks the bioactivity needed for many biomedical applications. Here the authors use glycoengineering–click chemistry to incorporate azide groups into BC in situ, and show enhanced BC-mediated wound healing.

This research identifies two neural factors linked to externalizing and internalizing symptoms through a longitudinal imaging-genetic cohort. Distinct neural configurations and cognitive-behavioral relevance highlight the need for tailored therapeutic strategies addressing psychiatric comorbidity across developmental stages.

Endocytosis of TFR1 plays a crucial role in extracelluar iron uptake. Here the authors revealed that PKCβII facilitates the endocytosis of TFR1 and increases cellular iron levels through the phosphorylation of AAK1, thus promoting ferroptosis of tumor cells.

This study shows that excessive atmospheric nitrogen deposition can enhance methane production and emissions by impacting microbial phosphorus acquisition due to the change of N/P ratios in oxygenated surface oceans.

The function of intermediate epithelial states in pulmonary fibrosis unknown. This study used RNA sensing technology to show selectively removal of alveolar epithelial stem cells trapping in an intermediate state reduced lung fibrosis.

Strong paramagnetism is generated in hydrogels rich in carbon–oxygen double bonds simply by coupling with diamagnetic Ca cations. These paramagnetic hydrogels are applied as magnetic resonance imaging contrast agents and magnetic drug carriers.

Li-metal batteries suffer from sluggish kinetics at low temperatures. Here, authors propose a guideline for rational electrolyte solvent screening and design a class of asymmetric ethers, which bestows the Li metal pouch cell with a high specific energy of 345.3 Wh kg⁻¹ over 40 cycles at −40 °C.

Highly ionically conductive and flexible solid-state composite battery electrolytes are engineered by alternately stacking inorganic Li_xM_yPS₃ (M = Cd or Mn) nanosheets with lithium-containing organic polymers in a perpendicular orientation to the surface of the electrodes.

The study develops a global, long-term rice dataset (GlobalRice500) and reveals that paddy rice widely cools the land surface, reducing global mean daytime land surface temperature by up to 0.27 °C. The findings highlight the biophysical role of rice in climate regulation.

In this attempt at xenotransplantation of a lung from a genetically modified pig into a brain-dead recipient, although the grafted lung initially maintained viability and functionality, antibody-mediated rejection rapidly occurred, contributing to xenograft damage.

Here the authors reveal a study of 486,956 Han Chinese individuals showing that most people with genetic variants affecting drug response do not have the predicted adverse events, highlighting the challenges of implementing pharmacogenetics in clinical practice.

Dysregulation in proteolysis contributes to brain tumorigenesis. Here the authors report that USP10 deubiquitinase is enriched in glioma stem cells (GSCs), which antagonizes DTX3L-mediated ubiquitination of SATB2, a major driver of GSC proliferation and self-renewal.

By resonant excitation of an InAs quantum dot embedded in a microcavity, a deterministic single-photon source is demonstrated. Single-photon purity of 0.9795(6), photon indistinguishability of 0.9856(13), and an overall end-to-end efficiency of 0.712(18) are simultaneously obtained.

The authors here show that the TRIM21–OTUD6A axis controls AKT activity through K27-linked ubiquitination, which is further regulated by S6K1-mediated phosphorylation, introducing a putative therapeutic strategy against AKT-driven cancers.

Untargeted metabolomics faces challenges in metabolite origin inference and metabolite annotation. Here, the authors present TidyMass2, a user-friendly computational framework with metabolite origin inference and feature-based functional module analysis to enhance biological interpretation.

Inspired by nature, this study reports a dual-gradient aerogel via freeze-casting. It blends flexibility with rigidity, offers high sensitivity and wide range, withstands extreme heat and cold, with promise for integration in spacesuits.

This study defines a two-receptor entry mechanism for coxsackievirus A6: heparan sulfate for initial attachment and KRM1 for uncoating. Protective antibodies that block KRM1 binding were identified, offering a path for therapeutic development.