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The switching behavior of oxide-based memristors is governed by uncontrolled formation and rupture of conductive filaments. Here Li et al. report a device with ultrathin elemental oxygen reservoir layer to regulate the random migration of oxygen vacancy, enabling switching speed of ~10 ns and high energy efficiency.

Despite rapid development of model algorithms, more evidence is needed on the widespread clinical implementation of auto-segmentation tools. In this prospective, multicenter, observational trial, the authors find that AI-assisted delineation performs better than manual delineation while improving time efficiency and reducing performance metrics variability across centers and physicians with varying expertise.

High-latitude soils are future soil organic carbon loss hotspots, with losses dominated by particulate organic carbon (POC). The fraction of POC in total SOC (f_POC) is a key indicator, emphasizing the climate importance of preserving POC.

Authors reconstruct the molecular evolution of severe fever with thrombocytopenia syndrome virus (SFTSV) in East Asia. SFTSV splits into two lineages with diversity driven by segment-specific reassortment; transmission occurs via distinct networks.

RNA editing influences gene regulation in cancer. Here, the authors show that EZH2 regulates RNA editing by ADAR1 through remodeling its interactome and nuclear transport, thereby promoting MDM2 expression and prostate cancer progression.

Protein complexes are the machinery of life, yet mapping their structures across different species is challenging. This study presents an atlas of 1.1million cross-kingdom structures, revealing 181,671 high-confidence complexes that uncover new higher-order structures and evolutionary links.

Cellular responses to stimuli can involve learned behaviors through memory formation. Here, the authors show that cancer cells encode gene expression into cellular memories during therapy resistance via the transcription factor AP-1.

This study explores the role of protein hyperacetylation in heart failure with preserved ejection fraction (HFpEF). It identifies Dlat as a key regulator of mitochondrial fatty acid oxidation, offering insights for clinical HFpEF interventions.

This study reveals an sRNA-centered signaling pathway that activates nitrate respiration and enhances Cronobacter sakazakii virulence in oxygen-limited host environments, offering important insights into therapeutic strategies.

This study reveals that the rice false smut fungus disrupts floret development and suppresses immunity by secreting the effector Sxp1, which targets a lipid transfer protein and interferes with lipid signalling required for pollen fertility and immune responses.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

RNA-sequencing’s conversion of molecules to reads confines analysis to relative fold-changes, a metric unreliable across batches. Here, the authors introduce TranScale, a spike-in method with 100 biomimetic standards that converts reads into absolute quantities to resolve systemic biases.

Recent advances in molecular diagnostics underscore the need for improved sensitivity and specificity in cancer detection, yet multi-type nucleic acid response logic gates remain underexplored. Here, the authors introduce a dual-biomarker platform using rolling circle amplification and nucleic acid logic gates targeting miR-21 and lncRNA MALAT1, enhancing diagnostic accuracy in lung cancer detection.

This Article calculates how three barriers (water, steep mountains and national borders) limit urban growth and interconnectivity for more than 13,000 cities around the world. It found that natural barriers are associated with denser, smaller, greener and less land-hungry cities.

Soil bacterial and fungal necromass carbon is linked with plant species richness with a stronger positive correlation in the topsoil than in the subsoil, according to observations along a 3,000 km transect in grasslands on the Tibetan plateau.

Combining metabolic theory with global datasets, Li et al. show that root water content is a stronger predictor of root growth traits than the widely considered root nitrogen, better reflecting fast acquisition strategies and leaf–root alignment.

Aluminium offers an attractive alternative anode for lithium-ion batteries, but its practical performance falls far short of the theoretical promise. Here, the authors present a yolk-shell structured nanocomposite anode of aluminium core and titanium oxide shell which displays outstanding electrochemical properties.

Li₅FeO₄ is a high-capacity prelithiation agent but suffers from poor air stability. Here, authors apply a carbon coating strategy to significantly improve its resistance to moisture, enabling over 92% capacity retention after 72 h exposure to ambient air.

Sepsis’s profound heterogeneity complicates prognosis and stratification. Here, the authors show that SepsisFormer and SMART, explainable AI models integrating coagulation–inflammation markers, enable outcome prediction, real-time risk assessment, and subgroup identification to guide sepsis therapy.

Machine learning models using PacBio kinetic signals enable high-sensitivity detection of dZ-DNA and single-nucleotide A/Z base calling to explore the biological roles and biotechnological potential of 2,6-diaminopurine.

Stable inorganic solid-state electrolytes are crucial for reliable all-solid-state battery development. Here, the authors report a Li-In|Li_6.8Si_0.8As_0.2S₅I|Ti₂S lab-scale cell with a long cycle life of almost 62500 cycles at 2.44 mA cm⁻², 30 °C and 30 MPa.

Age-related obesity is a major health issue with unclear causes. This work reveals that the enzyme GSNOR promotes obesity by reducing mitochondria in fat, leading to tissue “whitening” and identifying it as a potential therapeutic target.

The slow redox kinetics of polysulfides and the difficulties in decomposition of Li₂S are two serious obstacles to lithium-sulfur batteries. Here, the authors report an isolated Fe-Co heteronuclear diatomic catalyst to achieve high efficiency bifunctional catalysis for lithium-sulfur batteries.

Photocatalytic four-component reaction is a green and efficient synthetic strategy. Here, the authors report a series of covalent organic frameworks via the photocatalytic four-component reaction, which are used for photocatalysis.

Population genomics has primarily focused on sequence polymorphisms rather than gene expression diversity. Here, the conduct RNA-seq for 328 common wheat lines to investigate the role of gene expression variation in shaping agronomic traits and their contributions to modern wheat improvement.

This study identifies a long non-coding RNA regulating anthocyanin biosynthesis in purple tea leaves, highlighting potential breeding targets.

Ceramic capacitors face challenges in energy storage performance at high temperatures, restricting their applications. Here the high-performance BaTiO₃-based capacitors, as a paradigm, are designed by constructing weakly coupled polar nanoclusters.

The researchers exploit lattice-anchoring-enhanced dynamic repair in organic–inorganic hybrid perovskites to demonstrate a single-crystal detector with a sensitivity of 165.6 μC mGy⁻¹ cm⁻³ and radiation stability under high-fluence 6-MeV X-rays (6.4 × 10¹¹ photons cm⁻²) and 1.2-MeV electrons (6 × 10¹⁶ electrons cm⁻²). The findings may have implications for diverse applications, including radiation therapy, astronomy and nuclear technology.

Dendrobium is a genus of mostly epiphytic and lithophytic orchids. Here, the authors conduct comparative genome analysis for 24 chromosome-level genome assemblies and genome skimming sequencing data for 204 species in this genus, and reveal genomic variation, biosynthesis and evolutionary adaptation in Dendrobium orchids.

This study shows that circulating proteins mediate the health effects of air pollution on multiple diseases and proposes a protein-based risk score for prediction of pollution-related disease susceptibility.

Xu et al. report that inhibition of the F-box protein FBXL2 enhances HER2 expression, rendering HER2-negative breast cancer sensitive to the anti-HER2–drug conjugate trastuzumab deruxtecan.

Resonant p-shell excitation of a Purcell-enhanced In(Ga)As quantum dot–micropillar system enables efficient biexciton loading, leading to efficient two-photon emission with strong two-photon correlations and a high two-photon fraction.

A foundation model validated in a prospective multi-centre cohort of 21,601 patients undergoing low-dose computed tomography screening for breast and lung cancer showed comparable performance to existing screening by radiologists.

Anthropogenic nitrogen enrichment reduces symbiotic nitrogen fixation, but environmental factors alone cannot explain this response. This meta-analysis shows that integrating both environmental factors and plant performance traits improves the predictive accuracy of symbiotic nitrogen fixation responses by 42.7%.

Protected areas (PAs) are central to China’s forest conservation strategy, yet their carbon storage effectiveness under different governance and management contexts remains uncertain. Here, authors show that stronger protection enables substantially greater forest carbon gains in China’s PAs, both now and in the future.

Much has been said about the high-energy, long-lasting potential of Li metal batteries, and yet little has been demonstrated at the cell scale. Here, Jun Liu and colleagues demonstrate a Li metal pouch cell with a 300 Wh kg⁻¹ energy density and a 200-cycle lifetime.

Imprinting by influenza viruses can cause a deleterious shift of nearly the entire memory recall response against key, conserved epitopes.

Quantum coin flipping is an essential cryptographic building block for distrustful scenarios. Here, the authors implement this protocol using polarisation-encoded single-photon states and show a quantum advantage compared to both classical realizations and implementations using faint laser pulses.

The efficacy of the TGF-β×PD-L1 bispecific antibody (BsAb) is not promising clinically. The authors here develop a Y101S, an antibody-drug conjugate targeting TGF-β, PD-L1, and STING, which manifests superior anti-tumor efficacy in preclinical models with the mechanism of enhanced CXCL16 mediated cytotoxic CXCR6⁺ T cells recruitment.

Primary alkyl amines are highly reactive in N-nucleophilic reactions with electrophiles but their α-C–H bonds are unreactive towards electrophiles due to their extremely low acidity. Combining 8-diazafluoren-9-one with an iridium catalyst, the authors demonstrate direct asymmetric α-C-H alkylation of unprotected primary alkyl amines with allylic carbonates.