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A dated phylogeny of 16,585 vascular plant species native to China reveals three major centres of endemism, including a potential new global biodiversity hotspot.

Inflammatory signaling profoundly influences cellular metabolism and stress responses. Here, the authors show that the IKK complex directly controls TFEB stability through β-TrCP2–dependent proteasomal degradation, mechanistically linking inflammation to lysosomal regulation.

The growth of the smallest aerosol particles is critical to their impacts on climate and air quality. Here, the concentration gradient of nanoparticles is shown to be an important microphysical mechanism for their rapid initial growth.

Although lithium–sulfur batteries are prized for their sustainability, practical energy densities are often limited by heavy host materials. The authors report a graphdiyne architecture that integrates anchoring and catalytic functions, enabling ultrahigh sulfur loading and exceptional energy densities, even in pouch-cell configuration.

Inborn errors of cell death (IECD) with autoinflammatory manifestations could be induced by excessive T cell death. Here the authors characterize IECD patients with autoinflammatory manifestations who possess overactive RIPK1 variants which promote T cell death, secretion of TNF and IFN-γ along with activation of monocytes and macrophages which promotes further autoinflammation.

The authors have applied an eight-tissue rat multi-omic dataset to analyze the gene regulatory landscape of endurance exercise training, identifying tissue-specific regulatory patterns involved in muscle function, metabolism and immune response.

Robustness checks and reproduction of analyses with existing and updated data based on 110 articles in economics and political science journals with data and code-sharing requirements found high levels of robustness and reproducibility and determined that robustness was not dependent on author characteristics or data availability.

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

Li and colleagues show that the transcription factor ZFP148 restrains the differentiation of antigen-specific CD8⁺ T cells toward cytolytic effector cells by repressing the expression of KLF2.

Development of the pangenome-informed genome assembly (PIGA) workflow enabled the generation of 1,116 diploid genome assemblies (55 de novo and 1,061 pangenome-informed), representing an extensive resource of medically relevant genic variations.

Androgen activity in the male embryonic hindbrain prolongs hindbrain differentiation in male individuals and drives sex differences in the incidence and prognosis of posterior fossa type A (PFA) ependymoma, an aggressive childhood brain tumour.

Here, the authors present archaeology of the Namorotukunan site in Kenya’s Turkana Basin that demonstrates adaptive shifts in hominin tool-making behaviour spanning 300,000 years and increasing environmental variability. They contextualize these findings with paleoenvironmental proxies, dating, and geological descriptions.

XRISM spectroscopy of the nucleus of the Circinus galaxy indicates elemental abundances suggestive of a dominant enrichment from core-collapse supernovae with progenitors below 20 solar masses; more massive stars may directly collapse into black holes.

Starburst galaxies are seen to host galaxy-scale winds, which are super-fast and could be powered entirely by the thermal pressure of gas heated by supernovae.

This study presents an organ-wide spatial transcriptomic analysis of human skin from different anatomical sites using a combination of MERFISH technology and existing datasets from healthy and diseased skin.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Here the authors provide an explanation for 95% of examined predicted loss of function variants found in disease-associated haploinsufficient genes in the Genome Aggregation Database (gnomAD), underscoring the power of the presented analysis to minimize false assignments of disease risk.

This work demonstrates a 3D-printed photonic lantern that efficiently combines many multimode VCSELs into a single multimode fiber with low loss, preserving brightness and enabling compact, scalable high-power laser systems.

Ultra-thin active layers for semi-transparent organic solar cells (ST-OSCs) are limited in cell-to-module efficiency. Here, the authors show thickness tolerance for ST-OSCs using aggregation control of acceptor in donor-diluted blends and the feasibility of building-integrated photovoltaics via a 600 cm² module.

A clinical trial testing whether monitoring ctDNA clearance during treatment for nasopharyngeal cancer could be used to inform decisions about an individual’s subsequent therapeutic programme shows promising results.

For proper mitochondrial inheritance, paternal sperm mitochondria must be eliminated. Here, authors identify ALKB-1 mediated tRNA demethylation as essential for this clearance in Caenorhabditis elegans, revealing an epitranscriptomic quality checkpoint tied to male fertility.

Single-nucleus chromatin and RNA sequencing identifies epigenetic chromatin domains that confer vulnerability to paediatric brain tumours such as ependymomas, providing insight into the development of such tumours despite ‘quiet’ genomes.

Genome-wide association meta-analysis identifies 58 independent risk loci for major anxiety disorders among individuals of European ancestry and implicates GABAergic signaling as a potential mechanism underlying genetic risk for these disorders.

The authors show that regenerating liver requires de novo pyrimidine synthesis and it uses ammonia as precursors differentially as it traverses the liver zones. Tracing studies and spatial metabolomics reveal that assimilation periportally is via the urea cycle, and pericentrally through conversion into glutamine.

Early Pleistocene artefacts at Calio suggest that Sulawesi was populated by hominins at around the same time as Flores, if not earlier.

Global Burden of Disease estimates show that between 1990 and 2023, the prevalence and burden of drug use disorders, inclusive of amphetamine, cannabis, cocaine and opioid use, have been increasing in high-income countries, particularly in the USA.

Scholl et al. show that PopZ forms filamentous condensates driven by its helical domain and inhibited by its disordered region. Phase-dependent conformations modulate client interactions and disruption of filamentation or condensation impairs cellular function and growth.

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

Alcohol oxidation to carbonyl compounds is a very useful functional group transformation in organic synthesis. Here, the authors perform the direct electrochemical oxidation of various alcohols to the corresponding ketones in a continuous-flow reactor without external oxidants, base or mediators.

Chimaeric antigen receptor macrophages including the MyD88 activation domain target mesothelin for treatment of lung cancer brain metastases.

Cobalt-based catalysts are regarded as a potentially cheaper alternative to platinum and chromium systems for the non-oxidative dehydrogenation of propane, although they often feature lower performance. Now mixed-valence Co^0/IIO_x clusters supported on silicalite-1 are identified as a competitive system for this reaction.

De novo designed proteins that target the transmembrane domain of G-protein-coupled receptors, created using iterative structural predictions, are able to act as agonist-positive, negative or biased allosteric modulators of downstream activity.

Small-cell lung cancer (SCLC) is a highly aggressive cancer type with immunosuppressed phenotype. Here, the authors find that depletion of nonhomologous end joining DNA repair regulator PRKDC is able to induce activation of the cGAS/STING pathway and potentiate the efficacy of immunotherapy in SCLC pre-clinical models.

The role of Leflunomide in αPD1-induced cardiotoxicity remains unclear. Here, the authors show that leflunomide mitigates αPD1-induced cardiac toxicity in melanoma-bearing mice through modulation of the microbiota-indole-3-propionic acid-heart axis.

KRAS is an oncogene that switches between a GDP-bound inactive state and a GTP-bound active state. Recently developed KRAS G12C inhibitors are specific to the GDP-bound inactive state. Here, the authors develop a class of covalent KRAS G12C inhibitors capable of targeting both states for the treatment of KRAS-driven cancer.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Global mean vegetation greenness reached a record high in the year 2025, extending the multi-decadal upward trend. A total of 68.2% of vegetated land surfaces experienced greening, particularly in grasslands and croplands in the Southern Hemisphere and in northern mid-latitudes.

Aqueous zinc metal batteries often face performance decay under thermal environments, originating from side reactions caused by aqueous electrolytes. Here, authors report an organic-inorganic-H₂O multiphase aqueous soggy-sand electrolyte that reconstructs hydrogen-bond networks, eliminates parasitic reactions, and promotes uniform Zn deposition at elevated temperature (140 ^oC).

Fabricating wide-bandgap perovskite films with a thickness of 1 μm on nano-textured silicon substrates remains a formidable challenge. Here, authors design an amphoteric coplanar conjugated molecule for improve bulk and interfacial properties of perovskites for high-efficiency tandem solar cells.

The growing demand for rare earth elements (REEs) underscores the need for sustainable recovery methods and a reliable supply. Here the authors establish a platform using a yeast to produce bio-oxalic acid for REE recovery, achieving 99% REE recovery from low-grade ore.