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Epstein–Barr virus (EBV) is a widespread herpesvirus linked to cancer and autoimmune disease. The authors in this work design and characterize a stabilized prefusion form of gB, an essential viral fusion protein, advancing EBV vaccine and therapeutic development.

The annual flood of Tonle Sap Lake supports over 20 million people’s livelihoods. Riverbed lowering due to sand mining and sediment diversion has substantially reduced the annual flood pulse and is projected to worsen if business continues as usual.

The tendency of small objects to stick together as they come into contact is a commonly observed phenomenon. Yet the interactions that govern this behaviour can be complex. A systematic study of the variation in the force between a particle and a solid surface as they are brought together finds many parallels with the characteristics of glassy and granular systems.

An approach combining BONCAT, stable isotope probing and metaproteomics showcases the hidden metabolic interconnectivity of microorganisms within an anaerobic digestion community.

Introduction of structured neutron waves carrying orbital angular momentum (OAM) in small-angle neutron scattering experiments provides novel approaches to the characterisation of material properties. Here the authors demonstrate the retrieval of phase information in far-field intensity profiles by means of an interferometric technique using helical neutron waves.

We conduct experiments in a wave tank and show that waves with realistic three-dimensional spreading can become two times steeper than two-dimensional waves before breaking, with three breaking regimes identified.

MAGPIE is a computational framework for co-registering spatially-resolved transcriptomics, metabolomics and tissue morphology for integrated downstream analysis. Case studies across lung, brain and breast reveal coordinated cross-modality molecular changes.

Xenotransplantation of a genetically edited pig kidney with a thymic autograft into a brain-dead human for 61 days with immunosuppression resulted in stable kidney function without proteinuria, and xenograft rejection was treated and reversed by the end of the study.

Nucleic acid aptamers have emerged as promising alternatives to antibodies. Here, we show that incorporating unnatural bases enhances binding affinity by stabilizing the aptamer conformation and enabling specific engagement with hydrophobic pockets— acting like both armor and sword.

dSHERLOCK is a nucleic acid platform for the quantification of double-stranded DNA targets using CRISPR/Cas and isothermal amplification and is applied to quantify pathogen C. auris in clinical surveillance swab samples.

The Schrödinger impact event carved two canyons on the moon comparable in size to the Grand Canyon of North America. The directions of those canyons imply little debris covers the > 4-billion-year-old units that will be explored by Artemis astronauts.

Electrically conductive hydrogels based on conducting polymers often rely on covalent and therefore irreversible crosslinking mechanisms. Here, the authors report a thermo-responsive conducting polymer that undergoes a fully reversible non-covalent crosslinking at 35 °C within less than a minute to form conductive hydrogels.

The authors experimentally realize the control of the topological charge of magnetic skyrmionic structures at room temperature in a Dzyaloshinskii-Moriya interaction (DMI) platform with spatially alternating signs. By modifying the DMI energy landscape through chemisorbed oxygen, a magnetic topological transition is realized.

An in situ multistep edge-contact process is developed for MoS₂ transistors, achieving quasi-non-volatile capacitorless two-transistor dynamic random-access memory with 5-bit accuracy and nanosecond write speeds.

Halving nitrogen waste could help meet a broad array of Sustainable Development Goals, with associated societal benefits topping US$1.3 trillion, according to an integrated assessment framework that evaluates cost-effectiveness and environmental impacts.

Paraoxonase-1 (PON1) is a liver-specific glycoprotein that has been shown to be a tumor suppressor in hepatocellular carcinoma (HCC). Here, the authors show that PON1 reduces HCC tumor growth due to regulation of lactic acid production and regulatory T cell-mediated immunosuppression.

Perineural invasion and cancer-induced nerve injury of tumour-associated nerves are associated with poor response to anti-PD-1 therapy, which can be reversed by combining anti-PD-1 therapy with anti-inflammatory interventions.

Drug transport by ABC exporters has been associated with multidrug resistance in cancer and bacterial infections. Here, we describe structures of an ABC heterodimer that illuminate drug transporter interactions and the role of lipids in facilitating drug expulsion across membranes.

A species-level dataset of sediment-dwelling macrofauna, sampled 2 years before and 2 months after a test of a commercial deep-sea mining machine, reveals losses of macrofaunal density and species richness within the machine’s tracks and community-level effects in both the tracks and an area impacted by sediment plumes.

The nucleus connects to the actin cytoskeleton for nuclear movement in migrating cells. Here, the authors show that the endoplasmic reticulum shields actin cables to generate asymmetric nucleo-cytoskeleton connections for nuclear positioning.

Despite extensive structural studies elucidating how antigens are anchored to antigen-presenting molecules and presented to T cells, little is known about the display mechanism of the lipid-antigen-presenting molecule CD1c. Here, by combining structural immunology, lipidomics, and biophysical analysis, the authors reveal that the CD1c binding cleft accommodates two different lipids, one of them with a bulky headgroup positioned sideways for display to T cells, rather than upwards, different from the conventional upright antigen-presentation mode

Optical aberrations can hinder fluorescence imaging of thick samples, reducing image signal, contrast, and resolution. Here, the authors introduce a deep learning-based strategy for aberration compensation, improving image quality without slowing image acquisition or introducing more optics.

Jupiter’s magnetodisk mediates mass, momentum, and energy exchange between Jupiter’s atmosphere, ionosphere, magnetosphere, and moon tori. Here, the authors show that pressure anisotropy-driven instabilities regulate its nonequilibrium dynamics.

Mapping of the neutrophil compartment using single-cell transcriptional data from multiple physiological and patological states reveals its organizational architecture and how cell state dynamics and trajectories vary during health, inflammation and cancer.

A geological, petrographic and geochemical survey of distinctive mudstone and conglomerate outcrops of the Bright Angel formation on Mars reveals textures, chemical and mineral characteristics, and organic signatures that warrant consideration as potential biosignatures.

Recent MPXV outbreaks underscore the need for better vaccines and treatments. Here, the authors isolate and structurally characterize potent antibodies interacting with A28 that they identify as a key viral surface protein essential for viral entry and that induces strong, protective antibody response in mice.

The author demonstrates that laser-driven ultracold Fermi gases can exhibit color-orbit-like coupling with SU(3) symmetry. This leads to color-like oscillations and other quantum-chromodyamics-like phenomena in an atomic physics laboratory.

Scanning tunnelling microscopy is used to image pristine electrostatically defined quantum Hall edge states in graphene with high spatial resolution and demonstrate their interaction-driven restructuring.

Hi-C methods for studying 3D genome structure typically require millions of cells and struggle with repetitive regions. Here, authors develop CiFi, combining 3C with PacBio HiFi sequencing, enabling chromatin analysis from as few as 60,000 cells and chromosome-scale assembly from small samples.

Integrative epigenomic profiling of hepatocellular carcinoma reveals dual regulation of the immunotherapeutic target GPC3 and identifies retrotransposons as potential biomarkers for prognosis and immunotherapy response prediction.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

There are limited in vitro and in vivo models to study human fetal exposure to environmental noise. Here, the authors develop a computational model to quantify fetal exposure to acoustic fields, obtaining acoustic transfer characteristics across the human audio range.

At elevated temperatures, electron hydrodynamics efficiently eliminate the ‘bulk Landauer–Sharvin’ resistance, demonstrating that hydrodynamics can dramatically modify the well-established rules obeyed by ballistic electrons.

When interfaced with a current-carrying heavy metal, spin orbit effects can generate a torque on the magnetization of a ferromagnet, understood as a bulk effect. Here, the authors show evidence of an interfacial contribution to such spin orbit torque in O-doped W/CoFeB thin film systems.

Perturbations to strongly lensed galaxy light in very long baseline interferometric imaging reveal a dark and unusually low-mass object at redshift z ≈ 0.9.

Synthetic anti-ferromagnets, where two ferromagnetic layers are coupled anti-ferromagnetically via a spacer, are known for their very large current-induced domain wall velocities. Here, Guan et al show that the velocity of the domain walls in synthetic anti-ferromagnetic nanowires can be tuned over a wide range due to reversible oxidization via ionic liquid gating.

The prevalence of Alzheimer’s disease neuropathological changes is reported based on blood-based biomarkers in a Norwegian population-based cohort.

The role of mosquito saliva proteins in viral infection remains incompletely understood. Here, the authors show that sialokinin facilitates viral dissemination while suppressing immune response and inflammation in chikungunya virus-infected mice.

Plasmid-mediated transmission plays a significant role in the spread of carbapenem-resistant Enterobacterales. Here, analyzing 1,115 carbapenemase-producing plasmids from Singapore, the authors suggest that maintenance of conserved genomes adapted for stable propagation across multiple species, enables evolutionarily successful carbapenemase plasmid genotypes to achieve hyperendemicity in the population.

Observations of a luminous quasar from the high-resolution spectrometer Resolve aboard XRISM revealed highly inhomogeneous wind structure outflowing from a supermassive black hole, which probably consists of up to a million clumps.

Jails are high-risk settings for transmission of pathogens. Here, the authors use genomic and epidemiological data to investigate the bacterial and clinical factors affecting transmission of MRSA in jails and impacts on wider community transmission dynamics.

Phase singularities are known to have applications in various branches of optics. Here the authors demonstrate that phase singularities can be created and controlled, all optically, in a simple thin film of organic molecules using cavity-free strong light-matter coupling.

Soft-elasticity in monodomain liquid crystal elastomers (LCEs) is promising for impact-absorbing applications but due to the lack of synthetic procedures which give monodomain devices of sufficient size, impact studies on LCEs have not been performed. Here the authors use direct-ink writing to fabricate bulk monodomain LCE devices and study their compressive soft-elasticity.

Here the authors report an analysis of two large nationwide cohort studies, the UK biobank and NHANES, suggesting that accelerated biological aging mediate a proportion of the association between social determinants of health and all-cause and cause-specific mortality.

Here, using pre-HIV-infection and non-HIV samples in a multi-modal study of microbiomes and metabolomes, the authors develop a taxon-specific measure of DISruption in COrrelations (DISCO) revealing system-wide dysbiosis preceding HIV-1 infection in men who have sex with men.