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It is known that liquid drops can be levitated by continuous vapour flow above a liquid surface. Here the authors combine the ultra-low friction provided by the bath with the interaction force between two drops due to interface deformations to study the dynamics of interactions between multiple objects.

Phototoxicity can distort live-cell microscopy results, yet tools to measure it are limited. Here, the authors present PhotoFiTT, a machine learning–based framework that quantifies light-induced stress on cells, helping researchers optimise imaging protocols while protecting sample health.

A spatial and single-cell transcriptomics study across multiple mammalian species identifies epidermal BMP signalling as a functional requirement for rete ridge formation, providing insight into mechanisms underlying hair density loss and wound healing.

The successful transport of a trapped proton cloud from the antimatter factory of CERN using a transportable, superconducting, autonomous and open Penning-trap system that can distribute antiprotons into other experiments is reported.

The highest-quality JWST spectra reveal that little red dots are young supermassive black holes shrouded in dense cocoons of ionized gas, where electron scattering, not Doppler motions, broadens their spectral lines.

Tryptophan depletion in melanoma cells after prolonged treatment with interferon-γ (IFNγ) results in ribosomal frameshifting and the production of aberrant peptides that can be presented to T cells and induce an immune response.

Natural systems often exhibit complex self-assembled mesophases driven by intricate enthalpic interactions, as seen in block copolymers and surfactants. Using Monte Carlo simulations authors reveal that even simple achiral hard particles can form diverse mesophases, including chiral structures, hexagonal columnar, gyroid and lamellar phases, driven purely by geometric frustration arising from particle shape.

Bacteria use diverse defence systems against phages, including a 164-residue prophage-encoded protein, Rip1, which senses conserved phage assembly rings to form membrane pores that block virion maturation and trigger premature host cell death.

Microglia can alter their properties to adopt a wide spectrum of cellular phenotypes. Here, the authors show that remodeling of microglial mitochondria accompanies microglial responses to challenges and aging, and provide evidence that these organelles play a role in regulating basal microglial morphology, gene expression, and inflammatory profile.

Interfacial water is of crucial importance in biology and engineering. Here, the authors identify structural transitions of interfacial water at graphite surfaces under varying electric fields and environmental conditions.

Phylodynamic modelling shows how the changing antibiotic landscape and genetic determinants of resistance shape real-world gonococcal dynamics. Experiments validated that determinants with identical resistance phenotype differed in impact on fitness.

Cryogenic-electron tomography within infected cell nuclei reveals a spectrum of herpesvirus capsid assembly intermediates. Vertex-specific structural differences between genome-filled and empty particles clarify capsid assembly within the native cellular environment.

This study shows that strain-stabilized interfacial polarization in metallic RuO₂/TiO₂ heterostructures modulates the work function by over 1 eV and the metallicity, establishing a new route to control the electronic properties of functional metals.

Host antibodies can alter the glycan binding of adhesin proteins from infectious bacteria, but the antibodies’ mechanisms of action remain unclear. Here, the authors define four mechanisms of modulation, including ligand mimicry and multiple modes of allosteric interference.

Transcriptional adaptation upregulates UTRN in Duchenne muscular dystrophy (DMD) patients, as supported by several lines of evidence, including the use of splice-switching antisense oligonucleotides to induce the skipping of out-of-frame exons of the DMD gene.

DNA polymerases are molecular machines that copy genetic material using a template. Here, authors characterize the ability of diverse polymerases to synthesize DNA without a template and show that environmental conditions can alter sequence composition, enabling guided kilobasescale DNA synthesis.

A study combining group decision-making tasks with fMRI shows that the brain’s dorsomedial prefrontal cortex uses basis functions, similar to those in the visual, motor and spatial domains, to represent patterns of social interaction.

Attention fluctuates over time and across contexts—how is this reflected in the brain? Fitting a dynamical systems model to fMRI data, Song and colleagues show that the geometry of neural dynamics along the attractor landscape reflects changes in attention.

Prenatal Zika virus (ZIKV) exposure can lead to a spectrum of developmental issues, but the mechanisms remain unclear. Here the authors show that prenatal ZIKV exposure in macaques disrupts neurodevelopment, causing prolonged maternal attachment and visual deficits at 3 months that normalize by 12 months, independent of sensory function.

Peroxidases have long been considered to use ferryl heme intermediates (Fe(IV) = O) to catalyze oxidative chemistries. Here, Williams et al. find that ferric-oxyl (Fe^III–O^•–) excited states exist along the catalytic reaction coordinate of a peroxidase.

This Review discusses how cytokine multimerization affects the engagement of cytokines with their receptors and their biological activity. The authors explain the relevance of cytokine multimerization in disease settings and the implications for cytokine-targeting therapies.

The deep learning model STARLING can generate accurate ensembles of intrinsically disordered regions of proteins using only protein sequence as input.

The authors present evidence for the coexistence and coupling of ferroelectricity and superconductivity at amorphous LaAlO3/KTaO3(111) interfaces. Furthermore, flipping ferroelectric polarization reduces interfacial conductivity by more than 1000 times, and simultaneously suppresses superconductivity

In this study, a post-hoc analysis of medical records for individuals being treated with Cobenfy investigates real-world effectiveness, identifying predictors of response and suggesting the existence of biologically distinct psychosis subgroups.

Neural mechanisms underlying active avoidance are not fully understood. Here authors show that avoidance actions are positively reinforced by learned safety signals. With training, control shifts from goal-directed to habitual behavior via distinct dorsal striatal circuits, like reward-based learning.

Greenwald, Nederlof and colleagues developed a computational pipeline analyzing multiplex imaging data and established spatial patterns within breast cancer microenvironment that are predictive of immune checkpoint blockade response across treatment time course.

Activity in a set of parabranchial neurons in the mouse brain is increased during chronic pain, predicts coping behaviour, and can be modulated by circuits activated by survival threats.

It remains unknown why only some sickle cell disease (SCD) patients develop lung thrombosis. Here, the authors show that an extracellular vesicle-dependent mechanism prevents lung thrombosis in SCD and how a CD39 polymorphism impairs this protection to promote lung thrombosis in subset of patients.

The viscosity of tumour cells is shown to govern their ability to disseminate through the bloodstream and extravasate, establishing a key biomechanical factor of metastasis.

Simulations of Milky Way-like star clusters show that most (>57%) stars form in multiples. Approximately 75% of binaries are gravitationally bound from the birth of the secondary, and ~40% of (eventual) single stars originated in a multiple system.

CRISPR-Cas12a catalyses RNA-guided DNA cleavage. Here, authors present structure-function studies of a high-fidelity Cas12a variant that reveal how helical transition of a conserved “bridge helix” facilitates R-loop propagation and DNA cleavage.

In a study of four brain-dead human decedents, extracorporeal liver cross-circulation using genetically modified pig livers provides essential hepatic functions, supporting the feasibility of this approach for temporary liver support as a bridge to organ transplantation.

Oriented growth is an important pathway for crystal growth. Here, the authors show that gibbsite nanoplates form mesocrystals through directed sliding and staggered stacking, as demonstrated by in situ microscopy and molecular simulations.

A global analysis of marine fish populations involving 243 recruitment and 266 spawner time series across 143 species finds that nonlinear dynamics are widespread and that the degree of nonlinearity is amplified by temperature variation and in fast-lived species.

This paper uses multiomics to profile a large cohort of meningioma samples to highlight the role of the tumor microenvironment in driving the epigenetic changes underpinning tumor classification and prediction of outcome.

Optically trapped CaOH molecules in parity-doublet states achieve coherence times exceeding vibrational lifetimes, which are a defining milestone for the use of polyatomic molecules in quantum science.

RNAi therapy has huge potential but effective delivery to target location is a major issue. Here, the authors report on the delivery of RNAi to tumors using self-agglomerating nanohydrogels that can overcome the different delivery barriers and supply multiple RNAi payloads.

Measuring the electron affinity, a fundamental chemical property, has been challenging for rare elements due to sensitivity limitations. Here, the authors present a novel ion-trap technique capable of performing high-precision affinity measurements with orders of magnitude fewer samples.

Tan and colleagues present “cycling molecular assemblies” that borrow cellular lipidation machinery to build nanostructures inside the Golgi apparatus. These tools enable rapid organelle imaging and selective destruction of cancer cells.

Atomic-resolution microscopy and AI reveal how metallic nanowires grow inside carbon nanotubes through atom-by-atom wetting, advancing understanding of how next-generation materials can be synthesized from the atomic scale up.

Dense calcium imaging combined with co-registered high-resolution electron microscopy reconstruction of the brain of the same mouse provide a functional connectomics map of tens of thousands of neurons of a region of the primary cortex and higher visual areas.

Germline and somatic interactions define actionable genomic patterns driving acquired therapy resistance in breast cancer.

Determinants of WEE1 inhibitor sensitivity in cancer cells are largely undefined. Here, the authors show that WEE1 inhibitors beyond their cell cycle perturbing effects also lead to paradoxical activation of the integrated stress response kinase GCN2.

This study reveals that caveolae and caveolin-1 form a front-rear asymmetry in migrating cells, coupling membrane tension to RhoA-GEF recruitment and activation. This mechanosensing feedback regulates cell polarity and promotes persistent migration.

Chromosome folding in early zebrafish development starts with formation of fountains. These patterns, also prominent in other systems, form at active enhancers, depend on transcription factors, and reflect preferential loading of loop extruding cohesin at enhancers.