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This study applies generalized linear mixed models (GLMM) and advanced transcriptome wide association study (TWAS) methods to improve the discovery of colorectal cancer risk transcription factors and genes, including potential druggable targets.

Global Burden of Disease estimates show that between 1990 and 2023, the prevalence and burden of drug use disorders, inclusive of amphetamine, cannabis, cocaine and opioid use, have been increasing in high-income countries, particularly in the USA.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

The authors show that exciton–polaritons—hybrid particles of light and matter—can be controlled in ways pure photons cannot, even when only a tiny amount of exciton character is present. In ultrathin WS₂, indirect emission feeds the polaritons and enables condensation at room temperature.

Atomically thin nitrogen crystals, termed nitrogene, have been theoretically predicted, but their synthesis has remained elusive so far. Here, the authors report experimental evidence of the formation of nitrogen-based crystalline structures compatible with nitrogene on Ag(100) surfaces via ion-beam-assisted epitaxy.

Fabrication of fully stretchable organic light-emitting diodes incorporating an intrinsically stretchable exciplex-assisted phosphorescent layer along with MXene-contact stretchable electrodes is described, demonstrating high efficiency and mechanical compliance for applications in next-generation wearable and deformable displays.

Solid-state batteries promise high energy and safety but face challenges in ion transport and scalability. Here, authors develop entropy-driven zwitterionic dry polymer electrolytes enabling scalable, high-energy all-solid-state batteries operating efficiently under practical conditions.

Tau protein has been observed to form condensates in various contexts. Here, the authors show that tau can form DNA-anchored droplets that organize nearby microtubules, pointing to a role in mitosis.

In this study, the authors present that patterned low-intensity ultrasound mimicking brainwave rhythms revitalizes spinal astrocytes to normalize pain signaling, reversing inflammation and providing long-lasting relief from neuropathic pain in mice.

SLFN11 is a predictive marker of chemosensitivity that results in elevated replication stress, but how it regulates replication fork dynamics remains unclear. Here, the authors use super-resolution microscopy to determine how SLFN11 inhibits the function of RFWD3- PRIMPOL to suppress fork restart.

SARS-CoV-2 variants resistant to current antivirals pose a significant threat, especially to high-risk patients. The authors identify a deletion mutation in M^pro that confers resistance to ensitrelvir but increases susceptibility to nirmatrelvir, suggesting potential for sequential or alternative therapeutic strategies in prolonged antiviral treatments.

The interactions of CAR-T cells and solid tumors are modeled on a chip.

Tuberculosis detection methods in centralized facilities are bottlenecks in low resource areas. Here, the authors develop a portable lab-in-a-cartridge system that detects TB biomarkers in urine with 92% sensitivity in 40 minutes enabling decentralized TB diagnosis.

The Taiwan Precision Medicine Initiative recruited and genotyped more than half a million Taiwanese participants, almost all of Han Chinese ancestry, and performed comprehensive genomic analyses and developed polygenic risk score prediction models for numerous health conditions.

Systematic analysis from the Global Burden of Disease study reported that, despite global improvements from 1990 to 2021, dietary iron deficiency-associated disease burden remains high in women, children and residents in low socio-demographic index countries.

The authors develop an elasto-electromagnetic mechanism for small autonomous robots, mimicking muscle contraction using elastomeric materials and magnetic forces. The system achieves significant force, large contraction ratios, rapid response, and low-voltage operation, enhancing robot adaptability and efficiency.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Atherosclerosis is the leading cause of death worldwide. Here, the authors show that defective vascular smooth muscle cell tafazzin promotes mitochondrial dysfunction and atherosclerosis, highlighting tafazzin as a potential therapeutic target.

Benefits of breastfeeding are well established, but a comprehensive study about its impacts on hospitalizations is lacking. Here, the authors use Korean nationwide birth cohort data (n = 1,608,540) and find that breastfeeding for at least 6 months was associated with a lower risk for subsequent hospital admissions.

An analysis of memory T cells induced by messenger RNA vaccination reveals that they maintain polyfunctionality in response to the Omicron spike protein.

Here, the authors perform large trans-ancestry fine-mapping analyses identifying large numbers of association signals and putative target genes for colorectal cancer risk, advancing our understanding of the genetic and biological basis of this cancer.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Electron-phonon coupling is thought to be too weak to be responsible for the superconducting Cooper pairing of the kagome metals AV₃Sb₅, but an experimental measurement is lacking. Here, the authors use ARPES measurements to find that electron-phonon coupling in CsV₃Sb₅ is strong enough to support the experimental superconducting transition.

To ensure the reliable operation of anode-less solid-state lithium metal battery, herein, the authors report the role of metal interlayer as the interface control strategy for achieving the stable lithium plating and stripping using the multiple operando and in-situ analysis.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

A meta-analysis of genome-wide association studies of type 2 diabetes (T2D) identifies more than 600 T2D-associated loci; integrating physiological trait and single-cell chromatin accessibility data at these loci sheds light on heterogeneity within the T2D phenotype.

Higher dimensional vortical structures are being explored in optical and acoustic systems via complex wave interference. However, deterministic generation has not been reported. Here, the authors demonstrate emergent 3D optical vortices in a gradient-thickness optical cavity.

Chemotherapy is commonly used for the treatment of cancer but resistance often occurs. Here, the authors identify mitochondrial DLAT as driver of chemotherapy resistance via interaction with (MTHFD2) and develop a decoy peptide which blocks this interaction, restoring sensitivity to chemotherapy.

Molybdenum disulphide may be prepared by lithiation and exfoliation; however the process requires a long lithiation and produces low yields. Here, the authors show that metal naphthalenides may be used for the intercalation, and that the resulting products are of high quality and may be inkjet-printed.

Kong et al. report 1-nm-thick epitaxial AlN passivation for 1.5-µm-diameter InGaN red micro-LEDs by Ar plasma assisted atomic layer deposition, resulting in an efficiency of 6.5% at 649 nm. A near-complete device transfer to polyimide substrates further enables high-resolution flexible micro-LEDs.