Search

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

Park et al. report a field-tailoring strategy by using n-type InAs as the absorber and p-type InAs as the hole transport layer to suppress leakage current for colloidal quantum dot photodetectors, enabling a low dark current of 9.7E-7 A cm2 and fast response time of 24 ns at 1,500 nm.

Three-body low-energy s-wave states play an important role in few-body physics and associated universal phenomena, yet their experimental observation in nuclear system has been elusive. Here, the authors identify the three-body s-wave properties in neutron-rich ¹⁰He nuclei with improved statistics and sensitivities.

The interplay between heavy fermion systems and geometric flat bands is often hindered by a scarcity of material realizations. Here, the authors report on the coexistence of geometrically frustrated flat bands and Kondo resonance states near the Fermi level in YbCr₆Ge₆.

Engineered molecular circuits encoded in RNA can act as programmable therapeutics that sense cellular states and elicit precise responses within diseased cells. Here, the authors introduce a model delivery system with layered control of targeted infection, conditional replication, drug-inducible viral clearance, and molecular circuit-based cargo regulation, demonstrating a versatile platform for precise RNA viral vector delivery.

Here, the authors show that the Saccharibacteria Nanosynbacter lyticus strain TM7x elicits limited immune activation in the oral cavity, and binds to gingival epithelial cells via a T4P-dependent mechanism, leading to clustering of TLR2 receptors and subsequent caveolin-mediated endocytosis.

Coronary artery disease has several genetic risk factors. Here, the authors develop a model that combines germline and somatic genetic drivers to predict coronary artery disease risk, identifying high-risk individuals not detected by polygenic risk scores alone.

The authors developed a microfluidic human stem cell model of the embryonic spinal cord. The model mimics complete dorsoventral patterning, reveals new retinoic acid-BMP signaling crosstalk, and enables direct tracking of neural crest cell migration.

The authors from the ALICE collaboration identify multiple species of mesons and baryons and measure the anisotropic flow with non-flow removal techniques in pp and p-Pb collisions at the LHC, identifying the hallmark of quark flow associated with an expanding quark-gluon plasma.

Aging boosts diabetic kidney disease risk via shared renal pathology. Renal RORγ is downregulated in diabetes/aging; its tubule-specific loss worsens injury, and overexpression protects. RORγ stabilizes INSIG1 via YOD1/CAB39, blocking SREBP2/STING.

IL-17RA signaling on Paneth progenitors, via ADAM17, modulates Paneth cell dedifferentiation and their ability to replenish the intestinal crypt post-irradiation injury.

This study by Lai et al. reveals a noncanonical role for DRP1: during inflammation it enters the nucleus and activates NF-κB– lipocalin-2 signaling, driving neuroinflammatory gene expression independently of mitochondrial dysfunction.

When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

An early event after lung injury is extracellular matrix remodelling. Here, the authors show that thrombospondin-1 (TSP1) from megakaryocytes/platelets protects the lung’s extracellular matrix, particularly basement protein COL6. Mice without TSP1 had greater lung damage and neutrophil activity, showing TSP1 reduces injury severity.

KRAS G12C inhibitors have improved outcomes but mainly in non-small cell lung cancer and colorectal cancer, despite it being a well-established oncogene in a range of cancer types. Here, the authors present a first-in-human phase I/II clinical trial investigating the next-generation KRAS G12C inhibitor, olomorasib, in KRAS G12C-mutant advanced solid tumors.

Robustness checks and reproduction of analyses with existing and updated data based on 110 articles in economics and political science journals with data and code-sharing requirements found high levels of robustness and reproducibility and determined that robustness was not dependent on author characteristics or data availability.

DEUP1 is dispensable for centriole amplification but essential for basal foot integrity in multiciliated cells. Localized to a CNTRL-adjacent basal foot subdomain, DEUP1 loss disrupts planar polarity, CSF flow, and long-term ciliary maintenance.

Approach and avoidance behavior is disrupted in many psychiatric disorders, but the neural circuits that support this behavior are unknown. Here, the authors identify a theta-mediated limbic circuit that support approach and avoidance decision-making, contributing to a network understanding of psychiatric disorders, especially those characterized by maladaptive avoidance.

The authors have applied an eight-tissue rat multi-omic dataset to analyze the gene regulatory landscape of endurance exercise training, identifying tissue-specific regulatory patterns involved in muscle function, metabolism and immune response.

A large-scale study on the replicability of claims from social and behavioural science journals reports that about half of the results replicate in the same patterns as the original study.

Macrophage-dependent phagocytosis elicits robust antitumor immunity. Nevertheless, therapeutic strategies harnessing phagocytosis have been met with limited success. Here the authors demonstrate that dual-phagocytosis checkpoint blockade, achieved by simultaneously targeting CD47 and CD24, greatly enhances tumor cell phagocytosis thus increasing antigen-presentation capacity, cGAS-STING activation and T cell infiltration into the tumor microenvironment, ultimately fostering robust antitumor immunity in preclinical mouse models of glioblastoma.

The CCTG PA.7 randomized phase II trial compared chemotherapy with and without dual immune checkpoint inhibition in patients with metastatic pancreatic ductal adenocarcinoma. Here, the authors report long-term survival and exploratory analysis of the CCTG PA.7 trial, identifying a pattern of mutations linked to improved immunotherapy response.

Using nasal brush biopsies from the olfactory region, single-cell profiling revealed neuroimmune alterations in Alzheimer’s Disease detectable at a pre-clinical stage, offering an accessible window into early neurodegenerative disease in humans.

This study reveals that declining anthropogenic aerosols can amplify the weakening of the Northern Hemisphere Hadley circulation, highlighting the critical role of aerosol reductions in driving tropical circulation changes in the 21st century.

Managing hydrocephalus relies on non-specific symptoms. Here, the authors report a 0.28-gram implant that measures intracranial pressure long term, tested in pediatric and adult patients.

A study of reproducibility in a stratified random sample of 600 papers published from 2009 to 2018 in 62 journals spanning the social and behavioural sciences finds higher reproducibility among more recent papers and papers from journals that require data sharing.

Plasma ctDNA testing for FGFR alterations in metastatic urothelial carcinoma shows high concordance with tissue testing and identifies additional patients with actionable alterations. Here, the authors show that clinical uptake of ctDNA FGFR testing can be combined with tissue-based approaches.

This study develops and validates a prognostic staging framework for Alzheimer’s disease by integrating cognitive status with blood-based biomarkers, and neuroimaging data, to improve risk stratification across the disease continuum.

Patients with myelodysplastic syndromes (MDS) have limited therapeutic options. Here the authors show that functionally impaired NK cells contribute to immune escape of pre-malignant clones in early stage MDS and that NK adoptive cell therapy can be considered to prevent or delay the development of MDS.

An analysis of whole-exome sequencing data linked to longitudinal electronic health records from 44,028 British South Asians finds new gene–phenotype associations and identifies 2,991 genes with rare biallelic predicted loss-of-function genotypes.

A technique called condense-seq has been developed to measure nucleosome condensability and used to show that mononucleosomes contain sufficient information to condense into large-scale compartments without requiring any external factors.

Age-related microbiome changes increase medium-chain fatty acid-producing bacteria, driving GPR84-mediated myeloid inflammation, impaired vagal signalling and hippocampal dysfunction; targeting this gut–brain pathway restores memory in aged mice.

Longitudinal metatranscriptomics in a prospective cohort of 1,164 adults hospitalized for COVID-19 reveals that azithromycin offered no apparent anti-inflammatory benefit but enriched the respiratory microbiome with potential pathogens and antimicrobial resistance genes.

In atopic dermatitis (AD), skin barrier disruption leads to chronic inflammation. Here, the authors use single-cell sequencing to map human skin, uncovering AD-specific cell states and populations involved in immune responses and cell differentiation.

The authors present an archaeological sequence and paleoenvironmental proxies from the Buhais Rockshelter (UAE) dating to between 60-16,000 years ago. They demonstrate that human occupation of this arid landscape corresponded with increased water availability, expanding a limited archaeological record in this region.

The excitatory neuron diversity and specialized connectivity of complex, multilayered mammalian neocortex are driven by mammalian-specific cis-regulatory elements bound by ZBTB18, deletion of which disrupts gene expression and results in projection patterns resembling those of non-mammalian brains.

SingleBrain integrates publicly available single-nucleus RNA sequencing and genotype data from 983 individuals of European ancestry, mapping eQTLs across major brain cell types and subtypes and providing insights into the genetic regulation of brain disorders.

A bioelectronic device incorporating triphylite (LiFePO₄) as electrode is used for lithium-ion-specific inhibition of peripheral and central nervous system activities in rats and in mice.

Many vascular‑disease risk loci lack defined causal genes. Here, the authors integrate functional genomics and CRISPR screens to identify genes influencing smooth muscle cell behaviour, validating roles for FES, BCAR1, CARF and SMARCA4, with Fes loss promoting atherosclerosis and hypertension.

Lunar rocks, not subject to complex crustal dynamics, reveal evolutionary aspects of the Earth-Moon system. The authors find that lunar ilmenite (age: 3.78 Ga) can host excess titanium in a trivalent state due to redox conditions not found on Earth.

In this study, Agathos et al. examine alterations in thalamocortical network connectivity during cognitive restructuring of negative cognitions in individuals with post-traumatic stress disorder, using ultrahigh-field 7-T functional MRI and dynamic causal modeling.

Results of the phase 2 POLAR trial show that biomarker-guided treatment in patients with metastatic pancreatic cancer based on homologous repair deficiency leads to encouraging clinical response rates in immune cell-infiltrated tumors.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Genomic and transcriptomic profiling reveals divergent clonal evolution and TME remodeling in gastric cancer peritoneal metastasis, highlighting substantial heterogeneity and the need for metastasis-specific therapeutic strategies.

Analysis combining multiple global tree databases reveals that whether a location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

Recent work has revealed quantum coherent phase slips and current quantization in superconductors, phenomena dual to Cooper pair tunneling and voltage quantization. By combining the two effects, the authors demonstrate a Bloch transistor, a device that delivers quantized current and features a unique phase-locking mechanism.

Owing to electron localization, two-dimensional materials are not expected to be metallic at low temperatures, but a field-induced quantum metal phase emerges in NbSe₂, whose behaviour is consistent with the Bose-metal model.