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Authors reconstruct the molecular evolution of severe fever with thrombocytopenia syndrome virus (SFTSV) in East Asia. SFTSV splits into two lineages with diversity driven by segment-specific reassortment; transmission occurs via distinct networks.

Lead halide perovskites are promising for artificial photosynthesis but are unstable in seawater. Here, the authors report multisite atomic-chlorine passivation to stabilize CsPbI₃ quantum dots in a hydrophobic covalent organic framework, enabling efficient H₂O₂ photosynthesis directly from seawater.

Extrachromosomal circular DNA (eccDNA) is a regulatory element involved in genomic stability and gene regulation. This study identifies widespread eccDNA in early mammalian embryos. These eccDNAs arise from active genomic regions, increase during a major wave of gene activation, and can regulate key developmental genes.

Maternal obesity is known to cause systemic lipid dysregulation, yet its effect on lipid reprogramming during the maternal-to-zygotic transition (MZT) remains unknown. Here, they show that obesity disrupts very-long-chain fatty acids (VLCFAs) storage in oocytes, impairing peroxisomal protein import in 2-cell embryos.

Global travel hubs could be key in future pandemic surveillance efforts. Here, using a global metapopulation model calibrated to epidemiology, phylogeography and air travel, the authors show that traveler-focused genomic surveillance at key hubs can speed up detection of SARS-CoV-2 variants under resource constraints.

IMiD-based PROTACs may degrade IKZF1/3 with hematologic effects. This study profiles these liabilities using hematopoietic assays showing stem cell rewiring and interferon activation and introduces a CRBN ligand that reduces them.

Thermochromic materials are promising for optical switching devices, though many examples are sensitive to environmental conditions. Here the authors report a phase-separating thermochromic ionogel with a wide temperature stability and enhanced mechanical properties.

Cultivated banana is threatened by Fusarium oxysporum f. sp. cubense tropical race 4 (TR4). In this study, the authors assemble the genome of Musa cheesmanii, a wild banana species that is highly resistant to TR4, and use it in crossbreeding with two cultivars to enhance disease resistance.

Recently, superconductivity was achieved in La3Ni2O7 and (La,Pr)3Ni2O7 thin films at ambient pressure due to in-plane compressive strain. Here, the authors report the enhancement of the superconducting onset from about 30 K to over 48 K by applying hydrostatic pressure to the films.

Euglenophytes evolved via secondary endosymbiosis, exemplifying plastid evolution. Here, the authors solve Euglena gracilis’ photosystem I structure, revealing specific protein organizations and structural features for far-red light absorption. This work informs the engineering of photosystem.

Manipulating cellular mechanotransduction is important for research and therapeutics. Here, the authors report on magnetically controlled gear-like MOFbots to stimulate microvilli, triggering intracellular signal and delivering therapeutics into cells via mechanotransduction controlled membrane permeability.

The reprocessability of covalent adaptable networks often comes at the expense of mechanical performance and thermomechanical stability. Herein, the authors introduce a dynamic N-hydroxyphthalimide-urethane bond to achieve thermomechanical stability and reprocessability in covalent adaptable networks.

Defects in quantum materials can reveal hidden electronic behaviour. Now a hidden chiral current state intertwined with a charge density wave has been observed in a kagome superconductor doped with magnetic impurities.

Androgen activity in the male embryonic hindbrain prolongs hindbrain differentiation in male individuals and drives sex differences in the incidence and prognosis of posterior fossa type A (PFA) ependymoma, an aggressive childhood brain tumour.

A set of hydroxy promoters physically mixed with cobalt oxides for syngas to light olefins conversion using Fischer–Tropsch synthesis is shown to boost catalyst performance as well as simplifying the process and increasing sustainability.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

In a phase 1b trial, patients with treatment-naive metastatic pancreatic adenocarcinoma received the CD73 inhibitor quemliclustat plus gemcitabine and nabpaclitaxel with or without the anti-PD1 antibody zimberelimab, showing encouraging clinical response rates and survival in quemliclustat-treated patients.

In a phase 1 trial, the in vivo generation of anti-BCMA CAR-T cells by lentiviral delivery was feasible and did not lead to dose-limiting toxicities in five patients with relapsed or refractory multiple myeloma.

Five nuclear spins in silicon and the [[4, 2, 2]] code are used to demonstrate a universal logical gate set and to execute a variational quantum eigensolver computation of the ground-state energy of a water molecule.

Façade-integrated photovoltaics (FIPV) present a promising yet early-stage solution for mitigating building emissions. Combining global building datasets, climate projections and façade-scale simulations, researchers estimate that FIPV could deliver substantial economic and climate benefits.

Digital array modulation microscopy uses natural Gaussian illumination and virtual detection modulation, together with a single-spectrum reconstruction algorithm, for three-dimensional super-resolution imaging with 300-nm and 100-nm axial and lateral resolution, respectively.

This work shows that XKR8-mediated plasma membrane lipid scrambling facilitates NET formation. Activated by caspase-3, XKR8 links ROS to downstream Ca²⁺ signaling and is essential for effective antifungal immunity.

ANNEVO advances accurate and scalable ab initio gene annotation of evolutionarily diverse genomes using deep learning approach modeling sequence evolution and long-range dependencies and mixture of experts (MoE) architecture.

Nontrivial topologies are long believed to survive only in gapped systems, yet recent progress suggests their existence even at quantum critical points. By preparing low-lying states on a superconducting processor up to 100 qubits and applying entanglement Hamiltonian tomography, the authors experimentally observe these nontrivial topological properties and suggest low-lying states as useful quantum resources.

The growth of high-quality organic single crystals is essential for probing intrinsic optoelectronic properties and molecular packing. Here, the authors present an additive-directed cocrystallization strategy to grow Y6-additive cocrystals with tunable thickness and controlled morphology.

Natural variation of the F-box protein ZmFBL41 in maize confers resistance to Rhizoctonia solani, the causal fungus for banded leaf and sheath blight in maize, through decreased interaction of ZmFBL41 with the cinnamyl alcohol dehydrogenase ZmCAD.

14-3-3 proteins play roles in plant growth and stress responses. Here the authors describe a phosphorylation-dependent ubiquitination switch that governs the activity of a rice 14-3-3 protein and immune reprogramming during M. oryzae invasion.

An integrated multi-taxa biogeographic analysis of 183 cavefish species endemic to China suggest that the origin and diversification of cavefishes are closely linked to the evolution of karst landscape since the late Eocene.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

The response of soil carbon to warming is critical feedback that has been difficult to constrain. This study uses a long-term experiment to show that precipitation modulates microbial and therefore carbon dynamics; drought leads to carbon loss with warming, but wet conditions increase soil carbon.

Cervical spondylosis is a highly prevalent degenerative disease that lacks visible lesions on medical images, making its diagnosis heavily reliant on scarce expert experience. Here the authors show a cascade-ensemble deep learning framework that achieves expert-level accuracy in diagnosing cervical degeneration by integrating multi-modal imaging data and analyzing key clinical indicators

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

GGC repeat expansions causing oculopharyngeal myopathy with or without leukoencephalopathy are located in small open reading frames and translated into polyglycine proteins that form cellular aggregates, driving neuronal and muscle cell dysfunction.

Increased glycolysis in pancreatic cancer promotes immune escape by altering the tumor microenvironment. Here, the authors show that lactate-driven histone lactylation via PCAF increases CXCL1 expression, recruiting neutrophils and enabling immunosuppression, and PCAF inhibition improves anti-PD-1 therapy in pancreatic cancer mouse models.

The authors demonstrate that targeted protein degradation of the dengue virus capsid suppresses infection through capsid-dependent pathways rather than classical inhibition, revealing a new antiviral strategy effective against resistant viral variants.

Yang et al. compare neoadjuvant triple therapy versus direct hepatectomy in patients with resectable intermediate or advanced hepatocellular carcinoma. The findings indicate that the neoadjuvant regimen improves overall and event-free survival but is associated with a higher risk of serious adverse events and postoperative complications.

Fibre integrated circuits created by first preparing circuitry on extremely thin and flexible substrates and then mechanically rolling them up demonstrate microdevice density reaching 100,000 transistors per centimetre and excellent stability under harsh service conditions.