Search

Trace benzene poses a risk to the health and safety of humans, resulting in a challenging task. Here authors synthesise double-walled Al-based MOF ZJU-520(Al) with trace benzene adsorption (5.98 mmol g^–1) and excellent benzene/cyclohexane separation ability.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

In China, adopting zero-carbon buildings at a 1.5 percent annual rate could reduce 1.21 gigatonnes of carbon dioxide emissions annually, with cost reductions through the use of recycled materials, according to socio-economic data and a building carbon emission simulation model.

Diabetes can contribute to pancreatic cancer development as well as be a consequence of it. Here, the authors report that diabetes-induced senescence of endothelial cells promotes pancreatic cancer progression.

Allergic asthma is episodic and associated with seasonal changes which may have links with UV exposure levels. Here the authors propose a link between UVB exposure and ILC2 function through α-MSH released from the pituitary gland which accumulates in the serum and alters ILC2 function through the MC5R receptor.

Angiogenesis-targeting secretome therapies may provide a new therapy for ischemic heart disease. Here, the authors show that CCL28 promotes angiogenesis via CCR10 signaling, and recombinant CCL28 offers therapeutic potential in ischemic models, including diabetic conditions.

The functional roles of circular RNAs (circRNAs) in the progression of colorectal cancer remain to be studied. Here the authors report that an alternatively-circularized circMAN1A2(2,3,4,5) promotes colorectal cancer cell proliferation via enhancing target mRNA stability.

Trained and validated on multimodal data from 14.5 million images from multicountry datasets, a foundation model is shown to increase diagnostic and referral accuracy of clinicians when used as an assistant in a trial involving 16 ophthalmologists and 668 patients.

Familial spastic paraplegia (SPG) is a rare heritable neurodegenerative disorders. Here, the authors show SPG80-associated protein UBAP1 deficiency disrupts lysosomal and mTORC1 signal, indicating rapamycin could potentially benefit SPG80 patients.

Tailored to provide diabetes management recommendations from large training and validation datasets, an artificial intelligence system integrating language and computer vision capabilities is shown to improve self-management of patients in a prospective implementation study.

The Mannich reaction has long been used by chemists for the synthesis of stereoselective synthesis of β-amino-carbonyl compounds. Here, the authors show a catalytic homo-Mannich reaction of cyclopropanols with in situ-formed imines, furnishing chiral 2,6-disubstituted piperidines in good yields with high diastereoselectivities due to the use of a diketiminate-complexed copper.

Green and sustainable ⁹⁰Sr uptake is urgently needed for radionuclides remediation. Here the authors propose an efficient strategy based on the electrochemically switched ion exchange (ESIX) method to enhance ⁹⁰Sr uptake using the electroactive ion exchange material.

Structural variations (SV) contribute to inter-individual variability. Here, the authors describe a first-generation multi-ancestry Asian SV catalogue containing 73,035 SVs from 8392 Singaporeans to provide insights into Asian SV diversity.

Both the pyrroloindoline core and N–CF3 moiety hold significant importance in medicinal chemistry. Herein, the authors present a simple approach to assembling such intriguing skeletons from tryptamine-derived isocyanides through a cascade sequence, which includes an oxidative trifluorination and a subsequent halogenative cyclization.

NICER is a broad-spectrum nanovaccine based on a nanovesicle system that can induce an effective immune response via epigenetic regulation to target both cancer stem-like cells and bulk tumour cells to prevent tumour recurrence.

The low activity of PylRS hinders the efficient production of ncAA containing proteins. Here, authors apply machine learning to engineer the tRNA-binding domain of PylRS, obtaining variants with improved stop codon suppression efficiency and achieving higher yields of proteins containing various ncAAs.

Here, the authors sample air and surfaces in hospital rooms of COVID-19 patients, detect SARS-CoV-2 RNA in air samples of two of three tested airborne infection isolation rooms, and find surface contamination in 66.7% of tested rooms during the first week of illness and 20% beyond the first week of illness.

The evolutionary emergence of a nested fibrillar centre–dense fibrillar component may have optimized pre-rRNA processing.

The genetic basis of grapevine thermotolerance remains poorly understood. Here, the authors identify WRKY transcription factor TTC4 as a positive regulator of thermotolerance and reveal its possible upstream repressor SPL13 and downstream target genes HSP18.1 and APX3.

A microwave-rate soliton microcomb whose repetition rate can be modulated at 75 MHz. Moreover, the repetition rate can be locked to an external microwave reference by direct injection locking or feedback locking without external modulation.

Red, green and blue CdSe/ZnSe quantum dot light-emitting diodes combine efficient operation with high brightness.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

This study reports that grassland degradation reduces ecosystem functionality while promoting soil biodiversity, highlighting the role of this diversity in sustaining degraded grasslands.

Excitation-dependent multicolour emission is desirable, but hard to obtain. Here, the authors report the development of a molecular symmetry breaking strategy to all excitation-dependent multicolour emissions from one chemical entity.

DeepRETStroke is a deep learning system using retinal photographs to detect silent brain infarction and predict future stroke events.

The diagnosis and prognosis of chronic kidney disease (CKD) relies on invasive renal biopsies, which can be clinically constrained. Here, the authors develop a non-invasive model using retinal images that can be used to screen for CKD and identify five common pathological types of CKD.

Wang and colleagues show that an AI-assisted designed peptide obstructs GSDMD pores and inhibits IL-1β and IL-18 release and pyroptosis.

Influenza virus infection is a global health threat and vaccines are required that show broad protection against a range of viral subtypes. Here the authors present a universal influenza vaccine based on Escherichia coli Nissle 1917 that activates innate and adaptive humoral and mucosal immunity, providing both immediate and long-term protection against influenza A virus infection in a murine model.

This study demonstrated that different types of HC-Pros from potyviruses exhibit varying capacities to inhibit HEN1. This results in distinct levels of autophagic AGO1 degradation, which in turn leads to differences in RNA silencing suppression efficiency.

By inducible and constitutive overexpressing ClpD-GFP to result in the accumulation of precursor proteins, this study presents comprehensive mechanistic insights in cellular responses to chloroplast precursor protein overaccumulation stress (cPOS).

Lenses made from metamaterials often suffer from narrow operational bandwidth and complex design. Here, Zheng et al.demonstrate an ultrathin graphene oxide lens with farfield three-dimensional subwavelength focusing from the visible to near infrared and an absolute focusing efficiency greater than 32%.

An ex vivo model and pre-clinical study in a brain-dead recipient provide enzyme-converted O organs to avoid hyperacute rejection in ABO-incompatible kidney transplant patients.

Wood and colleagues report that the XPO1 inhibitor selinexor activates PI3Ky-dependent AKT signaling in AML via upregulation of P2RY2 and demonstrate a synergistic effect of combining selinexor with inhibition of prosurvival AKT signaling.

Zhang et al. present a sequential electrochemical process that enables synergetic physical damage and chemical oxidation of antibiotic-resistant bacteria and antibiotic resistance genes, providing an efficient and residue-free water disinfection approach.

Prostate cancer is heterogenous in response to therapy. Here, the authors analyse genomics, transcriptomics, proteomics and phosphoproteomics data from 145 prostate cancer patients to identify NANS as a therapeutic target in prostate cancer.