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High-latitude soils are future soil organic carbon loss hotspots, with losses dominated by particulate organic carbon (POC). The fraction of POC in total SOC (f_POC) is a key indicator, emphasizing the climate importance of preserving POC.

Pre-harvest sprouting (PHS) causes severe yield and quality loss in cereal crops worldwide. Here, the authors report a cyclic nucleotide-gated channel/Ca^2 + -permeable channel encoding protein negatively regulate PHS and its involvement in modulating of calcium and hormonal signaling pathways in wheat.

Researchers demonstrate a minimalist terahertz wireless transceiver in integrated photonics. They break the longstanding constraint between source purity and DSP complexity, realizing 144 Gbps high-speed transmission at subterahertz frequency.

SLCO4C1 is known for regulating kidney diseases. This study showed SLCO4C1 regulates hepatic cAMP uptake to suppress lipogenesis in MASLD. Targeting this pathway by FGF21 or forskolin suppressed lipogenesis.

StrucGAP is a structural glycoproteomics analysis platform that distills multi-dimensional information of glycoproteome datasets into structural and functional insights towards mechanistic studies.

Spatial principles of regulatory elements in primate cortex are poorly understood. Here, authors show a chromatin accessibility atlas identifying primate-specific cis-elements associated with psychiatric disease risks in specific cell types.

Converting light alkanes into useful olefins is hard because strong bonds and heat drive overoxidation. This study uses a copper-doped titanium dioxide photocatalyst to steer bond breaking, yielding ethylene and hydrogen.

This study presents a prefusion-stabilized vaccine candidate against Hantaan virus. The DNA and mRNA-LNP formats induce lasting neutralizing immunity in female mice, highlighting a promising advance in vaccine development.

Neuromorphic devices are currently constrained by their limited functionality. Zhi et al. report a ferroelectric heterostructure device that integrates Boolean, optoelectronic synaptic and photodetection operations, offering a pathway to realizing integrated sensing-memory-computing systems.

N-desethyl-fluornitrazene is a µ-opioid receptor agonist derived from nitazenes that has supramaximal intrinsic efficacy that produces analgesia with minimal adverse effects in rodent models.

Immune imprinting narrows the vaccine recall response towards dominant epitopes but protection against rapidly evolving viruses is enhanced if the breadth of responses is preserved. Here authors show in a ferret model that introducing optimized antigenic variation between prime and boost vaccines diversify the targeted epitopes and thus broadens immunity in a ferret model of influenza vaccination.

The genetic basis underlying resistance to Sclerotinia stem rot (SSR) in oilseed rape remains elusive. Here, the authors identify BnaA07.MKK9 as a pivotal regulator of SSR resistance in oilseed rape by GWAS, providing new insights into plant defense mechanisms against necrotrophic pathogens.

Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme conditions. Here, the authors show that the natural product P57 induces hypothermia by targeting pyridoxal kinase and has a potential application in therapeutic hypothermia.

BioMedAgent is a self-evolving LLM multi-agent framework that learns to use various bioinformatics tools and chain them into executable workflows for autonomously carrying out diverse biomedical data tasks initiated by natural-language prompts.

Perovskite–organic-based solar cells typically show poor reverse-bias stability. By modulating the deep trap state in the bulk-heterojunction region, organic and perovskite–organic tandem solar cells show largely improved stability under reverse biases up to –40 V.

Alternative targets are required for tumor therapy. The authors here show that transmembrane protein 175 (TMEM175) knock out in macrophages improves aPD-1 treatment prognosis with the mechanism of enhanced NLRP3 expression and antigen cross-presentation of macrophages.

In mice, a circuit between the spinal cord and various regions of the brain, centring on spinal-cord-projecting neurons in the rostral ventromedial medulla, has a key role in driving chronic pain.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

The Taiwan Precision Medicine Initiative (TPMI) has built a cohort of more than half a million individuals with Han Chinese ancestry, providing a rich resource of genetic and medical data for this group.

Controlling site selectivity in carbonyl desaturation to prepare α,β-unsaturated carbonyl compounds is challenging. Now, engineered ‘ene’-reductases are shown to enable the biocatalytic desaturation of cyclic ketones to enones with high site divergence. This platform allows late-stage functionalization of complex molecules, including terpenoids, and provides access to chiral enones via desaturative kinetic resolution.

Bioresorbable piezoelectric materials are key for bioelectronic–tissue integration but remain challenging to realize. Here, the authors develop flexible Rochelle salt/PLLA nanofibers that enable effective nerve regeneration and wireless monitoring of intestinal motility.

Mechanical response of semiconducting polymers affects their electrical properties, yet the detail remains elusive. Zhong et al. examine the multiscale structural evolution of conjugated polymer thin films during uniaxial deformation and link it to mechanical resilience and solar cell performance.

Ruan and colleagues show that vascular resident macrophage-derived Sparcl1 has a protective effect during aorta aneurysm progression by interfering with FGF2-induced dysfunctional lymphangiogenesis, TLS formation and immune cell recruitment.

The physics of resonant electro-optic microcomb generation is underexplored, limiting their potential applications. Now several technological advances are realized by studying the state space of a thin-film lithium niobate photonic frequency comb.

The precise molecular and physiological functions of the iron transporter Slc22a17 remain poorly understood. Here authors report mice lacking Slc22a17 expression in the brain suffer from iron overload, oxidative stress, and learning deficits.

A clinical trial testing whether monitoring ctDNA clearance during treatment for nasopharyngeal cancer could be used to inform decisions about an individual’s subsequent therapeutic programme shows promising results.

A unified optoelectronics platform comprising dual-comb generation, modulation and metasurface-enabled beam steering serves as a transmitter for any standards between 2G and 6G. This architecture reduces power usage and costs, enabling a direct link between edge data-centre devices and the wireless network.

A single-crystalline aluminum nitride seed layer improves crystal alignment in scandium-doped aluminum nitride films, and subsequent removal eliminates polarity mismatch, enabling high-performance film bulk acoustic resonators and wideband filters.

A model, trained to generate synthetic, patient-specific angiography images, reduced radiation exposure to patients and clinicians by two-thirds in a multicenter randomized controlled trial involving 1,068 patients.

Colorectal cancer has high recurrence and metastasis rates making treatment difficult. Here, the authors report on peptide modified cell membrane coated cobalt based metal-organic frameworks which degrades and forms, in situ, photothermal materials with H₂S, allowing for immune-photothermal therapy.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

Cross-dehydrogenative coupling (CDC) allows the efficient construction of C−C and C−heteroatom bonds. Now, single-platinum-atom-decorated graphitic carbon nitride is applied as a heterogeneous photocatalyst for CDC reactions between (hetero)arenes and nucleophiles without external oxidants.

Axially chiral arylpyrroles hold significant promise in catalysis, medicinal chemistry and materials science. Here, the authors report a copper-catalyzed dynamic kinetic asymmetric (4 + 1) cyclization enabling atroposelective synthesis of arylpyrroles with single stereogenic axes or 1,2-diaxes from 1,3- enynes and amines.

Wan, Li, Cao and colleagues report a feedback crosstalk between THY1⁺ cancer stem cells and neutrophils via migrasome-mediated release of mitochondria, which induces a pseudohypoxic state and promotes metastasis.

The alga Aureococcus anophagefferens can form dense brown-tide blooms partly because it adapts well to light changes. This study reveals two glutamate residues in its light-harvesting proteins as critical for dissipating excess light energy, supporting its survival and bloom formation.

An integrated photonics scheme is presented for the manufacture of communication systems supporting the use of fibre and wireless infrastructures simultaneously, addressing the long-standing bandwidth mismatch between the two domains and demonstrating ultrahigh data rates.

Surface plasmon-mediated steady-state and on-demand electronic spin modulation effectively activates light-driven plasmonic catalysis, facilitating polarization reactant activation and preferential reaction pathway modulation.