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RNA polymerase II (RNAPII) is typically considered as an essential enzyme. Here the authors show that natural degradation of RNAPII drives chromatin reorganization in growing oocytes, preparing the chromatin for genome activation after fertilization.

Natural variation in the promoter of OsTPS8 contributes to differences in grain chalkiness and seed vigor between indica and japonica rice subspecies by altering trehalose-6-phosphate biosynthesis and α-amylase levels.

This study finds that plastic mulch substantially increases crop yields but also contaminates soils and pollutes the environment. The authors propose biodegradable films, AI-driven farming, and policy reforms to address the productivity–sustainability trade-offs.

Grain number per panicle (GNP) is a yield-determining trait of rice. Here, the authors identify a GSK3-like kinase-encoding gene GNP2 and a bZIP transcription factor-encoding gene GNP5, demonstrating their synergistic regulation of GNP and showing that specific allele combinations of these genes enhance rice yield in field conditions.

A genome-wide association study in rice identifies variation in SBRR1 associated with sheath blight resistance. Introducing the SBRR1-R allele into a commercial rice variety reduces yield loss under severe exposure to sheath blight disease.

Thymine DNA glycosylase (TDG) was identified as a synthetic-lethal target in p53-deficient cancers through alterations in double-stranded RNA accumulation. A covalent small-molecule inhibitor of TDG exhibited potent efficacy against p53-deficient tumors.

Alzheimer’s disease is characterized by the accumulation of amyloid plaques in the brain. Here, Liu et al. develop a new method, Amyloid-ID, which uses light to label and analyze amyloid deposits in brain tissues, revealing their protein composition and associated molecules.

Aortic aneurysm and dissection are lethal vascular diseases lacking effective medical therapy. Here the authors show that calcium channel blocker use increases AAD risk, worsens disease progression in models and patients, and may impair post-repair outcomes, warranting caution in at-risk hypertension.

Dissipative many body systems provide quantum-enhanced sensitivity to external near gap-closing points. Here, the authors demonstrate record sensitivity in a Rydberg-atomic platform in correspondence of folded hysteresis trajectories under external microwave driving

Low temperature is a major factor limiting productivity in rice. Here the authors show that theCTB4a gene confers cold tolerance to japonicavarieties adapted to cold habitats at the booting stage of development, and propose that CTB4a acts via an interaction with the beta subunit of ATP synthase.

An intratumoural vaccination chimera reprograms tumour cells into an antigen-presenting state with restored anti-tumour immunity.

Newly developed mouse models that enable cell-specific analyses of proteostasis dynamics across the lifespan of the mice reveal key aspects of neuronal proteostasis with ageing.

This study presents the structure and mechanism of the algal bicarbonate channel LciA and its application in engineering FNT family proteins to achieve bicarbonate transport activity, expanding the toolbox to boost plant photosynthesis.

Fibre integrated circuits created by first preparing circuitry on extremely thin and flexible substrates and then mechanically rolling them up demonstrate microdevice density reaching 100,000 transistors per centimetre and excellent stability under harsh service conditions.

This study provides new insights into the role of endoglin (ENG) as a co-receptor in endothelial cells and addresses a gap-in-knowledge on how ENG could be involved in both TGF-β and BMP9 signalling. Such knowledge greatly facilitates therapeutic targeting of ENG-related pathways.

Sonomate is a digital assistant for ultrasound examinations, supporting users through feedback, anatomical recognition and interactive question answering.

This study demonstrates a low-energy photon device based on the kagome metal RbV₃Sb₅. It demonstrates that Fermi surface reconstruction, driven by a phase transition, leads to the emergence of van Hove singularities near the Fermi level.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

PanoSpace enhances low-resolution spatial transcriptomics data to reconstruct continuous tissue maps at single-cell resolution. In cancer tissues and mouse brain, it refines cell localization, identity, gene expression and microenvironmental interactions.

Nanopore sequencing offers rapid DNA readout but suffers from severe insertion/deletion errors. Here, authors devise medium-length DNA fragments using a PNC-LDPC coding scheme, with an efficient cleavage library preparation to quickly recover original data at very low coverages without assembly.

It is difficult to spatially resolve molecular orbitals of molecules on highly reactive semiconductor surfaces. Here, Xu et al.use scanning tunnelling microscopy to study pyridazine molecules on a clean germanium surface, and hybridized molecular orbitals are directly imaged.

This work identifies the two-dimensional sliding ferroelectric metal with ferrimagnetism, enabling electric-field-driven triply-coupled switching with simultaneous reversal of the net magnetization, out-of-plane polarization, and spin splitting.

The development of novel two-dimensional antiferromagnets is crucial for enhancing the performance of spintronic devices. Here, authors realize the synthesis of CrOCl monolayer films and nanosheets that exhibit excellent performance.

Inhibitor-induced kinase degradation is a common event that positions supercharging of endogenous degradation circuits as an alternative to classical proximity-inducing degraders.

ATG16L1 is a key autophagic protein. Here, the authors elucidate the molecular basis of ATG16L1 interactions with FIP200 and ATG8 family proteins, showing that the interaction of ATG16L1 with FIP200 is indispensable for the effective autophagic flux.

Due to the strong exchange interactions between the rare-earth and iron sublattices, rare-earth orthoferrites, such as YbFeO₃, offer a rich platform for exploring spin dynamics and spin transport phenomena. Here, the authors report multi-step type-II spin switching in Mn-doped YbFeO₃ and investigate the underlying mechanism using an extended Weiss model.

While visual-tactile sensors promise high perception resolution at low cost, they often sacrifice compliance to maintain optical stability, hindering non-planar contact perception. The authors present FlexiRay, a soft gripper merging visual-tactile sensing with a compliant Fin Ray structure.

This study identifies 245 genetic loci associated with head-to-body ratios using 38,202 bone density scan images from the UK Biobank, revealing genetic links to skeletal and brain development, disease susceptibility, and human evolutionary adaptation.

Distributed quantum sensing typically requires shared reference frames to coordinate measurements. Here, authors develop a reversed-encoding protocol that circumvents this requirement, enabling Heisenberg-limited precision in quantum networks without frame alignment.

The authors conducted a genome-wide association study of bipolar disorder (BD) in Han Chinese and integrated PGC4 East Asian and European datasets, discovering 23 novel loci, prioritizing 39 credible risk genes and implicating BD-related cell types and druggable targets.

Here, authors use Cryo-FIB and Cryo-TEM to reveal the atomic structures of the sulfide electrolyte/Si electrode interfaces, showing that the continuous lithium-ion consumption during interfacial reaction rather than interface impedance leads to capacity fade and battery failure.

Phospholipid remodeling governs cell fate, yet its ferroptosis-related mechanisms remain elusive. Here, we report the cryo-EM structure of phospholipid remodeler TMEM164, identify its lipid remodeling mechanism, and discover Montelukast S- enantiomer as a potent inhibitor.

The authors realize a two-dimensional hybrid perovskite with robust multiaxial ferroelectricity and nonlinear optical response via molecular fluorination and lone pair expression of Ge²⁺, enabling prominent piezoelectric sensing in composite device

Alternative polyadenylation is involved in plant responses to various stresses. Here, the authors show how a cis-natural antisense RNA promotes proximal polyadenylation of its cognate SlSPX5 gene in response to phosphate starvation in tomato.

This study discovers that tRNA directly binds and regulates the membrane protein FKS1, a β-1,3-glucan synthase essential for fungal cell wall formation. Cryo-EM and biochemical analyses show how tRNA and GSR1 control FKS1 activity and fungal growth.

This study presents the high-resolution cryo-EM structure of the ammonia monooxygenase (AMO) complex, revealing a homotrimeric assembly with five subunits, a dinuclear copper active site, a putative proton transport pathway with distinct electrostatic features for substrate handling.

The mechanisms underlying the limited response to immune checkpoint blockade (ICB) in most patients remain elusive. This study identifies GBP2 as a key enhancer of T cell-mediated ferroptosis and ICB efficacy through phase separation and STAT1 activation.

Gene redundancy in prokaryotes remains understudied. This analysis shows redundant genes are widespread, with pathogens accumulating more than non-pathogens, and are linked to virulence of Acinetobacter baumannii.

It is unclear how early-life urbanicity influences adult neurobehavioral traits. This study reveals that earlier menarche mediates the relationship between early-life urbanicity and adult neurobehavioral traits associated with mental disorders.

Growth signaling has been involved in the biological program of aging. Here the authors identify ARMH4 as a pro-aging factor by enhancing IGF1R/FGFR1 signal transduction and their expressions, thereby forming a positive feedback circuit in aging.

Viruses such as EBV use various mechanisms to avoid antiviral responses. Here the authors propose that the EBV protein BRRF2 is secreted via extracellular vesicles from NPC cells, disrupts the cGAS-STING pathway, reduces cGAS-DNA phase separation and the subsequent antiviral response.

The authors study microstructured UTe₂ by high-field transport, focusing on the field-reinforced superconducting phase. They reveal a highly-directional vortex pinning force typical of quasi-2D superconductors, indicating a vortex lock-in state and consistent with a change of order parameter from the low-field superconducting phase.

Human Glucose-6- phosphate Transporter (G6PT1) is critical for systemic glucose homeostasis. By integrating multiple cryo-EM structures with functional validation, the study elucidates the molecular mechanism of G6PT1 and its dysregulation in glycogen storage disease.

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

Fano resonant optical coatings (FROCs) present an ideal platform for structural coloring from thin-film metamaterials. This platform provides full-color gamut coverage at greater than 61% of the CIE gamut, with exceptionally high purity (up to 99%) and high brightness. FROCs exhibit tunable iridescence, cost-effective and scalable manufacturing, and significant advantages over existing structural coloring schemes.

Zero-dimensional metal halides exhibit intriguing photophysical properties; however, developing their general design principles remains challenging. Now it has been shown that two-dimensional perovskites can be converted into zero-dimensional octahedral metal halides through solvent incorporation. The resulting materials feature near-unity photoluminescence quantum yields. Structural rigidity and the choice of metal cation are key parameters to tune the exciton recombination dynamics.

Spent LiCoO₂ batteries pose challenges for sustainable recycling. Here, the authors develop a flash Joule heating method to upcycle spent LiCoO₂ into a sulfur-stabilized Li₆CoO₄ lithium donor, enabling efficient lithium replenishment and improving full-cell durability.

The authors here show that the TRIM21–OTUD6A axis controls AKT activity through K27-linked ubiquitination, which is further regulated by S6K1-mediated phosphorylation, introducing a putative therapeutic strategy against AKT-driven cancers.