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3D printing is useful for the preparation of soft materials with specific architectures, but can be limited by rheological complexity and nozzle limitations. Here, the authors report the development of a method using yield-stress inks in a fluid bath, with the filaments driven upwards or downwards.

Broadly applicable genetically encoded probes and peptide-based compounds specifically inhibit Gα_s, the prototypical signal transducer of G-protein-coupled receptors, providing new mechanistic insights into signaling at the subcellular scale.

Recent work has revealed quantum coherent phase slips and current quantization in superconductors, phenomena dual to Cooper pair tunneling and voltage quantization. By combining the two effects, the authors demonstrate a Bloch transistor, a device that delivers quantized current and features a unique phase-locking mechanism.

Drugs that rescue function of episodic ataxia 1 (EA1) mutant potassium channels are lacking. Here, Manville et al identify and describe the molecular basis for Native American botanical ataxia remedies that directly rescue EA1 mutant channels.

Electrochemical CO reduction to multi-carbon products offers a carbon-negative approach to produce chemicals, but the intricate reaction pathways lead to a broad spectrum of products. Now it has been shown that alkali cations alter the mechanistic pathways that govern the reaction selectivity involved in the formation of hydrocarbons versus oxygenates.

Here, Yang-Jensen et al. demonstrate that a scalable microbial protein lysate from Methylococcus capsulatus Bath reshapes gut microbiota and T cells and, via fermentation-driven GLP-2 receptor mimicry, protects against gastrointestinal inflammation while providing sustainable protein nutrition

Removing excess energy (cooling) and reducing noise in superconducting quantum circuits is central to improved coherence. Lucas et al. demonstrate cooling of a superconducting resonator and its noisy environment to sub-mK temperatures by immersion in liquid ³He.

A strategy based on the design of a composite coating that enables slip-enhanced close-contact melting inside sealed phase-change thermal batteries to improve charging rates enables high-performance thermal energy storage over a wide range of temperatures.

Using a non-human primate model, the authors identified the tissue sites of initial viral rebound after discontinuation of antiretroviral therapy, demonstrating that such rebound preferentially occurs in the gastrointestinal tract-associated lymphoid tissues.

Dietary changes can impact the microbial constitution of the gastrointestinal tract and modulate the local immune response. Here, the authors show supplementation using lysates of Methylococcus capsulatus Bath result in changes to the microbiota, modulate Treg populations and metabolic read outs in a dietary control murine model.

Plants utilize anion channels to adapt to environmental stresses. Here, authors elucidate the coordinated regulatory mechanisms within the SLAH family and demonstrate that tRNA molecules directly bind to and inhibit the SLAH1 anion channel.

A cortical premotor network in HVC, once initiated, can sustain and regulate the sequential production of zebra finch song syllables without major extrinsic inputs.

Decoherence of the nuclear spin bath causes decoherence of electron spin qubits in the solid state. Here, Chekhovich et al.use spin-echo measurements to demonstrate the suppression of nuclear spin fluctuations in semiconductor quantum dots via strain-induced quadrupolar interactions.

Donahue et al. show that ageing is associated with changes in ER morphology. ER-phagy drives age-associated ER remodelling through tissue-specific factors.

Direct air capture is a promising technology to mitigate the rising atmospheric CO₂ concentrations contributing to climate change. Here a covalent organic framework with high CO₂ capacity and cycling stability is reported to be capable of selectively and rapidly removing CO₂ from open air.

González-Gualda, Reinius et al. demonstrate that platinum-based chemotherapy-induced senescence promotes malignancy in ovarian and lung cancer via TGFβ ligands, with evidence in mouse models validated in clinical samples. Concomitantly blocking TGFβ signaling with chemotherapy reduces tumor burden and increases survival in mice.

Neurovascular interaction is critical for normal brain vascular development. Here, the authors show that neuronal NMDARs regulate brain vascular development via VEGF-induced global Ca2+ activities of endothelial tip cells.

The dopamine motivating animals to perform a current behavior also desensitizes local D₂ dopamine receptors. Dopamine signaling is less effective in subsequent rounds, resulting in repetition-induced devaluation of behavior.

dSHERLOCK is a nucleic acid platform for the quantification of double-stranded DNA targets using CRISPR/Cas and isothermal amplification and is applied to quantify pathogen C. auris in clinical surveillance swab samples.

An algorithm that combines deep learning, Bayesian optimization and computer vision techniques can be used to autonomously tune a semiconductor spin qubit from a grounded device to Rabi oscillations.

Targeting neurons that regulate energy balance may offer new approaches for obesity treatment. Here, authors show that chemogenetic and pharmacological manipulation of GABAergic neurons in the DRN/vlPAG increases adaptive thermogenesis and reduces weight gain in mice fed a highfat diet.

Understanding the mechanisms underlying the survival of drug tolerant persister cells following chemotherapy remains elusive. Here, multi-omics analysis and experimental approaches show that the germ-cell-specific H3K4 methyltransferase PRDM9 promotes metabolic rewiring in glioblastoma stem cells.

Near-term quantum computers hold many promises but remain limited to a moderate number of qubits. This Article presents a pathway for modeling correlated materials with a reduced number of qubits, bringing quantum computing to materials modeling.

Studies of Bloch oscillations in many-body systems remain limited due to their interaction-induced damping. Now, such oscillations have been observed in a solitonic wave packet of atoms in a Bose gas at the mesoscopic scale.

Here the authors show that PARP inhibition activates SIRT-1–FOXO1 signaling to drive transcriptional and metabolic reprogramming of CD8⁺ T cells into central memory T cells with superior recall capacity and efficacy in adoptive therapy.

Many biological systems appear to organize their dynamics close to a critical point. Now it is shown that the protein array mediating Escherichia coli chemosensing is near-critical, enabling large signal amplification without compromising response speeds.

Experimental realizations of discrete time crystals have mainly involved 1D models with Ising-like couplings. Here, the authors realize a 2D discrete time crystal with anisotropic Heisenberg coupling on a quantum simulator based on superconducting qubits, uncovering a rich phase diagram.

An efficient quantum thermal simulation algorithm that exhibits detailed balance, respects locality, and serves as a self-contained model for thermalization in open quantum systems.

A combination of biochemical, cell biological and electron microscopy analyses reveal a ‘nucleotide code’ that coordinates Lis1–dynein binding stoichiometry, which in turn governs Lis1’s ability to relieve dynein autoinhibition.

The [1,2]-Wittig rearrangement of allylic ethers is traditionally considered to proceed via formation and recombination of radical pairs. Now it has been shown that an alternative reaction cascade, involving initial enantioselective [2,3]-rearrangement followed by base-promoted anionic fragmentation–recombination that proceeds with high enantiospecificity, allows a catalytic enantioselective [1,2]-Wittig process.

Examples of materials with non-trivial band topology in the presence of strong electron correlations are rare. Now it is shown that quantum fluctuations near a quantum phase transition can promote topological phases in a heavy-fermion compound.

Controlling the hydrothermal reaction kinetics during the fabrication of Sb₂(S,Se)₃ solar cells is challenging. Chen Qian et al. show that sodium sulfide buffers the pH and allows a controlled release of Se, enabling a certified efficiency of 10.7%.

Using a frequency-comb nuclear magnetic resonance spectroscopy technique it is possible to probe the fluctuations in the nuclear spin bath of a self-assembled quantum dot and reveal long nuclear spin correlation times over one second.

Here they demonstrate a therapeutic intervention elevating levels of CYP450-derived lipids to control the expansion of intermediate monocytes in tissue and peripheral blood, presenting a first in class therapeutic approach for treating chronic inflammatory disease.

The Josephson effect produces a supercurrent between two superconductors separated by an insulator, but it also leads to more exotic effects like electric quantum diffraction. Here, the authors show the appearance of Fraunhofer diffraction for thermal currents in a thermally biased Josephson junction.

Extrachromosomal circular DNAs (ecDNAs) are prevalent in human cancers and are thought to drive tumor evolution and drug resistance by amplifying oncogenes. Here, authors develop ec3D to reconstruct three-dimensional ecDNA structures, revealing how their spatial organization rewires regulatory circuits.

Wei et al. perform spatial transcriptomic profiling on synovial tissue biopsy samples from individuals with recent-onset rheumatoid arthritis, finding TGFβ signaling and fibrogenic fibroblast activation drive a treatment-refractory tissue phenotype.

Genomic and transcriptomic analysis of samples from patients with multiple myeloma, followed by in vitro validation, indicate mechanisms of antigen escape in response to GPRC5D T cell-engager talquetamab, including biallelic deletions, small nucleotide variants, insertion-deletions and chromatin silencing.

Hepatocyte-specific GPR110 mediates metabolic dysfunction-associated steatohepatitis progression by regulating hepatic oestrogen sensitivity in a sex-specific manner, specifically in female mice.